Tissue distribution, metabolism, and clearance of the convulsant trimethylolpropane phosphate in rats

Drug Metabolism and Disposition

Volumn 26, Issue 11, 1998, Pages 1058-1062

  Rossi III, John ^a   Jung, Anne E ^b   Ritchie, Glenn D ^b   Lindsey, James W ^a   Nordholm, Alan F ^a  

^a NAVAL MEDICAL RESEARCH CENTER   (United States)

^b WRIGHT PATTERSON AIR FORCE BASE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONVULSANT AGENT; PROPANE; TRIMETHYLOLPROPANE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILIARY EXCRETION; CONTROLLED STUDY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; KIDNEY CLEARANCE; MALE; METABOLISM; NEUROMODULATION; NONHUMAN; PRIORITY JOURNAL; RAT; TISSUE DISTRIBUTION;

ANIMALIA;

EID: 0031739944     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Bellet EM and Casida JE (1973) Bicyclic phosphorus esters: high toxicity without cholinesterase inhibition. Science (Washington DC) 18:1135-1136.
2. Borchard RE, Barnes CD and Eltherington LG (1990) Drug Dosage in Laboratory Animals: A Handbook. The Telford Press, Caldwell, NJ.
3. Bowery NG, Collins RF and Hill RG (1976) Bicyclic phosphorus esters that are potent convulsants and GABA antagonists. Nature (Lond) 261:601-603.
4. Casida JE, Eto M, Moscioni AD, Engel JL, Milbrath DS and Verkade JG (1976) Structure-toxicity relationships of 2,6,7-trioxabicyclo[2.2.2]octanes and related compounds. Toxicol Appl Pharmacol 36:261-279.
5. +2-sedimented microsomes from the rat liver. Biochem Pharmacol 21:3249-3256.
6. Gearhart JM, Hambel JM and Kinkead ER (1990a) Dose and sex specific kinetics of trimethylolpropane phosphate (TMPP) after dermal absorption, in 1989 Toxic Hazard Research Unit Annual Report: AAMRL-TR-90-051 (Kutzman RS, Wall HG and Vinegar A, eds) pp 243-239, H. G. Armstrong Aerospace Medical Research Laboratory (NMRI-90-92), Bethesda, MD.
7. Gearhart JM, Hambel JM and Kinkead ER (1990b) Development of a physiologically-based model of trimethylolpropane phosphate (TMPP) dermal absorption, in 1990 Toxic Hazard Research Unit Annual Report: AAMRL-TR-90-063 (Wall HG, Vinegar A and Kinkead EA, eds) pp 232-239, H. G. Armstrong Aerospace Medical Research Laboratory (NMRI-90-115), Bethesda, MD.
8. Gilbert ME (1992) A characterization of chemical kindling with the pesticide endosulfan. Neurotoxicol Teratol 14:151-158.
9. Higgins GM and Gardier RW (1990) Gamma-aminobutyric acid antagonism produced by an organophosphate-containing combustion product. Toxicol Appl Pharmacol 105:103-112.
10. Hun HW (1976) Pharmacokinetic studies on pentylenetetrazol in dogs. J Pharm Sci 65:1038-1041.
11. A receptor supramolecular complexes in rat brain. J Neurochem 52:1064-1070.
12. Kalman DA, Voorhees KJ, Osborne O and Einhorn IN (1985) Production of a bicyclophosphate neurotoxic agent during pyrolysis of synthetic lubricant oil. J Fire Sci 3:322-329.
13. Kimmerle G, Eben A, Groning P and Thyssen J (1976) Acute toxicity of bicyclic phosphorous esters. Arch Toxicol 35:149-152.
14. Ko IK and Husein EA (1971) The metabolic fate of pentylenetetrazol in the rat. Can J Physiol Pharmacol 49:356-365.
15. Lin J, Cassell J, Ritchie GD and Rossi J III (1998) Repeated exposure to trimethylolpropane phosphate induces CNS sensitization and facilitates electrical kindling. Physiol Behav, in press.
16. Lindsey JW, Prues SL, Alva C, Ritchie GD and Rossi J III (1998) Trimethylolpropane phosphate (TMPP) perfusion into the nucleus accumbens of the rat: electroencephalographic, behavioral and neurochemical correlates. Neurotoxicology 19:215-226.
17. Loscher W, Honack D, Fassbender CP and Nolting B (1991) The role of technical, biological and pharmacological factors in the laboratory evaluation of anticonvulsant drugs. III. Pentylenetetrazole seizure models. Epilepsy Res 8:171-189.
18. Lowry OH, Rosebrough NJ, Farr AL and Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193:265-275.
19. Mason CR and Cooper RM (1972) A permanent change in convulsive threshold in normal and brain-damaged rats with repeated small doses of pentylenetetrazol. Epilepsia 13:663-674.
20. Meyers GB (1977) A proposed treatment for trimethylolpropane phosphite poisoning. J Occup Med 1:261-262.
21. 14C. J Exp Med 94:431-453.
22. Narayanan TK and Carpenter RL (1993) Metabolism and disposition of trimethylolpropane phosphate (TMPP) in Fischer-344 rats. Toxicologist 13:284.
23. Ono J, Vieth RF and Walson PD (1990) Electrocorticographical observation of seizures induced by pentylenetetrazole (PTZ) injection in rats. Funct Neurol 5:345-352.
24. Petajan JH, Voorhees KJ, Packham SC, Baldwin RC, Einhorn IN, Grunnet ML, Dinger BG and Birky MM (1975) Extreme toxicity from combustion products of a fire-retarded polyurethane foam. Science (Washington DC) 187:742-744.
25. Provaznik M, Wyman JF, Serve P and Uddin DE (1987) Evaluation of the acute dermal toxicity of a thermally decomposed specification L-23699 synthetic aircraft lubricant. J Cutan Ocular Toxicol 6:299-308.
26. Razman IM and Levy G (1985) Kinetics of drug action in disease states. XIV. Effect of infusion rate on pentylenetetrazol concentrations in serum, brain and cerebrospinal fluid of rats at onset of convulsions. J Pharmacol Exp Ther 234:624-628.
27. Rossi J III, Forrest VJ and Gearhart J (1990) An evaluation of the role of pnenotypic sex on trimethylolpropane phosphate (TMPP) induced toxicity in the rat. Neurosci Abstr 16:394.
28. Rossi J III, Nocjar C, Vaningan M, Moore TJ, Ademujohn CY, Ritchie GD and Panksepp J (1995) Neurobehavioral assessment of the effects of subconvulsive doses of potent convulsant (TMPP) in three strains of rats. Neurosci Abstr 21:984.
29. Rossi J III, Ritchie GD, Buring MS, Ademujohn CY, Smith J, Morton T and Langley M (1994) Chemical kindling of EEG epileptiform but not behavioral seizure response in two strains of rats. Neurosci Abstr 20:1459.
30. Rossi J III, Ritchie GD, Narayanan TK and Buring MS (1993) Clinical and subclinical seizure induction by trimethylolpropane phosphate (TMPP). Neurosci Abstr 19:603.
31. Soto-Otero R, Mendez-Alvarez E, Sierra-Paredes EG, Galan-Valiente J, Aguilar-Veiga E and Sierra-Marcuno G (1989) Simultaneous determination of the two components of picrotoxin in serum by reversed-phase high-performance liquid chromatography with application to the pharmacokinetic study in rats. J Pharm Biomed Anal 7:369-375.
32. Wyman J, Pritzer E, Williams F, Rivera J, Durkin A, Serve P, von Minden D and Macys D (1993) Evaluation of shipboard formation of a neurotoxicant (trimethylolpropane phosphate) from thermal decomposition of synthetic aircraft engine lubricant. Am Ind Hyg Assoc 54:584-592.
33. Wyman J, Porvaznik M, Serve P, Hobson D and Uddin DE (1987) High temperature decomposition of Military Specification L-23699 synthetic aircraft lubricant. J Fire Sci 5: 162-177.
34. Wyman J, Stokes J, Goehring M, Buring M and Moore T (1995) Data collection interface for isolated perfused rat liver: recording oxygen consumption, perfusion pressure, and pH. Toxicol Methods 1:1-14.