Inhibition of tumor angiogenesis by roxithromycin, a 14-membered ring macrolide antibiotic

Cancer Letters

Volumn 131, Issue 2, 1998, Pages 137-143

  Yatsunami, Jun ^a,b   Tsuruta, Nobuko ^a   Hara, Nobuyuki ^a   Hayashi, Shin Ichiro ^b  

^a KYUSHU UNIVERSITY   (Japan)

^b SAGA UNIVERSITY   (Japan)

Author keywords

Angiogenesis; Endothelial cell; Macrolides; Roxithromycin

Indexed keywords

FUMAGILLOL CHLOROACETYLCARBAMATE; INTERLEUKIN 8; JOSAMYCIN; MACROLIDE; ROXITHROMYCIN; VASCULOTROPIN;

AIR SAC; ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CELL GROWTH; CONTROLLED STUDY; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; INTRAPERITONEAL DRUG ADMINISTRATION; LUNG CANCER; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTI-BACTERIAL AGENTS; CARCINOMA, SQUAMOUS CELL; CELL CULTURE TECHNIQUES; CELL DIVISION; CELL MOVEMENT; COLLAGEN; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG COMBINATIONS; ENDOTHELIAL GROWTH FACTORS; ENDOTHELIUM, VASCULAR; HUMANS; INTERLEUKIN-8; LAMININ; LUNG NEOPLASMS; LYMPHOKINES; MALE; MICE; MICE, INBRED ICR; NEOVASCULARIZATION, PATHOLOGIC; PROTEOGLYCANS; ROXITHROMYCIN; TUMOR CELLS, CULTURED; UMBILICAL VEINS; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 0031726243     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(98)00110-4     Document Type: Article

References (23)

1. J. Folkman, Tumor angiogenesis, in: J. Mendelsohn, P.M. Howley, M.A. Israel, L.A. Liotta (Eds.), The Molecular Basis of Cancer, W.B. Saunders, Philadelphia, PA, 1995, pp. 206-232.
2. Folkman J. Clinical applications of research on angiogenesis. N. Engl. J. Med. 333:1995;1757-1763.
3. Folkman J. Angiogenesis in cancer, vascular, rheumatoido and other disease. Nat. Med. 1:1995;27-31.
4. O'Reilly M.S., Holmgren L., Shing Y., Chen C.C., Rosenthal R.A., Moses M., Lane W.S., Cao Y., Sage E.H., Folkman J. Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma. Cell. 79:1994;315-328.
5. O'Reilly M.S., Boehm T., Shing Y., Fukai N., Vasios G., Lane W.S., Flynn E., Birkhead J.R., Olsen B.R., Folkman J. Endostatin: an endogenous inhibitor of angiogenesis and tumor growth. Cell. 88:1997;277-285.
6. Umeki S. Anti-inflammatory action of erythromycin. Chest. 104:1993;1191-1193.
7. Kadota J., Saito O., Kohno S., Hara K. A mechanism of erythromycin treatment in patients with diffuse panbronchiolitis. Am. Rev. Respir. Dis. 147:1993;153-159.
8. Oishi K., Sonoda F., Kobayashi S., Iwagaki A., Nagatake T., Matsushima K., Matsumoto K. Role of interleukin-8 (IL-8) and an inhibitory effect of erythromycin on IL-8 release in the airways of patients with chronic airway diseases. Infect. Immun. 62:1994;4145-4152.
9. Takizawa H., Desaki M., Ohtoshi T., Kikutani T., Okazaki H., Sato M., Akiyama N., Shoji S., Hiramatsu K., Ito K. Erythromycin suppresses interleukin-6 expression by human epithelial cells: a potential mechanism of its anti-inflammatory action. Biochem. Biophys. Res. Commun. 210:1995;781-786.
10. Smith D.R., Polverini P.J., Kunkel S.L., Orringer M.B., Whyte R.I., Burdick M.D., Wilke C.A., Strieter R.M. Inhibition of interleukin-8 attenuates angiogenesis in bronchogenic carcinoma. J. Exp. Med. 179:1994;1409-1415.
11. Yatsunami J., Tsuruta N., Ogata K., Wakamatsu K., Takayama K., Kawasaki M., Nakanishi Y., Hara N., Hayashi S. Interleukin-8 participates in non-small cell, but not small cell carcinoma of the lung. Cancer Lett. 120:1997;101-108.
12. Abe T., Okamura K., Ono M., Kohno K., Mori T., Hori S., Kuwano M. Induction of vascular endothelial tubular morphogenesis by human glioma cells. J. Clin. Invest. 92:1993;54-61.
13. Angiolillo A.L., Sgadari C.S., Taub D.D., Liao S., Farber J.M., Maheshuwari S., Kleinman H.K., Reaman G.H., Tosato G. Human interferon-inducible protein 10 is a potent inhibitor of angiogenesis in vivo. J. Exp. Med. 182:1995;155-162.
14. Grant G., Tashiro K., Segui-Real B., Yamada Y., Martin G., Kleinman H. Two different laminin domains mediate differentiation of human endothelial cells into capillary-like structures in vitro. Cell. 58:1989;933-943.
15. Ingber D., Fujita T., Kishimoto S., Sudo K., Kanamaru T., Brem H., Folkman J. Synthetic analogs of fumagillin that inhibit angiogenesis and suppress tumour growth. Nature. 348:1990;555-557.
16. Plate K.H., Breier G., Weich H.A., Risau W. Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo. Nature. 359:1992;845-848.
17. P.J. Polverini, Macrophage-induced angiogenesis: a review, in: C. Sorg (Ed.), Macrophage-Derived Cell Regulatory Factors, Karger, Basel, 1989, pp. 54-73.
18. Koch A.E., Polverini P.J., Kunkel S.L., Harlow L.A., DiPietro L.A., Elner V.M., Strieter R.M. Interleukin-8 as a macrophage derived mediator of angiogenesis. Science. 258:1992;1798-1801.
19. Wright P.S., Cross-Doersen D., Miller J.A., Jones W.D., Bitonti A.J. Inhibition of angiogenesis in vitro and in ovo with an inhibitor of cellular protein kinases, MDL 27032. J. Cell. Physiol. 152:1992;448-457.
20. Tamargo R.J., Bok R.A., Brem H. Angiogenesis inhibition by minocycline. Cancer Res. 51:1991;672-675.
21. Konno S., Adachi M., Asano K., Kawazoe T., Okamoto K., Takahashi T. Influence of roxithromycin on cell-mediated immune responses. Life Sci. 51:1992;107-112.
22. Hamada K., Kita E., Sawaki M., Mikasa K., Narita N. Antitumor effect of erythromycin in mice. Chemotherapy. 41:1995;59-69.
23. Mikasa K., Sawaki M., Kita E., Hamada K., Teramoto S., Sakamoto M., Maeda K., Konishi M., Narita N. Significant survival benefit to patients with advanced non-small lung cancer from treatment with clarithromycin. Chemotherapy. 43:1997;288-296.