Can high maternal melatonin concentrations be responsible for inducing fetal pathologies, and can melatonin participate in immunohormonal homeostasis by determining prohormone convertase activity? - Hypothesis and facts

Medical Hypotheses

Volumn 51, Issue 4, 1998, Pages 269-280

  Ciesla, W ^a  

^a MEDICAL UNIVERSITY OF LODZ   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERMEDIN; BETA ENDORPHIN; CORTICOTROPIN; CORTICOTROPIN[1-39]; CYCLIC AMP; CYCLIC GMP; DIMER; ESTRADIOL; FURIN; HYDROCORTISONE; MELANIN; MELATONIN; MONOMER; PROOPIOMELANOCORTIN; PROTEIN KINASE C; PROTEIN TYROSINE KINASE; TESTOSTERONE; VIMENTIN;

CHROMOSOME ABERRATION; CIRCADIAN RHYTHM; ENZYME ACTIVITY; ENZYME SYNTHESIS; FETUS DISEASE; HOMEOSTASIS; HORMONE BLOOD LEVEL; HUMAN; IMMUNE SYSTEM; NONHUMAN; PLACENTA; PRIORITY JOURNAL; REVIEW;

EID: 0031727909     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-9877(98)90046-9     Document Type: Article

References (100)

1. Drobnik J. Effect of pineal gland on levels of some connective tissue elements in the rats. Eur Pin Soc News 1993; 30: 19-20.
2. Estin Ch, Vernadakis A. Primary glial cells and brain fibroblasts interaction in culture. Brain Res Bull 1986; 16: 723-731.
3. Miles A, Philbrick D. Melatonin - perspectives in laboratory medicine and clinical research. Crit Rev Clin Lab Sci 1987; 25: 231-233.
4. Sewerynek E, Lewiński A. Melatonin inhibits mitotic activity of adrenocortical cells in vivo and in organ culture. J Pineal Res 1989; 7: 1-12.
5. Silman R E, Street C, Holland D, Chard T, Falconer J, Robinson J S. The pars intermedia and the fetal pituitary-adrenal axis. Ciba Found Symp 1981; 81: 180-195.
6. Sato S M, Mains R E. The synthesis and processing of pro-ACTH/endorphin in the developing rat pituitary. Ann NY Acad Sci 1987; 512: 286-299.
7. Silman R E, Chard T, Lowry P J, Smith I, Young I M. Human foetal pituitary peptides and parturition. Nature 1976; 260: 716-718.
8. Bertagna X. Proopimelanocortin-derived peptides. Endocrinol Metab Clin North Am 1994; 23: 467-485.
9. Vieau D, Seidah N G, Mbikay M, Chretien M, Bertagna X. Expression of the prohormone convertase PC2 correlates with the presence of corticotropin-like intermediate lobe peptide in human adrenocorticotropin-secreting tumors. J Clin Endocrinol Metab 1994; 79: 1503-1506.
10. Steinhilber D, Brungs M, Werz O et al. The nuclear receptor for melatonin represses 5-lipooxygenase gene expression in human B lymphocytes. J Biol Chem 1995; 270: 7037-7040.
11. Wiesenberg I, Missbach M, Kahlen J P, Schrader M, Carlberg C. Transcriptional activation of the nuclear receptor RZR alpha by the pineal gland hormone melatonin and identification of CGP 52608 as a synthetic ligand. Nucleic Acids Res 1995; 23: 327-333.
12. Sharma R, Tewari K, Singhal K C, Gupta M. Zinc levels in maternal and cord blood and in amniotic fluid - a possible marker for foetal malformation. Indian J Physiol Pharmacol 1994; 38: 300-302.
13. Nikolov V, Tsachev K, Marinov B. The zinc concentration of the maternal serum and the amniotic fluid in pregnancies with fetal neural defects in the second trimester. Akush Ginekol Sofiia 1993; 32: 8-10.
14. Ovadia H, Nitsan P, Abramsky O. Characterisation of opiate binding sites membranes of rat lymphocytes. J Neuroimmunol 1989; 21: 93-102.
15. Boyd G S, McNamara B, Suckling K E, Tocher D R. Cholesterol metabolism in the adrenal cortex. J Steroid Biochem 1983; 19: 1017-1027.
16. Prieto J, Subira M L, Castillo A. Opioid peptides modulate the organisation of vimentin filaments, phagocytic activity and expression of surface molecules in monocytes. Scand J Immunol 1989; 29: 391-398.
17. MacFarland R T, Zelus B D, Beavo J A. High concentrations of a cGMP-stimulated phosphodiesterase mediate ANP-induced decreases in cAMP and steroidogenesis in adrenal glomerulosa cells. J Biol Chem 1991; 266: 136-142.
18. Lin A M, Schaad N C, Schulz P E, Coon S L, Klein D C. Pineal nitric oxide synthase: characteristics, adrenergic regulation and function. Brain Res 1994; 651: 160-168.
19. Tapp E. The pineal gland in malignancy. In: Reiter R J, ed. Pineal Gland, Vol. III: Extra-reproductive Effects. Boca Raton, FL: CRC Press: 171.
20. Poffenbarger M, Fuller G M. Is melatonin a microtubule inhibitor? Exp Cell Res 1976; 103: 135-141.
21. Diaz-Lopez B, Marin-Fernandez B. Effects of melatonin administration to rats upon different parameters of the offspring. Reproduction 1983; 7: 1-7.
22. Honnebier W J, Jobis A C, Swaab D F. The effect of hypophysial hormones and human chorionic gonadotropin (HCG) on the anencephaly fetal adrenal cortex and a parturition in the human. J Obstet Gynaec Br Commonw 1974; 81: 423-428.
23. Cuckle H S, Wald N J, Densem J W, Canick J, Abell K B. Second trimester amniotic fluid oestriol, dehydroepiandrosterone sulphate, and human chorionic gonadotropin levels in Down's syndrome. Br J Obstet Gynaec 1991; 98: 1160-1162.
24. Seifer D B, Collins R L. Current concepts of β-endorphin physiology in female reproductive dysfunction. Fertil Steril 1990; 54: 757-771.
25. Lewiński A, Szymczykiewicz P, Sewerynek E, Wajs E. Effects of pinealectomy and melatonin administration on certain indices of ovarian hyperplasia and or hypertrophy in rats with both ovaries intact or after unilateral ovariectomy. J Pineal Res 1993; 14: 117-127.
26. Horton T H, Ray S L, Rollag M D, Yellon S M, Stetson M H. Maternal transfer of photoperiodic information in Siberian hamsters: effects of melatonin implants are dependent on photoperiod. Biol Reprod 1992; 47: 291-296.
27. Weaver D R. Keohan J T. Reppert S M. Definition of prenatal sensitive period for maternal-fetal communication of day length. Am J Physiol 1987; 253: E701-704.
28. Glass J D, Dolan P L. Melatonin acts in the brain to mediate seasonal steroid inhibition of luteinizing hormone secretion in the white-footed mouse (Peromyscus leucopus). Proc Soc Exp Biol Med 1988; 188: 375-380.
29. Branchaud C T, Goodyer C G, Hall C S, Ararto J S, Silman R E, Giroud C J. Steroidogenic activity of hACTH and related peptides on the human neocortex and fetal adrenal cortex in organ culture. Steroids 1978; 31: 557-572.
30. McKenna T J, Cunningham S K. The pathogenesis of adrenal and extra adrenal hyperandrogenism. J Steroid Biochem Mol Biol 1993; 45: 117-121.
31. Chowen-Breed J, Fraser H M, Vician L, Damassa D A, Clifton D K, Steiner R A. Testosterone regulation of proopiomelanocortin messenger ribonucleic acid in the arcuate nucleus of the male rat. Endocrinology 1989; 124: 1697-1702.
32. Limone P, Scipioni T, Calvelli P et al. αMelanocyte-stimulating hormone antagonizes the inhibitory effect of corticotropin-releasing hormone on luteinizing hormone secretion during the luteal phase in normal women. J Clin Endocrinol Metab 1994; 79: 571-575.
33. Redei E, Li L, Halasz I, McGivern R F, Aird F. Fast glucocorticoid feedback inhibition of ACTH secretion in the ovariectomized rat: effect of chronic estrogen and progesterone. Neuroendocrinology 1994; 60: 113-123.
34. Scott Whisnant C, Curto K, Goodman R L. Immunocytochemical localisation of beta endorphin and gonadal steroid regulation of proopiomelanocortin messenger ribonucleic acid in the ewe. Neuroendocrinology 1992; 56: 812-821.
35. Pepe G J, Davies W A, Albrecht E D. Activation of the baboon fetal pituitary-adrenocortical axis at midgestation by estrogen: enhancement of fetal pituitary proopiomelanocortin messenger ribonucleic acid expression. Endocrinology 1994; 135: 2581-2587.
36. Lu F, Yang K, Challis J R. Regulation of ovine fetal pituitary function by corticotrophin-releasing hormone, arginine vasopressin and cortisol in vitro. J Endocrinol 1994; 143: 199-208.
37. O'Connell Y, McKenna T J, Cunningham S K. Effects of proopiomelanocortin-derived peptides on adrenal steroidogenesis in guinea-pig adrenal cells in vitro. J Steroid Biochem Mol Biol 1993; 44: 77-83.
38. Harbour D V, Galin F S, Hughes T K, Smith E M, Blalock J E. Role of leucocyte-derived pro-opiomelanocortin peptides in endotoxic shock. Circ Shock 1991; 35: 181-191.
39. Heijnen C J, Zijlstra J, Kavelaars A, Croiset G, Ballieux R E. Modulation of the immune response by POMC-derived peptides. I. Influence on proliferation of human lymphocytes. Brain Behav Immun 1987; 1: 284-289.
40. Savino W, Gagnerault M C, Bach J F, Dardenne M. Neuroendocrine control of thymic hormonal production. II. Stimulatory effects of endogenous opioids on thymulin production by cultured human and murine thymic epithelial cells. Life Sci 1990; 46: 1687-1697.
41. Folch H, Ojeda F, Esquivel P. Rise in thymocyte number and thymulin serum level induced by noise. Immunol Lett 1991; 30: 301-305.
42. Papiernik M. The thymus micro-environment and T lymphocytes differentiation. Reprod Nutr Rev 1984; 24: 179-187.
43. Bach J F, Dardenne M. Thymulin, a zinc-dependent hormone. Med Oncol Tumor Pharmacother 1989; 6: 25-29.
44. Mandler R N, Biddson W E, Mandler R, Serrate S A. βEndorphin augments the cytolytic activity and interferon production on natural killer cells. J Immunol 1986; 136: 934-939.
45. Morgan E L, McClurg M R, Janda J A. Suppression of human β-lymphocyte activation by β-endorphin. J Neuroimmunol 1990; 28: 209-217.
46. Prepin J. Fetal thymus and thymuline stimulate the in vitro proliferation of oogonia in the fetal rat ovary. C R Acad Sci III 1991; 313: 407-411.
47. Torbek V E. Cell composition and ultrastructure of the thymus in offspring during changes in the hormonal background in the mother-fetus functional system. Arkh Anat Gistol Embriol 1988; 95: 80-84.
48. Lotz M, Vaughan J H, Carson D A. Effect of neuropeptides on production of inflammatory cytokines by human monocytes. Science 1988; 241: 1218-1220.
49. Alvarez Mon M, Kehrl J M, Fauci A S. A potential role for adrenocorticotropin in regulating human B lymphocyte functions. J Immunol 1985; 135: 3823-3826.
50. De Angelo L, Michael S D. The effect of antisera to thymosin alpha 1 on the course of autoimmune ovarian dysgenesis in neonatally thymectomized mice. J Reprod Immunol 1987; 11: 41-53.
51. Ohtaki S. Quantitative interactions in weight of lymphoid organs and steroid hormonal organs in hamster under serial experimental conditions. Br J Exp Pathol 1988; 69: 1-16.
52. Bednarek J, Furmaniak J. Wedlack N et al. Steroid 21-hydroxylase is a major autoantigen involved in adult onset autoimmune Addison's disease. FEBS Lett 1992; 309: 51-55.
53. Uibo R, Perheentupa J, Ovod V, Krohn K J E. Characterisation of adrenal autoantigens recognized by sera from patients with autoimmune polyglandular syndrome (APS) type I. J Autoimmun 1994; 7: 399-411.
54. Reul J M, Stec I, Wiegers G J et al. Prenatal immune challenge alters the hypothalamic-pituitary-adrenocortical axis in adult rats. J Clin Invest 1994; 93: 2600-2607.
55. Kravchenco I V, Furalew V A. Secretion of immunoreactive corticotropin releasing factor and adrenocorticotropic hormone by T- and B-lymphocytes in response to cellular stress factors. Biochem Biophys Res Commun 1994; 204: 828-834.
56. Molsted-Pedersen L, Pedersen J F. Congenital malformations in diabetic pregnancies: clinical viewpoints. Acta Paediatr Scand Suppl 1985; 320: 79-84.
57. Drogovoz S M, Ryzhenko I M. The tocolytic activity of melatonin. Eksp Klin Farmakol 1993; 56: 23-25.
58. Blumenfeld Z, Jaffe R B. Hypophysiotropic and neuromodulatory regulation of adrenocorticotropin in the human fetal pituitary gland. J Clin Invest 1986; 78: 288-294.
59. Lebrethon M C, Jaillard C, Naville D, Begeot M, Saez J M. Regulation of corticotropin and steroidogenic enzyme mRNAs in human fetal adrenal cells by corticotropin, angiotensin-II and transforming growth factor beta 1. Mol Cell Endocrinol 1994; 106: 137-143.
60. Bartanusz V, Jezova D. Angiotensin II induces reduced oxytocin but normal corticotropin release in rats with lesions of the subfornical organ. Fundam Clin Pharmacol 1994; 8: 539-545.
61. Suda T, Tozawa F, Ushiyama T et al. Effects of protein kinase-C-related adrenocorticotropin secretagogues and interleukin-1 on proopiomelanocortin gene expression in rat anterior pituitary cells. Endocrinology 1989; 124: 1444-1449.
62. Vara F, Schneider J A, Rozengurt-E. Ionic responses rapidly elicited by activation of protein kinase C in quiescent Swiss 3T3 cells. Proc Natl Acad Sci USA 1985; 82: 2384-2388.
63. Kapas S, Purbrick A, Hinson J P. Role of tyrosine kinase and protein kinase C in the steroidogenic actions of angiotensin II, alpha-melanocyte-stimulating hormone and corticotropin in the rat adrenal cortex. Biochem J 1995; 305: 433-438.
64. Kapas S, Purbrick A, Barker S, Vinson-G P, Hinson J P. Alpha melanocyte stimulating hormone induced inhibition of angiotensin II receptor-mediated events in the rat adrenal zona glomerulosa. J Mol Endocrinol 1994; 13: 95-104.
65. Barrett P Q, Isales C M. The role of cyclic nucleotides in atrial natriuretic peptide-mediated inhibition of aldosterone secretion. Endocrinology 1988; 122: 799-808.
66. Olcese I, Muller D, Munker M, Schmidt C. Natriuretic peptides elevate cyclic 3′,5′-guanosine monophosphate levels in cultured rat pinealocytes: evidence for guanylate cyclase-linked membrane receptors. Mol Cell Endo 1994; 103: 95-100.
67. Koch B, Lutz-Bucher B. Indirect relationship between vasopressin-induced secretion of ACTH and cyclic nucleotides in cultured anterior pituitary cells [published erratum appears in Eur J Pharmacol 1990;182: 616]. Eur J Pharmacol 1989; 159: 53-60.
68. Tan T T, Yang Z, Huang W, Lim A T. ANF(1-28) is a potent suppressor of pro-opiomelanocortin (POMC) mRNA but a weak inhibitor of beta EP-LI release from AtT-20 cells. J Endocrinol 1994; 143: R1-R4.
69. Lopez-Gonzales M A, Calvo J R, Osuna C, Guerrero J M. Interaction of melatonin: evidence for binding sites coupled to potentiation of cyclic AMP stimulated by vasoactive intestinal peptide and activation of cyclic GMP. J Pineal Res 1992; 12: 97-104.
70. Magistretti P J, Schorderet M. VIP and noradrenaline act synergistically to increase cyclic AMP in cerebral cortex. Nature 1984; 308: 280-282.
71. Spessert R. Vasoactive intestinal peptide stimulation of cyclic guanosine monophosphate formation: father evidence for a role of nitric oxide synthase and cytosolic guanylate cyclase in rat pinealocytes. Endocrinology 1993; 132: 2513-2517.
72. Williams J A. Mechanism of hormone secretion and action. In: Greenspan F S, ed. Basic and Clinical Endocrinology. San Francisco, CA: Appleton & Lange, 1991: 1-20.
73. Ji I, Zeng H, Ji T H. Receptor activation of and signal generation by the lutropin/choriongonadotropin receptor: cooperation of Asp397 of the receptor and alpha lys91 of the hormone. J Biol Chem 1993; 268: 22971-22974.
74. Hidaka A, Minegishi T, Kohn L D. Thyrotropin like luteinizing hormone (LH) and chorionic gonadotropin (CG) increases cAMP and inositol phosphate levels in cells with recombinant human LH/CG receptor. Biochem Biophys Res Commun 1993; 196: 187-195.
75. 2+, and phorbol esters on ouabaine-induced depression of acetylcholine response in Helix neurons. Cell Mol Neurobiol 1992; 12: 153-161.
76. Judd A M, Login I S, Kovacs K et al. Characterisation of the MMQ cell, a prolactin-secreting clonal cell line that is responsive to dopamine. Endocrinology 1988; 123: 2341-2350.
77. Raue F, Zink A, Scherubi H. Regulation of calcitonin secretion in vitro. Horm Metab Res 1993; 25: 473-476.
78. Logsdon C D. Stimulation of pancreatic ocinar cell growth by CCK epidermal growth factor and insulin in vitro. Am J Physiol 1986; 251: G487-G494.
79. Esteve J P, Voysse N, Susini C et al. Bimodal regulation of pancreatic function in vitro by sandostatin 28. Am J Physiol 1983; 245: G208-G216.
80. Sugden L A, Sugden D, Klein D C. α1-adrenoceptor activation elevates cytosolic calcium in rat pinealocytes by increasing net influx. J Biol Chem 1987; 262: 741-745.
81. Lin A M, Schaad N C, Schulz P E, Coon S L, Klein D C. Pineal nitric oxide synthase: characteristics, adrenergic regulation and function. Brain Res 1994; 651: 160-168.
82. Maronde E, Middendorff R, Mayer B, Olcese J. The effect of NO-donors in bovine and rat pineal cells: stimulation of cGMP and cGMP-independent inhibition of melatonin synthesis. J Neuroendocrinol 1995; 7: 207-214.
83. Spessert R, Gupta B B P, Seidel A, Maitra S K, Vollarth L. Involvement of cyclic guanosine monophosphate (cGMP) and cytosolic guanylate cyclase in the regulation of synaptic ribbon numbers in rat pineal gland. Brain Res 1992; 570: 95-100.
84. White B H, Klein D C. Developmental appearance of pineal adrenergic guanosine 3′5′-monophosphate response is determined by a process downstream from elevation of intracellular calcium: possible involvement of a diffusable factor. Endocrinology 1993; 132: 1026-1034.
85. Spessert R. Vasoactive intestinal peptide stimulation of cyclic guanosine monophosphate formation: further evidence for a role of nitric oxide synthase and cytosolic guanylate cyclase in rat pinealocytes. Endocrinology 1993; 132: 2513-2517.
86. Vanecek J, Sugden D, Weller J, Klein D C. Atypical synergistic α1 and B-adrenergic regulation of adenosine 3′,5′-monophosphate and guanosine 3′,5′-monophosphate in rat pinealocytes. Endocrinology 116: 2167-2173.
87. Logan A, Weatherhead B. Post-tyrosinase inhibition of melanogenesis by melatonin in hair follicles in vitro. J Invest Dermatol 1980; 74: 47-50.
88. Jimbow K, Alena F, Dixon W, Hara H. Regulatory factors of pheo- and eumelanogenesis in melanogenic compartments. Pigment Cell Res 1992; Suppl. 2: 36-42.
89. Hegedus Z L, Altschule M D. Studies on aminochromes. 3. Transformation of epinephrine, adrenochrome and adrenolutin into plasma-soluble melanins during incubation in human blood plasma. Arch Biochem Biophys 1968; 126: 388-392.
90. Costa C, Bertazzo A, Allegri G, Toffano G, Curcuruto O, Traldi P. Melanin biosynthesis from dopamine. II. A mass spectrometric and collisional spectroscopic investigation. Pigment Cell Res 1992; 5: 122-131.
91. Napolitano A, Corradini M G, Prota G. A reinvestigation of the structure of melanochrome. Tetrahedron Lett 1985; 26: 2805-2808.
92. Aroca P, Solano F, Salinas C, Garcia-Borron J C, Lozano J A. Regulation of distal mammalian melanogenesis: the role of dopachrome tautomerase and ratio between 5,6-dihydroxyindole-2-carboxylic acid and 5,5-dihydroxyindole. Biochim Biophys Acta 1992; 208: 155-163.
93. Sealy R C, Felix C C, Hyde J S, Swartz H M. Structure and rectivity of melanins: influence of free radicals and metal ions. In: Pryor W A, ed. Free Radicals in Biology. New York: Academic Press, Vol. IV, 1980: 209-259.
94. Menon I A, Haberman H F. Mechanisms of action of melanins. Br J Dermatol 1977; 97: 109-112.
95. Hegedus Z L, Kuttab S H, Altschule M D. Studies on rheomelanins. VI. The apparent lipofuscin characteristics of rheomelanins. Arch Int Physiol Biochim 1980; 88: 265-271.
96. Hegedus Z L. Studies on rheomelanins. IV. The apparent occurrence in vivo of rheomelanins in human blood. Arch Int Physiol Biochim 1977; 85: 539-555.
97. Forrest F M. Evolutionary role of neuromelanin. Psychopharmacol Bull 1974; 10: 43-47.
98. Forrest F M. Evolutionary origin of extrapyramidal disorders in drug related mental patients, its significance, and the role of neuromelanins. Adv Biochem Psychopharmacol 1974; 9: 255-268.
99. Milunsky A. Prenatal Diagnosis of Neural Tube Defects. In: Genetic Disorders on the Fetus. New York: Plenum Press, 1979: 379-400.
100. Sandyk R, Anastasiadis P G, Anninos P A, Tsagas N. The pineal gland and spontaneous abortions: implications for therapy with melatonin and magnetic field. Int J Neurosci 1992; 62: 243-250.