GABA(A) receptor modulates the activity of inner hair cell afferents in guinea pig cochlea

Hearing Research

Volumn 125, Issue 1-2, 1998, Pages 147-153

  Arnold, Thomas ^a   Oestreicher, Elmar ^a,b   Ehrenberger, Klaus ^c   Felix, Dominik ^a  

^a UNIVERSITY OF BERN   (Switzerland)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^c UNIVERSITY OF VIENNA   (Austria)

Author keywords

Efferent auditory system; GABA receptor; Guinea pig; Inner hair cell; Iontophoretic technique

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID B RECEPTOR; ACETYLCHOLINE; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; GLUTAMIC ACID; N METHYL DEXTRO ASPARTIC ACID; RECEPTOR SUBTYPE;

ANIMAL EXPERIMENT; ARTICLE; COCHLEA; GABAERGIC SYSTEM; GUINEA PIG; HAIR CELL; IONTOPHORESIS; NERVE CELL EXCITABILITY; NONHUMAN; PRIORITY JOURNAL; SENSORY NERVE CELL;

ACETYLCHOLINE; ACTION POTENTIALS; AFFERENT PATHWAYS; ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID; ANIMALS; AUDITORY PATHWAYS; BACLOFEN; BICUCULLINE; COCHLEA; ELECTROPHYSIOLOGY; GAMMA-AMINOBUTYRIC ACID; GLUTAMIC ACID; GUINEA PIGS; HAIR CELLS, INNER; IONTOPHORESIS; MUSCIMOL; N-METHYLASPARTATE; RECEPTORS, GABA-A;

EID: 0031729075     PISSN: 03785955     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5955(98)00144-0     Document Type: Article

References (17)

1. B receptor subtypes. TINS. 11:1988;112-116.
2. B receptor site distribution in the rat central nervous system. Neuroscience. 20:1987;365-383.
3. Eybalin M. Neurotransmitters and neuromodulators of the mammalian cochlea. Physiol. Rev. 73:1993;309-373.
4. Eybalin M., Parnaud C., Geffard M., Pujol R. Immunoelectron microscopy identifies several types of GABA-containing efferent synapses in the guinea-pig organ of Corti. Neuroscience. 24:1988;29-38.
5. Eybalin M., Pujol R. Cochlear neuroactive substances. Arch. Otorhinolaryngol. 246:1989;228-234.
6. Felix D., Ehrenberger K. A microiontophoretic study of the role of excitatory amino acids at the afferent synapses of mammalian inner hair cells. Eur. Arch. Otorhinolaryngol. 248:1990;1-3.
7. Felix D., Ehrenberger K. The efferent modulation of mammalian inner hair cell afferents. Hear. Res. 64:1992;1-5.
8. Fex J., Altschuler R.A. Glutamic acid decarboxylase immunoreactivity of olivocochlear neurons in the organ of Corti of guinea pig and rat. Hear. Res. 15:1984;123-131.
9. Fex J., Altschuler R.A. Neurotransmitter-related immunocytochemistry of the organ of Corti. Hear. Res. 22:1986;249-263.
10. Klinke R. Neurotransmission in the inner ear. Hear. Res. 22:1986;235-243.
11. Klinke R., Oertel W. Evidence that GABA is not the afferent transmitter in the cochlea. Exp. Brain Res. 28:1977;311-314.
12. Oestreicher E., Arnold W., Ehrenberger K., Felix D. Dopamine regulates the glutamatergic inner hair cell activity in guinea pigs. Hear. Res. 107:1997;46-52.
13. Ohmori Y., Kuriyama K. Negative coupling of K-aminobutyric acid (GABA) B receptor with phosphatidylinositol turnover in the brain. Neurochem. Int. 15:1989;359-363.
14. Plinkert P.K., Zenner H.P. Physiologie und Pathophysiologie des Corti-Organs. Eur. Arch. Otorhinolaryngol. Suppl. I:1995;53-114.
15. Sivilotti L., Nistri A. GABA receptor mechanisms in the central nervous system. Prog. Neurobiol. 36:1991;35-92.
16. Warr W.B., Guinan J.J. Efferent innervation of the organ of corti: two separate systems. Brain Res. 173:1979;152-155.
17. Wojcik W.J., Neff N.H. K-Aminobutyric acid B receptors are negatively coupled to adenylate cyclase in brain, and in the cerebellum these receptors may be associated with granule cells. Mol. Pharmacol. 25:1983;24-28.