The effect of vehicle on corneal penetration of triturated ketoconazole and itraconazole

Ophthalmic Surgery and Lasers

Volumn 29, Issue 11, 1998, Pages 926-929

  Guzek, James P ^a   Roosenberg, Joann M ^b   Gano, David L ^b   Wessels, Izak F ^b,c,d  

^a Jerry L Pettis Memorial VA Medical Center   (United States)

^b LOMA LINDA UNIVERSITY   (United States)

^c UNIVERSITY OF TENNESSEE COLLEGE OF MEDICINE   (United States)

^d NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG VEHICLE; ITRACONAZOLE; KETOCONAZOLE;

ANIMAL TISSUE; ARTICLE; BIOASSAY; CONCENTRATION (PARAMETERS); CORNEA; CORNEA STROMA; DRUG ABSORPTION; DRUG PENETRATION; DRUG TISSUE LEVEL; NONHUMAN; PRIORITY JOURNAL; RABBIT;

ANIMALS; ANTIFUNGAL AGENTS; CORNEAL STROMA; FOLLOW-UP STUDIES; ITRACONAZOLE; KETOCONAZOLE; OPHTHALMIC SOLUTIONS; RABBITS; VEHICLES;

EID: 0031727337     PISSN: 10823069     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (7)

1. Torres MA, Mohammed J, Cavazos Adams H, Martinez LA. Topical ketoconazole for fugal keratitis. Am J Ophthalmol. 1985;100:293-298.
2. Komadin TG, Wilkes TKI, Shock JP. Treatment of Aspergillus fumigatus keratitis in rabbits with oral and topical ketoconazole. Am J Ophthalmol. 1985;99:476-479.
3. Hemady RK, Chu W, Foster CS. Intraocular penetration of ketoconazole in rabbits. Cornea. 1992;11:329-333.
4. Levine HB, Stevens DA, Cobb IM, et al. Miconazole in coccidioidomycosis: I. Assay of activity in mice and in vitro. J Infect Dis. 1975;132:407-414.
5. Maurice DM, Mishima S. Ocular pharmacokinetics. In: Sears MI, ed. Pharmacology of the Eye: Handbook of Experimental Pharmacology. New York: Springer Verlag; 1984:19.
6. O'Day DM, Head WS, Robinson RD, Clanton JA. Bioavailability and penetration of topical amphotericin B in the anterior segment of the rabbit eye. J Ocul Pharmacol. 1986;2:371-378.
7. National Institutes of Health. Guide to the Care and Use of Laboratory Animals. National Institutes of Health Publication No. 85-23 (revised 1985). Bethesda, MD: National Institutes of Health.