Do patients with advanced breast cancer benefit from chemotherapy?

British Journal of Cancer

Volumn 78, Issue 11, 1998, Pages 1488-1494

  Ramirez, A J ^a,c   Towlson, K E ^a   Leaning, M S ^b   Richards, M A ^a   Rubens, R D ^b  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^b Preferred Health Systems LLC   (United States)

^c ST THOMAS HOSPITAL   (United Kingdom)

Author keywords

Advanced breast cancer; Palliative chemotherapy; Patient benefit

Indexed keywords

4' IODOESORUBICIN; CYCLOPHOSPHAMIDE; DOXORUBICIN; EPIRUBICIN; FLUOROURACIL; METHOTREXATE; MITOMYCIN; MITOXANTRONE; NAVELBINE;

ADULT; ADVANCED CANCER; ARTICLE; BREAST CANCER; CANCER CHEMOTHERAPY; CLINICAL TRIAL; COST BENEFIT ANALYSIS; DISTRESS SYNDROME; DYSPNEA; FATIGUE; FEMALE; FUNCTIONAL ASSESSMENT; HUMAN; LETHARGY; LIVER METASTASIS; MAJOR CLINICAL STUDY; META ANALYSIS; PRIORITY JOURNAL; PSYCHOLOGIC ASSESSMENT; TREATMENT FAILURE; TREATMENT OUTCOME; WELLBEING; XEROSTOMIA;

EID: 0031738961     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/bjc.1998.711     Document Type: Article

References (18)

1. Baum M, Priestman T, West R and Jones E (1980) A comparison of subjective responses in a trial comparing endocrine with cytotoxic treatment in advanced carcinoma of the breast. In Proceedings of The Second EORTC Breast Cancer Working Conference, pp. 223-226, Pergamon Press: Oxford
2. Coates A, Gebski V, Bishop J, Jeal P, Woods R, Snyder R, Tattersall M, Byrne M, Harvey V, Gill G, Simpson J, Drummond R, Browne J, Van Cooten R and Forbes J (1987) Improving the quality of life during chemotherapy for advanced breast cancer: a comparison of intermittent and continuous treatment strategies. N Engl J Med 317: 1490-1495
3. De Haes J, Van Knippenberg F and Neijt J (1990) Measuring psychological and physical distress in cancer patients: structure and application of the Rotterdam Symptom Checklist. Br J Cancer 62: 1034-1038
4. Fraser S, Dobbs H, Ebbs S, Fallowfield L, Bates T and Baum M (1993) Combination or mild single-agent chemotherapy for advanced breast cancer? CMF vs epirubicin measuring quality of life. Br J Cancer 67: 402-406
5. Glimelius B, Hoffman K, Olafsdottir M, Pahlman L, Sjorden P and Wennberg A (1989) Quality of life during cytostatic therapy for advanced symptomatic colorectal carcinoma: a randomised comparison of two regimens. Eur J Cancer Clin Oncol 25: 829-835
6. Gregory W, Smith P, Richards M, Twelves C, Knight R and Rubens R (1993) Chemotherapy of advanced breast cancer: outcome and prognostic factors. Br J Cancer 68: 988-995
7. Kaasa S, Mastekaasa A and Naess S (1988) Quality of life of lung cancer patients in a randomised clinical trial evaluated by a psychosocial well-being questionnaire. Acta Oncol 27: 335-342
8. Macauley V and Smith I (1986) Advanced breast cancer. In Randomised Trials in Cancer: A Critical Review by Sites. Slevin M and Staquet M (eds). pp. 273-357. Raven Press: New York
9. Maher E (1992) The use of palliative radiotherapy in the management of breast cancer. Eur J Cancer 28: 707-710
10. Maher E, Hopwood P, Macbeth F, Mansi J and Radstone D (1994) Measurement of outcome in palliative oncology. J Cancer Care 3: 94-102
11. Richards M, Hopwood P, Ramirez A, Twelves C, Ferguson J, Gregory W, Swindell R, Scrivener W, Miller J, Howell A and Rubens R (1992) Doxorubicin in advanced breast cancer: influence of schedule on response, survival and quality of life. Eur J Cancer 28A: 1023-1028
12. Rubens R, Towlson K, Ramirez A, Coltart S, Slevin M, Terrell C and Timothy R (1992) Appropriate chemotherapy for palliating advanced cancer. Br Med J 304: 35-40
13. Slevin M (1992) Quality of life: philosophical question or clinical reality? Br Med J 305: 466-469
14. Slevin M, Stubbs L, Plant H, Wilson P, Gregory W and Armes P (1990) Attitudes to chemotherapy: comparing views of patients with cancer with those of doctors, nurses and general public. Br J Cancer 300: 1458-1460
15. Steiner R, Stewart J, Cantwell B, Minton M, Knight R and Rubens R (1983) Adriamycin alone or combined with vincristine in the treatment of advanced breast cancer. Eur J Cancer Clin Oncol 19: 1553-1557
16. Tannock I, Boyd N, Deboer G, Erlichman C, Fine S, Larocque G, Mayers C, Perrault and Sutherland H (1988) A randomised trial of two close levels of cyclophosphamide, methotrexate and fluorouracil chemotherapy for patients with metastatic breast cancer. J Clin Oncol 6: 1377-1387
17. Twelves C, Dobbs N, Ramirez A, Summerhayes M, Richards M, Towlson K and Rubens R (1994a) Iododoxorubicin in advanced breast cancer: a phase II evaluation of clinical activity and quality of life. Br J Cancer 69: 726-731
18. Twelves C, Dobbs N, Curnow A, Coleman R, Stewart A, Tyrrell C, Canney P and Rubens R (1994b) A phase II multicentre. UK centre of vinorelbine in advanced breast cancer. Br J Cancer 70: 990-993