Intranuclear iron deposition in hepatocytes and renal tubular cells in mice treated with ferric nitrilotriacetate

Virchows Archiv

Volumn 433, Issue 6, 1998, Pages 543-548

  Kondo, Asami ^a   Deguchi, Jiro ^b   Okada, Shigeru ^a  

^a OKAYAMA UNIVERSITY MEDICAL SCHOOL   (Japan)

^b DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

Author keywords

Ferric nitrilotriacetate; Ferritin; Intranuclear iron deposition; Renal tumours

Indexed keywords

CARCINOGEN; FERRITIN; IRON; NITRILOTRIACETATE IRON;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL NUCLEUS; CONTROLLED STUDY; ELECTRON MICROSCOPY; FEMALE; IMMUNOHISTOCHEMISTRY; KIDNEY TUBULE CELL; KIDNEY TUMOR; LIVER CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SEX DIFFERENCE;

ANIMALS; CELL NUCLEUS; CYTOPLASM; FEMALE; FERRIC COMPOUNDS; IRON; KIDNEY NEOPLASMS; KIDNEY TUBULES; LIVER; MALE; MICE; MICROSCOPY, ELECTRON; NITRILOTRIACETIC ACID; RANDOM ALLOCATION; SEX FACTORS;

EID: 0031743986     PISSN: 09456317     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004280050287     Document Type: Article

References (32)

1. Awai M, Narasaki M, Yamanoi Y, Seno S (1979) Induction of diabetes in animals by parenteral administration of ferric nitrilotriacetate: a model of experimental hemochromatosis. Am J Pathol 95:663-674
2. Bacon BR, Tavilli AS, Brittenham GM, Park CH, Recknagel RO (1983) Hepatic lipid peroxidation in vivo in rats with chronic iron overload. J Clin Invest 71:429-439
3. Beaumont C, Swatantra KJ, Bogard M, Nordmann Y, Drysdale J (1987) J Biol Chem 262:10529-10623
4. Beaumont C, Dugast I, Renaudie F, Souroujon M, Grandchmp B (1989) J Biol Chem 264:7498-7504
5. Birkhead M, Luke B, Mann S (1982) Intracellular localization of lead in tissues of the mute swan. Tissue Cell 14:691-701
6. Bothwell TH, Charlton RW, Cook JD, Finch CA (eds) (1979) Iron metabolism in man: storage iron, nature of ferritin. Blackwell Scientific, Oxford London Edinburgh, pp 312-315
7. Bradbear RA, Bain C, Siskind V, Schofield FD, Webb S, Axelsen EM, Halliday JW, Bassett ML, Powell LW (1985) Cohort study of internal malignancy in genetic hematochromatosis and chronic nonalcoholic liver diseases. J Natl Cancer Inst 75:81-84
8. Cai CX, Birk DE, Linsaynayer TF (1997) Ferritin is a developmentally regulated nuclear protein of avian corneal epithelial cells. J Biol Chem 272:12832-12839
9. Cairo G, Tacchini L, Pogliaghi G, Anzon E, Tomasi A, Bernelli-Zazzera A (1995) Induction of ferritin synthesis by oxidative stress. J Biol Chem 270:700-703
10. Deguchi J, Miyamoto M, Okada S (1995) Sex hormone-dependent renal cell carcinogenesis induced by ferric nitrilotriacetate in Wistar rats. Jpn J Cancer Res 86:1068-1071
11. Fawcett DW (ed) (1994) A textbook of histology: the cell, nuclear envelope. Chapman & Hall, New York, London, pp 9-11
12. Goetz W, Richter MD (1961) Intranuclear aggregates of ferritin in liver cells of mice treated with saccharated iron oxide. J Biophys Biochem Cytol 9:263-270
13. Gurgueira SA, Meneghinis R (1996) An ATP dependent iron transport system in isolated rat liver nuclei. J Biol Chem 271: 13616-13620
14. Iancu TC, Rabinowiz H, Brissot P, Guillouzo A, Deugnier Y, Bourel M (1985) Iron overload of the liver in the baboon: an ultrastructural study. J Hepatol 1:261-275
15. Haddow A, Horning ES (1960) On the carcinogenicity of an iron dextran complex. J Natl Cancer Inst 24:109-147
16. Honda T, Massover WH (1981) Serum ferritin from siderotic mice contains iron. Br J Haematol 49:653-657
17. Ladda R (1962) Intranuclear ferritin. Exp Cell Res 28:595-597
18. Li JL, Okada S, Hamazaki S, Ebina Y, Midorikawa O (1987) Subacute nephrotoxicity and induction of renal cell carcinoma in mice treated with ferric nitrilotriacetate. Cancer Res 47: 1867-1869
19. Li JL, Okada S, Hamazaki S, Deng IL, Midorikawa O (1988) Sex differences in ferric nitrilotriacetate-induced lipid peroxidation and nephrotoxicity in mice. Biochim Biophys Acta 963: 82-87
20. Matsuno T, Mori M, Awai M (1985) Distribution of ferritin and hemosiderin in the liver, spleen and bone marrow of normal, phlebotomized and iron overloaded rats. Acta Med Okayama 39:347-360
21. Moore RD, Mumaw YR, Schoenberg MD (1961) The transport and distribution of colloidal iron and its relation to the ultrastructure of the cell. J Ultrastruct Res 5:244-256
22. Nakamura T, Mori M, Awai M (1988) Process of carbonyl iron absorption from the rat duodenal mucosa. Acta Pathol Jpn 38: 1377-1390
23. Niederau C, Fischer R, Sonnenberg A, Stremmel W, Tampisch HJ, Strohmeyer G (1985) Survival and causes of death in cirrhotic and non-cirrhotic patients with primary hemochromatosis. N Engl J Med 313:1256-1262
24. Okada S (1996) Iron-induced tissue damage and cancer: the role of reactive oxygen species-free radicals. Pathol Int 46:311-332
25. Okada S, Midorikawa O (1982) Induction of the rat renal adenocarcinoma by Fe-nitrilotriacetate (Fe-NTA) in rats. Jpn Arch Intern Med 29:485-491
26. Okada S, Fukunaga Y, Hamazaki S, Yamada Y, Toyokuni S (1991) Sex differences in the localization and severity of ferric nitrilotriacetate-induced lipid peroxidation in the mouse kidney. Acta Pathol Jpn 41:221-226
27. Park CH, Bacon BR, Brittenham GM, Tavill AS (1987) Pathology of dietary carbonyl iron overload in rats. Lab Invest 57:555-563
28. Perls M (1867) Nachweis von Eisenoxyd in gewissen Pigmenten. Virchows Arch [A] 39:42-48
29. Smith AG, Carthew P, Francis JE, Edward RE, Dinsdale D (1990) Characterization and accumulation of ferritin in hepatocyte nuclei of mice with iron overload. Hepatology 12: 1399-1405
30. Toyokuni S, Okada S, Hamazaki S, Minamiyama Y, Yamada Y, Liang P, Fukunaga Y, Midorikawa O (1990) Combined histochemical and biochemical analysis of sex hormone dependence of ferric nitrilotriacetate-induced renal lipid peroxidation in ddY mice. Cancer Res 50:5574-5580
31. Toyokuni S, Mori T, Dizdaroglu M (1994) DNA base modifications in renal chromatin of Wistar rats treated with renal carcinogen, ferric nitrilotriacetate. Int J Cancer 57:123-128
32. Umemura T, Sai K, Takagi A, Hasegawa R, Kurokawa Y (1990) Formation of 8-hydroxydeoxyguanosine (8-OH-dG) in rat kidney DNA after intraperitoneal administration of ferric nitrilotriacetate (Fe-NTA). Carcinogenesis 11:345-347