Sphingosylphosphorylcholine stimulates mitogen-activated protein kinase via a Ca2+-dependent pathway

American Journal of Physiology - Cell Physiology

Volumn 275, Issue 5 44-5, 1998, Pages

  Chin, Ting Y U ^a   Chueh, Sheau Huei ^a  

^a NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

Author keywords

ATP; Bradykinin; Cytosolic calcium concentration; Lysophosphatidic acid; Platelet derived growth factor; Porcine aortic smooth muscle cells

Indexed keywords

1 [[6 (3 METHOXYESTRA 1,3,5(10) TRIEN 17BETA YL)AMINO]HEXYL] 1H PYRROLE 2,5 DIONE; ADENOSINE TRIPHOSPHATASE (CALCIUM); ADENOSINE TRIPHOSPHATASE INHIBITOR; ADENOSINE TRIPHOSPHATE; BRADYKININ; CALCIUM; CALMIDAZOLIUM; CHOLINE DERIVATIVE; DNA; GUANINE NUCLEOTIDE BINDING PROTEIN; INOSITOL 1,4,5 TRISPHOSPHATE; LYSOPHOSPHATIDIC ACID; MITOGEN ACTIVATED PROTEIN KINASE; N (6 AMINOHEXYL) 5 CHLORO 1 NAPHTHALENESULFONAMIDE; PERTUSSIS TOXIN; PHOSPHOLIPASE C INHIBITOR; PLATELET DERIVED GROWTH FACTOR; SPHINGOSYLPHOSPHORYLCHOLINE; STAUROSPORINE; THAPSIGARGIN; UNCLASSIFIED DRUG;

ANIMAL CELL; AORTA; ARTICLE; CONTROLLED STUDY; DNA SYNTHESIS; ENZYME ACTIVATION; NONHUMAN; PRIORITY JOURNAL; SMOOTH MUSCLE FIBER; SWINE;

EID: 0031730471     PISSN: 03636143     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpcell.1998.275.5.c1255     Document Type: Article

References (13)

1. Bading, H., and M. E. Greenberg. Stimulation of protein tyrosine phosphorylation by NMDA receptor activation. Science 253: 912-914, 1991.
2. Bokemeyer, D., A. Sorokin, and M. J. Dunn. Multiple intracellular MAP kinase signaling cascades. Kidney Int. 49: 1187-1198, 1996.
3. + current in guinea-pig atrial myocytes by sphingosine-1-phosphate. J. Physiol. (Lond.) 489: 701-707, 1995.
4. Cook, S. J., B. Rubinfeld, I. Albert, and F. McCormick. RapV12 antagonizes Ras-dependent activation of ERK1 and ERK2 by LPA and EGF in Rat-1 fibroblasts. EMBO J. 12: 3475-3485, 1993.
5. Crespo, P., N. Xu, W. F. Simonds, and J. S. Gutkind. Ras-dependent activation of MAP kinase pathway mediated by G-protein βγ subunits. Nature 369: 418-420, 1994.
6. Cunningham, A. J., and A. Szenberg. Further improvements in the plaque technique for detecting single antibody-forming cells. Immunology 14: 599-601, 1968.
7. Desai, N. N., R. O. Carlson, M. E. Mattie, A. Olivera, N. E. Buckley, T. Seki, G. Brooker, and S. Spiegel. Signaling pathways for sphingosylphosphorylcholine-mediated mitogenesis in Swiss 3T3 fibroblasts. J. Cell Biol. 121: 1385-1395, 1993.
8. Desai, N. N., and S. Spiegel. Sphingosylphosphorylcholine is a remarkably potent mitogen for a variety of cell lines. Biochem. Biophys. Res. Commun. 181: 361-366, 1991.
9. Dikic, I., G. Tokiwa, S. Lev, S. A. Courtneidge, and J. Schlessinger. A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation. Nature 383: 547-550, 1996.
10. Eguchi, S., T. Matsumoto, E. D. Motley, H. Utsunomiya, and T. Inagami. Identification of an essential signaling cascade for mitogen-activated protein kinase activation by angiotensin II in cultured rat vascular smooth muscle cells. J. Biol. Chem. 271: 14169-14175, 1996.
11. Faure, M., T. A. Voyno-Yasenetskaya, and H. R. Bourne. cAMP and βγ subunits of heterotrimeric G proteins stimulate the mitogen-activated protein kinase pathway in COS-7 cells. J. Biol. Chem. 269: 7851-7854, 1994.
12. 2+ indicators with greatly improved fluorescence properties. J. Biol. Chem. 260: 3440-3450, 1985.
13. q-mediated mitogen-activated protein kinase activation. J. Biol. Chem. 270: 17148-17153, 1995.