Protection by α-tocopherol but not ascorbic acid from hydrogen peroxide induced cell death in normal human breast epithelial cells in culture

Free Radical Research

Volumn 29, Issue 3, 1998, Pages 227-234

  Dabrosin, Charlotta ^a   Öllinger, Karin ^a  

^a LINKÖPING UNIVERSITY HOSPITAL   (Sweden)

Author keywords

tocopherol; Ascorbic acid; Breast; Oestradiol; Progesterone

Indexed keywords

ALPHA TOCOPHEROL; ASCORBIC ACID; HYDROGEN PEROXIDE;

ARTICLE; BREAST EPITHELIUM; CELL CULTURE; CELL DEATH; CONTROLLED STUDY; CULTURE MEDIUM; DRUG EFFECT; HUMAN; HUMAN CELL;

ASCORBIC ACID; BREAST; CELL DEATH; CELLS, CULTURED; EPITHELIAL CELLS; ESTRADIOL; FEMALE; HUMANS; HYDROGEN PEROXIDE; L-LACTATE DEHYDROGENASE; PROGESTERONE; VITAMIN E;

EID: 0031740353     PISSN: 10715762     EISSN: None     Source Type: Journal    
DOI: 10.1080/10715769800300261     Document Type: Article

References (30)

1. Ames, B., Shigenaga, M. and Hagen, T. (1993) Oxidants, antioxidants and the degenerative diseases of ageing. Proceedings of the National Academy of Sciences, USA, 90, 7915-7922.
2. Malins, D. and Haimanot, R. (1991) Major alterations in the nucleotide structure of DNA in cancer of the female breast. Cancer Research, 51, 5430-5432.
3. Howe, G., Hirohata, T., Hislop, T., Iscovitch, J., Yuan, J., Katsouyanni, K., Lubin, F., Marubini, E., Modan, B. and Rohan, T. (1990) Dietary factors and risk of breast cancer: combined analysis of 12 case-control studies. Journal of the National Cancer Institute, 82(7), 561-569.
4. Block, G. (1991) Vitamin C and cancer prevention: the epidemiological evidence. American Journal of Clinical Nutrition, 53, 270S-282S.
5. Block, G., Patterson, B. and Subar, A. (1992) Fruit, vegetables, and cancer prevention: a review of the epidemiological evidence. Nutrition and Cancer, 18(1), 1-29.
6. Kimmick, G., Bell, R. and Bostick, R. (1997) Vitamin E and breast cancer: a review. Nutrition and Cancer, 27(2), 109-117.
7. Kushi, L., Fee, R., Sellers, T., Zheng, W. and Folsom, A. (1996) Intake of vitamins A, C, and E and postmenopausal breast cancer. American Journal of Epidemiology, 144(2), 165-174.
8. Hunter, D., Manson, J., Colditz, G., Stampfer, M.J., Rosner, B., Hennekens, C.H., Speizer, F.E. and Willett W.C. (1993) A prospective study of the intake of vitamins C, E, and A and the risk of breast cancer. New England Journal of Medicine, 329(4), 234-240.
9. Collaborative Group on Hormonal Factors in Breast Cancer. (1997) Breast cancer and hormonal replacement therapy: collaborative reanalysis of data from 51 epidemiological studies of 52,705 women with breast cancer and 108,411 women without breast cancer. Lancet, 350, 1047-1059.
10. DuPont, W. and Page, D. (1985) Risk factors for breast cancer in women with proliferative breast disease. New England Journal of Medicine, 312, 146-151.
11. London, S., Connolly, J., Schnitt, S. and Colditz, G. (1992) A prospective study of benign breast disease and the risk of breast cancer. JAMA, 267, 941-944.
12. Dwivedy, I., Devanesan, P., Cremonesi, E., Rogan, E. and Cavalieri, E. (1992) Synthesis and characterization of estrogens 2,4- and 3,4-quinones. Comparison of DNA adducts formed by the quinones versus horseradish peroxidase-activated catechol estrogens. Chemical Research in Toxicology, 5, 828-833.
13. Dabrosin, C., Hammar, M. and Öllinger, K. (1998) Impact of oestradiol and progesterone on antioxidant activity in normal breast epithelial cells in culture. Free Radical Research, 28, 241-249.
14. Dabrosin, C., Öllinger, K., Ungerstedt, U. and Hammar, M. (1997) Variability of glutathione levels in normal breast tissue and subcutaneous fat during the menstrual cycle: an in vivo study with microdialysis technique. Journal of Clinical Endocrinology and Metabolism, 82(5), 1382-1384.
15. Stampfer, M. (1985) Isolation and growth of human mammary epithelial cells. Journal of Tissue Culture Methods, 9, 107-115.
16. Valverius, E., Bates, S., Stampfer, M., Clark, R., McCromick, F., Salomon, D., Lippman, M. and Dickson, R. (1989) Transforming growth factor α production and epidermal growth factor receptor expression in normal and oncogene transformed human mammary epithelial cells. Molecular Endocrinology, 3, 203-214.
17. Vassault, A. (1985) Lactate dehydrogenase: UV-method with puryvate and NADH. In: Bergemeyer H.U. (ed.), Methods of Enzymatic Analysis. Academic Press, London, Vol. 3, pp. 118-125.
18. Lang, J., Gohil, K. and Packer, L. (1986) Simultaneous determination of tocopherols, ubiquinols, and ubiquinones in blood, plasma, tissue homogenates, and subcellular fractions. Analytical Biochemistry, 157, 106-116.
19. Fariss, M. (1990) Oxygen toxicity: unique cytoprotective properties of vitamin E succinate in hepatocytes. Free Radical Biology & Medicine, 9, 333-343.
20. Honegger, C., Langemann, H., Krenger, W. and Kempf, A. (1989) Liquid chromatographic determination of common water-soluble antioxidants in biological samples. Journal of Chromatography, 487, 463-468.
21. Hinsberg, W., Milby, K. and Zare, R. (1981) Determination of insulin in serum by enzyme immunoassay with fluorimetric detection. Analytical Chemistry, 53(9), 1509-1512.
22. Danner, D., Brignac, P., Arceneaux, D. and Patel, V. (1973) The oxidation of phenol and its reaction product by horseradish peroxidase and hydrogen peroxide. Archives of Biochemistry and Biophysics, 156, 759-763.
23. Frei, B., England, L. and Ames, B. (1989) Ascorbate is an outstanding antioxidant in human blood plasma. Proceedings of the National Academy Sciences, USA, 86, 6377-6381.
24. Halliwell, B. (1996) Vitamin C: Antioxidant or prooxidant in vivo? Free Radical Research, 25(5), 439-454.
25. Öllinger, K. and Roberg, K. (1997) Nutrient deprivation of cultured rat hepatocytes increases the desferrioxamine-available iron pool and augments the sensitivity to hydrogen peroxide. Journal of Biological Chemistry, 272(38), 23707-23711.
26. Packer, J., Slater, T. and Willson, R. (1979) Direct observation of a free radical interaction between vitamin E and vitamin C. Nature, 278, 737-738.
27. Burton, G.W. (1994) Vitamin E: molecular and biological function. Proceedings of the Nutrition Society, 53(2), 251-261.
28. Charpentier, A., Groves, S., Simmons-Menchaca, M., Turley, J., Zhao, B., Sanders, B.G. and Kline, K. (1993) RRR-α-tocopheryl succinate inhibits proliferation and enhances secretion of transforming growth factor-β (TGF-β) by human breast cancer cells. Nutrition and Cancer, 19, 225-239.
29. London, R., Sundaram, G., Schultz, M., Nair, P. and Goldstein, P. (1981) Endocrine parameters and α-tocopherol therapy and patients with mammary dysplasia. Cancer Research, 41, 3811-3813.
30. Bendich, A. and Machlin, L. (1988) Safety of oral intake of vitamin E. American Journal of Clinical Nutrition, 48, 612-619.