Effects of doxorubicin on diastolic function, contractile reserve, and ventricular-vascular coupling in piglets

Pediatric Cardiology

Volumn 19, Issue 6, 1998, Pages 450-457

  Cassidy, S C ^a   Chan, D P ^a   Rowland, D G ^a   Allen, H D ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

Cardiac catheterization; Diastole drug effects; Doxorubicin; Myocardial contraction drug effects; Piglets; Pressure volume relationships

Indexed keywords

DOXORUBICIN; ISOPRENALINE;

ANIMAL EXPERIMENT; ARTICLE; CARDIOTOXICITY; CONTROLLED STUDY; DIASTOLE; DOSE RESPONSE; HEART FUNCTION; HEART HEMODYNAMICS; HEART MUSCLE CONTRACTILITY; INTRAVENOUS DRUG ADMINISTRATION; NONHUMAN; PRESSURE VOLUME CURVE; SOLID TUMOR; SWINE;

ANIMALS; ANIMALS, NEWBORN; ANTINEOPLASTIC AGENTS; BLOOD PRESSURE; DIASTOLE; DOSE-RESPONSE RELATIONSHIP, DRUG; DOXORUBICIN; HEART CATHETERIZATION; INFUSIONS, INTRAVENOUS; MYOCARDIAL CONTRACTION; STROKE VOLUME; SWINE; VASCULAR RESISTANCE;

EID: 0031738705     PISSN: 01720643     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002469900355     Document Type: Article

References (44)

1. Baan J, van der Velde ET (1988) Sensitivity of left ventricular end-systolic pressure-volume relation to type of loading intervention in dogs. Circ Res 62:1247-1258
2. Boucek RJ Jr, Buck SH, Scott F, et al (1993) Anthracycline-induced tension in permeabilized cardiac fibers: evidence for the activation of the calcium release channel of sarcoplasmic reticulum. J Mol Cell Cardiol 25:249-259
3. Brown KA, Blow AJ, Weiss RM, Stewart JA (1989) Acute effects of doxorubicin on human left ventricular systolic and diastolic function. Am Heart J 118:979-982
4. Cassidy SC, Chan DP, Allen HD (1995) Diastolic ventricular function in piglets does not change with early maturation. Pediatr Res 37:23A [abstract]
5. Cassidy SC, Chan DP, Allen HD (1997) Left ventricular systolic function, arterial elastance, and ventricular-vascular coupling: a developmental study in piglets. Pediatr Res 42:273-281
6. Cassidy SC, McGovern JJ, Chan DP, Allen HD (1997) Effects of commonly used adrenergic agonists on left ventricular function and systemic vascular resistance in young piglets. Am Heart J 133: 174-183
7. Cassidy SC, Teitel DF (1992) The conductance volume catheter technique for measurement of left ventricular volume in young piglets. Pediatr Res 31:85-90
8. Cassidy SC, Teitel DF (1997) Left ventricular pressure and volume data acquisition and analysis using LabVIEW. Comput Biol Med 27:141-149
9. Cittadini A, Fazio S, D'Ascia C, et al (1991) Subclinical cardiotoxicity by doxorubicin: a pulsed Doppler echocardiographic study. Eur Heart J 12:1000-1005
10. Earm YE, Ho WK, So I (1994) Effects of adriamycin on ionic-currents in single cardiac myocytes of the rabbit. J Mol Cell Cardiol 26:163-172
11. Ellis CN, Ellis MB, Blakemore WS (1987) Effect of adriamycin on heart mitochondrial DNA. Biochem J 245:309-312
12. Ewer MS, Ali MK, Gibbs HR, et al (1994) Cardiac diastolic function in pediatric patients receiving doxorubicin. Acta Oncol 33: 645-649
13. Gaasch WH, Carroll JD, Blaustein AS, Bing OH (1986) Myocardial relaxation: effects of preload on the time course of isovolumetric relaxation. Circulation 73:1037-1041
14. Glantz SA, Slinker BK (1990) Primer of Applied Regression and Analysis of Variance. McGraw-Hill, New York, pp 272-315
15. Glower DD, Spratt JA, Snow ND, et al (1985) Linearity of the Frank-Starling relationship in the intact heart: the concept of preload recruitable stroke work. Circulation 71:994-1009
16. Hausdorf G, Morf G, Beron G, et al (1988) Long term doxorubicin cardiotoxicity in childhood: non-invasive evaluation of the contractile state and diastolic filling. Br Heart J 60:309-315
17. Holmberg SR, Williams AJ (1990) Patterns of interaction between anthraquinone drugs and the calcium-release channel from cardiac sarcoplasmic reticulum. Circ Res 67:272-283
18. Isner JM, Ferrans VJ, Cohen SR, et al (1983) Clinical and morphologic cardiac findings after anthracycline chemotherapy: analysis of 64 patients studied at necropsy. Am J Cardiol 51:1167-1174
19. Kass DA, Grayson R, Marino P (1990) Pressure-volume analysis as a method for quantifying simultaneous drug (amrinone) effect on arterial load and contractile state in vivo. J Am Coll Cardiol 16:726-732
20. Kass DA, Wolff MR, Ting CT, et al (1993) Diastolic compliance of hypertrophied ventricle is not acutely altered by pharmacologic agents influencing active processes. Ann Int Med 119:466-473
21. Keung EC, Toll L, Ellis M, Jensen RA (1991) L-type cardiac calcium channels in doxorubicin cardiomyopathy in rats morphological, biochemical, and functional correlations. J Clin Invest 87: 2108-2113
22. Leandro J, Dyck J, Poppe D, et al (1994) Cardiac dysfunction late after cardiotoxic therapy for childhood cancer. Am J Cardiol 74: 1152-1156
23. Lee BH, Goodenday LS, Muswick GJ, et al (1987) Alterations in left ventricular diastolic function with doxorubicin therapy. J Am Coll Cardiol 9:184-188
24. Lipshultz SE, Colan SD, Gelber RD, et al (1991) Late cardiac effects of doxorubicin therapy for acute lymphoblastic leukemia in childhood. N Engl J Med 324:808-815
25. max-end-diastolic volume relation in closed-chest dogs. Circ Res 56:808-815
26. Marchandise B, Schroeder E, Bosly A, et al (1989) Early detection of doxorubicin cardiotoxicity: interest of Doppler echocardiographic analysis of left ventricular filling dynamics. Am Heart J 118:92-98
27. Ondrias K, Borgatta L, Kim DH, Ehrlich BE (1990) Biphasic effects of doxorubicin on the calcium release channel from sarcoplasmic reticulum of cardiac muscle. Circ Res 67:1167-1174
28. Pessah IN (1992) Calcium release channel of sarcoplasmic reticulum: an important target for doxorubicin-mediated cardiotoxicity. Adv Exp Med Biol 311:409-410
29. 2+ release channel from rat cardiac sarcoplasmic reticulum: possible receptor-mediated mechanism of doxorubicin cardiomyopathy. Mol Pharm 37:503-514
30. Porta EA, Joun NS, Matsumura L, Nakasone B, Sablan H (1983) Acute adriamycin cardiotoxicity in rats. Res Commun Chem Pathol Pharmacol 41:125-137
31. Rabkin SW, Godin DV (1985) Adriamycin cardiotoxicity and calcium entry blockers: the need for caution in the combination. Can J Cardiol 1:IV-VII [review]
32. Sagawa K, Maughan L, Suga H, Sunagawa K (1988) Cardiovascular interaction. In Cardiac Contraction and the Pressure-Volume Relationship. Oxford University Press, New York, pp 232-298
33. Sagawa K, Maughan L, Suga H, Sunagawa K (1988) Chamber pressure-volume relation versus muscle tension-length relation. In Cardiac Contraction and the Pressure-Volume Relationship. Oxford University Press, New York, pp 42-109
34. Schmitt K, Tulzer G , Merl M, et al (1995) Early detection of doxorubicin and daunorubicin cardiotoxicity by echocardiography: diastolic versus systolic parameters. Eur J Pediatr 154:201-204
35. Singal PK, Deally CM, Weinberg LE (1987) Subcellular effects of adriamycin in the heart: a concise review. J Mol Cell Cardiol 19:817-828 [review]
36. Starling MR, Montgomery DG, Mancini GBJ, Walsh RA (1987) Load independence of the rate of isovolumic relaxation in man. Circulation 76:1274-1281
37. Steinherz LJ, Graham T, Hurwitz R, et al (1992) Guidelines for cardiac monitoring of children during and after anthracycline therapy: Report of the Cardiology Committee of the Children's Cancer Group. Pediatrics 89:942-949
38. Stoddard MF, Seeger J, Liddell NE, et al (1992) Prolongation of isovolumetric relaxation time as assessed by Doppler echocardiography predicts doxorubicin-induced systolic dysfunction in humans. J Am Coll Cardiol 20:62-69
39. Suga H (1979) Total mechanical energy of a ventricle model and cardiac oxygen consumption. Am J Physiol 236:H498-H505
40. Suga H, Goto Y, Kawaguchi O, et al (1993) Ventricular perspective on efficiency. Basic Res Cardiol 88:43-65
41. Suga H, Hayashi T, Shirahata M, Ninomiya I (1980) Critical evaluation of left ventricular systolic pressure volume areas as predictor of oxygen consumption rate. Jpn J Physiol 30:907-919
42. Suga H, Hisano R, Goto Y, Yamada O, Igarashi Y (1983) Effect of positive inotropic agents on the relation between oxygen consumption and systolic pressure volume area in canine left ventricle. Circ Res 53:306-318
43. Sunagawa K, Maughan WL, Burkoff D, Sagawa K (1983) Left ventricular interaction with arterial load studied in isolated canine ventricle. Am J Physiol 245:H773-H780
44. Tomlinson CW, McGrath GM, McNeill JH (1986) Adriamycin cardiomyopathy: pathological and membrane functional changes in a canine model with mild impairment of left ventricular function. Can J Cardiol 2:368-374