Vulnerability to aging in the rat serotonergic system

Acta Neuropathologica

Volumn 96, Issue 6, 1998, Pages 581-595

  Nishimura, Akira ^a   Ueda, Shuichi ^b   Takeuchi, Yoshihiro ^a   Matsushita, Hiroko ^a   Sawada, Tadashi ^a   Kawata, Mitsuhiro ^a  

^a KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

^b DOKKYO MEDICAL UNIVERSITY   (Japan)

Author keywords

Aberrant fiber; Aging; Immunocytochemistry; Raphe nuclei; Serotonin

Indexed keywords

ADOLESCENT; AGED; AGING; AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL STRUCTURE; CINGULATE GYRUS; CONTROLLED STUDY; CORPUS STRIATUM; DENTATE GYRUS; FRONTAL CORTEX; HYPOTHALAMUS; NONHUMAN; PARIETAL LOBE; PRIORITY JOURNAL; RAT; SEROTONINERGIC NERVE CELL; THALAMUS; VASCULARIZATION;

AGING; ANIMALS; BRAIN; DIENCEPHALON; IMMUNOHISTOCHEMISTRY; MALE; NERVE DEGENERATION; NERVE FIBERS; RATS; RATS, WISTAR; SEROTONIN; TELENCEPHALON;

EID: 0031739344     PISSN: 00016322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004010050939     Document Type: Article

References (38)

1. Armstrong DM, Hersh LB, Gage FH (1988) Morphologic alterations of cholinergic processes in the neocortex of aged rats. Neurobiol Aging 9: 199-205
2. Azmitia EC, Segal M (1978) An autoradiographic analysis of the differential ascending projections of the dorsal and median raphe nuclei in the rat. J Comp Neurol 179: 641-668
3. Duchen LW (1992) General pathology of neurons and neuroglia. In: Adams JH, Duchen LW (eds) Greenfield's neuropathlogy, 5th edn. Edward Arnold, London, pp 1-68
4. Giuffrida R, Licata F, Volsi GL, Sanatagelo F, Sapienza S (1991) Immunocytochemical localization of serotoninergic afferents to vestibular nuclei in the rat. Eur J Physiol 419: R33.47
5. Gourmelon P, Amyx HL, Baron H, Lemercier G, Court L, Gibbs CJ Jr (1987) Sleep abnormalities with REM disorder in experimental Creutzfeldt-Jakob disease in cats: a new pathlogical feature. Brain Res 411: 391-396
6. Halliday GM, Blumbergs PC, Cotton RGH, Blessing WW, Geffen LB (1990) Loss of brainstem serotonin- and substance P-containing neurons in Parkinson's disease. Brain Res 510: 104-107
7. Hornung JP, Fritschy JM, Tork I (1990) Distribution of two morphologically distinct sbsets of serotoninergic axons in the cerebral cortex of the marmoset. J Comp Neurol 297: 165-181
8. Imai H, Steindler DA, Kitai ST (1986) The organization of divergent axonal projections from the midbrain raphe nuclei in the rat. J Comp Neurol 243: 363-380
9. Kishimoto T, Sasa M, Takaori S (1991) Inhibition of lateral vestibular nucleus neurons by 5-hydroxytryptamine derived from the dorsal raphe nucleus. Brain Res 553: 229-237
10. Kitt CA, Walker LC, Molliver ME, Price DL (1989) Serotoninergic neurites in senile plaques in cingulate cortex of aged nonhuman primate. Synapse 3: 12-18
11. Köhler C, Chan-Palay V, Haglund L, Steinbusch H (1980) Immunohistochemical localization of serotonin nerve terminals in the lateral entorhinal cortex of the rat: demonstration of two separate patterns of innervation from the midbrain raphe. Anat Embryol (Berl) 160: 121-129
12. Kosofsky BE, Molliver ME (1987) The serotonergic innervation of cerebral cortex: different classes of axon terminals arise from dorsal and median raphe nuclei. Synapse 1: 153-168
13. Lidov HGW, Grzanna R, Molliver ME (1980) The serotonin innervation of the cerebral cortex in the rat. An immunohistochemical analysis. Neuroscience 5: 207-227
14. Mamounas LA, Molliver ME (1988) Evidence for dual serotonergic projections to neocortex: axons from the dorsal and median raphe nuclei are differentially vulnerable to the neurotoxin p-chloroamphetamine (PCA). Exp Neurol 102: 23-36
15. Mamounas LA, Mullen CA, O'Hearn E, Molliver ME (1991) Dual serotonergic projections to forebrain in the rat: morphologically distinct 5-HT axon terminals exhibit differential vulnerability to neurotoxic amphetamine derivatives. J Comp Neurol 314: 558-586
16. Molliver DC, Molliver ME (1990) Anatomic evidence for a neurotoxic effect of (±)-fenfluramine upon serotonergic projections in the rat. Brain Res 511: 165-168
17. Mulligan KA, Törk I (1988) Serotonergic innervation of the cat cerebral cortex. J Comp Neurol 270: 86-110
18. Nishimura A, Ueda S, Takeuchi Y, Sawada T, Kawata M (1995) Age-related decrease of serotonergic fibres and S-100b immunoreactivity in the rat dentate gyrus. NeuroReport 6: 1445-1448
19. O'Hearn E, Molliver ME (1984) Organization of raphe-cortical projections in rat: a quantitative retrograde study. Brain Res Bull 13: 709-726
20. O'Hearn E., Battaglia G, DeSouza EB, Kuhar MJ, Molliver ME (1988) Methylenedioxyamphetamine (MDA) and methylenedioxymethamphetamine (MDMA) cause selective ablation of serotonergic axon terminals in forebrain: immunocytochemical evidence for neurotoxicity. J Neurosci 8: 2788-2803
21. Paxinos G, Watson C (1986) The rat brain in stereotaxic coordinates. Academic Press, New York
22. Steinbusch HWM (1981) Distribution of serotonin-immunoreactivity in the central nervous system of the rat. Cell bodies and terminals. Neuroscience 6: 557-618
23. Steinbusch HWM, Van Luijtelaar MGPA, Dijkstra H, Tonnaer JADM (1990) Aging and regenerative capacity of the rat serotonergic system. Ann NY Acad Sci 600: 384-404
24. Takeuchi Y, Sano Y (1983) Immunohistochemical demonstration of serotonin nerve fibers in the neocortex of the monkey (Macaca fuscata). Anat Embryol (Berl) 166: 155-168
25. Takeuchi Y, Sano Y (1984) Serotonin nerve fibers in the primary visual cortex of the monkey. Quantitative and immunoelectronmicroscopical analysis. Anat Embryol (Berl) 169: 1-8
26. Takeuchi Y, Kimura H, Sano Y (1982) Immunohistochemical demonstration of serotonin neurons in the brainstem of the rat and cat. Cell Tissue Res. 224: 247-267
27. Takeuchi Y, Fujiwara K, Ishimura K, Aoki S, Okano S, Yamazoe I, Yoshioka H, Sawada T (1992) Effects of neonatal asphyxia on the serotonin neuron system in the developing brain studied by immunohistochemistry. Dev Neurosci 14: 394-402
28. Ueda S, Gu XF, Whitaker-Azmitia PM, Naruse I, Azmitia EC (1994) Neuro-glial neurotrophic interaction in the S-100b retarded mutant mouse (Polydactyly Nagoya). Immunocytochemical and neurochemical studies. Brain Res 633: 275-283
29. Van Luijtelaar MGPA, Steinbusch HWM, Tonnaer JADM (1988) Aberrant morphology of serotonergic fibers in the forebrain of the aged rat. Neurosci Lett 95: 93-96
30. Van Luijtelaar MGPA, Steinbusch HWM, Tonnaer JADM (1989) Similarities between aberrant serotonergic fibers in the aged and 5,7-DHT denervated young adult rat brain. Exp Brain Res 78: 81-89
31. Van Luijtelaar MGPA, Wouterlood FG, Tonnaer JADM, Steinbusch HWM (1991) Ultrastructure of aberrant serotonin-immunoreactive fibers in the caudate putamen complex of the aged rat. Synapse 8: 162-168
32. Van Luijtelaar MGPA, Tonnaer JADM, Steinbusch HWM (1992) Aging of the serotonergic system in the rat forebrain: an immunocytochemical and neurochemical study. Neurobiol Aging 13: 201-215
33. Vertes RP (1991) A PHA-L analysis of ascending projections of the dorsal raphe nucleus in the rat. J Comp Neurol 313: 643-668
34. Vertes RP, Kocsis B (1994) Projections of the dorsal raphe nucleus to the brainstem: PHA-L analysis in the rat. J Comp Neurol 340: 11-26
35. Waterhouse BD, Mihailoff GA, Baack JC, Woodward DJ (1986) Topographical distribution of dorsal raphe neurons projecting to motor, sensorimotor, and visual cortical areas in the rat. J Comp Neurol 249: 460-476
36. Wilson MA, Ricaurte GA, Molliver ME (1989) Distinct morphologic classes of serotonergic axons in primates exhibit differential vulnerability to the psychotropic drug 3,4-methylenedioxymethamphetamine. Neuroscience 28: 121-137
37. Yamamoto T, Hirano A (1985) Nucleus raphe dorsalis in Alzheimer's disease: neurofibrillary tangles and loss of large neurons. Ann Neurol 17: 573-577
38. Zhou FC, Bledsoe S, Lumeng L, Li TK (1994) Reduced serotonergic immunoreactive fibers in the forebrain of alcohol-preferring rats. Alcohol Clin Exp Res 18: 571-579