Passive transfer of Lambert-Eaton Myasthenic Syndrome induces dihydropyridine sensitivity of I(Ca) in mouse motor nerve terminals

Journal of Neurophysiology

Volumn 80, Issue 3, 1998, Pages 1056-1069

  Xu, You Fen ^a   Hewett, Sandra J ^a,b   Atchison, William D ^a  

^a MICHIGAN STATE UNIVERSITY   (United States)

^b UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3,4 DIAMINOPYRIDINE; AUTOANTIBODY; CADMIUM; CALCIUM CHANNEL; CALCIUM ION; DIHYDROPYRIDINE; NIFEDIPINE; NITRENDIPINE; OMEGA AGATOXIN IVA; OMEGA CONOTOXIN MVIIC; TETRYLAMMONIUM; VERAPAMIL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN SYNAPTOSOME; CALCIUM CURRENT; CONTROLLED STUDY; EATON LAMBERT SYNDROME; FACILITATION; FOREBRAIN; MALE; MOTOR NERVE; MOUSE; NERVE ENDING; NONHUMAN; PERINEURIUM; PRIORITY JOURNAL; RAT;

EID: 0031732139     PISSN: 00223077     EISSN: None     Source Type: Journal    
DOI: 10.1152/jn.1998.80.3.1056     Document Type: Article

References (62)

1. ANDERSON, A. J. AND HARVEY, A. L. ω-Conotoxin does not block the verapamil-sensitive calcium channels at mouse motor nerve terminals. Neurosci. Lett. 82: 177-180, 1987.
2. ATCHISON, W. D. Dihydropyridine-sensitive and -insensitive components of acetylcholine release from rat motor nerve terminals. J. Pharmacol. Exp. Ther. 251: 672-678, 1990.
3. ATCHISON, W. D., ADOATE, L., AND BEAMAN, C. M. Effects of antibiotics on uptake of calcium into isolated nerve terminals. J. Pharmacol. Exp. Ther. 45: 394-401, 1988.
4. ATCHISON, W. D. AND O'LEARY, S. M. Bay K increases release of acetylcholine at murine neuromuscular junctions. Brain Res. 419: 315-319, 1987.
5. BARRY, E.L.R., VIGLIONE, M. P., KIM, Y. I., AND FROEHNER, S. C. Expression and antibody inhibition of P-type calcium channels in human small-cell lung carcinoma cells. J. Neurosci. 15: 274-283, 1995.
6. 3H]-nitrendipine binding by the calcium antagonists verapamil and diltiazem in rat brain synaptosomes. J. Pharmacol. Exp. Ther. 229: 333-339, 1984.
7. BRIGANT, J. L. AND MALLART, A. Presynaptic currents in mouse motor endings. J. Physiol. (Lond.) 333: 619-636, 1982.
8. CARBONI, E. AND WOJCIK, W. J. Dihydropyridine binding sites regulate calcium influx through specific voltage-sensitive calcium channels in cerebellar granule cells. J. Neurochem. 50: 1279-1286, 1988.
9. 2+ channel blockers. Eur. J. Pharmacol. 131: 1-12, 1986.
10. COUSIN, M. A., HURST, H., AND NICHOLLS, D. G. Presynaptic calcium channel and field-evoked neurotransmitter release from cultured cerebellar granule cells. Neuroscience 81: 151-161, 1997.
11. CRUZ, L. J. AND OLIVERA, B. M. Calcium channel antagonists: ω-conotoxin defines a new high affinity site. J. Biol. Chem. 261: 6230-6233, 1986.
12. CULL-CANDY, S. G., MILEDI, R., TRAUTMANN, A., AND UCHITEL, O. D. On the release of transmitter at normal, myasthenia gravis and myasthenicsyndrome affected human endplates. J. Physiol. (Lond.) 299: 621-638, 1980.
13. FUKUNAGA, H. A., ENGEL, A. C, LANG, B., NEWSOM-DAVIS, J., AND VINCENT, A. Passive transfer of Lambert-Eaton myasthenic syndrome with Igs from man to mouse depletes the presynaptic active zones. Proc. Natl. Acad. Sci. USA 80: 7636-7640, 1983.
14. GARCIA, K. D. AND BEAM, K. G. Reduction of calcium currents by Lambert-Eaton syndrome sera: motor neurons are preferentially affected, and L-type currents are spared. J. Neurosci. 16: 4903-4913, 1996.
15. GLOSSMANN, H. AND STRIESSNIG, J. Structure and pharmacology of voltagedependent calcium channels (Abstract). ISI Atlas Sci. Pharmacol. 202: 208, 1988.
16. 2+ channels of human neuroblastoma IMR 32 cells by Lambert-Eaton myasthenic syndrome (LEMS) IgGs. Neurosci. Lett. 18: 50-56, 1994.
17. GRAY, E. G. AND WHITTAKER, V. P. The isolation of nerve endings from brain: an electron microscopic study of cell fragments derived by homogenization and centrifugation. J. Anat. 96: 79-96, 1962.
18. HAJELA, R. K. AND ATCHISON, W. D. The proteins synaptotagmin and syntaxin are not general targets of Lambert-Eaton myasthenic syndrome autoantibody. J. Neurochem. 64: 1245-1251, 1995.
19. 2 and β subunit segments from human spinal cord RNA. Ann. NY Acad. Sci. 841: 115-118, 1998.
20. HAMILTON, B. R. AND SMITH, D. O. Calcium currents in rat motor nerve terminals. Brain Res. 584: 123-131, 1992.
21. 2+ into rat cortical synaptosomes. Brain Res. 566: 320-324, 1991.
22. HEWETT, S. J. AND ATCHISON, W. D. Disruption of synaptosomal calcium channel function by Lambert-Eaton Myasthenic immunoglobulin is serum dependent. Brain Res. 599: 317-323, 1992a.
23. HEWETT, S. J. AND ATCHISON, W. D. Specificity of Lambert-Eaton Myasthenic Syndrome immunoglobulin for nerve terminal calcium channels. Brain Res. 599: 324-332, 1992b.
24. 2+ channels in freshly dissociated rat cerebellar Purkinje neurons by diltiazem and verapamil. Brain Res. 695: 88-91, 1995.
25. KATZ, E., FERRO, G., WEISZ, G., AND UCHITEL, O. D. Pharmacological characterization of the calcium channels involved in transmitter release at reinnervating mouse neuromuscular junctions. Soc. Neurosci. Abstr. 21: 340, 1995.
26. KIM, Y. I. Passive transfer of the Lambert-Eaton Myasthenic Syndrome: neuromuscular transmission in mice injected with plasma. Muscle Nerve 8: 162-172, 1985.
27. KIM, Y. I. AND NEHER, E. Igs from patients with Lambert-Eaton syndrome block voltage-dependent calcium channels. Science 239: 405-408, 1988.
28. LAMBERT, E. H., EATON, L. M., AND ROOKE, E. D. Defect of neuromuscular conduction associated with malignant neoplasm. Am. J. Physiol. 187: 612-613, 1956.
29. LAMBERT, E. H. AND ELMQVIST, D. Quantal components of the endplate potentials in the myasthenic syndrome. Ann. NY Acad. Sci. 183: 183-199, 1971.
30. LANG, B., NEWSOM-DAVIS, J., PEERS, D., PRIOR, C., AND WRAY, D. W. The effect of myasthenic syndrome antibody on presynaptic calcium channels in the mouse. J. Physiol. (Lond.) 390: 257-270, 1987.
31. LANG, B., NEWSOM-DAVIS, J., PRIOR, C., AND WRAY, D. Antibodies to motor nerve terminals: an electrophysiological study of a human myasthenic syndrome transferred to mouse. J. Physiol. (Lond.) 344: 335-345, 1983.
32. LANG, B., NEWSOM-DAVIS, J., WRAY, D., AND VINCENT, A. Autoimmune aetiology for myasthenic (Eaton-Lambert) syndrome. Lancet ii: 224-226, 1981.
33. LENNON, V. A., LAMBERT, E. H., WHITTINGHAM, S., AND FAIRBANKS, V. Autoimmunity in the Lambert-Eaton Myasthenic Syndrome. Muscle Nerve 5: S21-S25, 1982.
34. LENNON, V. A., THOMAS, J. K., GRIESMANN, G. E., O'SULLEABHAIN, P. E., ANTHONY, J. W., WOPPMANN, A., GEORGE, P. M., AND LAMBERT, E. H. Calcium-channel antibodies in the Lambert-Eaton syndrome and other paraneoplastic syndromes. N. Engl. J. Med. 332: 1467-1474, 1995.
35. LOWRY, O. H., ROSEBROUGH, N. J., FARR, A. L., AND RANDALL, R. J. Protein measurements with the folin phenol reagent. J. Biol. Chem. 193: 265-275, 1951.
36. MALLART, A. Electric current flow inside perineurial sheaths of mouse motor nerves. J. Physiol. (Lond.) 368: 567-575, 1982.
37. MALLART, A. A calcium-activated potassium current in motor nerve terminals of the mouse. J. Physiol. (Lond.) 368: 577-591, 1985.
38. MALLART, A. Some properties of calcium current in mouse motor endings, In: Calcium, Neuronal Function and Transmitter Release, edited by R. Rahamimoff and S. B. Kaza. The Hague: Martinus Nijhoff, 1986, p. 35-46.
39. 3H]-aspartate release and neuronal calcium influx by verapamil, diltiazem and dextromethorphan: evidence for non-L/non-N voltage-sensitive calcium channels. Eur. J. Pharmacol. 192: 9-17, 1991.
40. MARQUEZE, B., MARTIN-MOUTOT, N., LEVEQUE, C., AND COURAUD, F. Characterization of the ω-conotoxin binding molecule in rat brain synaptosomes and cultured neurons. Mol. Pharmacol. 34: 87-90, 1988.
41. MCARDLE, J. J., ANGAUT-PETIT, D., MALLART, A., BOURNAND, R., FAILLE, L., AND BRIGANT, J. L. Advantages of the triangularis sterni muscle of the mouse for investigations of synaptic phenomena. Neurosci. Methods 4: 109-115, 1981.
42. MILLER, R. J. Multiple calcium channels and neuronal function. Science 235: 46-52, 1987.
43. NACHSHEN, D. A. AND BLAUSTEIN, M. P. The effects of some organic "calcium antagonists" on calcium influx in presynaptic nerve terminals. Mol. Pharmacol. 16: 579-586, 1979.
44. PEERS, C., LANG, B., NEWSOM-DAVIS, J., AND WRAY, D. W. Selective action of myasthenic syndrome antibodies on calcium channels in a rodent neuroblastoma × glioma cell line. J. Physiol. (Lond.) 421: 239-308, 1990.
45. PENNER, R. AND DREYER, F. Two different presynaptic calcium currents in mouse motor nerve terminals. Pflügers Arch. 406: 190-197, 1986.
46. 2+ flux in a human small cell carcinoma line. Nature 317: 737-739, 1985.
47. SCATCHARD, G. The attractions of proteins for small molecules and ions. Ann. NY Acad. Sci. 51: 660-672, 1949.
48. 2+-dependent potentials at neuromuscular junctions of the mouse. Brain Res. 595: 215-219, 1992.
49. SHER, E., CANAL, N., PICCOLO, G., GOTTI, C., SCOPPETTA, C., EVOLI, A. AND CLEMENTI, F. Specificity of calcium channel autoantibodies in Lambert-Eaton myasthenic syndrome. Lancet ii: 640-643, 1989a.
50. SHER, E., PANDIELLA, A., AND CLEMENTI, F. Voltage-operated calcium channels in small cell lung carcinoma cell lines: pharmacological, functional, and immunological properties. Cancer Res. 50: 3892-3896, 1989b.
51. SMITH, D. O., CONKLIN, M. W., JENSEN, P. J., AND ATCHISON, W. D. Decreased calcium currents in motor nerve terminals of mice with Lambert-Eaton myasthenic syndrome. J. Physiol. (Lond.) 487: 115-123, 1995.
52. STANDEN, N. B. AND STANFIELD, P. R. A binding site model for calcium channel inactivation that depends on calcium entry. Proc. R. Soc. Lond. B Biol. Sci. 217: 101-110, 1982.
53. SUGIURA, Y. AND Ko, C. P. Novel modulatory effect of L-type calcium channel at newly formed neuromuscular junctions. J. Neurosci. 17: 1101-1111, 1997.
54. SUSZKIW, J. B., O'LEARY, M. E., MURAWSKY, M. M., AND WANG, T. Presynaptic calcium channels in rat cortical synaptosomes: fast kinetics of phasic calcium influx in rat brain synaptosomes. J. Neurosci. 6: 1349-1357, 1986.
55. TABTI, N., BOURET, C., AND MALLART, A. Three potassium currents in mouse motor nerve terminals. Pflügers Arch. 413: 395-400, 1989.
56. TURNER, T. J. AND GOLDIN, S. M. Calcium channels in rat brain synaptosomes: identification and pharmacological characterization. J. Neurosci. 5: 841-849, 1985.
57. UCHITEL, O. D., PROTTI, D. A., SANCHEZ, V., CHERKSEY, B. D., SUGIMORI, M., AND LUNAS, R. Voltage dependent calcium channel mediates presynaptic calcium influx and transmitter release in mammalian synapses. Proc. Natl. Acad. Sci. USA 89: 3330-3333, 1992.
58. VIGLIONE, M. P., O'SHAUGHNESSY. T. J., AND KIM, Y. I. Inhibition of calcium currents and exocytosis by Lambert-Eaton syndrome antibodies in human lung cancer cells. J. Physiol. (Lond.) 488: 303-317, 1995.
59. VINCENT, A., LANG, B., AND NEWSOM-DAVIS, J. Autoimmunity to the voltage-gated calcium channel underlies the Lambert-Eaton syndrome, a paraneoplastic disorder. Trends. Neurosci. 12:496-502, 1989.
60. WAGNER, J. A., SNOWMAN, A. M., BUSWAS, A., OLIVERA, B. M., AND SNYDER, S. H. ω-Conotoxin binding to a high affinity receptor in brain: characterization, calcium sensitivity, and solubilization. J. Neurosci. 8: 3354-3359, 1988.
61. + currents of mouse motor nerve terminals. J. Phannacol. Exp. Ther. 279: 1229-1236, 1996.
62. YAN, C.-H., Xu, Y. F., AND ATCHISON, W. D. Comparative blocking actions of ω-agatoxin-IVA and ω-conotoxin-MVIIC on rat forebrain synaptosomes and neuromuscular junctions. Soc. Neurosci. Abstr. 20: 71, 1994.