Altered tissue distribution and elimination of amikacin encapsulated in unilamellar, low clearance liposomes (MiKasome®)

Pharmaceutical Research

Volumn 15, Issue 11, 1998, Pages 1775-1781

  Fielding, Robert M ^a   Lewis, Ramilla O ^b   Moon McDermott, Lotus ^b  

^a Biologistic Services Boulder   (United States)

^b GILEAD SCIENCES   (United States)

Author keywords

Amikacin; Ammoglycosides; Elimination excretion; Liposomes; MiKasome; Tissue distribution

Indexed keywords

AMIKACIN; LIPOSOME;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BACTERICIDAL ACTIVITY; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG HALF LIFE; GRAM NEGATIVE INFECTION; NONHUMAN; PRIORITY JOURNAL; RAT; TISSUE DISTRIBUTION;

AMIKACIN; ANIMALS; DRUG CARRIERS; LIPOSOMES; MALE; METABOLIC CLEARANCE RATE; RATS; RATS, SPRAGUE-DAWLEY; TISSUE DISTRIBUTION;

EID: 0031726732     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1011925132473     Document Type: Article

References (20)

1. ®). In M. C. Woodle and G. Storm (eds.), Long-Circulating Liposomes: Old Drugs, New Therapeutics, Springer-Verlag, New York, 1998, Ch. 15.
2. J. A. Karlowsky and G. G. Zhanel. Concepts on the use of liposomal antimicrobial agents: applications for aminoglycosides. Clin. Infect. Dis. 15:654-667 (1992).
3. E. T. Eng. Prophylactic and therapeutic treatment of Gram-negative septicemia with liposomal and non-liposomal encapsulated amikacin in immunocompromized mice. Thesis presented to California State Polytechnic University, Pomona, CA, 1996.
4. C. E. Swenson, K. A. Stewart, J. L. Hammett, et al. Pharmacokinetics and in vivo activity of liposome-encapsulated gentamicin. Antimicrob. Agents Chemother. 34: 235-240 (1990).
5. L. E. Bermudez, A. O. Yau-Young, J.-P. Lin, J. Cogger, and L. S. Young. Treatment of disseminated mycobacterium avium complex infection of beige mice with liposome-encapsulated aminoglycosides. J. Infect. Dis. 161:1262-1268 (1990).
6. W. O. Caster, J. Poncelet, A. B. Simon, and W. D. Armstrong. Tissue weights of the rat. Proc. Soc. Exp. Biol. Med. 91:122-126 (1956).
7. W. J. Jusko. Guidelines for collection and analysis of pharmacokinetic data. In W. E. Evans et al. (eds.), Applied Pharmacokinetics, 3rd edition. Applied Therapeutics, Inc., Vancouver, WA, 1992, Chapter 2.
8. D. P. McIntosh, R. J. Cooke, A. J. McLachlan, P. T. Dudley-Yates, and M. Rowland. Pharmacokinetics and tissue distribution of cisplatin and conjugates of cisplatin with carboxymethyldextran and A5B7 monoclonal antibody in CD1 mice. J. Pharm. Sci. 86:1478-1483 (1997).
9. ®): reduced clearance and volume of distribution in rats. Pharm. Res. 13:S-479 (1996).
10. B. Davies and T. Morris. Physiological parameters in laboratory animals and humans. Pharm. Res. 10:1095-1095 (1993).
11. F. C. Luft and S. A. Kleit. Renal parenchymal accumulation of aminoglycoside antibiotics in rats. J. Infect. Dis. 130:656-659 (1974).
12. I. A. J. M. Bakker-Woudenberg, M. T. ten Kate, L. E. T. Stearne-Cullen, and M. C. Woodle. Efficacy of gentamicin or ceftazidime entrapped in liposomes with prolonged blood circulation and enhanced localization in Klebsiella pneumoniae infected lung tissue. J. Infect Dis. 171:938-947 (1995).
13. F. Liu and D. Liu. Serum independent liposome uptake by mouse liver. Biochim. Biophys. Acta. 1278:5-11 (1996).
14. H. Harashima, Y. Ohnishi, and H. Kiwada. In vivo evaluation of the effect of the size and opsonization on the hepatic extraction of liposomes in rats: an application of the Oldendorf method. Biopharm. Drug Disp. 13:549-553 (1992).
15. S. D. Nightingale, S. L. Saletan, C. E. Swenson et al. Liposome-encapsulated gentamicin treatment of Mycobacterium avium - Mycobacterium intracellulare complex bacteremia in AIDS patients. Antimicrob. Agents Chemother. 37:1869-1872 (1993).
16. K. J. Huang, K.-F. Luk, and P. L. Beaumier. Volume of distribution and transcapillary passage of small unilamellar vesicles. Life Sci. 31:949-955 (1982).
17. A. H. Stirk and J. D. Baldeschwieler. Mechanism of endocytosis of surface-modified liposomes by mouse peritoneal macrophages. In K. Yagi (ed.), Medical Application of Liposomes, Japan Scientific Societies Press, Tokyo, 1990, pp. 31-41.
18. E. A. Forssen, R. Male-Brune, J. P. Adler-Moore, M. J. A. Lee, P. G. Schmidt, T. B. Krasieva, S. Shimizu, and B. J. Tromberg. Fluorescence imaging studies for the disposition of daunorubicin liposomes (DaunoXome) within tumor tissue. Cancer Res. 56:2066-2075 (1996).
19. R. M. Fielding, A. W. Singer, L. H. Wang, S. Babbar, and L. S. S. Guo. Relationship of pharmacokinetics and tissue distribution to reduced toxicity of colloidal amphotericin B in dogs. Antimicrob. Agents Chemother. 36(2):299-307 (1992).
20. M. Y. Huang and J. Schacht. Formation of a cytotoxic metabolite from gentamicin by liver. Biochem. Pharmacol 40:R11-R14 (1990).