Fleroxacin vs ciprofloxacin in the management of typhoid fever. A randomised, open, comparative study in Nigerian patients

Clinical Drug Investigation

Volumn 16, Issue 4, 1998, Pages 279-288

  Chukwuani, C M ^a   Onyemelukwe, G C ^b   Okonkwo, P O ^c   Coker, H A B ^a   Ifudu, N D ^a  

^a UNIVERSITY OF LAGOS   (Nigeria)

^b AHMADU BELLO UNIVERSITY   (Nigeria)

^c UNIVERSITY OF NIGERIA   (Nigeria)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; CIPROFLOXACIN; FLEROXACIN;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED STUDY; COUGHING; DRUG EFFICACY; DRUG SAFETY; FEMALE; FOLLOW UP; HUMAN; MAJOR CLINICAL STUDY; MALE; NIGERIA; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TONIC CLONIC SEIZURE; TYPHOID FEVER; VERTIGO; VOMITING;

EID: 0031739211     PISSN: 11732563     EISSN: None     Source Type: Journal    
DOI: 10.2165/00044011-199816040-00002     Document Type: Article

References (20)

1. Xeusch GT. Antimicrobial therapy for enteric infections and typhoid fever: state of the art. Rev Infect Dis 1988; 10 Suppl. 1: 199-205
2. Gilman RH. General considerations in the management of typhoid fever and dysentery. Scand J Gastroenterol 1989; 24 Suppl. 169: 11-8
3. Rodriguez-Noriega E, Andrade-Villanueva J, Amaya-Tapia G. Quinolones in the treatment of Salmonella carriers. Rev Infect Dis 1989; 11 Suppl. 5 1179-87
4. Goldstein FW, Chumpitay JC, Guovara JM, et al. Plasmid-medicated resistance to multiple antibiotics in Salmonella typhi. J Infect Dis 1986; 153: 261-6
5. Dupont HL. Quinolones in Salmonella typhi infection. Drugs 1993; 45 Suppl. 3: 119-24
6. Manek N, Andrew JM, Wise R. In vivo activity of Ro 23-6240, a new fluoroquinolone derivative, compared with that of other antimicrobial agents. Antimicrob Agents Chemother 1986; 30 (2): 330-2
7. Hohl P, Von Graevenity A, Zollinjer-Iten J. Effects of fleroxacin in vitro on common bacteria causing diarrhea, including Vibrionaceace. Rev Infect Dis 1988; 10 Suppl 1: 209-10
8. Chin MX, Brittain DC, Neu HC. In vitro activity of Ro 23 -6240, a new fluoroquinolone derivative, compared with that of other antimicrobial agents. Antimicrob Agents Chemother 1986; 30 (2): 675-80
9. Arnold K, Hong CS, Nelwan R, et al. Randomized comparative study of fleroxacin and chloramphenicol in typhoid fever. Am J Med 1993; 94 Suppl. 3A: 195s-200
10. Ramirez CA, Bran JL, Mejia CR, et al. Open prospective study of the clinical efficacy of ciprofloxacin. Antimicrob Agents Chemother 1985; (28): 128-32
11. Limson BM. Short course quinolone therapy of typhoid fever in developing countries. Drugs 1995; 49 Suppl. 2: 136-8
12. Waiz A. The new quinolones in the treatment of diarrhoea and typhoid fever. Drugs 1995; 49 Suppl. 2: 132-5
13. Stanley PJ, Flegg PJ, Mandai BK, et al. Open study of ciprofloxacin in enteric fever. J Antimicrob Chemother 1989; 23: 789-791
14. Chukwuani CM, Coker HAB, Oduola AMJ, et al. Single dose pharmacokinetic study of ciprofloxacin and fleroxacin in healthy adult Nigerian volunteers. Chemotherapy. In press
15. Sorgel F, Kinzig ML. Pharmacokinetics of gyrase inhibitors. I. Basic chemistry and gastro-intestinal disposition. Clin Pharmacokinet 1990; 19: 445-555
16. Wain J, Hoa NT, Chinh NT, et al. Quinolone-resistant Salmonella typhi in Viet Nam: molecular basis of resistance and clinical response to treatment. Clin Infect Dis 1997; 25 (6): 1404-10
17. Abejar NH, Damano EM, Babanban AB. Fleroxacin vs chloramphenicol in enteric fever: an open randomized parallel study. Phil J Intern Med 1993; 31: 327-30
18. Zavala-Trujillo I, Nava-Zavala A, Marcano MG, et al. Fleroxacin in the treatment of enteric fever and Salmonellosis in adults. Rev Infect Dis 1989; 11 Suppl. 5: S1188-89
19. Rowe B, Ward LR, Threlfall EJ. Multidrug-resistant Salmonella typhi: a worldwide epidemic. Clin Infect Dis 1997; 24 Suppl. 1: S106-9
20. Piabhakar H, Kaur H, Lal M. Prevalence of multi-drug resistant Salmonella typhi in Ludhiana Punjab. Indian J Med Sci 1996; 50 (8): 277-9