The Caenorhabditis elegans RAD51 homolog is transcribed into two alternative mRNAs potentially encoding proteins of different sizes

Molecular and General Genetics

Volumn 260, Issue 2-3, 1998, Pages 289-294

  Rinaldo, C ^a   Ederle, S ^b   Rocco, V ^a   La Volpe, A ^a  

^a INSTITUTE OF GENETICS AND BIOPHYSICS ADRIANO BUZZATI TRAVERSO   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

Caenorhabditis elegans; DMC1; Homologous recombination; RAD51; Trans splicing

Indexed keywords

MESSENGER RNA; RECA PROTEIN;

ARTICLE; CAENORHABDITIS ELEGANS; EVOLUTION; GENETIC CODE; GENETIC RECOMBINATION; GENETIC TRANSCRIPTION; NONHUMAN; PRIORITY JOURNAL; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY;

ALTERNATIVE SPLICING; AMINO ACID SEQUENCE; ANIMALS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CHROMOSOME MAPPING; CLONING, MOLECULAR; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; MOLECULAR SEQUENCE DATA; PHYLOGENY; RAD51 RECOMBINASE; RNA, MESSENGER; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY, AMINO ACID; TRANSCRIPTION, GENETIC;

BACTERIA (MICROORGANISMS); CAENORHABDITIS ELEGANS; EUKARYOTA; INVERTEBRATA; NEMATODA; PROKARYOTA;

EID: 0031736475     PISSN: 00268925     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004380050897     Document Type: Article

References (21)

1. Aboussekhra A, Chanet R, Adjiri A, Fabre F (1992) Semidominant suppressors of Srs2 helicase mutations of Saccharomyces cerevisiae map in the RAD51 gene, whose sequence predicts a protein with similarities to procaryotic RecA proteins. Mol Cell Biol 12:3224-3234
2. Bairoch A, Boeckmann B (1994) The SWISS-PROT protein sequence data bank: current status. Nucleic Acids Res 22:3578-3580
3. Basile G, Aker M, Mortimer RK (1992) Nucleotide sequence and transcriptional regulation of the yeast recombinational repair gene RAD51. Mol Cell Biol 12:3235-3246
4. Bezzuhova O, Shinohara A, Mueller RG, Ogawa H, Buerstedde JM (1993) A chicken RAD51 homologue is expressed at high levels in lymphoid and reproductive organs. Nucleic Acids Res 21:1577-1580
5. Bishop DK, Park D, Xu L, Kleckner N (1992) DMCl: a meiosis-specific yeast homolog of E. coli recA required for recombination, synaptonemal complex formation, and cell cycle progression. Cell 69:439-456
6. Blumenthal T, Steward K (1997) RNA processing and gene structure. In: Riddle DL, Blumenthal T, Meyer BJ, Priess JR (eds) C. elegans II. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York, pp 117-146
7. Cangiano G, La Volpe A (1993) Repetitive DNA sequences located in the terminal portion of the Caenorhabditis elegans chromosomes. Nucleic Acids Res 21:1133-1139
8. Conrad R, Thomas J, Spieth J, Blumenthal T (1991) Insertion of part of an intron into the 5′ untranslated region of a Caenorhabditis elegans gene converts it into a trans-spliced gene. Mol Cell Biol 11:1921-1926
9. Felsenstein J (1985) Confidence limits on phytogenies: an approach using the bootstrap. Evolution 39:783-791
10. Gish W, States DJ (1993) Identification of protein coding regions by database similarity search. Nat Genet 3:266-272
11. La Volpe A, Ciaramella M, Bazzicalupo P (1988) Structure, evolution and properties of a novel repetitive DNA family in Caenorhabditis elegans. Nucleic Acids Res 16:8213-8231
12. Macshima K, Morimatsu K, Shinohara A, Horii T (1995) RAD51 homologues in Xenopus laevis: two distinct genes are highly expressed in ovary and testis. Gene 160:195-200
13. McCombie WR, Adams MD, Kelley JM, FitzGerald MG, Utterback TR, Khan M, Dubnick M, Kerlavage AR, Venter JC, Fields C (1992) Caenorhabditis elegans expressed sequence tags identify gene families and potential disease gene homologues. Nat Genet 1:124-131
14. Ogawa T, Shinohara A, Nabetani A, Ikeya T, Yu X, Egelman EH, Ogawa H (1993) RecA-like recombination proteins in eukaryotes: functions and structures of RAD51 genes. Cold Spring Harbor Symp Quant Biol 58:567-576
15. Rockmill B, Sym M, Scherthan H, Roeder GS (1995) Roles for two RecA homologs in promoting meiotic chromosome synapsis. Genes Dev 9:2684-2695
16. Sambrook J, Fritsch E, Maniatis T (1989) Molecular cloning. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York
17. Shinohara A, Ogawa H, Ogawa T (1992) Rad51 protein involved in repair and recombination in S. cerevisiae is a RecA-like protein. (Published erratum appears in Cell 71:following 180). Cell 69:457-470
18. Shinohara A, Ogawa H, Matsuda Y, Ushio N, Ikeo K, Ogawa T (1993) Cloning of human, mouse and fission yeast recombination genes homologous to RAD51 and recA. (Published erratum appears in Nat Genet 5:312) Nat Genet 4:239-243
19. Solovyev VV, Salamov AA, Lawrence CB (1994) Predicting internal exons by oligonucleotide composition and discriminant analysis of spliceable open reading frames. Nucleic Acids Res 22:5156-5163
20. Sung P, Stratton SA (1996) Yeast Rad51 recombinase mediates polar DNA strand exchange in the absence of ATP hydrolysis. J Biol Chem 271:27983-27986
21. Terasawa M, Shinohara A, Hotta Y, Ogawa H, Ogawa T (1995) Localization of RecA-like recombination proteins on chromosomes of the lily at various meiotic stages. Genes Dev 9:925-934