Long-term haematological alterations in female B6C3F1 mice treated with busulphan

Comparative Haematology International

Volumn 8, Issue 3, 1998, Pages 125-136

  Andrews, C M ^a   Williams, T C ^a   Turton, J A ^b  

^a GLAXOSMITHKLINE   (United Kingdom)

^b UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Busulphan; Chloramphenicol succinate; Haematological changes; Mouse

Indexed keywords

BUSULFAN; CHLORAMPHENICOL HEMISUCCINATE; DRINKING WATER;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE MARROW; COMPARATIVE STUDY; CONTROLLED STUDY; ERYTHROPOIESIS; FEMALE; HEMATOLOGICAL PARAMETERS; HUMAN; INTRAPERITONEAL DRUG ADMINISTRATION; LEUKOPENIA; LYMPHOCYTE COUNT; LYMPHOMA; MORTALITY; PANCYTOPENIA; PERIPHERAL LYMPHOCYTE; RAT; SPLEEN CELL;

EID: 0031726977     PISSN: 09387714     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02642503     Document Type: Article

References (45)

1. Andrews CM, Spurling NW, Turton JA (1992) Complete automated evaluation of haematological parameters using the Technicon H*1 haematology system: experimental studies with busulphan in the mouse. Human Exp Toxicol 11:583
2. 1 mice induced by busulphan. Human Exp Toxicol 12:430
3. 1 mice using flow cytometry. Comp Haematol Int 3:102-115
4. Andrews CM, Dash LM, Williams TC, Craig Gray J, Turton JA (1997) Long-term effects of busulphan on lymphocyte subpopulations in female B6C3F1 mice. Comp Haematol Int 7:230-237
5. Appelbaum RF, Fefer A (1981) The pathogenesis of aplastic anemia. Semin Hematol 18:241-257
6. Bhoopalam N, Price K, Norgello H, Barone-Varelas J, Fried W (1986) Busulfan and chloramphenicol induced T cell lymphoma: cell surface characteristics and functional properties. Clin Exp Immunol 64:646-655
7. Boggs DR, Boggs SS (1980) The effect of graded, single doses of busulfan on murine erythrpoiesis. Proc Soc Exp Biol Med 163:181-186
8. Botnik LE, Hannon EC, Hellman S (1979) A long lasting priloiferative defect in the hematopoietic stem cell compartment following cytotoxic drugs. Int J Radiat Oncol Biol Phys 5:1621-1625
9. Boyd RL, Caro J, Halka KG, Erslev AJ (1986) Granulopoiesis in long-term culture by marrow from mice with busulphan-induced chronic latent aplasia. Int J Cell Cloning 4:357-367
10. Down JD, Berman AJ, Warhol M et al. (1989) Late tissue-specific toxicity of total body irradiation and busulfan in a murine bone marrow transplant model. Int J Radiat Oncol Biol Phys 17:109-116
11. Elson LA (1955) A comparison of the effects of radiation and radiomimetic chemicals on the blood. Br J Haematol 1:104-116
12. FAO/WHO Expert Committee on Food Additives: Chloramphenicol (1988) In: Toxicological evaluation of certain veterinary drug residues in food, WHO Food Additive Series 23. World Health Organisation, Geneva, pp 1-71
13. Farris GM, Everitt JI, Irons RD, Popp JA (1993) Carcinogenicity of inhaled benzene in CBA mice. Fund Appl Toxicol 20:503-507
14. Festing MFW (1987) Genetic factors in toxicology: implications for toxicological screening. CRC Crit Rev Toxicol 18:1-26
15. Fitchen JH, Cline MJ (1980) The effect of granulopoietic stress in mice with 'latent' bone marrow failure. Exp Hematol 8:788-794
16. Geary CG (1978) Aplastic anaemia. Baillière Tindall, London
17. Haak HL (1980) Experimental drug-induced aplastic anaemia. Clin Haematol 9:621-639
18. Halka KG. Caro J, Erslev AJ (1987) Long-term marrow cultures from mice with busulphan-induced chronic latent aplasia. J Lab Clin Med 109: 698-705
19. Hall AG, Tilby MJ (1992) Mechanisms of actions of, and modes of resistance to, alkylating agents used in the treatment of haematological malignancies. Blood Rev 6:163-173
20. 1 mouse. Human Exp Toxicol 17:8-17
21. Hunstein W (1965) Ist myleran (busulphan) eine leukämogene substanz? Schweiz Med Wochenschr 95:1437-1439
22. IARC (1990) Monographs on the evaluation of carcinogenic risk of chemicals to humans. Chloramphenicol, vol. 50. IARC, Lyon, pp 169-193
23. Ideriha NM, Vugman I, Falcão RP (1984) Ectopic bone marrow development in experimental busulfan-induced hypoplastic anemia in mice. Blut 48:277-284
24. Irons, RD, Colagiovanni DB, Stillman WS (1996) Murine thymic lymphoma is associated with a species-specific haematopoietic progenitor cell subpopluation. Toxicology 113:59-67
25. Irons RD, Stillman WS (1996) The effects of benzene and other leukaemogenic agents on haematopoietic stem and progenitor cell differentiation. Eur J Haematol 57 (suppl):119-124
26. 2-adrenergic stimulation of erythropoiesis in busulfan treated mice. Exp Hematol 8:742-748
27. Josvasen N, Boyum A (1973) Haematopoiesis in busulphan-treated mice. Scand J Haematol 11:78-86
28. Karnofsky DA (1967) Late effects of immunosuppressive anticancer drugs. Fed Proc 26:925-932
29. McManus PM, Weiss L (1984) Busulfan-induced chronic bone marrow failure: changes in cortical bone, marrow stromal cells, and adherent cell colonies. Blood 64:1036-1041
30. Miller AM, Arimura GK, Gross MA, Yunis AA (1978) In vitro evidence for genetically determined variations in marrow erythroid sensitivity. Exp Hematol 6:455-460
31. Morley A, Blake J (1974a) An animal model of chronic hypoplastic marrow failure. I. Late marrow failure after busulfan. Blood 44:49-56
32. Morley A, Blake J (1974b) Haemopoietic precursor cells in experimental hypoplastic marrow failure. Aust J Exp Biol Med Sci 52:909-914
33. Morley A, Trainor K, Blake J (1975) A primary stem cell lesion in experimental chronic hypoplastic marrow failure. Blood 45:681-688
34. Morley A, Trainor K, Remes J (1976) Residual marrow damage: possible explanation for idiosyncrasy to chloramphenicol. Br J Haematol 32:525-531
35. Morley AA, Trainor KJ, Seshadri RS (1978) Chronic hypoplastic marrow failure and residual injury. Blood Cells 4:253-266
36. Pazdernik TL, Corbett MD (1980) Role of chloramphenicol reduction products in aplastic anaemia. Pharmacology 20:87-94
37. Robin E, Berman M, Bhoopalam N, Cohen H, Fried W (1981) Induction of lymphomas in mice by busulfan and chloramphenicol. Cancer Res 41:3478-3842
38. Udupa KB, Okamura H, Reissmann KR (1972) Granulopoiesis during myleran-induced suppression of transplantable hematopoietic stem cells. Blood 39:317-325
39. Upton AC, Wolff FF, Sniffen EP (1961) Leukemogenic effect of myleran on the mouse thymus. Proc Soc Exp Biol Med 108:464-467
40. Vincent PC (1986) Drug-induced aplastic anaemia and agranulocytosis: incidence and mechanisms. Drugs 31:52-63
41. Wathen LM, DeGowin RL, Gibson P et al. (1982) Residual injury to the hemopoietic microenvironment following sequential radiation and busulfan. Int J Radiat Oncol Biol Phys 8:1315-1322
42. Yallop D, Andrews CM, Holt D et al. (1998) Chloramphenicol is haemotoxic at high dose levels in the mouse but not in the rat. Human Exp Toxicol 17:57
43. Young NS (1996) Immune pathophysiology of acquired aplastic anaemia. Eur J Haematol 57 (suppl):55-59
44. Yunis AA (1978) Mechanisms underlying marrow toxicity from chloramphenicol and thiamphenicol. In: Silver R, Le Bue J, Gordon AS (eds) The year in haematology. Plenum. New York, pp 143-170
45. Yunis AA, Bloomberg GR (1964) Chloramphenicol toxicity: clinical features and pathogenesis. Progress in Haematol 4:138-159