Blast maturity and CD34 expression determine the effects of the differentiating agents KH1060 and 9-cis-retinoic acid on the differentiation and clonogenicity of non-M3 acute myeloid leukaemia cells

Leukemia

Volumn 12, Issue 11, 1998, Pages 1741-1748

  Pallis, M ^a,b   Turzanski, J ^a   Russell, N H ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b NOTTINGHAM CITY HOSPITAL   (United Kingdom)

Author keywords

4 Hydroxyphenyl retinamide; 9 Cis retinoic acid; AML; KH1060

Indexed keywords

CD11B ANTIGEN; CD34 ANTIGEN; CYTOTOXIC AGENT; FENRETINIDE; LEXACALCITOL; ONCOPROTEIN; RETINOIC ACID;

ACUTE GRANULOCYTIC LEUKEMIA; APOPTOSIS; ARTICLE; BLAST CELL; CELL DIFFERENTIATION; CELL VIABILITY; CLINICAL ARTICLE; CLONOGENESIS; CONTROLLED STUDY; HUMAN; HUMAN CELL; LEUKEMIA CELL; LYMPHOCYTE CLONE; PRIORITY JOURNAL;

EID: 0031726652     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.leu.2401197     Document Type: Article

References (17)

1. Koeffler HO. Induction of differentiation of human acute myelogenous leukemia cells: therapeutic implications. Blood 1983; 72: 709-721.
2. Sachs L. Control of normal differentiation and the phenotyic reversion of malignancy in myeloid leukemia cells. Nature 1978; 274: 535-538.
3. Collins SJ, Tsau S. Retinoic acid receptors in hematopoiesis. Curr Top Microbiol Immunol 1996; 21: 7-15.
4. Bunce CM, Brown C, Hewison M. Vitamin D and hematopoiesis. Trends Endocrinol Metab 1997; 8: 245-251.
5. Grignani F, Fagioli M, Alcalay M, Letizia L, Pandolfi PP, Donti E, Biondi A, Coco FL, Grignani F, Pelicci PC. Acute promyelocytic leukaemia: from genetics to treatment. Blood 1994; 83: 10-25.
6. Grillier I, Umiel T, Elstner E, Collins S, Koeffler H. Alterations of differentiation, clonal proliferation, cell cycle progression and bcl-2 expression in RARa-altered sublines of HL-60. Leukemia 1997; 11: 393-400.
7. Lishner M, Curtis JE, Minkin S, McCulloch EA. Interaction between retinoic acid and cytosine arabinoside affecting the blast cells of acute myeloblastic leukemia. Leukemia 1989; 3: 784-788.
8. Yang GS, Minden MD, McCulloch EA. Regulation by retinoic acid and hydrocortisone of the anthracycline sensitivity of blast cells of acute myeloblastic leukemia. Leukemia 1994; 8: 2065-2075.
9. Elstner E, Linker-Israeli M, Umiel T, Le J, Grillier I, Said JW, Shintaku P, Krajewski J, Reed JC, Binderup L, Koeffler HP. Combination of a potent 20-epi-vitamin D3 analogue (KH1060) with 9-cis-retinoic acid irreversably inhibits clonal growth, decreases bcl-2 expression and induces apoptosis in HL-60 leukemic cells. Cancer Res 1996; 56: 3570-3576.
10. James S, Williams M, Kelsey S, Newland A, Colston K. Interaction of vitamin D derivatives and granulocyte-macrophage colony-stimulating factor in leukaemic cell differentiation. Leukemia 1997; 11: 1017-1025.
11. Elstner E, Linker-Israeli M, Le J, Umiel T, Michl P, Said JW, Binderup L, Reed JC, Koeffler HP. Synergistic decrease of clonal proliferation, induction of differentiation and apoptosis of acute promyelocytic leukemia cells after combined treatment with novel 20-epi vitamin D3 analogs and 9-cis retinoic acid. J Clin Invest 1997; 99: 349-360.
12. Kizaki M, Ikeda Y, Tanosaki R, Nakajima H, Morikawa M, Sakashita A, Koeffler HP. Effects of novel retinoic acid compound, 9-cis-retinoic acid, on proliferation, differentiation, and expression of retinoic acid receptor-a and retinoid-X receptor-a RNA by HL60 cells. Blood 1993; 82: 3592-3599.
13. Sakashita A, Kizaki M, Pakkala S, Schiller C, Tsuruoka N, Tomosaki R, Cameron JF, Dawson MI, Koeffler P. 9-cis-retinoic acid: effects on normal and leukemic hematopoiesis in vitro. Blood 1993; 81: 1009-1016.
14. Delia D, Aiello A, Lombardi L, Pelicci P, Grignani F, Grignani F, Formelli F, Menard S, Costa A, Veronesi U, Pierotti M. N-(4-hydroxyphenyl)retinamide induces apoptosis of malignant haematopoietic cell lines including those unresponsive to retinoic acid. Cancer Res 1993; 53: 6036-6041.
15. Dipetrantonio A, Hsieh T-C, Wu JM. Differential effects of retinoic acid (RA) and N-(4-hydroxyphenyI) retinamide (4-HPR) on cell growth, induction of differentiation, and changes in p34(cdc2), bcl-2, and actin expression in the human promyelocytic HL-60 leukemic cells. Biochem Biophys Res Comm 1996; 224: 837-842.
16. Campos L, Sabido O, Rouault J-P, Guyotat D. Effects of BCL-2 antisense oligodeoxynucleotides on in vitro proliferation and survival of normal marrow progenitors and leukemic cells. Blood 1994; 84: 595-600.
17. Hu Z-B, Minden MD, McCulloch EA. Direct evidence for the participation of bcl-2 in the regulation by retinoic acid of the Ara-C sensitivity of leukemic stem cells. Leukemia 1995; 9: 1667-1673.