Neurotrophin receptors in Alzheimer's disease

Progress in Brain Research

Volumn 117, Issue , 1998, Pages 71-89

  Salehi, A ^a   Verhaagen, J ^a   Swaab, D F ^a  

^a NETHERLANDS INSTITUTE FOR NEUROSCIENCE   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

NEUROTROPHIN RECEPTOR;

ALZHEIMER DISEASE; CONFERENCE PAPER; DRUG RECEPTOR BINDING; FOREBRAIN; GENETIC REGULATION; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; NERVE FIBER TRANSPORT; NEUROFIBRILLARY TANGLE; OLIVARY NUCLEUS; PRIORITY JOURNAL; TISSUE DISTRIBUTION;

EID: 0031741514     PISSN: 00796123     EISSN: None     Source Type: Book Series    
DOI: 10.1016/s0079-6123(08)64009-1     Document Type: Conference Paper

References (142)

1. R.F. Alderson A.L. Alterman Y.-A. Barde R.M. Lindsay Brain-derived neurotrophic factor increases survival and differentiated functions of rat septal cholinergic neurons in culture Neuron 5 1990 297 306
2. S.J. Allen D. Dowbarn G.K. Wilcock Morphometrical immunochemical analysis of neurons in the nucleus basalis of Meynert in Alzheimer's disease Brain Res. 454 1988 272 281
3. S.J. Allen S.H. MacGowan J.J.S. Treanor R. Feeney G.K. Wilcock D. Dawbarn Normal B-NGF content in Alzheimer's disease cerebral cortex and hippocampus Neurosci. Lett. 131 1991 135 139
4. S.J. Allen D. Dawbarn S.D. Eckford G.K. Wilcock M. Ashcroft S.M. Colebrook R. Feeney S.H. MacGowan Cloning of a non-catalytic form of human trkB and distribution of messenger RNA for trkB in human brain Neuroscience 60 1994 825 834
5. C.A. Altar J.A. Siuciak P. Wright N.Y. Ip R.M. Lindsay S.J. Wiegand In situ hybridization of trkB and trkC receptors mRNA in rat forebrain and association with high-affinity binding of [125I]BDNF, [125I]NT-4/5 and [125I]NT-3 Eur. J. Neurosci. 6 1994 1389 1405
6. L.S.H. Appel Unifying hypothesis for cause of amyotrophic lateral sclerosis, Parkinson and Alzheimer's disease Ann. Neurol. 10 1981 499 505
7. E. Arenas H. Persson Neurotrophin-3 prevents the death of adult central noradrenergic neurons in vivo Nature 367 1994 368 371
8. T. Arendt V. Bigl A. Arendt A. Tennstedt Loss of neurons in the NBM in Alzheimer's disease, paralysis agitans and Korsakoff's disease Acta Neuropathol. 61 1983 101 108
9. T. Arendt H.G. Zvegintseva T.A. Leontovich Dendritic changes in the basal nucleus of Meynert and in the diagonal band nucleus in Alzheimer's disease - A quantitative Golgi investigation Neuroscience 19 1983 1265 1278
10. T. Arendt V. Bigl A. Arendt Neuron loss in the nucleus basalis of Meynert in Creutzfeldt-Jakob-Disease Acta Neuropathol. 65 1984 85 88
11. P.V. Arriagada J.H. Growdon E.T. Hedley-Whyte B.T. Hyman Neurofibrillary tangles but not senile plaques parallel severity of Alzheimer's disease Neurology 42 1992 631 639
12. F. Boissière S. Hunot B. Faucheux A. Mouatt-Prigent Y. Agid E.C. Hirsch High affinity neurotrophin receptors in cholinergic neurons in the human brain CR Acad Sci Paris/Life Science 317 1994 997 1003
13. F. Boissière B. Faucheux M. Ruberg Y. Agid E.C. Hirsch Decreased TrkA gene expression in cholinergic neurons of the striatum and basal forebrain of patients with Alzheimer's disease Exp. Neurol 145 1997 245 252
14. D.M. Bowen J.S. Benton J.A. Spillane C.C. Smith S.J. Allen Choline acetyltransferase activity and histopathology of frontal neocortex from biopsies of demented patients J. Neurol. Sci. 57 1982 191 202
15. C. Brayne C. Gill F.A. Huppert C. Barkley E. Gehlhaar D.M. Girling E.S. Paykel Incidence of clinically diagnosed subtypes of dementia in an elderly population. Cambridge Project for Later Life Br. J. Psychiatry 167 1995 255 262
16. M.A. Burke W.C. Mobley J. Cho S.J. Wiegand R.M. Lindsay E.J. Mufson J.H. Kordower Loss of developing cholinergic basal forebrain neurons following excitotoxic lesions of the hippocampus: Rescue by neurotrophins Exp. Neurol. 130 1994 178 195
17. S.E. Buxser L. Watson G.L. Johnson A comparison of binding properties and structure of NGF receptor on PC12 pheochromocytoma and A875 melanoma cells J. Cell. Biochem. 22 1983 219 233
18. V. Chan-Palay Galanin hyperinnervates surviving neurons of the human basal nucleus of Meynert in dementias of Alzheimer's and Parkinson's disease: A hypothesis for the role of galanin in accentuating cholinergic dysfunction in dementia J. Comp. Neurol. 273 1988 543 557
19. M.V. Chao M.A. Bothwell A.H. Ross H. Koprowski A.A. Lanahan C.R. Buck A. Sehgal Gene transfer and molecular cloning of the human NGF receptor Science 232 1986 518 521
20. B. Cheng M.P. Mattson Glucose deprivation elicits neurofibrillary tangle-like antigenic changes in hippocampal neurons: Prevention by NGF and bFGF Exp. Neurol. 117 1992 114 123
21. H.C. Chui W. Bondareff C. Zarow U. Slager Stability of neuronal number in the human nucleus basalis of Meynert with aging Neurobiol. Aging 5 1984 83 88
22. P.D. Coleman Toward rational therapy for Alzheimer's disease Neurobiol Aging 15 1994 S77 S78
23. D. Collerton Cholinergic function and intellectual decline in Alzheimer's disease Neuroscience 19 1986 1 28
24. B. Conner D. Young P. Lawlor W. Gai H. Waldvogel P.L.M. Faull M. Dragunow Trk receptor alterations in Alzheimer's disease Mol. Brain Res. 42 1996 1 17
25. K.A. Crutcher S.A. Scott S. Liang W.V. Everson J. Weingartner Detection of NGF-like activity in human brain tissue: increased levels in Alzheimer's disease J. Neurosci. 13 1993 2540 2550
26. R. Curtis K.M. Adryan J.L. Stark Park J.S. D.L. Compton G. Weskamp L.J. Huber M.V. Chao R. Jaenisch K.-F. Lee R.M. Lindsay P.S. DiStefano Differential role of the low affinity neurotrophin receptors (p75) in retrograde axonal transport of the neurotrophins Neuron 14 1995 1201 1211
27. D. Dawbarn S.J. Allen F.M. Semenenko Coexistence of choline acetyltransferase and nerve growth factor receptors in the rat basal forebrain Neurosci. Lett. 94 1988 138 144
28. M.D. Ehlers D.R. Kaplan D.L. Price V.E. Koliatsos NGF-stimulated retrograde transport of trkA in the mammalian nervous system J. Cell. Biol. 130 1995 149 156
29. P. Etienne Y. Robitaille P. Wood S. Gauthier N.P.V. Nair R. Quirion Nucleus basalis neuronal loss, neuritic plaque and choline acetyltransferase activity in advanced Alzheimer's disease Neuroscience 19 1986 1279 1291
30. W. Fischer A. Bjorklund K. Chen F.H. Gage NGF improves spatial memory in aged rodents as a function of age J. Neurosci 11 1991 1889 1906
31. L. Fratiglioni M. Viitanen E. VonStrauss B. Winblad Late-onset Alzheimer's disease: Incidence data from the Kungsholmen project, Stockholm Iqbal K. Winblad B. Nishimura T. Takeda M. Wisniewski H.M. Chichester: Alzheimer's Disease: Biology, Diagnosis and Therapeutics 1997 John Wiley & Sons Ltd 49 53
32. J. Frisén V.M.K. Verge K. Fried M. Risling H. Persson H. Trotter T. Hökfelt D. Lindholm Characterization of glial trkB receptors: Differential response to injury in the central and peripheral nervous systems Proc. Natl. Acad. Sci. U.S.A. 90 1993 4971 4975
33. T.D. Garver G.A. Oyler K.A. Harris R. Polavarapu Z. Damuni R.A. Lehman M.L. Billingsley Tau phosphorylation in brain slices: Pharmacological evidence for convergence effects of protein phosphatase on tau and mitogen-activated protein kinase Mol. Pharmacol. 47 1995 745 756
34. M. Goedert A. Fine S.P. Hunt A. Ulrich Nerve growth factor mRNA in peripheral and central rat tissues and in the human central nervous system: Lesion effects in the rat brain and levels in Alzheimer's disease Mol. Brain Res. 1 1986 85 92
35. M. Goedert A. Fine D. Dawbarn G.K. Wilcock M.V. Chao Nerve growth factor receptor mRNA distribution in human brain: Normal levels in basal forebrain in Alzheimer's disease Mol. Brain Res 5 1989 1 7
36. H. Gnahn F. Hefti R. Heumann M.E. Schwab H. Thoenen NGF-mediated increase of choline acetyltransferase (ChAT) in the neonatal rat forebrain: Evidence for a physiological role of NGF in the brain Brain Res. 285 1983 45 52
37. J. Hedreen R.G. Struble P.J. Whitehouse D.L. Price Topography of the magnocellular basal forebrain system in human brain J. Neuropath. Exp. Neurol. 43 1984 1 21
38. F. Hefti A. David J. Hartikka Chronic intera-ventricular injection of nerve growth factor elevates hippocampal choline acetyltransferase activity in adult rats with partial septo-hippocampal lesions Brain Res. 293 1984 305 311
39. F. Hefti Nerve growth factor promotes survival of septal cholinergic neurons of the fimbrial transection J. Neurosci. 6 1986 2155 2162
40. F. Hefti W.J. Weiner Nerve growth factor and Alzheimer's disease Ann. Neurol. 20 1986 275 281
41. F. Hefti D.C. Mash Localization of nerve growth factor receptors in the normal human brain and in Alzheimer's disease Neurobiol. Aging 10 1989 75 87
42. F. Hefti Neurotrophic factor therapy for nervous system degenerative diseases J. Neurobiol. 25 1994 1418 1453
43. B.L. Hempstead D. Martin-Zanca D.R. Kaplan L.F. Parada M.V. Chao High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor Nature 350 1991 678 683
44. W.T.J.M.C. Hermens J. Verhaagen Viral vectors, tools for gene transfer in the nervous system Prog. Neurobiol. 55 1998 399 432
45. G.A. Higgins E.J. Mufson NGF receptor gene expression is decreased in the nucleus basalis in Alzheimer's disease Exp. Neurol. 106 1989 222 236
46. J.C. Hoehner L. Olsen B. Sandstedt D.R. Kaplan S. Påhlman Association of neurotrophin receptor expression and differentiation in human neuroblastoma Am. J. Pathol. 147 1995 102 113
47. D.M. Holtzman Y. Li K. Chen F.H. Gage C.J. Epstein W.C. Mobley Nerve growth factor reverses neuronal atrophy in a Down syndrome model of age-related neurodegeneration Neurology 43 1993 2668 2673
48. H. Honjo Y. Ogino K. Naitoh M. Urabe J. Kitawaki J. Yasuda T. Yamamoto S. Ishihara H. Okada T. Yonezawa In vivo effects by estrone sulfate on the central nervous system-senile dementia (Alzheimer's type) J. Steroid Biochem 34 1989 521 525
49. W.J. Hoogendijk C.W. Pool D. Troost E. van Zwieten D.F. Swaab Image analyser-assisted morphometry of the locus coeruleus Alzheimer's disease, Parkinson's disease and amyotrophic sclerosis Brain 118 1995 131 143
50. N.Y. Ip T.N. Stitt P. Tapley R. Klein D.J. Glass J. Fandl L.A. Greene M. Barbacid G.D. Yancopoulos Similarities and differences in the way neurotrophins interact with the Trk receptors in neuronal and nonneuronal cells Neuron 10 1993 137 149
51. D.R. Kaplan B.L. Hempstead D. Martine-Zanca M.V. Cheo L.F. Parada The trk proto-oncogene product: A signal transducting receptor for nerve growth factor Science 252 1991 554 558
52. D.R. Kaplan D. Martin-Zanca L.F. Parada Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product by NGF Nature 350 1991 158 160
53. R. Katzman The prevalece and malignancy of Alzheimer's disease Arch. Neurol. 33 1976 217 218
54. R. Klein V. Nanduri S. Jing F. Lamballe P. Tapley S. Bryant C. CordonCardo R. Jones L.F. Reichardt M. Barbacid The trkB tyrosine protein kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3 Cell 66 1991 395 403
55. R. Klein R.J. Smeyne W. Wurst L.K. Long B.A. Auerbach A.L. Joyner M. Barbacid Targeted disruption of the trkB neurotrophin receptor gene results in nervous system lesions and neonatal death Cell 75 1993 113 132
56. R. Klein I. Silos-Santiago R.J. Smeyne S.A. Lira R. Brambilla S. Bryant L. Zhang W.D. Snider M. Barbacid Disruption of the neurotrophin-3 receptor gene trkC eliminates Ia muscle afferents and results in abnormal movements Nature 368 1994 249 251
57. M. Kojima N. Takahashi T. Ikeuchi H. Hatanaka Nerve growth factor (NGF)-mediated up-regulation of low-affinity NGF receptor gene expression in cultured basal forebrain cholinergic neurons from postnatal 3-day-old rats Mol. Brain Res. 16 1992 267 273
58. V.E. Koliatsos D.L. Price G.K. Gouras M.H. Cayouette L.E. Burton J.W. Winslow Highly selective effects of nerve growth factor, brain-derived neurotrophic factor, and neurotrophin-3 on intact and injured basal forebrain magnocellular neurons J. Comp. Neurol. 343 1994 247 262
59. S. Korsching G. Auburger R. Heumann J. Scott H. Theonen Levels of nerve growth factor and its mRNA in the cental nervous system of the rat correlates with cholinergic innervation EMBO J. 4 1985 1389 1393
60. F. Lamballe R. Klein M. Barbacid TrkC, a new member of the family of tyrosine protein Kinases, is a receptor for neurotrophin-3 Cell 66 1991 967 979
61. T.H. Large S.C. Bodary D.O. Clegg G. Weskamp U. Otten L.F. Reichardt Nerve growth factor gene expression in the developing rat brain Science 234 1986 352 355
62. E.B. Larson W.A. Kukull R.L. Katzman Cognitive impairment: Dementia and Alzheimer's disease Ann. Rev. Pub. Health 501 1992 431 449
63. G. Le Gal La Salle J.J. Robert S. Berrard V. Ridoux L.D. Stratford-Perricaudet M. Perricaudet J. Mallet An Adenovirus vector for gene transfer into neurons and glia in the brain Science 259 1993 988 990
64. V.M. Lee J.Q. Trojanowski The disordered neuronal cytoskeleton in Alzheimer's disease Curr. Opin. Neurobiol 2 1992 653 656
65. V.M.-Y. Lee Disruption of the cytoskeleton in Alzheimer's disease Curr. Opin. Neurobiol 5 1995 663 668
66. E.S. Levine Dreyfus C.F. I.B. Black M.R. Plummer Brain-derived neurotrophin factor rapidly enhances synaptic transmission in hippocampal neurons via postsynaptic tyrosine kinase receptors Proc. Natl. Acad. Sci. USA 92 1995 8074 8077
67. P. Lowes-Hommel J.Z. Gertz R. Ferszt J. Cerros-Navarro The basal nucleus of Meynert revised, the nerve cell number decreases with age Arch. Gerontol. Geriatr. 8 1989 21 27
68. S.B. MacMahon M.P. Armanini L.H. Ling H.S. Phillips Expression and coexpression of trk receptors in subpopulations of adult primary sensory neurons projecting to identified peripheral targets Neuron 12 1994 1161 1171
69. D.M.A. Mann P.O. Yates B. Marcyniuk Alzheimer's presenile dementia, senile dementia of the Alzheimer type and Down's syndrome in middle age from an age related continuum of pathological changes Neuropathol. Appl. Neurobiol. 10 1984 185 207
70. E. Masliah L.A. Hansen S. Quijada R. DeTeresa M. Alford J. Kauss R. Terry Late onset dementia with argyrophilic grains and or atypical progressive supranuclear palsy Ann. Neurol. 29 1991 389 396
71. P. McGeer L.E. McGeer G.J. Suzuki C. Dolman E.T. Nagai Aging, Alzheimer's disease and the cholinergic system of the basal forebrain Neurology 34 1984 741 745
72. S.B. McMahon M.P. Armanini L.H. Ling H.S. Phillips Expression and coexpression of Trk receptors in subpopulations of adult primary sensory neurons projecting to identified peripheral targets Neuron 1994 12 1994 1161 1171
73. P.J. McMillan C.A. Singer D.M. Dorsa The effects of ovariectomy and estrogen replacement on trkA and choline acetyltransferase mRNA expression in the basal forebrain of the adult female Sprague-Dawley rat J. Neurosci. 16 1996 1860 1865
74. S.O. Meakin U. Suter C.C. Drinkwater A.A. Welcher E.M. Shooter The rat trk protooncogene product exhibits properties characteristic of the slow nerve growth factor receptor Proc. Natl. Acad. Sci. U.S.A. 89 1992 2374 2378
75. J.-P. Merlio P. Ernfors M. Jaber H. Persson Molecular cloning of rat trkC and distribution of cells expressing messenger RNAs for members of the trk family in the rat central nervous system Neuroscience 51 1992 513 532
76. M.M. Mesulam E.J. Musfan A.I. Levey B.H. Wainer Atlas of cholinergic neurons in the forebrain and brain stem of the macaque based on monoclonal choline acetyltransferase immunohistochemistry and acetylcholinesterase histochemistry Neuroscience 12 1984 669 689
77. W.C. Mobley J.L. Rutkowski G.I. Tennekoon J. Gemski K. Buchanan M.V. Johnston Nerve growth factor increases choline acetyltransferase activity in developing basal forebrain neurons Brain Res. 387 1986 53 62
78. W.C. Mobley R.L. Neve S.B. Prusiner M.P. McKinley Nerve growth factor increases mRNA levels for the prion protein and the β-amyloid protein precursor in developing hamster brain Proc. Natl. Acad. Sci. U.S.A. 85 1988 9811 9815
79. J.K. Morse S.L. Wiegand K.A. Anderson Y. You N. Cai P.S. DiStefano C.A. Altar R.M. Lindsay R.F. Alderson Brain-derived neurotrophin factor (BDNF) prevents the degeneration of medial septal cholinergic neurons following a fimbria transection J. Neurosci. 13 1993 4146 4156
80. M. Moshnyakov U. Arumae M. Saarma MRNAs for one, two or three members of trk receptor family are expressed in single rat trigeminal ganglion neurons Mol. Brain. Res. 43 1996 141 148
81. E.J. Mufson L.N. Presley J.H. Kordower Nerve growth factor receptor immunoreactivity within nucleus basalis (ch4) in Parkinson's disease: Reduced cell number and colocalization with cholinergic neurons Brain Res. 531 1991 19 30
82. E.J. Mufson J.H. Kordower Cortical neurons express nerve growth factor receptors in age and Alzheimer disease Proc. Natl. Acad. Sci. U.S.A. 89 1992 569 573
83. E.J. Mufson J.M. Conner J.H. Kordower Nerve growth factor in Alzheimer's disease: Defective retrograde transport to nucleus basalis Neuroreport 6 1995 1063 1066
84. E.J. Mufson N. Lavine S. Jaffar J.H. Kordower R. Quirion H.U. Saragovi Reduction in p140-TrkA receptor protein within the nucleus basalis and cortex in Alzheimer's disease Exp. Neurol. 146 1997 91 103
85. Y. Muragaki N. Timothy S. Leight B.L. Hempstead M.V. Chao J.Q. Trojanowski V.M.-V. Lee Expression of trk receptors in the developing and adult human central and peripheral nervous system J. Comp. Neurol. 356 1995 387 397
86. K. Murase T. Nabeshima Y. Robitaille R. Quirion M. Ogawa K. Hayashi NGF level of is not decreased in the serum, brain-spinal fluid, hippocampus, or parietal cortex of individuals with Alzheimer's disease Biochem. Biophys. Res. Commun. 193 1993 198 203
87. R. Nagai P.L. McGeer J.H. Peng E.G. McGeer C.E. Dolman Choline acetyltransferase immunohis-tochemistry in brains of Alzheimer's disease patients and controls Neurosci. Lett. 36 1983 195 199
88. I. Nakano A. Hirano Loss of large neurons of the medial septal nucleus in an autopsy case of Alzheimer's disease J. Neuropathol. Exp. Neurol. 41 1982 341
89. A. Oehm I. Behrmann W. Falk M. Pawlita G. Maier C. Klas M. Li-Weber S. Richards J. Dhein B.C. Trauth Purification and molecular cloning of the APO-1 cell surface antigen, a member of the tumor necrosis factor/nerve growth factor receptor superfamily. Sequence identity with the Fas antigen J. Biol. Chem. 267 1992 10709 10715
90. Y. Ohyagi T. Tabira Effects of growth factors and cytokines on expression of amyloid beta protein precursor mRNAs in cultured neural cells Mol. Brain. Res. 18 1993 127 132
91. M.I. Olson C.M. Shaw Presenile dementia and Alzheimer's disease in mongolism Brain 92 1969 147 156
92. L. Olson A. Nordberg H. von Holst L. Bäckman T. Ebendahl Alafuzoff L. K. Amberla P. Hartvig A. Herlitz A. Lilja H. Lundquist B. Långstron B. Meyerson A. Persson M. Viitanen B. Winblad Seiger Ä Nerve growth factor affects 11C-nicotine binding, blood flow, EEG and verbal episodic memory in an Alzheimer patient J. Neurol. Transm. 4 1992 79 95
93. A. Ott M.M.B. Breteler F. van Harskamp J.J. Claus N.J.M. Van Der Cammen D.E. Grobee A. Hofman Prevalence of Alzheimer's disease and vascular dementia: association with education. The Rotterdam study BMJ 310 1995 970 973
94. A. Paganini-Hill Oestrogen replacement therapy and Alzheimer's disease Br. J. Obstet. Gynaeco 13 1996 80 86 Suppl
95. A. Paganini-Hill V.W. Henderson Estrogen deficiency and risk of Alzheimer's disease in women Am. J. Epidemiol. 140 1994 256 261
96. A.M. Palmer A.W. Procter G.C. Stratmann D.M. Bowen Excitatory amino acid-releasing and cholinergic neurones in Alzheimer's disease Neurosci. Lett 66 1986 199 204
97. L.F. Parada P. Tsoulfas L. Tessarollo J. Blair S.W. Reid D. Soppet The Trk family of tyrosine kinases: Receptors for NGF-related neurotrophins Cold Spring Harb. Symp. Quant. Biol 57 1992 43 51
98. A. Parent R. Boucher J. O'Reilly-Fromentin Acetylcholinesterase-containing neurons in palidal complex, morphologic characteristics and projection towards the neocortex Brain Res. 230 1981 356 361
99. R.C.A. Pearson M.V. Sofroniew A.C. Cuello T.P.S. Powell F. Eckenstein M.M. Esiri G.K. Wilcock Persistence of cholinergic neurons in the basal nucleus in a brain with senile dementia of the Alzheimer type demonstrated immunohistochemical staining for choline acetyltransferase Brain Res. 289 1983 375 379
100. A. Persson M. Viitanen B. Winblad B. Olson Intracranial infusion of purified nerve growth factor to an Alzheimer patient: The first attempt of a possible future treatment strategy Behav. Brain. Res. 57 1993 255 261
101. R.H. Perry J.M. Candy E.K. Perry D. Irving G. Blessed A.F. Fairbairn B.E. Tomlinson Extensive loss of choline acetyltransferase activity is not related to neuronal loss in the nucleus of Meynert in Alzheimer's disease Neurosci. Lett. 33 1982 311 315
102. E.K. Perry The cholinergic hypothesis 10 years on Br. Med, Bull. 42 1986 63 69
103. Philips H.S. Hains J.M. G. Laramee A. Rosenthal J.W. Winslow Widespread expression of BDNF but not NT3 by target areas of basal forebrain cholinergic neurons Science 250 1990 290 294
104. T. Ragot N. Vincent P. Chafey E. Vigne H. Gilgenkrantz D. Couton J. Cartaud P. Briand J.-C. Kaplan M. Perricaudet A. Khan Efficient adenovirus-mediated transfer of a human minidystrophin gene to skeletal muscle o Mdx mice. Nature 361 1993 647 650
105. L. Regeur C. Badsberg Jansen H. Pakkenberg S.M. Evans B. Pakkenberg No global neocortical nerve cell loss in brains from patients with senile dementia of Alzheimer's type Neurobiol. Aging 15 1993 347 352
106. C.E. Ribak G.W. Kramer Cholinergic neurons in the basal forebrain of the cat have direct projection to the sensorimotor cortex Exp. Neurol. 75 1982 453 465
107. P.M. Richardson V.M.K.V. Issa R.J. Riopelle Distribution of neuronal receptors for nerve growth factor in the rat J. Neurosci. 6 1986 2312 2321
108. J.O. Rinne L. Paljärvi U.K. Rinne Neuronal size and density in the nucleus basalis of Meynert in Alzheimer's disease J. Neurol. Sci. 79 1987 67 76
109. A. Salehi P.J. Lucassen C.W. Pool N.K. Gonatas R. Ravid D.F. Swaab Decreased neuronal activity in the nucleus basalis of Meynert in Alzheimer's disease as suggested by the size of the Golgi apparatus Neuroscience 4 1994 871 880
110. A. Salehi J.A. Van de Nes M.A. Hofman N.K. Gonatas D.F. Swaab Early cytoskeletal changes as shown by Alz-50 are not accompanied by decreased neuronal activity Brain Res 678 1995 28 39
111. A. Salehi R. Ravid N.K. Gonatas D.F. Swaab Decreased activity of hippocampal neurons in Alzheimer's disease is not related to the presence of neurofibrillary tangles J. Neuropathol. Exp. Neurol 54 1995 704 709
112. A. Salehi S. Heyn N.K. Gonatas D.F. Swaab Decreased protein synthetic activity of the hypothalamic tuberomamillary nucleus in Alzheimer's disease as suggested by the size of the Golgi apparatus Neurosci. Lett 193 1995 1 4
113. A. Salehi J. Verhaagen P.A. Dijkhuizen D.F. Swaab Co-localization of high affinity neurotrophin receptors in nucleus basalis of Meynert neurons and their differential reduction in Alzheimer's disease Neuroscience 75 1996 373 387
114. S.A. Scott E.J. Mufson J.A. Weingartner K.A. Skau K.A. Crutcher Nerve growth factor in Alzheimer's disease: increased levels throughout the brain coupled with declines in nucleus basalis J. Neurosci. 15 1995 6213 6221
115. Seiger Å A. Nordberg H. von Holst L. Bäckman T. Ebendal I. Alafuzoff K. Amberla P. Hartvig A. Herlitz A. Lilja H. Lundqvist B. Längström B. Meyerson A. Persson M. Viitanen Wnblad B. L. Olson Intracranial infusion of purified nerve growth factor to an Alzheimer pateint: the first attempt of a possible future treatment strategy Behav. Brain Res. 57 1993 255 261
116. B.R. Seizinger G. Rouleau A.H. Lane L.J. Ozelius A.G. Faryniarz J. Iannazzi W. Hobbs J.C. Roy B. Falcone S. Huson P.S. Harper D.M. Parry J.L. Baden M.A. Spence J.F. Gusella DNA linkage analysis in Von Recklinghausen neurofibromalosis J. Med. Genet. 24 1987 529 530
117. N.R. Sims D.M. Bowen C.C. Smith R.H. Flack A.N. Davison J.S. Snowden D. Neary Glucose metabolism and acetylcholine synthesis in relation to neuronal activity in Alzheimer's disease Lancet 16 1980 333 336
118. M. Seiler M.E. Schwab Specific retrograde transport of nerve growth factor (NGF) from neocortex to nucleus basalis in the rat Brain Res. 300 1984 33 39
119. D.L. Shelton L.F. Reichart Studies on the expression of the ß nerve growth factor (NGF) gene in the cental nervous system: Levels and regional distribution of NFG mRNA suggest that NGF function as a trophic factor for several distinct populations of neurons Proc. Natl. Acad. Sci, U. S. A. 83 1986 2714 2718
120. D.L. Shelton J. Sutherland J. Gripp T. Camerato M.P. Armanini H.S. Phillips K. Carrol S.D. Spencer A.D. Levinson Human trks: Molecular cloning, tissue distribution, and expression of extracellular domain immunoadhesins J. Neurosci. 15 1995 477 491
121. R. Smeyne R. Klein A. Schnapp L.K. Long S. Bryant A. Lewin S.A. Lira M. Barbacid Severe sensory and sympathetic neuropathies in mice carrying a disturbed trk/NGF receptor gene Nature 368 1994 246 249
122. T. Sobreviela D.O. Clary L.F. Reichardt M.M. Brandabur J.H. Kordower E.J. Mufson Trk-immunoreactivity profiles in the central nervous system: Colocalization with neurons containing p75 nerve growth factor receptor, choline acetyltransferase, and serotonin J. Comp. Neurol 350 1994 587 611
123. D. Soppet E. Escandon J. Maragos D.S. Middlemas S.W. Reid J. Blair L.E. Burton B.R. Stanton D.R. Kaplan T. Hunter K. Nikolics L.F. Parada The neurotrophic factor brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor Cell 65 1991 895 903
124. S.P. Squinto T.N. Stitt T.H. Aldrich S. Davis S.M. Bianco C. Radziejewski D.J. Glass P. Masiakowski M.E. Furth D.M. Valenzuela P.S. DiStefano G.D. Yancopoulos Trk B encodes a functional receptor for brain-derived neurotrophin factor and neurotrophin-3 but not nerve growth factor Cell 65 1991 885 893
125. O. Strada E.C. Hirsch F. Javoy-Agid S. Lehericy M. Ruberg J.J. Hauw Y. Agid Does loss of nerve growth factor receptors precede loss of cholinergic neurons in Alzheimer's disease? An study in the human striatum and basal forebrain J. Neurosci. 12 1992 4766 4774
126. T.-Q. Sun D.A. Fenstermacher Vos J.-M.H. Human artificial episomal chromosomes for cloning large DNA fragments in human cells Nature Genet. 8 1994 33 41
127. D.F. Swaab I. Grundke-Iqbal K. Iqbal H.P.H. Kremer R. Ravid J.A.P. Van de Nes Tau and ubiquitin in the human hypothalamus in aging and Alzheimer's disease Brain Res. 590 1992 239 249
128. F. Tagliavini G. Pilleri A neuropathological study in Alzheimer's disease, simple senile dementia, Pick's disease and Huntington chorea J. Neurol. Sci. 62 1983 243 260
129. F. Tagliavini G. Pilleri F. Gemigoni A. Lechi Neuron loss in the basal nucleus of Meynert in progressive supranuclear palsy Acta. Neuropathol. 61 1983 157 160
130. C.D. Torran-Allerand Mechanisms of estrogen action during neural development: Mediation by interactions with the neurotrophins and their receptors J. Steroid Biochem. Mol. Biol. 56 1996 169 178
131. J.J. Treanor D. Dawbarn S.J. Allen S.H. MacGowan G.K. Wilcock Low affinity nerve growth factor receptor binding in normal and Alzheimer's disease basal forebrain Neurosci. Lett. 121 1991 73 76
132. R.J. Rylett M.J. Ball E.H. Colhoun Evidence for high affinity choline transport in synaptosomes prepared from hippocampus and neocortex of patients with Alzheimer's disease Brain Res. 289 1983 169 175
133. G.R. Uhl D.C. Hilt J.C. Hedreen P.J. Whitehouse D.L. Price Pick's disease (labor sclerosis), depletion of neurons in the nucleus basalis of Meynert Neurology 33 1983 1470 1473
134. J.M. Verdi S.J. Birren C.F. Ibnez H. Persson D.R. Kaplan M. Benedetti M.V. Chao D.J. Anderson P75LNGFR regulates Trk signal transduction and NGF-induced neuronal differentiation in MAH cells Neuron 12 1994 733 745
135. B.H. Wainer Neurotrophic factors and Alzheimer's disease Neurobiol. Aging 10 1989 540 542
136. M.J. West P.D. Coleman D.G. Flood J.C. Troncoso Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease Lancet 344 1994 769 772
137. P.J. Whitehouse D.L. Price A.W. Clark J.T. Coyle M.R. Delong Alzheimer's disease, evidence for selective loss of cholinergic neurons in the nucleus basalis Ann. Neurol. 10 1981 122 126
138. P.J. Whitehouse D.L. Price R.G. Struble A.W. Clark J.T. Coyle M.R. Delong Alzheimer's disease and senile dementia; loss of neurons in the basal forebrain Science 215 1982 1237 1239
139. S.R. Whittemore T. Ebendal L. Lärkfors L. Olson A. Seiger I. Strömberg H. Persson Development and regional expression of beta nerve growth factor messenger RNA and protein in the rat central nervous system Proc. Natl. Acad. Sci. U.S.A 83 3 1986 817 821
140. L.R. Williams S. Varon G.M. Peterson K. Wictorin W. Fischer A. Björklund F.H. Gage Continuous infusion of nerve growth factor prevents basal forebrain neuronal death after fimbria fornix transection Proc. Natl. Acad. Sci. U.S.A. 83 1986 9231 9235
141. K.E. Wisniewski H.M. Wisniewski G.N. Wen Occurence of neuropathological changes and dementia of Alzheimer's disease in Down's syndrome Ann. Neurol. 17 1985 278 282
142. NTR causes increased basal forebrain cholinergic neuron size, choline acetyltransferase activity, and target innervation J. Neurosci 17 1997 7594 7605