Integration of growth factor, extracellular matrix, and retinoid signals during bronchial epithelial cell differentiation

Molecular and Cellular Biology

Volumn 18, Issue 11, 1998, Pages 6666-6678

  Moghal, Nadeem ^a   Neel, Benjamin G ^a  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN; GROWTH FACTOR; RETINOIC ACID RECEPTOR;

ARTICLE; AUTOPHOSPHORYLATION; BRONCHUS MUCOSA; CELL DIFFERENTIATION; EPITHELIUM CELL; EXTRACELLULAR MATRIX; LIGAND BINDING; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION;

EID: 0031742047     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.18.11.6666     Document Type: Article

References (75)

1. Alessi, D. R., A. Cuenda, P. Cohen, D. T. Dudley, and A. R. Saltiel. 1995. PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo. J. Biol. Chem. 270:27489-27494.
2. Apfel, C., F. Bauer, M. Crettaz, L. Forni, M. Kamber, F. Kaufmann, P. LeMotte, W. Pirson, and M. Klaus. 1992. A retinoic acid receptor alpha antagonist selectively counteracts retinoic acid effects. Proc. Natl. Acad. Sci. USA 89:7129-7133.
3. Ausubel, F., R. Brent, R. E. Kingston, D. D. Moore, J. G. Seidman, J. A. Smith, and K. Struhl (ed.). 1987. Current protocols in molecular biology, vol. 1. Greene Publishing Associates, New York, N.Y.
4. Bennett, A. M., S. E. Hausdorff, A. M. O'Reilly, R. M. Freeman, and B. G. Neel. 1996. Multiple requirements for SHPTP2 in epidermal growth factor-mediated cell cycle progression. Mol. Cell. Biol. 16:1189-1202.
5. Bennett, A. M., and N. K. Tonks. 1997. Regulation of distinct stages of skeletal muscle differentiation by mitogen-activated protein kinases. Science 278:1288-1291.
6. Berard, J., F. Laboune, M. Mukuna, S. Masse, R. Kothary, and W. E. C. Bradley. 1996. Lung tumors in mice expressing an antisense RARβ2 transgene. FASEB J. 10:1091-1097.
7. Bonfini, L., E. Migliaccio, G. Pelicci, L. Lanfrancone, and P. G. Pelicci. 1996. Not all Shc's roads lead to Ras. Trends Biochem. Sci. 21:257-261.
8. Chambon, P. 1996. A decade of molecular biology of retinoic acid receptors FASEB J. 10:940-954.
9. Chen, Q., M. S. Kinch, T. H. Lin, K. Burridge, and R. L. Juliano. 1994. Integrin-mediated cell adhesion activates mitogen-activated protein kinases. J. Biol. Chem. 269:26602-26605.
10. Clark, E. A., and J. S. Brugge. 1995. Integrins and signal transduction pathways: the road taken. Science 268:233-239.
11. Coolican, S. A., D. S. Samuel, D. Z. Ewton, F. J. McWade, and J. R. Florini. 1997. The mitogenic and myogenic actions of insulin-like growth factors utilize distinct signaling pathways. J. Biol. Chem. 272:6653-6662.
12. Cowley, S., H. Paterson, P. Kemp, and C. J. Marshall. 1994. Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH3T3 cells. Cell 77:841-852.
13. de The, H., A. Marchio, P. Tiollais, and A. Dejean. 1989. Differential expression and ligand regulation of the retinoic acid receptor α and β genes. EMBO J. 8:429-433.
14. de The, H., M. D. M. Vivanco-Ruiz, P. Tiollais, H. Stunnenberg, and A. Dejean. 1990. Identification of a retinoic acid responsive element in the retinoic acid receptor β gene. Nature (London) 343:177-180.
15. Dolle, P., E. Ruberte, P. Leroy, G. Morriss-Kay, and P. Chambon. 1990. Retinoic acid receptors and cellular retinoid binding proteins. I. A systematic study of their differential pattern of transcription during mouse organogenesis. Development 110:1133-1151.
16. Dudley, D. T., L. Pang, S. J. Decker, A. J. Bridges, and A. R. Saltiel. 1995. A synthetic inhibitor of the mitogen-activated protein kinase cascade. Proc. Natl. Acad. Sci. USA 92:7686-7689.
17. Edwards, G., and C. Streuli. 1995. Signaling in extracellular matrix-mediated control of epithelial cell phenotype. Biochem. Soc. Trans. 23:464-468.
18. Feng, G. S., C. C. Hui, and T. Pawson. 1993. SH2-comaining phosphotyrosine phosphatase as a target of protein-tyrosine kinases. Science 259:1607-1611.
19. Font de Mora, J., A. Porras, N. Ahn, and E. Santos. 1997. Mitogen-activated protein kinase activation is not necessary for, but antagonizes, 3T3-L1 adipocyte differentiation. Mol. Cell. Biol. 17:6068-6075.
20. Frangioni, J. V., N. Moghal, A. Stuart-Tilley, B. G. Neel, and S. L. Alper. 1994. The DNA binding domain of retinoic acid receptor β is required for ligand-dependent suppression of proliferation. J. Cell Sci. 107:827-838.
21. Gebert, J. F., N. Moghal, J. V. Frangioni, D. J. Sugarbaker, and B. G. Neel. 1991. High frequency of retinoic acid receptor β abnormalities in human lung cancer. Oncogene 6:1859-1868.
22. Geisen, C., C. Denk, B. Gremm, C. Baust, A. Karger, W. Bollag, and E. Schwarz. 1997. High-level expression of the retinoic acid receptor beta gene in normal cells of the uterine cervix is regulated by the retinoic acid receptor alpha and is abnormally down-regulated in cervical carcinoma cells. Cancer Res. 57:1460-1467.
23. Gray, T. E., K. Guzman, C. W. Davis, L. H. Abdullah, and P. Nettesheim. 1996. Mucociliary differentiation of serially passaged normal human tracheobronchial epithelial cells. Am. J. Respir. Cell Mol. Biol. 14:104-112.
24. Harkema, J., A. Mariassy, J. St. George, D. M. Hyde, and C. G. Plopper. 1991. Epithelial cells of the conducting airways, p. 3-39. In S. G. Farmer and D. W. P. Hay (ed.), The airway epithelium. Marcel Dekker, Inc., New York, N.Y.
25. Houle, B., C. Rochette-Egly, and W. E. C. Bradley. 1993. Tumor-suppressive effect of the retinoic acid receptor β in human epidermoid lung cancer cells. Proc. Natl. Acad. Sci. USA 90:985-989.
26. Hu, E., J. B. Kim, P. Sarraf, and B. M. Spiegelman. 1996. Inhibition of adipogenesis through MAP kinase-mediated phosphorylation of PPARγ. Science 274:2100-2103.
27. Hu, L., D. L. Crowe, J. G. Rheinwald, P. Chambon, and L. Gudas. 1991. Abnormal expression of retinoic acid receptors and keratin 19 by human oral and epidermal squamous cell carcinoma cell lines. Cancer Res. 51:3972-3981.
28. Jetten, A. M. 1989. Multistep process of squamous differentiation in tracheobronchial epithelial cells in vitro: analogy with epidermal differentiation. Environ. Health Perspect. 80:149-160.
29. Jetten, A. M., A. R. Brody, M. A. Deas, G. E. R. Hook, J. I. Rearick, and S. M. Thacher. 1987. Retinoic acid and substratum regulate the differentiation of rabbit tracheal epithelial cells into squamous and secretory phenotype. Lab. Investig. 56:654-664.
30. Jetten, A. M., and J. E. Shirley. 1986. Characterization of transglutaminase activity in rabbit tracheal epithelial cells. J. Biol. Chem. 261:15097-15101.
31. Johnson, G. R., B. Kannan, M. Shoyab, and K. Stromberg. 1993. Amphiregulin induces tyrosine phosphorylation of the epidermal growth factor receptor and p185erbB2. Evidence that amphiregulin acts exclusively through the epidermal growth factor receptor at the surface of human epithelial cells. J. Biol. Chem. 268:2924-2931.
32. Kannan, S., M. De Santis, M. Lohmeyer, D. J. I. Riese, G. H. Smith, N. Hynes, M. Seno, R. Brandt, C. Bianco, G. Perisco, N. Kenney, N. Normanno, I. Martinez-Lacaci, F. Ciardiello, D. F. Stern, W. J. Gullick, and D. J. Salomon. 1997. Cripto enhances the tyrosine phosphorylation of Shc and activates mitogen-activated protein kinase (MAPK) in mammary epithelial cells. J. Biol. Chem. 272:3330-3335.
33. Kato, S., H. Endoh, Y. Masuhiro, T. Kitamoto, S. Uchiyama, H. Sasaki, S. Masushige, Y. Gotoh, E. Nishida, H. Kawashima, D. Metger, and P. Chambon. 1995. Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase. Science 270:1491-1494.
34. Kazlauskas, A. 1994. Receptor tyrosine kinases and their targets. Curr. Opin. Genet. Dev. 4:5-14.
35. King, W. G., M. D. Mattaliano, T. O. Chan, P. N. Tsichlis, and J. S. Brugge. 1997. Phosphatidylinositol 3-kinase is required for integrin-stimulated AKT and Raf-1/mitogen-activated protein kinase pathway activation. Mol. Cell. Biol. 17:4406-4418.
36. Lechleider, R. J., R. M. Freeman, and B. G. Neel. 1993. Tyrosyl phosphorylation and growth factor receptor association of the human corkscrew homologue, SH-PTP2. J. Biol. Chem. 268:13434-13438.
37. Levitzki, A., and A. Gazit. 1995. Tyrosine kinase inhibition: an approach to drug development. Science 267:1782-1788.
38. Lin, C. Q., and M. J. Bissell. 1993. Multi-faceted regulation of cell ditterentiation by extracellular matrix. FASEB J. 7:737-743.
39. Lin, H., D. M. Carlson, J. St. George, C. G. Plopper, and R. Wu. 1989. An ELISA method for the quantitation of tracheal mucins from human and nonhuman primates. Am. J. Respir. Cell. Mol. Biol. 1:41-48.
40. Lorenz, U., K. S. Ravichandran, D. Pei, C. T. Walsh, S. J. Burakoff, and B. G. Neel. 1994. Lck-dependent tyrosyl phosphorylation of the phosphotyrosine phosphatase SH-PTP1 in murine T cells. Mol. Cell. Biol. 14:1824-1834.
41. Lotan, R. 1996. Retinoids in cancer chemoprevention. FASEB J. 10:1031-1039.
42. Lotan, R., X.-C. Xu, S. M. Lippman, J. Y. Ro, J. S. Lee, J. J. Lee, and W. K. Hong. 1995. Suppression of retinoic acid receptor-β in premalignant oral lesions and its up-regulation by isotretinoin. N. Engl. J. Med. 332:1405-1410.
43. Martin, C. A., L. M. Ziegler, and J. L. Napoli. 1990. Retinoic acid, dibutyryl-cAMP and differentiation affect the expression of retinoic acid receptors in F9 cells. Proc. Natl. Acad. Sci. USA 87:4804-4808.
44. McDowell, E. M., K. P. Keenan, and M. Huang. 1984. Effects of vitamin A-deprivation on hamster tracheal epithelium: a quantitative morphologic study. Virchows Arch. Cell Pathol. 45:197-219.
45. Mendelsohn, C., E. Ruberte, M. LeMeur, G. Morriss-Kay, and P. Chambon. 1991. Developmental analysis of the retinoic acid-inducible RAR-β2 promoter in transgenic animals. Development 113:723-734.
46. Migliaccio, E., S. Mele, A. E. Salcini, G. Pelicci, K.-M. V. Lai, G. Superti-Furga, T. Pawson, P. P. Di Fiore, L. Lanfrancone, and P. G. Pelicci. 1997. Opposite effects of the p52shc/p46shc and p66shc splicing isoforms on the EGF receptor-MAP kinase-fos signaling pathway. EMBO J. 16:706-716.
47. Mizushima, S., and S. Nagata. 1990. pEF-BOS, a powerful mammalian expression vector. Nucleic Acids Res. 18:5322.
48. Moghal N., and B. G. Neel. 1995. Evidence for impaired retinoic acid receptor-thyroid hormone receptor AF-2 cofactor activity in human lung cancer. Mol. Cell. Biol. 15:3945-3959.
49. Nervi, C., T. M. Vollberg, M. D. George, A. Zelent, P. Chambon, and A. M. Jetten. 1991. Expression of nuclear retinoic acid receptors in normal tracheobronchial cells and in lung carcinoma cells. Exp. Cell. Res. 195:163-170.
50. Okada, S., A. W. Kao, B. P. Ceresa, P. Blaikie, B. Margolis, and J. E. Pessin. 1997. The 66-kDa Shc isoform is a negative regulator of the epidermal growth factor-stimulated mitogen-activated protein kinase pathway. J. Biol. Chem. 272:28042-28049.
51. Pear, W. S., G. P. Nolan, M. L. Scott, and D. Baltimore. 1993. Production of high-titer helper-free retroviruses by transient transfection. Proc. Natl. Acad. Sci. USA 90:8392-8396.
52. Pelech, S. L., and J. S. Sanhera. 1992. Mitogen-activated protein kinases: versatile transducers for cell signaling. Trends Biochem. Sci. 17:233-238.
53. Pelicci, G., L. Lanfrancone, F. Grignani, J. McGlade, F. Cavallo, G. Forni, I. Nicoletti, F. Grignani, T. Pawson, and P. G. Pelicci. 1992. A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction. Cell 70:93-104.
54. Rearick, J. I., P. W. Albro, and A. M. Jetten. 1987. Increase in cholesterol sulfotransferase activity during in vitro squamous differentiation of rabbit tracheal epithelial cells and its inhibition by retinoic acid. J. Biol. Chem. 262: 13069-13074.
55. Rearick, J. I., M. Deas, and A. M. Jetten. 1987. Synthesis of mucous glyco-proteins by rabbit tracheal cells in vitro. Modulation by substratum, retinoids and cyclic AMP. Biochem. J. 242:19-25.
56. Rochette-Egly, C., S. Adam, M. Rossignol, J.-M. Egly, and P. Chambon. 1997. Stimulation of RARα activation function AF-1 through binding to the general transcription factor TFIIH and phosphorylation by CDK7. Cell 90: 97-107.
57. Rosales, C., V. O'Brien, L. Kornberg, and R. Juliano. 1995. Signal transduction by cell adhesion receptors. Biochim. Biophys. Acta 1242:77-98.
58. Salomon, D. S., R. Brandt, F. Ciardiello, and N. Normanno. 1995. Epidermal growth factor-related peptides and their receptors in human malignancies. Crit. Rev. Oncol. Hematol. 19:183-232.
59. Schlaepfer, D. D., S. K. Hanks, T. Hunter, and P. van der Geer. 1994. Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase. Nature (London) 372:786-791.
60. Schneller, M., K. Vuori, and E. Ruoslahti. 1997. αvβ3 integrin associates with activated insulin and PDGFβ receptors and potentiates the biological activity of PDGF. EMBO J. 16:5600-5607.
61. Schreiber, E., P. Matthias, M. M. Muller, and W. Schaffner. 1989. Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells. Nucleic Acids Res. 17:6419.
62. Sever, C. E., and J. Locker. 1991. Expression of retinoic acid α and β receptor genes in liver and hepatocellular carcinoma. Mol. Carcinog. 4:138-144.
63. Shifrin, V. I., and B. G. Neel. 1993. Growth factor-inducible alternative splicing of nontransmembrane phosphotyrosine phosphatase PTP-1B pre-mRNA. J. Biol. Chem. 268:25376-25384.
64. Shrivastava, A., C. Radziejewski, E. Campbell, L. Kovac, M. McGlynn, T. E. Ryan, S. Davis, M. P. Goldfarb, D. J. Glass, G. Lemke, and G. D. Yancopoulos. 1997. An orphan receptor tyrosine kinase family whose members serve as nonintegrin collagen receptors. Mol. Cell 1:25-34.
65. Swisshelm, K., K. Ryan, X. Lee, H. C. Tsou, M. Peacocke, and R. Sager. 1994. Down-regulation of retinoic acid receptor β in mammary carcinoma cell lines and its up-regulation in senescing normal mammary epithelial cells. Cell Growth Differ. 5:133-141.
66. Tang, T. L. 1994 Signal transduction by the SH2-contammg protein tyrosine phosphatase SH-PTP2. Thesis. Harvard University, Cambridge, Mass.
67. Traverse, S., N. Gomez, H. Paterson, C. Marshall, and P. Cohen. 1992. Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor. Biochem. J. 288:351-355.
68. Tsao, M. S., H. Zhu, A. Giaid, J. Viallet, T. Nakamura, and M. Park. 1993. Hepatocyte growth factor/scatter factor is an autocrine factor for human normal bronchial epithelial and lung carcinoma. Cell Growth Differ. 4:571-579.
69. Tsao, M. S., H. Zhu, and J. Viallet. 1996. Autocrine growth loop of the epidermal growth factor receptor in normal and immortalized human bronchial epithelial cells. Exp. Cell Res. 223:268-273.
70. Vivanco Ruiz, M. M., T. H. Bugge, P. Hirschmann, and H. G. Stunnenberg. 1991. Functional characterization of a natural retinoic acid response element. EMBO J. 10:3829-3838.
71. Vogel, W., G. D. Gish, F. Alves, and T. Pawson. 1997. The discoidin domain receptor tyrosine kinases are activated by collagen. Mol. Cell 1:13-23.
72. Wong, Y. C., and R. C. Buck. 1971. An electronic microscopic study of metaplasia of the rat tracheal epithelium in vitamin A deficiency. Lab. Investig. 24:55-66.
73. Wu, R., W. R. Martin, C. B. Robinson, J. A. St. George, C. G. Plopper, G. Kurland, J. A. Last, C. E. Cross, R. J. McDonald, and R. Boucher. 1990. Expression of mucin synthesis and secretion in human tracheobronchial epithelial cells grown in culture. Am. J. Respir. Cell Mol. Biol. 3:467-478.
74. Wu, R., Y. H. Zhao, and M. M. J. Chang. 1997. Growth and differentiation of conducting airway epithelial cells in culture. Eur. Respir. J. 10:2398-2403.
75. Yi, E. S., H. Lee, S. Yin, P. Piguet, I. Sarosi, S. Kaufmann, J. Tarpley, N. S. Wang, and T. R. Ulich. 1996. Platelet-derived growth factor causes pulmonary cell proliferation and collagen deposition in vivo. Am. J. Pathol. 149: 539-548.