Determination of bupivacaine and three of its metabolites in rat urine by capillary electrophoresis

Electrophoresis

Volumn 19, Issue 16-17, 1998, Pages 2997-3002

  Schieferecke, Mark A ^a   McLaughlin, Kieran J ^a   Faibushevich, Alexander A ^a   Lunte, Craig E ^a  

^a UNIVERSITY OF KANSAS   (United States)

Author keywords

Bupivacaine; Bupivacaine metabolites; Capillary electrophoresis; Drug analysis

Indexed keywords

ANESTHETICS; BIOMOLECULES; BODY FLUIDS; EXTRACTION; METABOLITES; PHASE SEPARATION; RATS;

BUPIVACAINE; BUPIVACAINE METABOLITE; CAPILLARY ELECTROPHORETIC METHODS; DRUG ANALYSIS; LOCAL ANAESTHETIC; MIGRATION TIME; PEAK HEIGHT; RAT URINE; REPRODUCIBILITIES;

CAPILLARY ELECTROPHORESIS;

3' HYDROXYBUPIVACAINE; 4' HYDROXYBUPIVACAINE; BUFFER; BUPIVACAINE; DESBUTYLBUPIVACAINE; DRUG METABOLITE; METHANOL; PRILOCAINE; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ANIMAL EXPERIMENT; CAPILLARY ELECTROPHORESIS; CONFERENCE PAPER; CONTROLLED STUDY; DRUG DETERMINATION; DRUG URINE LEVEL; FEMALE; NONHUMAN; PH; RAT; REPRODUCIBILITY; SOLID PHASE EXTRACTION;

EID: 0031743213     PISSN: 01730835     EISSN: None     Source Type: Journal    
DOI: 10.1002/elps.1150191633     Document Type: Conference Paper

References (22)

1. Burm, A. G. L., Drug Dispos. 1989, 16, 283-311.
2. Caldwell, J., Notarianni, L. J., Smith, R. L., Snedden, W., Proc. B.P.S. 1977, July 13-15, 135-136.
3. Goehl, T. J., Davenport, J. B., Stanley, M. J., Xenobiotica 1973, 3, 761-772.
4. Dennhardt, R., Fricke, M., Stoeckert, G., Reg. Anaesth. 1978, 1, 59-64.
5. Bouche, R., Lhoest, G., Pharm. Acta. Helv. 1976, 51, 223-225.
6. Kuhnert, P. M., Kuhnert, B. R., Stitts, J. M., Gross, T. L., J. Anesthesiology 1981, 55, 611-617.
7. Pihlajamaki, K., Kanto, J., Lindberg, R., Karanako, M., Kiilholma, P., Brit. J. Anaesth. 1990, 64, 556-562.
8. Mather, L. E., Long, G. J., Thomas, J., Clin. Pharmacol. Ther. 1971, 12, 935-943.
9. Reynolds, F., Brit. J. Anaesth. 1971, 43, 33-37.
10. Sullivan, N. W., Weiner, L., J. Chromatogr. 1987, 417, 236-238.
11. Michaelis, H. C., Geng, W., Kahl, G. F., Foth, H., J. Chromatogr. 1990, 527, 201-207.
12. Le Guevello, P., Le Corre, P., Chevanne, F., Le Verge, R., J. Chromatogr. 1993, 622, 284-290.
13. Lindberg, R. L. P., Kanto, J. H., Pihlajamaki, K. K., J. Chromatogr. 1986, 383, 357-364.
14. Kastrissios, H., Hung, M. F., Triggs, E. J., J. Chromatogr. 1992, 577, 103-107.
15. Gupta, R. N., Dauphin, A., J. Chromatogr. B 1994, 658, 113-119.
16. Yu, Z., Westerlund, D., J. Chromatogr. A 1996, 725, 149-155.
17. Yu, Z., Abdel-Rehim, M., Westerlund, D., J. Chromatogr. B 1994, 654, 221-230.
18. Soini, H., Riekkola, M. L., Novotny, M. V., J. Chromatogr. 1992, 608, 265-274.
19. Wolfisberg, H., Schmutz, A., Stotzer, R., Thormann, w., J. Chromatogr. A 1993, 652, 407-416.
20. Weinberger, R., Sapp, E., Moring, S., J. Chromatogr. 1990, 516, 271-285.
21. Leung, G. N. W., Tang, H. P. O., Tso, T. S. C., Wan, T. S. M., J. Chromatogr. A 1996, 738, 141-154.
22. nd International Symposium on High Performance Liquid Chromatography, St. Louis, May 1998, p. 216.