Heme arginate therapy for beta thalassemia: In vitro versus in vivo effects

Acta Haematologica

Volumn 100, Issue 2, 1998, Pages 82-84

  Rund, Deborah ^a   Fibach, Eitan ^a   Goldfarb, Ada ^a   Friedberg, Aviva ^a   Rachmilewitz, Eliezer ^a  

^a HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

Author keywords

Hemoglobin, fetal; Hemoglobinopathies; Thalassemia intermedia

Indexed keywords

HEME ARGINATE; HEMOGLOBIN; HEMOGLOBIN F;

ADULT; ARTICLE; BETA THALASSEMIA; CASE REPORT; ERYTHROID CELL; FEMALE; HEMOGLOBIN DETERMINATION; HUMAN; HUMAN CELL; INTRAVENOUS DRUG ADMINISTRATION; MALE; PRIORITY JOURNAL;

ADULT; ARGININE; BETA-THALASSEMIA; CELLS, CULTURED; FEMALE; HEME; HUMANS; INFUSIONS, INTRAVENOUS; MALE; TREATMENT OUTCOME;

EID: 0031728305     PISSN: 00015792     EISSN: None     Source Type: Journal    
DOI: 10.1159/000040870     Document Type: Article

References (9)

1. Porter P, Meints R, Mesner K: Enhancement of erythroid colony growth in culture by hemin. Exp Hematol 1979;7:11-16.
2. Rutherford T, Clegg J, Weatherall D: K562 human erythroleukemia cells. Nature 1979; 280:164-165.
3. Alter B, Schoenfield J, He L, Weinberg R: Effects of hemin on erythropoiesis. Adv Exp Med Biol 1989;271:95-102.
4. Fibach E, Kollia P, Schechter A, Noguchi C, Rodgers GP: Hemin-induced acceleration of hemoglobin production in immature cultured erythroid cells: Preferential enhancement of fetal hemoglobin. Blood 1995;85:2967-2974.
5. Tenhunen R, Tokola O, Linden I: Haem arginate: A new stable haem compound. J Pharm Pharmacol 1987;39:780-786.
6. Fibach E, Manor D, Oppenheim A, Rachmilewitz E: Proliferation and maturation of human erythroid progenitors in liquid culture. Blood 1989;73:100-103.
7. Epstein N, Epstein M, Boulet A, Fibach E, Rodgers G: Antibody based methods for quantitation of hemoglobins: Application to patients with sickle cell anemia treated with hydroxyurea. Eur J Haematol 1996;57:17-24.
8. Timonen T, Kauma H: Therapeutic effect of heme arginate in myelodysplastic syndromes. Eur J Haematol 1992;49:234-238.
9. Chalevelakis G, Karaoulis S, Yalouris A, Economopoulos T, Tountas N, Raptis S: Globin chain synthesis in myelodysplastic syndromes. J Clin Pathol 1991;44:134-138.