Varicella-zoster virus IE63, a virion component expressed during latency and acute infection, elicits humoral and cellular immunity

Journal of Infectious Diseases

Volumn 178, Issue 5 SUPPL., 1998, Pages

  Sadzot Delvaux, C ^a   Arvin, A M ^b   Rentier, B ^b  

^a Lab de Virologie Fondamentale   (Belgium)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CELLULAR IMMUNITY; CHICKENPOX; CONFERENCE PAPER; CONTROLLED STUDY; CYTOKINE PRODUCTION; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; HUMORAL IMMUNITY; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PURIFICATION; VARICELLA ZOSTER VIRUS; VIRUS EXPRESSION; VIRUS LATENCY; VIRUS REACTIVATION;

EID: 0031735037     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/514259     Document Type: Conference Paper

References (11)

1. Stevens JG, Wagner EK, Devi-Rao GB, Cook ML, Feldman LT. RNA complementary to a herpesvirus alpha gene mRNA is prominent in latently infected neurons. Science 1987;1056-9.
2. Hyman RW, Ecker JR, Tenser RB. Varicella-zoster virus RNA in human trigeminal ganglia. Lancet 1983;2:814-6.
3. Gilden DH, Rozenman Y, Murray R, Devlin M, Vafai A. Detection of varicella-zoster virus nucleic acid in neurons of normal human thoracic ganglia. Ann Neurol 1987;22:377-80.
4. Croen KD, Ostrove JM, Dragovic LJ, Straus SE. Patterns of gene expression and sites of latency in human nerve ganglia are differnet for vari-cella-zoster and herpes simplex viruses. Proc Natl Acad Sci USA 1988;85:9773-7.
5. Lungu O, Annunziato PW, Gershon A, et al. Reactivated and latent varicella-zoster virus in human dorsal root ganglia. Proc Natl Acad Sci USA 1995;92:10980-4.
6. Sadzot-Delvaux C, Debrus S, Nikkels A, Piette J, Rentier B. Varicellazoster virus latency in the adult rat is a useful model for human latent infection. Neurology 1995;12:518-20.
7. Vafai A, Murray RS, Wellish M, Devlin M, Gilden D. Expression of varicella-zoster virus and herpes simplex virus in normal human trigeminal ganglia. Proc Natl Acad Sci USA 1988;85:2362-6.
8. Meier JL, Holman RP, Croen KD, Smialek JE, Straus S. Varicella-zoster virus transcription in human trigeminal ganglia. Virology 1993;193:193-200.
9. Debrus S, Sadzot-Delvaux C, Nikkels AJ, Piette J, Rentier B. Varicellazoster virus gene 63 encodes an immediate early protein abundantly expressed during latency. J Virol 1995;69:3240-5.
10. Mahalingam R, Wellish M, Cohrs R, et al. Expression of protein encoded by varicella-zoster virus open reading frame 63 in latently infected human ganglionic neurons. Proc Natl Acad Sci USA 1996;93:2122-4.
11. Kinchington PR, Bookey D, Turse SE. The transcriptional regulatory proteins encoded by varicella-zoster virus open reading frames (ORFs) 4 and 63, but not ORF61, are associated with purified virus particles. J Virol 1995;69:4274-82.