Pharmacokinetics and biodistribution of radioimmunoconjugates of anti- CD19 antibody and single-chain Fv for treatment of human B-cell malignancy

Cancer Immunology Immunotherapy

Volumn 47, Issue 3, 1998, Pages 121-130

  Li, Quanzhi ^a   Hudson, Wendy ^a   Wang, Duo ^a   Berven, Erica ^a   Uckun, Fatih M ^a,b   Kersey, John H ^a,c  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

^c NONE   (United States)

Author keywords

Anti CD19; Biodistribution; Pharmacokinetics; Radioimmunoconjugates; Single chain Fv

Indexed keywords

CD19 ANTIGEN; IMMUNOTOXIN; MONOCLONAL ANTIBODY;

ARTICLE; B CELL LEUKEMIA; HUMAN; HUMAN CELL; LYMPHOMA; NUDE MOUSE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PURIFICATION; SCATCHARD PLOT;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD19; DRUG STABILITY; HUMANS; IMMUNOCONJUGATES; IMMUNOGLOBULIN FRAGMENTS; LYMPHOMA, B-CELL; MICE; MICE, NUDE; NEOPLASMS, EXPERIMENTAL; TISSUE DISTRIBUTION;

EID: 0031741632     PISSN: 03407004     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002620050512     Document Type: Article

References (32)

1. Adams GP, McCartney JE, Tai MS, Opermann H, Huston JS, Stafford WF III, Bookman MA, Fand I, Houston LL, Weiner LM (1993) Highly specific in vivo tumor targeting by monovalent and divalent forms of 741F8 anti-c-erbB-2 single-chain Fv. Cancer Res 53:4026
2. Badger CC, Krohn KA, Bernstein ID (1987) In vitro measurement of avidity of radiolabled antibodies. Nucl Med Biol 14:605
3. Bejcek BE, Wang D, Berven E, Pennell CA, Peiper SC, Poppema S, Uckun FM, Kersey JH (1995) Development and characterization of three recombinant single chain antibody fragments (scFvs) directed against the CD19 antigen. Cancer Res 55:2346
4. Buchner J, Pastan I, Brinkman U (1992) A method for increasing the yield of properly refolded recombinant fusion proteins: single-chain immunotoxins renaturation of bacterial inclusion bodies. Anal Biochem 205:263
5. 131I-labeled pan-B-cell monoclonal antibodies in nude mice bearing Raji Burkitt's lymphoma xenografts. Cancer Res 52:6476
6. 125I-labeled anti-tac disulfide-stabilized Fv fragments in nude mice with interleukin 2a receptor-positive tumor xenografts. Cancer Res 55:5323
7. Christensen El, Neilsen S (1991) Structural and functional features of protein handling in the kidney proximal tubule. Semin Nephrol 11:414
8. 177Lu]a-[2-(4-aminophenyl) ethyl]-1,4,7,10-tetraaza-cyclodecane-1,4,7,10-tetraaccetic acid-CC49 Fab radioimmnnoconjugate. Cancer Res 55:5288
9. Essig NZ, Wood JF, Howard AJ, Raag R, Whitlow M (1993) Crystallization of single-chain Fv proteins. J Mol Biol 234:897
10. Ghetie MN, Picker LJ, Richardson JA, Tucker K, Uhr JW, and Vittetta ES (1994) Anti-CD19 inhibits the growth of human B-cell tumor lines in vitro and of Daudi cells in SCID mice by inducing cell cycle arrest. Blood 83:1329
11. Huston JS, McCartney J, Tai M, Mottola C, Jin D, Warren F, Keck P, Opperman H (1993) Medical application of single-chain antibodies. Int Rev Immunol 10:195
12. Jagt RHCVD, Badger CC, Appelbaum FR, Press OW, Mathews DC, Eary JF, Krohn KA, Bernstein ID (1992) Localization of radiolabeled antimyeloid antibodies in human acute leukemia xenograft tumor model. Cancer Res 52:89
13. Jansen B, Uckun FM, Jaszaz WB, Kersey JH (1992) Establishment of human 1(4:11) leukemia in severe combined immunodeficiency mice and successful treatment using anti-CD19 (B43)-pokeweed antiviral protein immunotoxin. Cancer Res 52:406
14. Jurcic JG, Scheinberg DA (1994) Recent developments in the radioimmunotherapy of cancer. Curr Biol 6:715
15. [131]I anti-B1 (anti-CD20) antibody. N Engl J Med 329:459
16. Laemmli UK (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680
17. Leonard JL, Rosenberg IN (1978) Subcellular distribution of thyroxine 5′-deiodinase in the rat kidney: a plasma membrane location. Endocrinology 103:274
18. Lindmo T, Boven E, Cuttitta F, Fedorko J, Bunn Jr PA (1984) Determination of the immunoreactive fraction of radiolabeled monoclonal antibodies by linear extrapolation to binding at infinite antigen excess. J Immunol Methods 72:77
19. LoBuglio AF, Saleh MN (1992) Advances in monoclonal antibody therapy of cancer. Am J Med Sci 304:2142
20. Mach J, Pelegrin A, Buchegger E (1991) Imaging and therapy with monoclonal antibodies in non-hematopoietic tumors. Curr Biol 3:685
21. Milenic DE, Yokato T, Filpul DR, Finkelman MAJ, Dodd SW, Wood JE, Whitlow M, Snoy P, Schlom J (1991) Construction, binding properties, metabolism, and tumor targeting of a single-chain Fv derived from the pancarcinoma monoclonal antibody CC49. Cancer Res 51:6363
22. Pietersz GA, Li W, Sutton VR, Burgess J, McKenzie IFC, Zola H, Trapani JA (1995) In vitro and in vivo antitumor activity of a chimeric anti-CD 19 antibody. Cancer Immunol Immunother 41:53
23. Press OW, Eary JE, Appelbuum FR, Martin PJ Badger CC, Nelp WB, Glenn S, Butchko G, Fisher D, Porter B (1993) Radiolabeled antibody therapy of B-cell lymphoma with autologous bone marrow support. N Engl J Med 329:1219
24. Schott ME, Milenic DE, Yokota T, Whitlow, M, Wood JF, Fordyce WA, Cheng RC, Schlom J (1992) Differential metabolic patterns of unlimited versus radiometal chelated anticarcinoma single-chain Fv molecules. Cancer Res 52:6413
25. Tai M, McCartney JE, Adams GP, Jin D, Hudziak RM, Opermann H, Laminet AA, Bookman MA, Wolf EJ, Liu S, Huston JS, Stafford WK III, Fand I, Houston LL, Weiner LM, Huston JS (1995) Targeting c-erbB-2 expressing tumors using single-chain Fv monomers and dimers. Cancer Res 55:5983s
26. Truco M, Petris S, Garotta G, Ceppellini R (1980) Quantitative analysis of cell surface HLA structures by means of monoclonal antibodies. Hum Immunol 3:233
27. Uckun FM, Jaszcz W, Ambrus JL, Fauci AS, Gajl-Peczalska K, Song CW, Wick MR, Myers DE, Waddick K, Ledbetter JA (1988) Detailed studies on expression and function of CD19 surface determinants by using B43 monoclonal antibody and the clinical potential of anti-CD19 immunotoxins. Blood 71:13
28. Wang D, Berven E, Li Q, Uckun F, Kersey JH (1996) Optimization of conditions for formation and analysis of anti-CD19 FVS191 single-chain Fv homodimer (scKv′)2. Bioconjug Chem 8:64
29. Webber KO, Kreitman RJ, Paslan I (1995) Rapid and specific uptake of anti-tac disulfied stabilized Fv by interleukin-2 receptor-bearing tumors. Cancer Res 55:3318
30. Yang FE, Brown RS, Koral KE, Clavo AC, Jackson GA, Wahl RE (1992) Quantitative autoradiographic evaluation of the influence of protein dose on monoclonal antibody distribution in human ovarian adenocarcinoma xenografts. Cancer Immunol Immunother 35:365
31. Yokota T, Milenic DE, Whitlow M, Schlom J (1992) Rapid tumor penetration of single-chain Fv and comparison with other immunoglobulin forms. Cancer Res 52:3402
32. Zhu Z, Ghose T, Iles S, Yang C, Lee SHS, Fernandez LA, Lee CLY (1994) Pharmacokinetics, biodistribution and tumor localization of two anti-human B-cell chronic lymphocytic leukemia monoclonal antibodies and their F(ab)′2 fragments in a xenograft model. Cancer Letter 76:31