Acute, subchronic, and chronic toxicity studies with felbamate, 2- phenyl-1,3-propanediol dicarbamate

Toxicological Sciences

Volumn 45, Issue 2, 1998, Pages 225-232

  McGee, J H ^a   Erikson, D J ^a   Galbreath, C ^a   Willigan, D A ^a   Sofia, R D ^a  

^a Wallace Laboratories   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FELBAMATE;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; BRAIN INJURY; CHRONIC TOXICITY; CONTROLLED STUDY; ENZYME BLOOD LEVEL; ENZYME INDUCTION; FOOD INTAKE; HYPOXIA; MOUSE; NEUROPROTECTION; NONHUMAN; SEIZURE; TOXICITY TESTING;

ANIMALIA; ATAXIA; CANIS FAMILIARIS;

EID: 0031739843     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1006/toxs.1998.2519     Document Type: Article

References (12)

1. Leppik, I. E., Dreifuss, F. E., Pledger, G. W., Graves, N. M., Santilli, N., Drury, I., Tsay, J. Y., Jacobs, M. P., Bertram, E., Cereghino, J. J., Cooper, G., Sahlrrot, J. T., Sheridan, P., Ashworth, M., Lee, S. I., and Sierzant, T. L. (1991). Felbamate for partial seizures: Results of a controlled clinical trial. Neurology 41, 1785-1789
2. Litchfield, J. T., and Wilcoxon, F. (1949). A simplified method of evaluating dose-effect experiments. J. Pharmacol. Exp. Ther. 96, 99-113.
3. McCabe, R. T., Wasterlain, C. G., Kucharczyk, N., Sofia, R. D., and Vogel, J. R. (1993). Evidence for anticonvulsant and neuroprotectant action of felbamate mediated by strychnine-insensitive glycine receptors. J. Pharmacol. Exp. Ther. 264, 1248-1252.
4. Ritter, F. J., Leppik, I. E., Dreifuss, F. E., Rak, I., Santilli, N., Homzie, R., Dodson, W. E., Glauser, T. A., Sackellares, J. C., Olson, L., Garafolo, E. A., Shields, W. D., French, J., Sperling, M., Kramer, L. D., Kamin, M., Rosenberg, A., Shumaker, R., Perhach, J. L., and Dix, R. (1993). Efficacy of felbamate in childhood epileptic encephalopathy (Lennox-Gastaut syndrome). N. Engl. J. Med. 328, 29-33.
5. Sachdeo, R. C., Kramer, L. D., and Rosenberg, A. (1991). Felbamate double-blind monotherapy trial. Ann. Neurol. 30, 290. [Abstract]
6. Sachdeo, R., Kramer, L. D., Rosenberg, A., and Sachdeo, S. (1992). Felbamate monotherapy: Controlled trial in patients with partial onset seizures. Ann. Neurol. 32, 386-392.
7. Segelman, F. H., Kelton, E., Terzi, R. M., Kucharczyk, N., and Sofia, R. D. (1985). The comparative potency of phenobarbital and five 1,3-propanediol dicarbamates for hepatic cytochrome P450 induction in rats. Res. Commun. Chem. Pathol. 48, 467-470.
8. Swinyard, E. A., Sofia, R. D., and Kupferberg, H. J. (1986). Comparative anticonvulsant activity and neurotoxicity of felbamate and four prototype antiepileptic drugs in mice and rats. Epilepsia 27, 27-34.
9. Wallis, R. A., Panizzon, K. L., Fairchild, M. D., and Wasterlain, C. G. (1992). Protective effects of felbamate against hypoxia in the rat hippocampal slice. Stroke 23, 547-551.
10. Wallis, R. A., and Panizzon, K. L. (1993). Glycine reversal of felbamate hypoxic protection. Neuroreport 4, 951-954.
11. Wasterlain, C. G., Adams, L. M., Hattori, H., and Schwartz, P. H. (1992). Felbamate reduces hypoxic-ischemic brain damage in vivo. Eur. J. Pharmacol. 212, 275-278.
12. White, H. S., Harmsworth, W. L., Sofia, R. D., and Wolf, H. H. (1995). Felbamate modulates the strychnine-insensitive glycine receptor. Epilepsy Res. 20, 41-48.