Elderly patients with hypercholesterolaemia: A double-blind study of the efficacy, safety and tolerability of fluvastatin

Coronary Artery Disease

Volumn 9, Issue 9, 1998, Pages 583-590

  Lye, Michael ^a   Valacio, Reginaldo ^a   Reckless, John P D ^b   Ghosh, Ajit K ^c   Findlay, Iain N ^d   Ghosh, Mrinal K ^e   Passmore, A Peter ^f   Fulcher, Robert A ^g  

^a ROYAL LIVERPOOL UNIVERSITY HOSPITAL   (United Kingdom)

^b ROYAL UNITED HOSPITAL   (United Kingdom)

^c Pontefract General Infirmary   (United Kingdom)

^d ROYAL ALEXANDRA HOSPITAL   (United Kingdom)

^e ROTHERHAM GENERAL HOSPITAL   (United Kingdom)

^f BELFAST CITY HOSPITAL   (United Kingdom)

^g NORFOLK AND NORWICH HOSPITAL   (United Kingdom)

Author keywords

Adverse drug effects; Cardiovascular disease; Clinical trials; Elderly; Fluvastatin; Hypercholesterolaemia; Risk factor modification; Statins

Indexed keywords

ANTILIPEMIC AGENT; CHOLESTEROL; FLUINDOSTATIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; LOW DENSITY LIPOPROTEIN CHOLESTEROL;

ADULT; AGED; ARTICLE; BLEEDING DISORDER; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL DIET; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEPRESSION; DIARRHEA; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; ENDOCRINE DISEASE; FEMALE; GASTROINTESTINAL SYMPTOM; HUMAN; HYPERCHOLESTEROLEMIA; LETHARGY; LIPOPROTEIN BLOOD LEVEL; LIVER TOXICITY; MAJOR CLINICAL STUDY; MALE; MENTAL DISEASE; MULTICENTER STUDY; MUSCULOSKELETAL DISEASE; NEUROTOXICITY; PATIENT COMPLIANCE; PRIORITY JOURNAL; PRURITUS; RANDOMIZED CONTROLLED TRIAL; REPRODUCTIVE TOXICITY; RESPIRATORY TRACT DISEASE; SKIN TOXICITY; SLEEP DISORDER; URINARY TRACT DISEASE; VASCULAR DISEASE; VISUAL DISORDER;

EID: 0031733004     PISSN: 09546928     EISSN: None     Source Type: Journal    
DOI: 10.1097/00019501-199809090-00005     Document Type: Article

References (19)

1. Ettinger WH, Wahl PW, Kuller LH, Bush TL, Tracy RP, Manolio TA, et al. Lipoprotein lipids in older people. Results from the cardiovascular health study. Circulation 1992, 86:858-869.
2. Benefante R, Reed D. Is elevated serum cholesterol a risk factor for coronary heart disease in the elderly? JAMA 1990, 263:393-396.
3. Barrett-Connor E. Hypercholesterolaemia predicts early death from coronary heart disease in elderly men but not women: the Rancho Bernado Study. Ann Epidemiol 1992, 2:77-83.
4. Forette B, Tortrat D, Wolmark Y. Cholesterol as a risk factor for mortality in elderly women. Lancet 1989, 336:868-870.
5. Thompson GR. Cholesterol and the plasma lipoproteins. In: Hodgkinson M, editor. Clinical biochemistry of the elderly. Edinburgh & London: Churchill Livingstone; 1984; 17. pp. 296-311.
6. Mann JI, Lewis B, Shepherd J, Winder AF, Fenster S, Rose L, et al. Blood lipids and other cardiovascular risk factors, their prevalence in Britain. BMJ 1988, 296:1702-1706.
7. Winder AF, Jagger C, Garrick DP, Vallance D, Butowski P, Anderson J, et al. Lipid screening in an elderly population. Difficulty in interpretation and in detection of occult metabolic disease. J Clin Pathol 1996, 49:278-283.
8. La Rosa JC, Applegate W, Crouse JR III, Hunninghake DB, Grimm R, Knopp R, et al. Cholesterol lowering in the elderly. Results of the Cholesterol Reduction in Seniors Program (CRISP) Pilot Study. Arch Intern Med 1994, 154:529-539.
9. Blum CB. Comparison of properties of four inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. Am J Cardiol 1994, 73:3D-11D.
10. Beaumont JL, Carlson LA, Cooper GR, Fejfar Z, Fredrickson DS, Strasser T. Classification of hyperlipidaemias and hyperlipoproteinaemias. Bull World Health Organ 1970, 43:891-915.
11. Pyorala K, De Backer G, Graham I, Poole-Wilson P, Wood D. Prevention of coronary heart disease in clinical practice. Recommendations of the Task Force of the European Society of Cardiology, European Atherosclerosis Society and European Society of Hypertension. Eur Heart J 1994, 15:1300-1331.
12. Lipid Research Clinics Manual of Laboratory Operations. Department of Health Education and Welfare, Bethesda, USA, 1974. Publication No. (NIH) 75-628 (1974).
13. Siedel J, Hagele EO, Ziegenhorn J, Wahlefeld AW. Reagent for the enzymatic determination of serum total cholesterol with improved lipolytic efficiency. Clin Chem 1983, 29:1075-1080.
14. Katterman R, Jaworek D, Moller G, Assmann G, Bjorkhem I, Svensson L, et al. A multicentre study of a new enzymatic method of cholesterol determination. J Clin Chem Biochem 1984, 22:245-251.
15. Wahlfeld AW, et al. In: Bergmeyer HU, editor. Methods of enzymatic analysis. New York: Academic Press Inc; 1974. p. 1831.
16. Bettendge DJ, Dodson PM, Durrington PN, Hughes EA, Laker MF, Nicholls DP, et al. Management of hyperlipidaemia - guidelines of the British Hyperlipidaemia Association. Postgrad Med J 1993, 69:359-369.
17. Shepherd J, Cobbe SM, Ford I, Isles CG, Lorimer AR, Macfarlane PW, et al. Prevention of coronary heart disease with pravastatin in men with hypercholesterolaemia. N Engl J Med 1995, 333:1301-1307.
18. Scandinavian Simvastatin Survival Study Group. Randomized trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S). Lancet 1994, 344:1383-1389.
19. Stein Y. Comparison of European and USA guidelines for prevention of coronary heart disease. Atherosclerosis 1994, 110 (suppl):541-544.