Occupational respiratory allergy in bakery workers: A review of the literature

American Journal of Industrial Medicine

Volumn 34, Issue 6, 1998, Pages 529-546

  Houba, Remko ^a,b   Doekes, Gert ^a   Heederik, Dick ^a  

^a WAGENINGEN UNIVERSITY   (Netherlands)

^b MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

Baker's asthma; Exposure assessment; Exposure response relationships; Fungal alpha amylase allergens; Occupational asthma; Respiratory allergy; Wheat flour allergens

Indexed keywords

ALLERGEN; AMYLASE; FOOD ALLERGEN; FUNGAL AMYLASE; GLUCAN 1,4 ALPHA GLUCOSIDASE; GLUCOSE OXIDASE; PROTEINASE; UNCLASSIFIED DRUG;

ALLERGENICITY; ASPERGILLUS; CONJUNCTIVITIS; FLOUR; FOOD INDUSTRY; HUMAN; HUMAN CELL; HUMAN TISSUE; OCCUPATIONAL ASTHMA; OCCUPATIONAL EXPOSURE; REVIEW; RHINITIS; RISK ASSESSMENT; RISK FACTOR; SACCHAROMYCES CEREVISIAE;

EID: 0031744014     PISSN: 02713586     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0274(199812)34:6<529::AID-AJIM1>3.0.CO;2-I     Document Type: Review

References (179)

1. Adachi T, Alvarez AM, Aoki N, Nakamura R, Garcia VV, Matsuda T (1995): Screening of rice strains deficient in 16-kDa allergenic protein. Biosci Biotech Biochem 59:1377-1378.
2. Alday E, Moneo I, Lucena R, Curiel G (1995): Alpha-amylase hypersensitivity: diagnostic methods. Allergy 50(Suppl 26):88.
3. Alday E, Curiel G, Lopez-Gil MJ, Carreno D, Moneo I (1996): Occupational hypersensitivity to sesame seeds. Allergy 51:69-70.
4. Alvarez MJ, Tabar AI, Quirce S, Olaguíbel, Lizaso MT, Echechipía S, Rodríguez A, García BE (1996): Diversity of allergens causing occupational asthma among cereal workers as demonstrated by exposure procedures. Clin Exp Allergy 26:147-153.
5. Ameille J, Pairon JC, Bayeux MC, Brochard P, Choudat D, Conso F, Devienne A, Gamier R, Iwatsubo Y (1997): Consequences of occupational asthma on employment and financial status: A follow-up study. Eur Respir J 10:55-58.
6. Armentia A, Tapias J, Barber D, Martin J, de la Fuente R, Sanchez P, Salcedo G, Carreira J (1992): Sensitization to the storage mite Lepidoglyphus destructor in wheat flour respiratory allergy. Ann Allergy 68:398-403.
7. Armentia A, Sanchez-Monge R, Gomez L, Barber D, Salcedo G (1993): In vivo allergenic activities of eleven purified members of a major allergen family from wheat and barley flour. Clin Exp Allergy 23:410-415.
8. Baagöe KH (1933a): Mehlidiosynkrasie als Ursache vasomotorischer Rhinitis und Asthma. Acta Med Scand 80:310-322.
9. Baagöe K (1933b): Mehlidiosynkrasie als Ursache von vasomotorischer Rhinitis und Asthma. Klinische Wschr 12:792.
10. Baldo BA, Baker RS (1988): Inhalant allergies to fungi: reactions to bakers' yeast (Saccharomyces cerevisiae) and identification of bakers' yeast enolase as an important allergen. Int Archs Allergy Appl Immunol 86:201-208.
11. Baldo BA, Wrigley CW (1978): IgE antibodies to wheat flour components. Clin Allergy 8:109-124.
12. Baldo BA, Wrigley CW (1984): Allergies to cereals. Adv Cereal Sci Technol 6:289-356.
13. Baldo BA, Krilis S, Wrigley CW (1980): Hypersensitivity to inhaled flour allergens: Comparison between cereals. Allergy 35:45-56.
14. Baldo BA, Sutton R, Wrigley CW (1982): Grass allergens, with particular reference to cereals. Prog Allergy 30:1-66.
15. Balmes JR (1991): Surveillance for occupational asthma. In: Harber P and Balmes JR (eds), Occupational medicine - state of the art reviews. Vol. 6, Number 1. Hanley & Belfus, Philadelphia, pp 101-110.
16. Barber D, Sánchez-Monge R, Gómez L, Carpizo J, Armentia A, López-Otín C, Juan F, Salcedo G (1989): A barley flour inhibitor of insect α-amylase is a major allergen associated with baker's asthma disease. FEBS Lett 248:119-122.
17. Baur X (1993): Allergien im Backgewerbe. Allergologie 16:245.
18. Baur X, Czuppon AB (1995): Allergic reaction after eating α-amylase (Asp o 2)-containing bread. Allergy 50:85-87.
19. Baur X, Fruhmann G, Haug B, Rasche B, Reiher W, Weiss W (1986): Role of aspergillus amylase in baker's asthma. Lancet 1:43.
20. Baur X, Sauer W, Weiss W (1988): Baking additives as new allergens in baker's asthma. Respiration 54:70-72.
21. Baur X, Sauer W, Weiss W, Fruhmann G (1989): Inhalant allergens in modern baking industry. Immunol Allergy Pract 11:13-15.
22. Baur X, Chen Z, Sander I (1994a): Isolation and denomination of an important allergen in baking additives: α-amylase from Aspergillus oryzae (Asp o II). Clin Exp Allergy 24:465-470.
23. Baur X, Sander I, Jansen A, Czuppon AB (1994b): Sind Amylasen von Backmitteln und Backmehl relevante Nahrungsmittelallergene? Schweiz med Wschr 124:846-851.
24. Baur X, Pau M, Czuppon A, Fruhmann G (1996): Characterization of soybean allergens causing sensitization of occupationally exposed bakers. Allergy 51:326-330.
25. Belchi-Hernandez J, Mora-Gonzalez A, Iniesta-Perez J (1996): Baker's asthma caused by Saccharomyces cerevisiae in dry powder form. J Allergy Clin Immunol 97:131-134.
26. Belin L, Holmyr B, Ståhl A (1994): Assays for airborne fungal α-amylase in food and baking industries. Allergy Clin Immunol News (Suppl) 2:49.
27. Bergmann I, Rebohle E, Wallenstein G, Gemeinhardt H, Thürmer H (1976): Häufigkeit und Bedeutung von Schimmelpilzsensibilisierungen bei Werktätigen in der Backwarenindustrie. Allergie und Immunologie 22:297-301.
28. Beritic-Stahuljak D, Valic F, Cigula M, Butkovic D (1976): Simultaneous exposure to airborne flour particles and thermal load as cause of respiratory impairment. Im Arch Occup Environ Health 37:193-203.
29. Bermejo N, Maria Y, Gueant JL, Moneret-Vautrin DA (1991): Allergie professionnelle du boulanger à l'alpha-amylase fongique. Rev Fr Allergol 31:56-58.
30. Bernstein IL, Bernstein DI, Chan-Yeung M, Malo JL (1993): Definition and classification of asthma. In Bernstein IL, Chan-Yeung M, Malo JL, Bernstein DI (eds): "Asthma in the Workplace." New York: Marcel Dekker Inc., pp 1-4.
31. Besehe A de (1929): Serologische Untersuchungen über 'allergische Krankheiten' beim Menschen. Acta Pathol Microbiol Scand 6:115-144.
32. Birnbaum J, Latil F, Vervloet D, Senft M, Charpin J (1988): Rôle de l'alpha-amylase dans l'asthme du boulanger. Rev Mal Resp 5:519-521.
33. Blanco Carmona JG, Juste Picón S, Garcés Sotillos M (1991): Occupational asthma in bakeries caused by sensitivity to α-amylase. Allergy 46:274-276.
34. Blanco Carmona JG, Juste Picón S, Garcés Sotillos M, Rodriguez Gastón P (1992): Occupational asthma in the confectionery industry caused by sensitivity to egg. Allergy 47:190-191.
35. Blands J, Diamant B, Kallós P, Kallós-Deffner L, Løwenstein H (1976): Flour allergy in bakers: Identification of allergenic fractions in flour and comparison of diagnostic methods. Int Archs Allergy Appl Immunol 52:392-406.
36. Block G, Tse KS, Kijek K, Chan H, Chan-Yeung M (1983): Baker's asthma: Clinical and immunological studies. Clin Allergy 13:359-370.
37. Block G, Tse KS, Kijek K, Chan H, Chan-Yeung M (1984): Baker's asthma: Studies of the cross-antigenicity between different cereal grains. Clin Allergy 14:177-185.
38. Bohadana AB, Massin N, Wild P, Kolopp MN, Toamain JP (1994): Respiratory symptoms and airway responsiveness in apparently healthy workers exposed to flour dust. Eur Respir J 7:1070-1076.
39. Boisen S (1983): Comparative physico-chemical studies on purified trypsin inhibitors from the endosperm of barley, rye, and wheat. Z Lebensm Unters Forsch 176:434-439.
40. Bonnevie P (1958): Occupational allergy in bakery. In: "Occupational Allergy: Lectures Held During a Course on Occupational Allergy." Leiden, The Netherlands: Stenfert Kroese NV, pp 15-26.
41. Brisman J, Järvholm BG (1995): Occurrence of self-reported asthma among Swedish bakers. Scand J Work Environ Health 21:487-493.
42. Burdorf A, Lillienberg L, Brisman J (1994): Characterization of exposure to inhalable flour dust in Swedish bakeries. Ann Occup Hyg 38:67-78.
43. Burstyn I, Teschke K, Kennedy SM (1997): Exposure levels and determinants of inhalable dust exposure in bakeries. Ann Occup Hyg 41:609-624.
44. Burstyn I, Teschke K, Barlett K, Kennedy SM (1998): Determinants of wheat antigen and fungal α-amylase exposure in bakeries. Am Ind Hyg Assoc J 55:313-320.
45. Bush RK, Schroeckenstein D, Meier-Davis S, Balmes J, Rempel D (1988): Soybean flour asthma: detection of allergens by immunoblotting. J Allergy Clin Immunol 82:251-255.
46. Cannon J, Cullinan P, Newman Taylor A (1995): Consequences of occupational asthma. BMJ 311;602-603.
47. Chan-Yeung M (1990): Occupational asthma. Chest 98:148s-161s.
48. Charpin J, Lauriol-Mallea M, Renard M, Charpin H (1971): Étude de la pollution fungique dans les boulangeries. Acad Natl Med Jan 19:52-55.
49. Charpin D, Court E, Kleisbauer JP (1984): Enquête épidémiologique chez les boulangers. Arch Maladies Prof 45:381-382.
50. Cullinan P, Lowson D, Nieuwenhuijsen MJ, Sandiford C, Tee RD, Venables KM, McDonald JC, Newman Taylor AJ (1994): Work-related symptoms, sensitisation, and estimated exposure in workers not previously exposed to flour. Occup Environ Med 51:579-583.
51. DeMers MP, Orris P (1994): Occupational exposure and asthma mortality. JAMA 272:1575.
52. De Zotti R, Larese E Bovenzi M, Negro C, Molinari S (1994): Allergic airway disease in Italian bakers and pastry makers. Occup Environ Med 51:548-552.
53. De Zotti R, Molinari S, Larese F, Bovenzi M (1995): Pre-employment screening among trainee bakers. Occup Environ Med 52:279-283.
54. Diederich W, Lübbers P (1955): Das Mehlasthma als Berufskrankheit. Z Arbeitsmed Arbeitsschutz 5:189-197.
55. Dishoeck HAE van, Roux DJ (1939): Sensitization to flour and flour illnesses amongst flour workers. J Hygiene 39:674-679.
56. Edwards JH, McConnochie K, Trotman DM, Collins G, Saunders MJ, Latham SM (1983): Allergy to inhaled egg material. Clin Allergy 13:427-432.
57. Ehrlich RI (1994): Fatal asthma in a baker: A case report. Am J Ind Med 26:799-802.
58. Frangova Youroukova V, Stankova S, Ivanov S (1995): Sensitization to grain weevil in asymptomatic workers of bread industry. Eur Resp J 8(Suppl 19):272s.
59. Fränken J, Stephan U, Neuber K, Bujanowski-Weber J, Ulmer WT, König W (1991): Characterization of allergenic components of rye and wheat flour (Secale, Triticum vulgaris) by Western blot with sera of bakers: their effects on CD23 expression. Int Arch Allergy Appl Immunol 96:76-83.
60. Fränken J, Stephan U, Meyer HE, König W (1994): Identification of alpha-amylase inhibitor as a major allergen of wheat flour. Int Arch Allergy Immunol 104:171-174.
61. Gadborg E (1956): Allergy to flour. Thesis. Copenhagen, (as quoted by: Bonnevie P. Occupational allergy in bakery, 1958; and In Thiel H, Kallweit C (eds): Das Bäckerasthma: eine klassische allergische Berufskrankheit, 1984).
62. Gadborg E (1956): Allergy to flour. Thesis. Copenhagen, (as quoted by: Bonnevie P. Occupational allergy in bakery, 1958; and In Thiel H, Kallweit C (eds): Das Bäckerasthma: eine klassische allergische Berufskrankheit, 1984).
63. Gannon PFG, Burge PS (1993): The SHIELD scheme in the West Midlands Region, United Kingdom. Br J Ind Med 50:791-796.
64. García-Casado G, Armentia A, Sánchez-Monge R, Sánchez LM, Lopez-Otín C, Salcedo G (1995): A major baker's asthma allergen from rye flour is considerably more active than its barley counterpart. FEBS Lett 364:36-40.
65. García-Casado G, Armentia A, Sánchez-Monge R, Malpica JM, Salcedo G (1996): Rye flour allergens associated with baker's asthma. Correlation between in vivo and in vitro activities and comparison with their wheat and barley homologues. Clin Exp Allergy 26: 428-435.
66. Garcia-Olmedo F, Salcedo G, Sanchez-Monge R, Gomez L, Royo J, Carbonero P (1987): Plant proteinaceous inhibitors of proteinases and α-amylases. Oxford Surveys Plant Mol Cell Biol 4:275-334.
67. Gautrin D, Infante-Rivard C, Dao TV, Magnan-Larose M, Desjardins D, Malo JM (1997): Specific IgE-dependent sensitization, atopy, and bronchial hyperresponsiveness in apprentices starting exposure to protein-derived agents. Am J Respir Crit Care Med 155: 1841-1847.
68. Gemeinhardt H, Bergmann I (1977): Zum Vorkommen von Schimmelpilzen in Bäckereistäuben. Zbl Bakt Abt II 132:44-54.
69. Gómez L, Martin E, Hernández D, Sánchez-Monge R, Barber D, del Pozo V, de Andrés B, Armentia A, Lahoz C, Salcedo G, Palomino P (1990): Members of the α-amylase inhibitors family from wheat endosperm are major allergens associated with baker's asthma. FEBS Lett 261:85-88.
70. Grieshaber R, Rothe R (1995): Obstruktive Atemwegserkrankungen in Bäckereien. Staub 55:403-407.
71. Hartmann AL, Wüthrich B, Deflorin-Stolz R, Helfenstein U, Hewitt B, Guérin B (1985): Atopie-Screening: Prick-Multitest, Gesamt-IgE oder RAST? Schweiz med Wochenschr 115:466-475.
72. Hartmann AL (1986): "Berufsallergien bei Bäckern: Epidemiologie; Diagnose, Therapie und Prophylaxe; Versicherungsrecht." München-Deisenhofen, Germany: Dustri-Verlag Dr. Karl Feistle.
73. Hartmann AL (1989): Respirationsallergien bei Bäckern. Therapeutische Umschau 46:796-800.
74. Hendrick DJ, Davies RJ, Pepys J (1976): Bakers' asthma. Clin Allergy 6:241-250.
75. Hendrick DJ (1994): Management of occupational asthma. Eur Respir J 7:961-968.
76. Herling C, Svendsen UG, Schou C (1994): Demonstration of IgE-mediated allergy to the granary weevil (Sitophilus Granarius). J Allergy Clin Immunol 93:205.
77. Herxheimer H (1967): Skin sensitivity to flour in bakers' apprentices. Lancet 1:83-84.
78. Herxheimer H (1973): The skin sensitivity fo flour of bakers' apprentices. Acta Allerg 28:42-49.
79. Heyer N (1983): Backmittel als berufsbedingte Inhalationsallergene bei mehlverarbeitenden Berufen. Allergologie 6:389-392.
80. Houba R (1996): "Occupational Respiratory Allergy in Bakery Workers: Relationships With Wheat and Fungal α-Amylase Aeroallergen Exposure." Thesis. Wageningen, The Netherlands: Agricultural University Wageningen, Department of Occupational and Environmental Health, Wageningen.
81. Houba R, van Run P, Heederik D, Doekes G (1996a): Wheat antigen exposure assessment for epidemiologic studies in bakeries using personal dust sampling and inhibition ELISA. Clin Exp Allergy 26:154-163.
82. Houba R, Heederik DJJ, Doekes G, van Run PEM (1996b): Exposure-sensitization relationship for α-amylase allergens in the baking industry. Am J Respir Crit Care Med 154:130-136.
83. Houba R, van Run P, Doekes G, Heederik D, Spithoven J (1997a): Airborne levels of α-amylase allergens in bakeries. J Allergy Clin Immunol 99:286-292.
84. Houba R, Heederik D, Kromhout K (1997b): Grouping strategies for exposure to inhalable dust, wheat allergens and α-amylase allergens in bakeries. Ann Occup Hyg 41:287-296.
85. Houba R, Heederik D, Doekes G (1998): Wheat sensitization and work related symptoms in the baking industry are preventable: an epidemiologic study. Am J Respir Crit Care Med (in press).
86. James JM, Sixbey JP, Helm RM, Bannon GA, Burks AW (1997): Wheat α-amylase inhibitor: a second route of allergic sensitization. J Allergy Clin Immunol 99:239-244.
87. Järvinen KAJ, Pirilä V, Björksten F, Keskinen H, Lehtinen M, Stubb S (1979): Unsuitability of bakery work for a person with atopy: a study of 234 bakery workers. Ann of Allergy 42:192-195.
88. Jauhiainen A, Louhelainen K, Linnainmaa M (1993): Exposure to Dust and α-Amylase in Bakeries. Appl Occup Environ Hyg 8:721-725.
89. Jeffrey PM (1992): "Respiratory Problems in Workers in Small Bakeries." Glasgow: Dissertation for membership of the Faculty of Occupational Medicine of the Royal College of Physicians.
90. Johansson E, Johansson SGO, Hage-Hamsten M van (1994): Allergenic characterization of Acarus siro and Tyrophagus putrescentiae and their crossreactivity with Lepidoglyphus destructor and Dermatophagoides pteronyssinus. Clin Exp Allergy 24:743-51.
91. Jongedijk T, Meijler M, Houba R, Heederik D (1995): Tijdstudies en vergelijkende piekblootstellingsmetingen in ambachtelijke bakkerijen. Tijdschrift voor toegepaste Arbowetenschap 8:1-8.
92. Jorde W, Heyer N, Schata M (1986): Bäckereirohstoffe als berufsspezifische Allergene. Allergologie s552-s524.
93. Kanny G, Moneret-Vautrin DA (1995): α-Amylase contained in bread can induce food allergy. J Allergy Clin Immunol 95:132-133.
94. Keskinen H, Östman P, Vaheri E, Tarvainen K, Grenquist-Norden B, Karppinen O, Nordman H (1991): A case of occupational asthma, rhinitis and urticaria due to sesame seed. Clin Exp Allergy 21:623-624.
95. Klaustermeyer WB, Bardana EJ, Hale FC (1977): Pulmonary hypersensitivity to Alternaria and Aspergillus in baker's asthma. Clin Allergy 7:227-233.
96. Kolopp-Sarda MN, Massin N, Gobert B, Wild P, Moulin JJ, Béné MC, Faure GC (1994): Humoral immune responses of workers occupationally exposed to wheat flour. Am J Ind Med 26:671-679.
97. Korsgaard J, Dahl R, Iversen M, Hallas T (1985): Storage mites as a cause of bronchial asthma in Denmark. Allergol Immunopathol 13:143-149.
98. Lachance P, Cartier A, Dolovich J, Malo JL (1988): Occupational asthma from reactivity to an alkaline hydrolysis derivative of gluten. J Allergy Clin Immunol 81:385-390.
99. Lagier F, Cartier A, Malo JL (1990): Statistiques médico-légales sur l'asthme professionnel au Québec de 1986 à 1988. Rev Mal Resp 7:337-341.
100. Lavaud F, Perdu D, Prévost A, Vallerand H, Cossart C, Passemard F (1994): Baker's asthma related to soybean lecithin exposure. Allergy 49:159-162.
101. Lillienberg L, Brisman J (1994): Flour dust in bakeries: A comparison between methods. Ann Occup Hyg 38(Suppl 1):571-575.
102. Linko E (1947): On allergic rhinitis and bronchial asthma in bakers. Ann Med Intern Fenn 36:98-111.
103. Losada E, Hinojosa M, Moneo I, Dominguez J, Diez Gomez ML, Ibañez MD (1986): Occupational asthma caused by cellulase. J Allergy Clin Immunol 77:635-639.
104. Losada E, Hinojosa M, Quirce S, Sánchez-Cano M, Moneo I (1992): Occupational asthma caused by α-amylase inhalation: clinical and immunological findings and bronchial response patterns. J Allergy Clin Immunol 89:118-125.
105. Malmberg P (1990): Yrken/arbetsmiljöer med hög sjuklighet i respirations-organen. Arbete Och Hälsa 1990:6 (as quoted by Brisman J, Järvholm BG (1995): Occurrence of self-reported asthma among Swedish bakers. Scand J Work Environ Health 21:487-493.)
106. Malmberg P (1990): Yrken/arbetsmiljöer med hög sjuklighet i respirations-organen. Arbete Och Hälsa 1990:6 (as quoted by Brisman J, Järvholm BG (1995): Occurrence of self-reported asthma among Swedish bakers. Scand J Work Environ Health 21:487-493.)
107. Masalin KE, Degerth RK, Murtomaa HT (1988): Airborne sugar and flour dust in the Finnish confectionery industry. Appl Ind Hyg 3:231-235.
108. Mastrangelo G, Bombana S, Priante E, Gallo A, Saia B (1997): Repeated case-control studies as a method of surveillance for asthma in occupations. J Occup Environ Med 39:51-57.
109. Mena M, Sanchez-Monge R, Gomez L, Salcedo G, Carbonero P (1992): A major barley allergen associated with baker's asthma disease is a glycosylated monomeric inhibitor of insect α-amylase: cDNA cloning and chromosomal location of the gene. Plant Mol Biol 20:451-458.
110. Meredith S (1993): Reported incidence of occupational asthma in the United Kingdom, 1989-1990. J Epidemiol Commun Health 47:459-463.
111. Meredith SK, McDonald JC (1994): Work-related respiratory disease in the United Kingdom, 1989-1992: report on the SWORD project. Occup Med 44:183-189.
112. Meredith SK, Taylor VM, McDonald JC (1991): Occupational respiratory disease in the United Kingdom 1989: A report to the British Thoracic Society and the Society of Occupational Medicine by the SWORD project group. Br J Ind Med 48:292-298.
113. Moneo I, Alday E, Sanchez-Agudo L, Curiel G, Lucena R, Calatrava JM (1995): Skin-prick tests for hypersensitivity to α-amylase preparations. Occup Med 45:151-155.
114. Musk AW, Venables KM, Crook B, Nunn AJ, Hawkins R, Crook GD, Graneek BJ, Tee RD, Farrer N, Johnson DA, Gordon DJ, Darbyshire JH, Newman Taylor AJ (1989): Respiratory symptoms, lung function, and sensitisation to flour in a British bakery. Br J Ind Med 46:636-642.
115. Müsken H, Bergmann Kch (1992): Vorratsmilben: Biologie, Sensibilisierung, klinische Bedeutung. Allergologie 15:s189-s196.
116. Nakamura S (1972): On occupational allergic asthma of different kinds newly found in our allergy clinic. J Asthma Res 10:37-47.
117. Nakamura R, Matsuda T (1996): Rice allergenic protein and molecular-genetic approach for hypoallergenic rice. Biosci Biotech Biochem 60:1215-1221.
118. Nakazawa T, Toyoda T, Furukawa M, Taya T, Kobayashi S (1976): Inhibitory effects of various drugs on dual asthmatic responses in wheat flour-sensitive subjects. J Allergy Clin Immunol 58:1-9.
119. Newman Taylor AJ, Gordon S (1993): Laboratory animal and insect allergy. In Bernstein IL, Chan-Yeung M, Malo JL, Bernstein DI (eds): "Asthma in the Workplace." New York: Marcel Dekker Inc., pp 399-414.
120. Nieuwenhuijsen MJ, Sandiford CP, Lowson D, Tee RD, Venables KM, McDonald JC, Newman Taylor AJ (1994): Dust and flour aeroallergen exposure in flour mills and bakeries. Occup Environ Med 51:584-588.
121. Nieuwenhuijsen MJ, Lowson D, Venables KM, Newman Taylor AJ (1995a): Flour dust exposure variability in flour mills and bakeries. Ann Occup Hyg 39:299-305.
122. Nieuwenhuijsen MJ, Sandiford CP, Lowson D, Tee RD, Venables KM, Newman Taylor AJ (1995b): Peak exposure concentrations of dust and flour aeroallergen in flour mills and bakeries. Ann Occup Hyg 39:193-201.
123. Nordman H (1994): Occupational asthma: Time for prevention. Scan J Work Environ Health 20:108-115.
124. Park HS, Nahm DH (1996): Buckwheat flour hypersensitivity: an occupational asthma in a noodle maker. Clin Exp Allergy 26:423-427.
125. Pestalozzi C, Schnyder UW (1955): Zur Frage der Bäckerrhinitis und des Bäckerasthmas. Schweiz med Wschr 21:496-501.
126. Pfeil T, Schwabl U, Ulmer WT, König W (1990): Western blot analysis of water-soluble wheat flour (Triticum vulgaris) allergens. Int Arch Allergy Appl Immunol 91:224-231.
127. Popa V, Al-George S, Gavanescu O (1970): Occupational and non occupational respiratory allergy in bakers. Acta Allergol 25:159-177.
128. Popp W, Wagner C, Kiss D, Zwick H, Sertl K (1994): Prediction of sensitization to flour allergens. Allergy 49:376-379.
129. Posch A, Weiss W, Wheeler C, Dunn MJ, Görg A (1995): Sequence analysis of wheat grain allergens separated by two-dimensional electrophoresis with immobilized pH gradients. Electrophoresis 16:1115-1119.
130. Praml GJ, Mauermayer R, Hartmann AL (1986): Personenbezogene Erfassung des zeitlichen Verlaufes der Staubbelastung mit einem Tyndallometer und digitaler Speicherung. Staub-Reinhalt Luft 46:140-142.
131. Prichard MG, Ryan G, Musk AW (1984): Wheat flour sensitisation and airways disease in urban bakers. Br J Ind Med 41:450-454.
132. Prichard MG, Ryan G, Walsh BJ, Musk AW (1985): Skin test and RAST responses to wheat and common allergens and respiratory disease in bakers. Clin Allergy 15:203-210.
133. Quirce S, Cuevas M, Díez-Gómez ML, Fernández-Rivas M, Hinojosa M, González R, Losada E (1992): Respiratory allergy to Aspergillus-derived enzymes in bakers' asthma. J Allergy Clin Immunol 90:970-978.
134. Ramazzini B (±1700): De Morbis Artificium Diatriba. (Dutch translation 1724: "Historisse natuur-en genees-kundige verhandeling van de ziekten der konstenaars, ambagtslieden en handwerkers". Leyden: Joh. Arnold Langerak).
135. Revsbech P, Dueholm M (1990): Storage mite allergy among bakers. Allergy 45:204-208.
136. Rosenau Ch, Wittemann B, Sohmen R, Radandt S, Grieshaber R (1993): Sitophilus granarius (Kornkäfer): ein Berufsallergen bei Bäckern. Allergologie 16:246-248.
137. Rosenberg N, Rameix F, Demangeat G, Philippon JJ, Rigault MH, Schlacther T, Sandret N (1991): Prévalence de l'allergie respiratoire dans la boulangerie-pâtisserie parisienne en 1987. Arch Mal Prof 52:33-36.
138. Sallie BA, Ross DJ, Meredith SK, McDonald JC (1994): SWORD'93. Surveillance of work-related and occupational disease in the UK. Occup Med 44:177-182.
139. Sanchez-Monge R, Gomez L, Barber D, Lopez-Otin C, Armentia A, Salcedo G (1992): Wheat and barley allergens associated with baker's asthma: Glycosylated subunits of the α-amylase-inhibitor family have enhanced IgE-binding capacity. Biochem J 281:401-405.
140. Sánchez-Monge R, García-Casado G, Lopez-Otín C, Armentia A, Salcedo G (1997): Wheat flour peroxidase is a prominent allergen associated with baker's asthma. Clin Exp Allergy 27:1130-1137.
141. Sander I, Raulf-Heimsoth M, Düser M, Flagge A, Czuppon AB, Baur X (1997a): Differentiation between cosensitization and cross reactivity in wheat flour and grass pollen sensitized subjects. Int Arch Allergy Immunol 112:378-85.
142. Sander I, Neuhaus-Schröder C, Borowitzki G, Baur X, Raulf-Heimsoth M (1997b): Development of a two-site enzyme-linked immunosorbent assay for alpha-amylase from Aspergillus oryzae based on monoclonal antibodies. J Immunol Methods 210:93-101.
143. Sandiford CP, Tee RD, Newman Taylor AJ (1990): Identification of major allergenic flour proteins in order to develop assays to measure flour aeroallergen. Clin Exp Allergy 20(Suppl 1): 3.
144. Sandiford CP, Nieuwenhuijsen MJ, Tee RD, Newman Taylor AJ (1994a): Measurement of airborne proteins involved in Bakers' asthma. Clin Exp Allergy 24:450-456.
145. Sandiford CP, Tee RD, Newman Taylor AJ (1994b): The role of cereal and fungal amylases in cereal flour hypersensitivity. Clin Exp Allergy 24:549-557.
146. Sandiford CP, Nieuwenhuijsen MJ, Tee RD, Newman Taylor AJ (1994c): Determination of the size of airborne flour particles. Allergy 49:891-893.
147. Sandiford CP, Tee RD, Newman Taylor AJ (1995): Identification of crossreacting wheat, rye, barley and soya flour allergens using sera from individuals with wheat-induced asthma. Clin Exp Allergy 25:340-349.
148. Schata M, Jorde W (1992): Allergische Reaktionen durch α-Amylase in Backmitteln. Allergologie 15:57.
149. Schultze-Werninghaus G, Zachgo W, Rotermund H, Wiewrodt R, Merget R, Wahl R, Burow G, zur Strassen R (1991): Tribolium confusum (confused flour beetle, rice flour beetle): An occupational allergen in bakers. Demonstration of IgE antibodies. Int Arch Allergy Appl Immunol 94:371-372.
150. Schumacher F, Schmid P, Wüthrich B (1993): Zur Pizokel-Allergie: Ein Beitrag über die Buchweizenallergie. Schweiz Med Wochenschr 123:1559-1562.
151. Shamssain MH (1995): Respiratory symptoms and pulmonary function in flour processing workers in the baking industry. Am J Ind Med 27:359-365.
152. Singh A, Singh AB (1994): Airborne fungi in a bakery and the prevalence of respiratory dysfunction among workers. Grana 33:349-358.
153. Smith TA, Lumley KPS (1996): Work-related asthma in a population exposed to grain, flour and other ingredient dusts. Occup Med 46:37-40.
154. Smith TA, Lumley KPS, Hui EHK (1997): Allergy to flour and fungal amylase in bakery workers. Occup Med 47:21-24.
155. Sutton R, Skerritt JH, Baldo BA, Wrigley CW (1984): The diversity of allergens involved in bakers' asthma. Clin Allergy 14:93-107.
156. Tarvainen K, Kanerva L, Tupasela O, Grenquist-Nordén B, Jolanki R, Estlander T, Keskinen H (1991a): Allergy from cellulase and xylanase enzymes. Clin Exp Allergy 21:609-615.
157. Tarvainen K, Kanerva L, Grenquist-Norden B, Estlander T (1991b): Berufsallergien durch Cellulase, Xylanase und Alpha-Amylase. Z Hautkr 66:964-967.
158. Tee RD (1994): Allergy to storage mites: Review. Clin Exp Allergy 24:636-640.
159. Thiel H (1984): Inhalationsallergien bei Bäckern: Aktuelle Probleme des Mehlberufsasthmas. Lebensversicherungsmedizin 4:82-87.
160. Thiel H (1987): Probleme der berufsbedingten Inhalations-Allergien am Beispiel des Bäcker-Asthmas. Dermatosen 35:81-91.
161. Thiel H, Kallweit C (1984): Das Bäckerasthma - eine klassische allergische Berufskrankheit. Allergologie 7:407-414.
162. Thiel H, Ulmer WT (1980): Bakers' asthma: Development and possibility for treatment. Chest 78:400-405.
163. Torén K (1996): Self reported rate of occupational asthma in Sweden 1990-2. Occup Environ Med 53:757-761.
164. Valdivieso R, Moneo I, Pola J, Muñoz T, Zapata C, Hinojosa M, Losada E (1989): Occupational asthma and contact urticaria caused by buckwheat flour. Ann Allergy 63:149-152.
165. Valdivieso R, Subiza J, Subiza JL, Hinojosa M, Carlos E de, Subiza E (1994): Bakers' asthma caused by alpha amylase. Ann Allergy 73:337-342.
166. Valero A, Lluch M, Amat P, Serra E, Malet A (1996): Occupational egg allergy in confectionery workers. Allergy 51:588-589.
167. Vanhanen M, Tuomi T, Hokkanen H, Tupasela O, Tuomainen A, Holmberg PC, Leisola M, Nordman H (1996): Occup Environ Med 53:670-676.
168. Venables KM (1994): Prevention of occupational asthma. Eur Respir J 7:768-778.
169. Wallenstein G, Bergmann I, Rebohle E, Gemeinhardt H, Thürmer H (1980): Berufliche Atemtrakterkrankungen durch Schimmelpilze bei Getreidemüllern und Bäckern. Z Erkrank Atm Org 154:229-233.
170. Walsh BJ, Wrigley CW, Musk AW, Baldo BA (1985): A comparison of the binding of IgE in the sera of patients with bakers' asthma to soluble and insoluble wheat-grain proteins. J Allergy Clin Immunol 76:23-28.
171. Weiner A (1960): Occupational bronchial asthma in a baker due to Aspergillus: A case report. Ann Allergy 18:1004-1007.
172. Weiss W, Huber G, Engel KH, Pethran A, Dunn MJ, Gooley AA, Görg A (1997): Identification and characterization of wheat grain albumine/ globulin allergens. Electrophoresis 18:826-833.
173. Wiley K, Smith MM, Allan LJ, Griffin P (1997): Measurement of airborne flour exposure with a monoclonal antibody based immunoassay. Int Arch Allergy Immunol 114:278-284.
174. Wüthrich B (1976): Zum Allergenkatalog beruflicher Inhalationsallergien. Berufsdermatosen 24:123-131.
175. Wüthrich B (1994): Enzyme: potente inhalative und ingestive Allergene: Fehlende Deklarationspflicht von Backmitteln und Backmehl. Schweiz med Wschr 124:1361-1363.
176. Wüthrich B, Baur X (1990): Backmittel, insbesondere α-Amylase, als berufliche Inhalationsallergene in der Backwarenindustrie. Schweiz Med Wschr 120:446-450.
177. Yassin S, Wheals A (1992): Neurospora species in bakeries. J Appl Bacteriol 72:377-380.
178. Zuskin E, Mustajbegovic J, Schachter EN, Kern J (1994a): Respiratory symptoms and ventilatory function in confectionery workers. Occup Environ Med 51:435-439.
179. Zuskin E, Kanceljak B, Mustajbegovic J, Schachter EN (1994b): Immunologie findings in confectionery workers. Ann Allergy 73:521-526.