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note
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5 stands for the pentyloxy spacer and CBPh is the abbreviation for the cyanobiphenyl unit. The modification has yielded an amide linkage as indicated by NHCO. For the sake of simplicity, model compound propylamine is depicted as a dendrimer with a functionality of n = 1.
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65
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Synthetic procedure of the acid functionalized cyanobiphenyl unit is in good agreement with procedures used in: a) K. Lorenz, R. Mülhaupt, H. Frey, U. Rapp, F.-J. Mayer-Posner, Macromolecules 1995, 28, 6657; b) P. A. G. Cormack, B. D. Moore, D. C. Sherrington, Chem. Commun. 1996, 353.
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note
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Hydroxysuccinimidoyl derivatives of alkoxycyanobiphenyl units proved to be quite unreactive under normal dendritic coupling conditions, although succinimidoyl derivatives of tBOC-protected amino acid derivatives gave quantitative conversions.
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Although in the case of compound 9 the observed mass deviates from the calculated one, it was observed that changing of experimental conditions yielded a slight shift of the parent peak. However, there are no indications that the dendritic structure decomposes during analysis.
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70
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3743102702
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unpublished results
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Reactivity of the secondary amines towards pentafluorophenol esters has been also observed for other substituents. These sites, however, are not reactive towards the corresponding N-hydoxysuccinimidoyl derivatives. M. W. P. L. Baars, J. B. Cristensen, unpublished results.
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3743135172
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Differential scanning calorimetry data were obtained in the second heating run and/or first cooling run
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Differential scanning calorimetry data were obtained in the second heating run and/or first cooling run.
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76
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80
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0001236846
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Numbering is as follows
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13C) are identical to literature data: C. D. Poon, J. Afzal, M. Gangoda, B. M. Jung, Magn. Res. Chem. 1986, 24, 1014. Numbering is as follows:
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