Use of a gonadotropin-releasing hormone antagonist as a physiologic probe in polycystic ovary syndrome: Assessment of neuroendocrine and androgen dynamics

Journal of Clinical Endocrinology and Metabolism

Volumn 83, Issue 7, 1998, Pages 2343-2349

  Hayes, Frances J ^a   Taylor, Ann E ^a   Martin, Kathryn A ^a   Hall, Janet E ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; FOLLITROPIN; GONADORELIN; GONADORELIN ANTAGONIST; GONADORELIN RECEPTOR; LUTEINIZING HORMONE; PRASTERONE SULFATE; PROGESTERONE; TESTOSTERONE;

ADULT; ANDROGEN RELEASE; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GONADORELIN RELEASE; HUMAN; HYPERANDROGENISM; LUTEINIZING HORMONE RELEASE; NEUROENDOCRINOLOGY; OVARY POLYCYSTIC DISEASE; PRIORITY JOURNAL; TESTOSTERONE RELEASE;

ADOLESCENT; ADULT; ANDROGENS; DIPEPTIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; EVALUATION STUDIES; FEMALE; FOLLICLE STIMULATING HORMONE; HORMONE ANTAGONISTS; HUMANS; LUTEINIZING HORMONE; NEUROSECRETORY SYSTEMS; POLYCYSTIC OVARY SYNDROME; RECEPTORS, LHRH; SECRETORY RATE;

EID: 0031728153     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.83.7.2343     Document Type: Article

References (43)

1. Yen SSC. 1980 The polycystic ovary syndrome. Clin Endocrinol (Oxf). 12:177-207.
2. McKenna TJ. 1988 Pathogenesis and treatment of polycystic ovary syndrome. N Engl J Med. 318:558-562.
3. Barnes R, Rosenfield RL. 1989 Polycystic ovary syndrome: pathogenesis and treatment. Ann Intern Med. 110:386-399.
4. Franks S. 1995 Polycystic ovary syndrome. N Engl J Med. 333:853-861.
5. Yen SSC, Vela P, Rankin J. 1970 Inappropriate secretion of follicle-stimulating hormone and luteinizing hormone in polycystic ovarian disease. J Clin Endocrinol Metab. 30:435-442.
6. Rebar R, Judd HL, Yen SSC, Rakoff J, Vandenberg G, Naftolin F. 1976 Characterization of the inappropriate gonadotropin secretion in polycystic ovary syndrome. J Clin Invest. 57;1320-1329.
7. Waldstreicher J, Santoro NF, Hall JE, Filicori M, Crowley Jr WF. 1988 Hyperfunction of the hypothalamic-pituitary axis in women with polycystic ovarian disease: indirect evidence for partial gonadotrope desensitization. J Clin Endocrinol Metab. 66:165-172.
8. Franks S. 1989 Polycystic ovary syndrome: a changing perspective. Clin Endocrinol (Oxf). 31:87-120.
9. Taylor AE, McCourt B, Martin KA, et al. 1997 Determinants of abnormal gonadotropin secretion in clinically defined women with polycystic ovary syndrome. J Clin Endocrinol Metab. 82:2248-2256.
10. Conway GS, Honour JW, Jacobs HS. 1989 Heterogeneity of the polycystic ovary syndrome: clinical, endocrine and ultrasound features in 556 patients. Clin Endocrinol (Oxf). 30:459-470.
11. Batrinos ML. 1993 Diagnostic dilemmas in polycystic ovarian syndrome. Ann NY Acad Sci. 687:230-234.
12. Burger CW, Korsen T, van Kessel H, van Dop PA, Caron FJM, Schoemaker J. 1985 Pulsatile luteinizing hormone patterns in the follicular phase of the menstrual cycle, polycystic ovarian disease (PCOD) and non-PCOD secondary amenorrhea. J Clin Endocrinol Metab. 61:1126-1132.
13. Kazer R, Kessel B, Yen SCC. 1987 Circulating luteinizing hormone pulse frequency in women with polycystic ovary syndrome. J Clin Endocrinol Metab. 65:233-236.
14. Venturoli S, Porcu E, Fabbri R, et al. 1988 Episodic pulsatile secretion of FSH, LH, prolactin, oestradiol, oestrone, and LH circadian rhythms in polycystic ovary syndrome. Clin Endocrinol (Oxf). 28:93-107.
15. Barnes RB, Rosenfield RL, Burstein S, Ehrmann DA. 1989 Pituitary-ovarian responses to nafarelin in the polycystic ovary syndrome. N Engl J Med. 320:559-565.
16. Imse V, Holzapfel G, Hinney B, Kuhn W, Wuttke W. 1992 Comparison of luteinizing hormone pulsatility in the serum of women suffering from polycystic ovarian disease using a bioassay and five different immunoassays. J Clin Endocrinol Metab. 74:1053-1061.
17. Dunaif A, Mandeli J, Fluhr H, Dobrjansky A. 1988 The impact of obesity and chronic hyperinsulinemia on gonadotropin release and gonadal steroid secretion in the polycystic ovary syndrome. J Clin Endocrinol Metab. 66:131-139.
18. Hall JE, Taylor AE, Martin KA, Crowley Jr WF. 1993 New approaches to the study of the neuroendocrine abnormalities of women with the polycystic ovarian syndrome. Ann NY Acad Sci. 687:182-192.
19. Berga SL, Guzick DS, Winters SJ. 1993 Increased luteinizing hormone and alpha-subunit secretion in women with hyperandrogenic anovulation. J Clin Endocrinol Metab. 77:895-901.
20. Kletzky OA, Davajan V, Nakamura RM, Mishell DR. 1975 Classification of secondary amenorrhea based on distinct hormonal patterns. J Clin Endocrinol Metab. 41:660-668.
21. Crowley WF, Filicori M, Spratt DI, Santoro NF. 1985 The physiology of gonadotropin-releasing hormone (GnRH) secretion in men and women. Recent Prog Horm Res. 41:473-531.
22. Filicori M, Santoro N, Merriam GR, Crowley Jr WF. 1986 Characterization of the physiologic pattern of episodic gonadotropin secretion throughout the human menstrual cycle. J Clin Endocrinol Metab. 62:1136-1144.
23. Marshall JC, Dalkin AC, Haisenleder DJ, Paul SJ, Ortolano GA, Kelch RP. 1991 Gonadotropin-releasing hormone pulses: regulators of gonadotropin synthesis and ovulatory cycles. Recent Prog Horm Res. 47:155-187.
24. Hall JE, Taylor AE, Martin KA, Rivier J, Schoenfeld DA, Crowley Jr WF. 1994 Decreased release of gonadotropin-releasing hormone during the preovulatory midcycle luteinizing hormone surge in normal women. Proc Natl Acad Sci USA. 91:6894-6898.
25. Chang RJ, Laufer LR, Meldrum DR, et al. 1983 Steroid secretion in polycystic ovarian disease after ovarian suppression by a long-acting gonadotropin-releasing hormone agonist. J Clin Endocrinol Metab. 56:897-903.
26. Andreyko JL, Monroe SE, Jaffe RB. 1986 Treatment of hirsutism with a gonadotropin-releasing hormone agonist (Nafarelin). J Clin Endocrinol Metab. 63:854-859.
27. Steingold K, De Ziegler D, Cedars M, et al. 1987 Clinical and hormonal effects of chronic gonadotropin-releasing hormone agonist treatment in polycystic ovarian disease. J Clin Endocrinol Metab. 65:773-778.
28. Rittmaster RS, Thompson DL. 1990 Effect of leuprolide and dexamethasone on hair growth and hormone levels in hirsute women: the relative importance of the ovary and the adrenal in the pathogenesis of hirsutism. J Clin Endocrinol Metab. 70:1096-1102.
29. Hall JE, Whitcomb RW, RivierJE, Vale WW, Crowley Jr WF. 1990 Differential regulation of luteinizing hormone, follicle-stimulating hormone, and free α-subunit from the gonadotrope by gonadotropin-releasing hormone (GnRH): evidence from the use of two GnRH antagonists. J Clin Endocrinol Metab. 70:328-335.
30. Crowley Jr WF, Beitins I, Vale W, et al. 1980 The biologic activity of a potent analogue of gonadotropin-releasing hormone in a normal and hypogonadotropic man. N Engl J Med. 302:1052-1057.
31. Filicori M, Butler JP, Crowley Jr WF. 1984 Neuroendocrine regulation of the corpus luteum in the human: evidence for pulsatile progesterone secretion. J Clin Invest. 73:1638-1647.
32. Rao PN, Moore PH. 1976 Synthesis of new steroid haptens for radioimmunoassay. I. 15 α-carboxymethylmercaptotestosterone-bovine serum albumin conjugate: measurement of testosterone in male plasma without chromatography. Steroids. 28:101-109.
33. Hall JE. 1993 Polycystic ovarian disease as a neuroendocrine disorder of the female reproductive axis. Endocrinol Metab Clin North Am. 22:75-92.
34. Nett TM, Adams TE. 1977 Further studies on the radioimmunoassay of gonadotropin-releasing hormone: effect of radioiodination, antiserum and unextracted serum on levels of immunoreactivity in serum. Endocrinology. 101:1135-1144.
35. Levine JE, Bauer-Dantoin AC, Besecke LM, et al. 1991 Neuroendocrine regulation of the luteinizing hormone-releasing hormone pulse generator in the rat. Recent Prog Horm Res. 47:97-153.
36. Karsch FJ, Bowen JM, Caraty A, Evans NP, Moenter SM. 1997 Gonadotropin-releasing hormone requirements for ovulation. Biol Reprod. 56:303-309.
37. Ross EM, Gilman AG. 1985 Goodman and Gilman's the pharmacologic basis of therapeutics. New York: Macmillan; 35-48.
38. Cicero TJ, Owens DP, Schmoeker PF, Meyer ER. 1983 Morphine-induced supersensitivity to the effects of naloxone on luteinizing hormone secretion in the male rat. J Pharmacol Exp Ther. 225:34-41.
39. Apter D, Butzow T, Laughlin GA, Yen SSC. 1994 Accelerated 24-hour luteinizing hormone pulsatile activity in adolescent girls with ovarian hyperandrogenism: relevance to the developmental phase of polycystic ovarian syndrome. J Clin Endocrinol Metab. 79:119-125.
40. Spratt DI, Finkelstein JS, Butler JP, Badger TM, Crowley Jr WF. 1987 Effects of increasing the frequency of low doses of gonadotropin-releasing hormone (GnRH) on gonadotropin secretion in GnRH-deficient men. J Clin Endocrinol Metab. 64:1179-1186.
41. Besecke LM, Guendner MJ, Schneyer AL, Bauer-Dantoin AC, Jameson JL, Weiss J. 1996 Gonadotropin-releasing hormone regulated follicle-stimulating hormone-β gene expression through an activin/follistatin autocrine or paracrine loop. Endocrinology. 137:3667-3673.
42. Chang RJ, Mandel FP, Lu JKH, et al. 1982 Enhanced disparity of gonadotropin secretion by estrone in women with polycystic ovarian disease. J Clin Endocrinol Metab. 54:490-494.
43. Smith PF, Frawley LS, Neill JD. 1984 Detection of LH release from individual pituitary cells by the reverse hemolytic plaque assay: estrogen increases the fraction of gonadotropes responding to GnRH. Endocrinology. 115:2484-2486.