Effects of single oral administrations of haloperidol and d-amphetamine on prepulse inhibition of the acoustic startle reflex in healthy male volunteers

Behavioural Pharmacology

Volumn 9, Issue 7, 1998, Pages 567-576

  Kumari, V ^a,b   Mulligan, O F ^a   Cotter, P A ^a   Poon, L ^a   Toone, B K ^b   Checkley, S A ^a   Gray, J A ^a  

^a UNIVERSITY OF LONDON   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Acoustic startle reflex; d amphetamine; Dopamine; Habituation; Haloperidol; Humans; Prepulse inhibition (PPI); Schizophrenia; Smoking

Indexed keywords

DEXAMPHETAMINE; HALOPERIDOL;

ACOUSTIC REFLEX; ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; HABITUATION; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PREPULSE INHIBITION; RANDOMIZED CONTROLLED TRIAL; SCHIZOPHRENIA; SENSORIMOTOR FUNCTION; STARTLE REFLEX;

EID: 0031743687     PISSN: 09558810     EISSN: None     Source Type: Journal    
DOI: 10.1097/00008877-199811000-00012     Document Type: Article

References (40)

1. Abduljawad KAJ, Langley RW, Bradshaw CM, Szahadi E (1997a). Effects of clonidine and diazepam on the acoustic startle response and on its inhibition by 'prepulses' in man. J Psychopharmacol 11:29-34.
2. 2 dopamine receptors in prepulse inhibition of the startle reflex. J Psychopharmacol 11:273.
3. Bartlett EJ, Brodie JB, Simkowitz P, Schlosser R, Dewey SL, Lindenmayer J et al. (1998). Effect of haloperidol challenge on regional brain metabolism in neuroleptic-responsive and nonresponsive schizophrenic patients. Am J Psychiatr 155:337-343.
4. Braff DL, Stone C, Callaway E, Geyer M, Glick I, Bali L (1978). Prestimulus effects on human startle reflex in normals and schizophrenics. Psychophysiology 15:339-343.
5. Braff DL, Grillon C, Gdyer MA (1992). Gating and habituation of the startle reflex in schizophrenic patients. Arch Gen Psychiatry 49:206-215.
6. Braff DL, Perry W, Cadenhead KS, Swerdlow NR, Geyer MA (1995). Prepulse inhibitory deficits in schizophrenia: gender effects [Abstract]. Biol Psychiatry 37:654.
7. Bolino F, Michele V, Di Cicco L, Manna V, Danluzzo E, Casacchia M (1994). Sensorimotor gating and habituation evoked by electro-cutaneous stimulation in schizophrenia. Biol Psychiatry 36:670-679.
8. Caine SB, Geyer MA, Swerdlow NR (1995). Effects of D-sub-3/D-sub-2 dopamine receptor agonists and antagonists on prepulse inhibition of acoustic startle in the rat. Neuropsychopharmacology 12:139-145.
9. Corr PJ, Kumari V (1997). Sex differences in prepulse inhibition of the acoustic startle reflex: effect of prepulse-to-pulse intervals. J Psychophysiology (In press).
10. Dawe S, Gerada C, Russell MAH, Gray JA (1995). Nicotine intake in smokers increases following a single dose of haloperidol. Psychopharmacology 117:110-115.
11. Depoortere R, Perrault G, Sanger D (1997). Potentiation of prepulse inhibition of the startle reflex in rats: pharmacological evaluation of the procedure as a model for detecting antipsychotic activity. Psychopharmacology 132:366-374.
12. Geyer MA, Wilkinson LS, Humby T, Robbins T (1993). Isolation rearing produces a deficit in prepulse inhibition of acoustic startle similar to that in schizophrenia. Biol Psychiatry 34:361-372.
13. Graham FK (1975). The more or less startling effects of weak prestimuli. Psychophysiology 12:238-248.
14. Gray NS, Pickering AD, Hemsley DR, Dawling S, Gray JA (1992). Abolition of latent inhibition by a single 5-mg dose of d-amphetamine in man. Psychopharmacology 114:657-664.
15. Grillon C, Ameli R, Charney DS, Krystal JH, Braff DL (1992). Startle gating deficit occurs across prepulse intensities in schizophrenic patients. Biol Psychiatry 32:929-943.
16. Hamm A, Weike A, Bauer U, Valti D, Gallhofer B (1995). Prepulse inhibition in medicated and unmedicated patients [Abstract]. Soc Psychophysiol Res S:38.
17. Hoffman DC, Donovan H (1994). D-sub-1 and D-sub-2 receptor antagonists reverse prepulse inhibition deficits in an animal model of schizophrenia. Psychopharmacology 115:447-453.
18. Kumari V, Checkley SA, Gray JA (1996a). Effect of cigarette smoking on prepulse inhibition of the acoustic startle reflex in healthy male smokers. Psychopharmacology 128:54-60.
19. Kumari V, Corr PJ, Wilson GD, Kaviani H, Thornton JC, Checkley SA et al. (1996b). Personality and modulation of the startle reflex by emotionally-toned film clips. Personality Individ Diff 21:1029-1041.
20. Kumari V, Corr PJ, Cotter PA, Checkley SA, Gray JA (1997a). Effects of acute administration of d-amphetamine and haloperidol on procedural learning in man. Psychopharmacology 129:271-276.
21. Kumari V, Cotter PA, Checkley SA, Gray JA (1997b). Effect of acute subcutaneous nicotine on prepulse inhibition of the acoustic startle reflex in healthy male non-smokers. Psychopharmacology 132:389-395.
22. Kumari V, Toone B, Gray JA (1997c). Habituation and prepulse inhibition of the acoustic startle reflex: effects of smoking status and psychosis-proneness. Personality Individ Diff 23:183-191.
23. Kumari V, Cotter P, Mulligan O, Gray NS, Hemsley DR, Thornton JC, Corr PJ et al. Effect of d-amphetamine and haloperidol on latent inhibition in healthy male volunteers (Submitted).
24. Lubow RE (1973). Latent inhibition. Psychol Bull 79:398-407.
25. Mansbach RS, Geyer MA, Braff DL (1988). Dopaminergic stimulation disrupts sensorimotor gating in the rat. Psychopharmacology 94:507-514.
26. Mansbach RS, Brooks EW, Sanner MA, Stevin ZH (1998). Selective dopamine D4 receptor antagonists reverse apomorphine-induced blockade of prepulse inhibition. Psychopharmacology 135:194-200.
27. Matthews G, Jones DM, Chamberlain AG (1990). Refining the measurement of mood: the UWIST mood adjective checklist. Br J Psychology 81:17-42.
28. 2-dopamine receptor occupancy examined by PET after single oral doses of haloperidol. Psychopharmacology 106:433-438.
29. Ott DA, Mandel RJ (1995). Amphetamine sensitivity in open-field activity versus the prepulse inhibition paradigm. Brain Res Bull 37:219-222.
30. Rigdon GC, Vik K (1991). Prepulse inhibition as a screening test for potential antipsychotics. Drug Devel Res 23:91-99.
31. Schwarzkopf SB, Bruno JP, Mitra T (1993). Effects of haloperidol and SCH 23390 on acoustic startle and prepulse inhibition under basal and stimulated conditions. Prog Neuropsychopharmacol Biol Psychiatry 17:1023-1036.
32. Swerdlow NR, Auerbach A, Monroe SM, Hartson H, Geyer MA, Braff DL (1993). Men are more inhibited than women by weak prepulses. Biol Psychiatry 34:253-260.
33. Swerdlow NR, Geyer MA (1993). Clozapine and haloperidol in an animal model of sensorimotor gating deficits in schizophrenia. Pharmacol Biochem Behav 44:741-744.
34. Swerdlow NR, Braff DL, Taaid N, Geyer MA (1994). Assessing the validity of an animal model of deficient sensorimotor gating in schizophrenic patients. Arch Gen Psychiatry 51:139-154.
35. Swerdlow NR, Mansbach RS, Geyer MA, Pulvirenti L, Koob GF, Braff DL (1990). Amphetamine disruption of prepulse inhibition of acoustic startle is reversed by depletion of mesolimbic dopamine. Psychopharmacology 100:413-416.
36. Swerdlow NR, Caine SB, Braff DL, Geyer MA (1992). The neural substrates of sensorimotor gating of the startle reflex: a review of recent findings and their implications. J Psychopharmacology 6:176-190.
37. Thornton JC, Dawe S, Lee C, Capstiek C, Corr PJ, Cotter P et al. (1996). Effects of nicotine and amphetamine on latent inhibition in normal human subjects. Psychopharmacalogy 127:164-173.
38. Varty GB, Higgins GA (1995). Examination of drug-induced and isolation-induced disruptions of prepulse inhibition as models to screen antipsychotic drugs. Psychopharmacology 122:15-26.
39. Wan FJ, Swerdlow NR (1996). Sensorimotor gating in rats is regulated by different dopamine-glutamate interactions in the nucleus accumbens core and shell regions. Brain Res 722:168-176.
40. Wan SH, Matin SB, Azarnoff DL (1978). Kinetics, salivary excretion of amphetamine isomers, and effect of urinary pH. Clin Pharmacol Ther 23:585-590.