Inhibitory effect of tranilast on hypertrophic collagen production in the spontaneously hypertensive rat heart

Japanese Journal of Pharmacology

Volumn 78, Issue 2, 1998, Pages 161-167

  Umemura, Kazuo ^a   Kikuchi, Shinji ^a   Suzuki, Yasuhiro ^a   Nakashima, Mitsuyoshi ^a  

^a HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Cardiac collagen; Left ventricular hypertrophy; Myocardial stiffness; Spontaneously hypertensive rat; Tranilast

Indexed keywords

COLLAGEN; TRANILAST;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; COLLAGEN SYNTHESIS; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DRUG EFFECT; HEART LEFT VENTRICLE HYPERTROPHY; HEART LEFT VENTRICLE MASS; HEART OUTPUT; HEART RATE; HEART VENTRICLE ENDDIASTOLIC PRESSURE; HEART VENTRICLE PRESSURE; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT; SPONTANEOUSLY HYPERTENSIVE RAT; SYSTOLIC BLOOD PRESSURE;

EID: 0031736513     PISSN: 00215198     EISSN: None     Source Type: Journal    
DOI: 10.1254/jjp.78.161     Document Type: Article

References (30)

1. Aronow WS, Koenigberg M and Schwartz KS: Usefulness of echocardiographic left ventricular hypertrophy in predicting new coronary event and atherothrombotic brain infarction in patients over 62 years of age. Am J Cardiol 61, 1130-1132 (1988)
2. Aronow WS, Epstein S, Koenigsber GM and Schwart KS: Usefulness of echocardiographic left ventricular hypertrophy, ventricular tachycardia and complex ventricular arrhythmias in predicting ventricular fibrillation or sudden cardiac death in elderly patients. Am J Cardiol 62, 1124-1125 (1988)
3. Kannel WB and Abbott RD: A prognostic comparison of asymptomatic left ventricular hypertrophy and unrecognized myocardial infarction: the Framingham study. Am Heart J 111, 391-397 (1986)
4. Dougherty AH, Naccarelli GV, Gray EL, Hicks CH and Goldstein RA: Congestive heart failure with normal systolic function. Am J Cardiol 54, 778-782 (1984)
5. Fouad FM, Slominski JM and Tarazi RF: Left ventricular diastolic function in hypertension: relation to left ventricular mass and systolic function. J Am Coll Cardiol 3, 1500-1506 (1984)
6. Caidahl K, Eriksson H, Hartford M, Wikstrand J, Wallentin I, Arvidsson A and Svardsudd K: Dyspnea of cardiac origin in 67 year old men: (2) relation to diastolic left ventricular function and mass. The study of men born in 1913. Br Heart J 59, 329-338 (1988)
7. Weber KT, Pick R, Jalil JE, Janicki JS and Carroll EP: Patterns of myocardial fibrosis. J Mol Cell Cardiol 21, Suppl V, 121-131 (1989)
8. Jalil JE, Doering CW, Janicki JS, Pick R, Shroff SG and Weber KT: Fibrillar collagen and myocardial stiffness in the intact hypertrophied rat left ventricle. Circ Res 64, 1041-1050 (1989)
9. Villarreal FJ, Kim NN, Ungab GD, Printz MP and Dillmann WH: Identification of functional angiotensin II receptors on rat cardiac fibroblasts. Circulation 88, 2849-2861 (1993)
10. Crawford DC, Chobanian AV and Brecher P: Angiotensin II induces fibronectin expression associated with cardiac fibrosis in the rat. Circ Res 74, 727-739 (1994)
11. Eghbali M, Tomek R, Sukhatme VP, Woods C and Bhambi B: Differential effects of transforming growth factor-β and phorbol myristate acetate on cardiac fibroblasts: regulation of fibrillar collagen mRNA and expression of early transcription factors. Circ Res 69, 483-490 (1991)
12. 1, fibronectin, and collagen. Am J Physiol 262, H1861-H1866 (1992)
13. N-5′ Study Group in Children: A double blind controlled trial of N-(3′,4′-dimethoxycinnamoyl) anthranilic acid on children with bronchial asthma. Allergy 34, 213-219 (1979)
14. Okuda M, Ishikawa T, Saito Y, Shimizu T and Baba S: A clinical evaluation of N-5′ with perennial-type allergic rhinitis - A test by the multi-clinic, intergroup, double-blind comparative method. Ann Allergy 53, 178-185 (1984)
15. Suzawa H, Kikuchi S, Arai N and Koda A: The mechanism involved in the inhibitory action of tranilast on collagen biosynthesis of keloid fibroblasts. Jpn J Pharmacol 60, 91-96 (1992)
16. The TREAT Study Investigators: The impact of tranilast on restenosis following coronary angioplasty: the Tranilast Restenosis Angioplasty Trial (TREAT). Circulation 90, I-652 (1994)
17. Weber KT and Brilla CG: Pathological hypertrophy and cardiac interstitium. Fibrosis and renin-angiotensin-aldosterone system. Circulation 83, 1849-1865 (1991)
18. Pfeffer JM, Pfeffer MA, Mirsky I and Braunwald E: Regression of left ventricular hypertrophy and prevention of left ventricular dysfunction by captopril in the spontaneously hypertensive rat. Proc Natl Acd Sci USA 79, 3310-3314 (1982)
19. Umemura K, Zierhut W, Rudin M, Novosel E, Robertson E, Pedersen B and Hof RP: Effect of spirapril on left ventricular hypertrophy due to volume overload in rats. J Cardiovasc Pharmacol 19, 375-381 (1992)
20. Brilla CG, Janicki JS and Weber KT: Impaired diastolic function and coronary reserve in genetic hypertension: Role of interstitial fibrosis and medial thickening of intramyocardial coronary arteries. Circ Res 69, 107-115 (1991)
21. Norton GR, Tsotetsi J, Trifunovic B, Hartford C, Candy GP and Woodiwiss AJ: Myocardial stiffness is attributed to alterations in cross-linked collagen rather than total collagen or phenotypes in spontaneously hypertensive rats. Circulation 96, 1991-1998 (1997)
22. Grover-McKay M, Scholz TD, Burns TL and Skorton DJ: Myocardial collagen concentration and nuclear magnetic resonance relaxation times in the spontaneously hypertensive rat. Invest Radiol 26, 227-232 (1991)
23. Panizo A, Mindan FJ, Galindo MF, Cenarruzabeitia E, Hernandez M and Diez J: Are mast cells involved in hypertensive heart disease? J Hypertens 13, 1201-1208 (1995)
24. Poli O and Parola M: Oxidative damage and fibrogenesis. Free Radic Biol Med 22, 287-305 (1997)
25. Kikuchi S, Umemura K, Kondo K and Nakashima M: Tranilast, an anti-allergic drug, suppresses intimal hyperplasia after photochemically-induced endothelial injury in the spontaneously hypertensive rat. Eur J Pharmacol 295, 221-227 (1996)
26. Miyazawa K, Fukuyama J, Misawa K, Hamano S and Ujiie A: Tranilast antagonizes angiotensin II and inhibits its biological effects in vascular smooth muscle cells. Atherosclerosis 121, 167-173 (1996)
27. Cohn JN, Johnson G and Veterans Administration Cooperative Study Group: Heart failure with normal ejection fraction. Circulation 81, Suppl 3, III-48-III-53 (1990)
28. Kessler KM: Heart failure with normal systolic function. Arch Intern Med 1148, 2109-2111 (1988)
29. Soufer R, Wohlgeleernter D, Vita NA, Amuchestegui M, Sostman HA, Berger HJ and Zaret BL: Intact systolic left ventricular function in clinical congestive heart failure. Am J Cardiol 55, 1032-1036 (1985)
30. Bing OHL, Fanburg BI, Brooks WW and Matsushita S: The effect of the lathyrogen β-amino proprionitrile (BAPN) on the mechanical properties of experimentally hypertrophied rat cardiac muscle. Circ Res 43, 632-637 (1978)