Enantiomeric resolution of the calcium channel antagonist 8- benzylamino-8,11-oxapentacyclo[5.4.0.02,6.03,10.05.9]undecane (NGP 1- 01)

Pharmazie

Volumn 53, Issue 12, 1998, Pages 859-861

  Malan, S F ^a   Dockendolf, G ^a   Van Der Walt, J J ^a   Van Rooyen, J M ^a   Van Der Schyf, C J ^a,b,c  

^a NORTH WEST UNIVERSITY   (South Africa)

^b VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY   (United States)

^c VIRGINIA MARYLAND REGIONAL COLLEGE OF VETERINARY MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,3,4,6 TETRA O ACETYL BETA DEXTRO GLUCOPYRANOSYLISOTHIOCYANATE; 4 BENZYL 3 HYDROXY 4 AZAHEXACYCLO[5.4.1.0 2,6 .0 3,10 .0 5,9 .0 8,11]DODECANE; ACETYLMANDELOYLCHLORIDE; CALCIUM CHANNEL; CALCIUM CHANNEL BLOCKING AGENT; DICHLOROMETHANE; OXALIC ACID; SILICA GEL; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; DERIVATIZATION; DIASTEREOISOMER; DRUG DETERMINATION; DRUG HYDROLYSIS; DRUG PURITY; ENANTIOMER; GUINEA PIG; HEART MUSCLE CELL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NONHUMAN; STEREOCHEMISTRY;

ANIMALS; BRIDGED COMPOUNDS; CALCIUM CHANNEL BLOCKERS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ELECTROPHYSIOLOGY; GUINEA PIGS; HEART; MYOCARDIUM; PATCH-CLAMP TECHNIQUES; STEREOISOMERISM;

EID: 0031743124     PISSN: 00317144     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Kwon, Y.-W.; Triggle, D. J.: Chirality 3, 393 (1991)
2. Ravens, U.; Schopper, H. P.: Naunyn Schmiedebergs Arch. Pharmacol. 341, 232 (1990)
3. Kass, R. S.; Circ. Res. 61, 11 (1987)
4. Van der Schyf, C. J.: Squier, G. J.; Coetzee, W. A.; Pharmacol. Res. Commun. 18, 407 (1986)
5. Liebenberg, W.; Van Rooyen, P. H.; Van der Schyf, C. J.: Pharmazie 51, 20 (1996)
6. Van der Schyf, C. J.; Liebenberg, W.; Bornman, R.; Dekker, T. G.; Van Rooyen, P. H.; Fourie, T. G.; Matthee, E.; Snyckers, F. O.: S. Afr. J. Chem. 42, 46 (1989)
7. Marchand, A. P.; Arney, B. E.; Dave, P. R.; Satyanarayana, N.; Watson, W. H.; Nagel, A.: J. Org. Chem. 53, 2644 (1988)
8. Van der Walt, J. J.; Van der Schyf, C. J.; Van Rooyen, J. M.; De Jager, J.; Van Aarde, M. N.: S. Afr. J. Sci. 84, 448 (1988)
9. Du Preez, J. L.; Latter, A. P.: Drug Devel. Ind. Pharm.22, 1249 (1996)
10. Du Preez, J. L.; Lötter, A. P.; Guillory, J. K.: Pharmazie 51, 223 (1996)
11. Thayer, K.: Org. Synth. 12, 12 (1932)
12. Whitesell, J. K.; Reynolds, D.: J. Org. Chem. 48, 3548 (1983)
13. Bojarski, J.; Aboul-Enein, H. Y.: Biomed. Chromatogr. 10, 297 (1996)
14. Gorog, S.; Gazdag, M.: J. Chromatogr. B Biomed. Appl. 659, 51 (1994)
15. De Lorenzi, E.; Fell, A. F.; Caccialanze, G.; Massolini, G.; Kitsos, M.: J. Pharm. Biomed. Anal. 10, 909 (1992)
16. Subert, J.: Pharmazie 49, 3 (1994)
17. Vandenbosch, C.; Luc Massart, D.; Linder, W.: J. Pharm. Biomed. Anal. 10, 895 (1992)
18. Lobell, M.; Schneider, M. P.: J. Chromatogr. 633, 287 (1993)
19. Nimura, N.; Ogura, H.; Kinoshita, T.: J. Chromatogr. 202, 375 (1980)
20. Gal, J.: J. Chromatogr. 533, 349 (1985)
21. Hamil, O. P.; Marty, A.; Neher, E.; Sakman, B.; Sigworth, F. J.: Pflüg. Arch. 391, 85 (1981)
22. Cookson, R. C.; Crundwell, E.; Hill, R. R.; Hudec, J.; J. Chem. Soc. 3062 (1964)
23. Huet, F.; Lechevalier, A.; Pellet, M.; Conia, J. M.: Synthesis l, 63 (1978)
24. March, J.; in: Advanced organic chemistry 4th edn., p. 96, John Wiley and Sons, New York 1992
25. Mitra, R.; Morad, M.: Amer. J. Physiol. 249, H1056 (1985)