The effectiveness of taurine and levocarnitine in dogs with heart disease

Veterinary Clinics of North America - Small Animal Practice

Volumn 28, Issue 6, 1998, Pages 1495-1514

  Pion, P D ^a   Sanderson, S L ^a   Kittelson, M D ^a  

^a NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARNITINE; TAURINE;

AMINO ACID METABOLISM; CALCIUM BALANCE; DIET THERAPY; DOG DISEASE; HEART DISEASE; HEART MUSCLE METABOLISM; NONHUMAN; ORAL DRUG ADMINISTRATION; OSMOREGULATION; REVIEW;

CANIS FAMILIARIS;

EID: 0031728038     PISSN: 01955616     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0195-5616(98)50134-9     Document Type: Review

References (44)

1. M.A. Arsenian Carnitine and its derivatives in cardiovascular disease Prog Cardiovasc Dis 40 1997 265 286
2. J. Azuma A. Sawamura N. Awata Therapeutic effect of taurine in congestive heart failure: A double-blind crossover trial Clin Cardiol 8 1985 276 282
3. J. Bremer Carnitine-metabolism and functions Physiol Rev 63 1983 1420 1480
4. T.L. Broderic G. Panagakis D. DiDomenico l -Carnitine improvement of cardiac function is associated with a stimulation in glucose but not fatty acid metabolism in carnitine-deficient hearts Cardiovasc Res 30 1995 815 820
5. N.D. Costa R.H. Labuc Case report: Efficiacy of oral carnitine therapy for dilated cardiomyopathy in boxer dogs J Nutr 124 supp 1994 2687S 2692S
6. A.G. Engel C. Angelini Carnitine deficiency of human skeletal muscle associated with lipid storage myopathy: A new syndrome Science 179 1973 899 901
7. P.R. Fox J.A. Sturman Myocardial taurine concentrations in cats with cardiac disease and in healthy cats fed taurine-modified diets Am J Vet Res 53 1992 237 241
8. L.M. Freeman K.E. Michel D.J. Brown Idiopathic dilated cardiomyopathy in Dalmatians: Nine cases (1990–1995) JAVMA 209 1996 1592 1596
9. B. Gavaghan M.D. Kittleson Dilated cardiomyopathy in an American Cocker Spaniel with taurine deficiency Aust Vet J 75 1997 862 868
10. S. Gentile E. Bologna D. Terracina Taurine-induced diuresis and natriuresis in cirrhotic patients with ascites Life Sci 54 1994 1585 1593
11. T. Hamaguchi J. Azuma S. Schaffer Interaction of taurine with methionine: Inhibition of myocardial phospholipid methyltransferase J Cardiovasc Pharmacol 18 1991 224 230
12. G.A.D. Haslewood The biological significance of chemical differences in bile salts Biol Rev 39 1964 537 574
13. K.C. Hayes R.E. Carey S.Y. Schmidt Retinal degeneration associated with taurine deficiency in the cat Science 188 1975 949 951
14. R.J. Huxtable From heart to hypothesis: A mechanism for the calcium modulatory actions of taurine Adv Exp Med Biol 217 1987 371 387
15. R.J. Huxtable Physiological actions of taurine Physiol Rev 72 1992 101 163
16. R.J. Huxtable J. Chubb J. Azari Physiological and experimental regulation of taurine content in the heart Fed Pro 39 1980 2685 2690
17. J.G. Jacobsen L.L. Thomas L.H. Smith Jr. Properties and distribution of mammalian l- cysteine sulfinate carboxylases Biochem Biophys Acta 85 1964 103 116
18. B.W. Keene H.C. Mier K.M. Meurs Dietary l -carnitine deficiency and plasma l- carnitine concentrations in dogs [abstract] J Vet Intern Med 5 1991 134
19. B.W. Keene D.P. Panciera C.E. Atkins Myocardial l -carnitine deficiency in a family of dogs with dilated cardiomyopathy JAVMA 198 1991 647
20. W. Keene M.D. Kittleson J.E. Rush Myocardial carnitine deficiency associated with dilated cardiomyopathy in doberman pinschers [abstract] J Vet Intern Med 3 1989 126
21. S.W. Kim Q.R. Rogers J.G. Morris Dietary antibiotics decrease taurine loss in cats fed a canned heat-processed diet J Nutr 126 1996 509 515
22. G.A. Kramer M.D. Kittleson P.R. Fox Plasma taurine concentration in normal dogs and dogs with heart disease J Vet Intern Med 9 1995 253 258
23. M.D. Kittelson B. Keene P.D. Pion Results of the Multicenter Spaniel Trial (MUST): Taurine-, and Carnitine-responsive dilated cardiomyopathy in American Cocker Spaniels with decreased plasma taurine concentration J Vet Intern Med 11 1997 204 211
24. N. Lake Loss of cardiac myofibrils: Mechanism of contractile deficits induced by taurine deficiency Am J Physiol 264 4 Part 2 1993 H1323 H1326
25. B.E. Leibovitz Carnitine 1987 Advanced Research Press 1 13
26. P.A. Mayes Oxidation of fatty acids: Ketogenesis R.K. Murray D.K. Granner P.A. Mayes Harper’s Biochemistry 24 1996 Appleton & Lange East Norwalk, CT 224 235
27. J.R. Neely H.A. Morgan Relationship between carbohydrate metabolism and energy balance of heart muscle Annu Rev Physiol 36 1974 413 459
28. D.J. Paulson Carnitine deficiency-induced cardiomyopathy Mol Cell Biochem 180 1998 33 41
29. P.D. Pion M.D. Kittleson W.P. Thomas Clinical findings in cats with dilated cardiomyopathy and relationship of findings to taurine deficiency JAVMA 201 1992 267 274
30. P.D. Pion M.D. Kittleson W.P. Thomas Dilated cardiomyopathy in the cat: Response to taurine supplementation JAVMA 201 1992 275 284
31. P.D. Pion M.D. Kittleson M.L. Skiles Dilated cardiomyopathy associated with taurine deficiency in the domestic cat: Relationship to diet and myocardial taurine content Adv Exp Med Biol 315 1992 63 73
32. P.D. Pion M.D. Kittleson M.L. Skiles Dilated cardiomyopathy associated with taurine deficiency in the domestic cat: Relationship to diet and myocardial taurine content Adv Exp Med Biol 315 1992 63 73
33. P.D. Pion J. Lewis K. Greene Effect of meal-feeding and food deprivation on plasma and whole blood taurine concentrations in cats J Nutr 121 Suppl 11 1991 S177 S178
34. P.D. Pion M.D. Kittleson Q.R. Rogers Myocardial failure in cats associated with low plasma taurine: A reversible cardiomyopathy Science 237 1987 764 768
35. C.J. Rebouche D.J. Paulson Carnitine metabolism and functions in humans Annu Rev Nutr 6 1986 41 66
36. S. Sanderson C. Osborne P. Ogburn Canine cystinuria associated with carnitinu-ria and carnitine deficiency [abstract] J Vet Intern Med 9 1995 212
37. S. Sanderson K.L. Gross C.A. Osborne Dogs fed a high fat diet have reduced plasma taurine concentrations [abstract] FASEB J 10 1996 506
38. S. Sanderson C. Osborne K. Gross Reliability of canine plasma and whole blood taurine concentrations as indicators of cardiac and skeletal muscle taurine concentrations [abstract] J Vet Intern Med 12 1998 224
39. S.W. Schaffer M. Seyed-Mozaffari J. Kramer Effect of taurine depletion and treatment on cardiac contractility and metabolism Prog Clin Biol Res 179 1985 167 175
40. G. Schuller-Levis P.D. Mehta R. Rudelli Immunologic consequences of taurine deficiency in cats J Leukoc Biol 47 1990 321 331
41. 2 + sensitivity of chemically skinned rat heart J Physiol 422 1990 499511
42. J.A. Sturman A.D. Gargano J.M. Messing Feline maternal taurine deficiency: Effect on mother and offspring J Nutr 116 1986 655 667
43. K. Takihara J. Azuma N. Awata Beneficial effect of taurine in rabbits with chronic congestive heart failure Am Heart J 112 1986 1278 1284
44. M.E. Tripp M.L. Katcher H.A. Peters Systemic carnitine deficiency presenting as familial endocardial fibroelastosis: A treatable cardiomyopathy N Engl J Med 305 1981 385