Characterisation of the cardiovascular pharmacology of medetomidine in the horse and sheep

Research in Veterinary Science

Volumn 65, Issue 2, 1998, Pages 149-154

  Bryant, C E ^a,b   Thompson, J ^a   Clarke, K W ^a  

^a ROYAL VETERINARY COLLEGE   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 1 ADRENERGIC RECEPTOR STIMULATING AGENT; ALPHA 2 ADRENERGIC RECEPTOR; ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; MEDETOMIDINE; METHOXAMINE; N [2 (1,3,4,6,7,12B HEXAHYDRO 2' OXOSPIRO[2H BENZOFURO[2,3 A]QUINOLIZINE 2,4' IMIDAZOLIDIN] 3' YL)ETHYL]METHANESULFONAMIDE; PRAZOSIN;

ANIMAL EXPERIMENT; ARTICLE; BLOOD PRESSURE; BRADYCARDIA; CONTROLLED STUDY; HEART RATE; HORSE; HYPERTENSION; INTRAVENOUS DRUG ADMINISTRATION; NONHUMAN; SHEEP;

ANIMALIA; EQUIDAE; EQUUS CABALLUS; OVIS ARIES;

EID: 0031736071     PISSN: 00345288     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0034-5288(98)90167-9     Document Type: Article

References (32)

1. 2-adrenoceptor subtypes Annals of Medicine 27, 439-449
2. ALITALO, I (1986) Clinical experiences with Domosedan® in horses and cattle. A review. Acta Veterinaria Scandinavia Suppl. 82, 193-196
3. ATLAS. D. & BURSTEIN, Y. (1984) Isolation of an endogenous clonidine-displacing substance from rat brain. FEBS letters 170, 387-390
4. BRICCA, G., DONTENWILL, M., MOLINES, A., FELDMAN, J., BELCOURT, A. & BOUSQUET, P. (1989) The imidazoline preferring receptor: binding studies in bovine, rat and human brainstem. European Journal of Pharmacology 162, 1-9
5. 2 adrenoceptors in equine saphenous vein. Journal of Veterinary Pharmacological Therapy 19, 124-129
6. BRYANT, C E., CLARKE, K W. & THOMPSON, J. (1996) The cardiopulmonary effects of medetomidine in sheep and ponies. Research in Veterinary Science 60, 267-271
7. CLARKE, K. W. & HALL. L. W. (1969) 'Xylazine' - A new sedative for horses and came. Veterinary Record 85, 512-517
8. 2 adrenoceptor antagonist: L-659,066. Journal of Pharmacological and Experimental Therapy 245, 32-40
9. DOCHERTY, J. R., MacDONALD, A, & McGRATH, J. C. (1979) Further subclassificatlon of α-adrenoceptors in the cardiovascular system, vas deferens and anococcygeus of the rat. British Journal of Pharmacology 67,421P-422P
10. DREW, G M. & WHITING, S. B. (1979) Evidence for two distinct types of postsynaptic α;-adrenoceptor in vascular smooth muscle in vivo. British Journal of Pharmacalogy 67, 207-215
11. ENGLAND G W. C. & CLARKE, K. W. (1989) The use of medetomidine/fentanyl combinations in dogs. Acta Veterinaria Scandinavia Suppl. 85, 179-186
12. FELSON, D., ERNSBERGER, P., MEELEY, M. P. & REIS, D J. (1987) Clonidine displacing substance is biologically active on smooth muscle. European Journal of Pharmacology 142, 453-455
13. GARNER, A E. & LAKS, D A (1985) New implanted chronic catheter device for determining blood pressure and cardiac output in conscious dog. American Journal of Physiology 249, H861-684
14. HSU. W H (1981) Xylazine-induced depression and its antagonism by alpha adrenergic blocking agents Journal of Pharmacological Experimental Therapy 218, 188-192
15. JOCHLE, W & HAMM, D. (1986) Sedation and analgesia with Domosedan® (detomidine hydrochloride) in horses: dose response studies on efficacy and its duration. Acta Veterinaria Scandinavia Suppl 82, 69-84
16. 2-adrenergic receptor. Science 238, 650-656
17. LEHMANN, J., KOENIG-BERNARD, E. & VITOU, P. (1989) The imidazoline-preferring receptor Life Science 45, 1609-1615
18. 2-adrenergic receptor subtype-B and subtype-C Science 273, 803-805
19. 2A)-adrenergic receptor subtype. Science 273, 801-803
20. MATTHEWS, J. N., ALTMAN, D. G., CAMPBELL, M. & ROYSTON, P. (1990) Analysis of serial measurements in medical research. British Medical Journal 300, 230-235
21. 2-Adrenoceptor mediated pressor and chronotropic effects in the rat and rabbit. Journal of Cardiovascular Pharmacology 4, S101-107
22. MICHEL, M. C. & INSEL, P. A. (1989) Are there multiple imidazoline binding sites? Trends in Pharmacological Science 10, 342-344
23. 2, adrenoceptor agonists on airway pressure in anaesthetized sheep. Journal of Veterinary and Pharmacological Therapy 9, 157-163
24. SAVOLA, J M , RUSKOAHO, H., PUURUNEN, J., SALONEN, J. S. & KARKI, N. T. (1986) Evidence of medetomidine as a selective and potent agonist at alpha2-adrenoreceptors. Journal of Auton, Pharmacology 6, 275-284
25. SAVOLA, I. M. (1989) Cardiovascular actions of medetomidine and their reversal by atipamzole. Acta Veterinaria Scandinavica Suppl. 85, 39-48
26. TIBIRICA, E., FELDMAN, J. & BOUSQUET, P. (1992) Different mechanisms of action of centrally-acting imidazoline drugs in hypotension and sedation Fundamental and Clinical Pharmacology 6 (Suppl 1). 46s
27. TIMMERMANS, P. B. M. W. M . KWA. H. Y & VAN ZWIETEN, P A (1979) Possible subdivision of postsynapuc α-adrenoceptors; mediating presser responses in the pithed rat. Nauyn-Schmiedebergs. Arhives in Pharmacology 310, 180-193
28. 2 Adrenoceptors: Classification, localization, mechanisms and targets for drugs Journal of Medical Chemistry 25, 1389-1401
29. VAINIO. O, (1989) Introduction to the clinical pharmacology of medetomidine Acta Veterinaria Scandinavica Suppl. 85, 85-88
30. 2-adreno ceptor effects of detomidine. a novel veterinary sedative analgesic European Journal of Pharmacology 108, 163-169
31. 2 adrenoceptors in the sedative effect of detomidine a novel sedative-analgesic Journal of Veterinary and Pharmacological Theraps 8, 30-37
32. WIKBERG, J E., UHLEN, S, & CHHAJLANI, V (1991) Medetomidine stereoisu mers. delineate two closely related subtypes of idazoxan (imidazoline) I-receptors in the guinea pig European Journal of Pharmacology 193, 335-340