Lamina propria T cells

Chemical Immunology

Volumn 71, Issue , 1998, Pages 103-117

  MacDonald, Thomas T ^a   Pender, Sylvia L F ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; MATRIX METALLOPROTEINASE; T LYMPHOCYTE RECEPTOR;

CYTOTOXICITY; ENTERITIS; HUMAN; INTESTINE MUCOSA; LAMINA PROPRIA; NONHUMAN; NUTRITIONAL INTOLERANCE; PHENOTYPE; PRIORITY JOURNAL; REVIEW; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

EID: 0031725995     PISSN: 10150145     EISSN: None     Source Type: Journal    
DOI: 10.1159/000058721     Document Type: Review

References (68)

1. Spencer J, MacDonald TT, Isaacson PG: Heterogeneity of non-lymphoid cells expressing HLA-D region antigens in human fetal gut. Clin Exp Immunol 1987;67:415-424.
2. Spencer JM, Dillon SB, Isaacson PG, MacDonald TT: T cell subclasses in human fetal ileum. Clin Exp Immunol 1986;65:553-558.
3. Janossy G, Tidman N, Selby WS, Thomas JA, Granger S, Kung PC, Goldstein G: Human T lymphocytes of inducer and suppressor type occupy different microenvironments. Nature 1980;288:81-84.
4. Brandtzaeg P, Bosnes V, Halstensen TS, Scott H, Sollid LM, Valnes KN: T lymphocytes in human gut epithelium preferentially express the alpha/beta antigen receptor and are often CD45/UCHL1-positive. Scand J Immunol 1989;30:123-128.
5. Spencer J, Diss TC, Isaacson PG, MacDonald TT: Expression of disulphide-linked and non-disulphide linked forms of the gamma/delta T cell receptor in human small intestinal epithelium. Eur J Immunol 1989;19:1335-1338.
6. Farstad IN, Halstensen TS, Lien B, Kilshaw PJ, Lazarovitz AI, Brandtzaeg P: Distribution of β7 integrins in human intestinal mucosa and organised gut-associated lymphoid tissue. Immunology 1996;89:227-237.
7. Berg M, Murakawa Y, Camerini D, James SP: Lamina propria lymphocytes are derived from circulating cells that lack the Leu-8 lymph node homing receptor. J Immunol 1991;101:90-99.
8. Halstensen TS, Farstad IN, Scott H, Fausa O, Brandtzaeg P: Intraepithelial TcR αβ + lymphocytes express CD45RO more often than the TcRγδ counterparts in celiac disease. Immunology 1990;71: 460-466.
9. Schieferdecker HL, Ullrich R, Hirseland H, Zeitz M: T cell differentiation antigens on lymphocytes in the human intestinal lamina propria. J Immunol 1992;149:2816-2822.
10. Boirivant M, Pica R, DeMaria R, Testi R, Pallone F, Strober W: Stimulated human lamina propria T cells manifest enhanced Fas-mediated apoptosis. J Clin Invest 1996;98:2616-2622.
11. De Ruggero M, Boirivant M, Cifone MG, Roncaioli P, Hahne M, Tschopp J, Pallone F, Santoni A, Testi R: Functional expression of Fas and Fas ligand on human gut lamina propria T lymphocytes: A potential role for acidic sphingomyelinase pathway in normal immunoregulation. J Clin Invest 1996;97:316-322.
12. Akbar AN, Borthwick NJ, Wickremasinghe RG, Panayoitidis P, Pilling D, Bofill M, Krajewski S, Reed JC, Salmon M: Interleukin-2 receptor common γ chain signalling cytokines regulate activated T cell apoptosis in response to growth factor withdrawal: Selective induction of anti-apoptotic (bcl-2, bcl-xL) but not pro-apoptotic (bax, bcl-xS) gene expression. Eur J Immunol 1996;26:294-299.
13. Watanabe M, Ueno Y, Yajima T, Iwao Y, Tsuchiya M, Ishikawa H, Aiso S, Hibi T, Ishii H: Interleukin 7 is produced by human intestinal epithelial cells and regulates the proliferation of intestinal mucosal lymphocytes. J Clin Invest 1995;95:2495-2953.
14. Taguchi T, McGhee JR, Coffman RL, Beagley KW, Eldridge JH, Takatsu K, Kiyono H: Analysis of Th1 and Th2 cells in murine gut-associated tissues. Frequencies of CD4+ and CD8+ T cells that secrete IFN-γ and IL-5. J Immunol 1990;145:68-77.
15. Wilson AD, Bailey M, Williams NA, Stokes CR: The in vitro production of cytokines by mucosal lymphocytes immunized by oral administration of keyhole limpet hemocyanin using cholera toxin as an adjuvant. Eur J Immunol 1991;21:2333-2339.
16. Saparov A, Elson CO, Devore-Carter D, Bucy RP, Weaver CT: Single cell analyses of CD4+ T cells from αβ T cell receptor transgenic mice: A distinct mucosal cytokine phenotype in the absence of transgene-specific antigen. Eur J Immunol 1997;27:1774-1781.
17. Bao S, Goldstone S, Husband AJ: Localisation of IFN-gamma and IL-6 mRNA in murine intestine by in situ hybridisation. Immunology 1993;80:666-670.
18. Hauer AC, Breese EJ, Walker-Smith JA, MacDonald TT: The frequency of cells secreting interferon-γ, IL-4, IL-5 and IL-10 in the blood and duodenal mucosa of children with cows' milk hypersensitivity. Pediatr Res 1997;42:629-638.
19. Carol M, Lambrechts A, Van Gossum A, Libin M, Goldman M, Mascart-Lemone F: Spontaneous secretion of interferon-gamma and interleukin-4 by human intraepithelial and lamina propria gut lymphocytes. Gut 1998;42:643-649.
20. Niessner M, Volk BA: Altered Th1/Th2 cytokine profiles in the intestinal mucosa of patients with inflammatory bowel disease as assessed by quantitative reversed transcribed polymerase chain reaction (RT-PCR). Clin Exp Immunol 1995;101:428-435.
21. Autschbach F, Schurmann G, Qiao L, Merz H, Wallich R, Meuer SC: Cytokine messenger RNA expression and proliferation status of intestinal mononuclear cells in noninflamed gut and Crohn's disease. Virchows Arch 1995;426:51-60.
22. Targan SR, Deem DL, Liu M, Wang S, Nel A: Definition of a lamina propria T cell responsive state. Enhanced cytokine responsiveness of T cells stimulated through the CD2 pathway. J Immunol 1995;154:664-675.
23. Fuss IJ, Neurath M, Boirivant M, Klein JS, de la Motte C, Strong SA, Fiocchi C, Strober W: Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. J Immunol 1996;157:1261-1270.
24. Braunstein J, Qiao L, Autschbach F, Schurmann G, Meuer S: T cells of the human intestinal lamina propria are high producers of interleukin-10. Gut 1997;41:215-220.
25. Choy M-Y, Richman PI, Walker-Smith JA, MacDonald TT: Differential expression of CD25 (Interleukin-2 receptor) on lamina propria T cells and macrophages in the intestinal lesions in Crohn's disease and ulcerative colitis. Gut 1990;31:1365-70.
26. Mullin GE, Lazenby AJ, Harris ML, Bayless TM, James SP: Increased interleukin-2 messenger RNA in the intestinal mucosal lesions of Crohn's disease but not ulcerative colitis. Gastroenterology 1992;102:1620-1627.
27. Breese E, Braegger CP, Corrigan CP, Walker-Smith JA, MacDonald TT: Interleukin-2 and interferon-gamma-secreting T cells in normal and diseased human intestinal mucosa. Immunology 1993;78:127-131.
28. Kusugami K, Matsuura T, West GA, Youngman KR, Rachmilewitz D, Fiocchi C: Loss of interleukin-2-producing intestinal CD4+ T cells in inflammatory bowel disease. Gastroenterology 1991;101:1594-1605.
29. Karttunnen R, Breese E, MacDonald TT: Loss of interleukin-4 secreting cells in inflammatory bowel disease. J Clin Pathol 1994;11:1015-1018.
30. West GA, Matsuura T, Levine AD, Klein JS, Fiocchi C: Interleukin 4 in inflammatory bowel disease and mucosal immune reactivity. Gastroenterology 1996;110:1683-1695.
31. Desreumaux P, Brandt E, Gambiez L, Emilie D, Geboes K, Klein O, Ectors N, Cortot A, Capron M, Colombel JF: Distinct cytokine patterns in early and chronic ileal lesions of Crohn's disease. Gastroenterology 1997;113:118-126.
32. Parronchi P, Romagnani P, Annunziato F, Sampognaro S, Becchio A, Giannarini L, Maggi E, Pupilli C, Tonelli F, Romagnani S: Type 1 T-helper cell predominance and interleukin-12 expression in the gut of patients with Crohn's disease. Am J Pathol 1997;150:823-832.
33. Monteleone G, Biancone L, Marasco R, Morrone G, Marasco O, Luzza F, Pallone F: Interleukin 12 is expressed and actively released by Crohn's disease intestinal lamina propria mononuclear cells. Gastroenterology 1997;112:1169-1178.
34. Rugtveidt J, Nilsen EM, Bakka A, Carlsen H, Brandtzaeg P, Scott H: Cytokine profiles differ in newly recruited and resident subsets of mucosal macrophages from inflammatory bowel disease. Gastroenterology 1997;112:1493-505.
35. Halstensen TS, Scott H, Fausa O, Brandtzaeg P: Gluten stimulation of coeliac mucosa in vitro induces activation (CD25) of lamina propria CD4+ T cells and macrophages but no crypt-cell hyperplasia. Scand J Immunol 1993;38:581-590.
36. Lundin KE, Scott H, Hansen T, Paulsen G, Halstensen TS, Fausa O, Thorsby E, Sollid LM: Gliadin specific, HLA-DQ (α0501β10201) restricted T cells isolated from the small intestinal mucosa of celiac disease patients. J Exp Med 1993;178:187-196.
37. Nilsen EM, Lundin KEA, Krajci P, Scott H, Sollid LM, Brandtzaeg P: Gluten-specific, HLA-DQ restricted T cells from coeliac mucosa produce cytokines with Th1 or Th0 profile dominated by interferon-γ. Gut 1995;37:766-776.
38. Kontakou M, Przemioslo RT, Sturgess RP, Limb GA, Ellis HJ, Day P, Ciclitira PJ: Cytokine mRNA expression in the mucosa of treated coeliac patients after wheat peptide challenge. Gut 1995;37:52-37.
39. Beckett CG, Dell'Olio D, Kontakou M, Przemioslo RT, Rosen-Bronson S, Ciclitira PJ: Analysis of interleukin-4 and interleukin-10 and their association with the lymphocytic infiltrate in the small intestine of patients with coeliac disease. Gut 1996;39:818-823.
40. Breese EJ, Farthing MJG, Kumar P, MacDonald TT: Interleukin-2 and interferon-gamma producing cells in the lamina propria in coeliac disease. Dig Dis Sci 1994;39:2243.
41. Elson CO, Sartor RB, Tennyson GS, Riddell RH: Experimental models of inflammatory bowel disease. Gastroenterol 1995;109:1344-1367.
42. MacDonald TT: Cytokine gene deleted mice in the study of gastrointestinal inflammation. Eur J Gastoenterol Hepatol 1997;9:1051-1055.
43. Mizoguchi A, Mizoguch E, Chiba C, Spiekermann GM, Tonegawa S, Nagler-Anderson C, Bhan AK: Cytokine imbalance and autoantibody production in T cell receptor-alpha mutant mice with inflammatory bowel disease. J Exp Med 1996;183:847-856.
44. Simpson SJ, Hollander GA, Mizoguchi E, Allen D, Bhan AK, Wang B, Terhorst C: Expression of pro-inflammatory cytokines by TCR αβ+ and TCR γδ+ T cells in an experimental model of colitis. Eur J Immunol 1997;27:17-25.
45. Powrie F, Leach MW, Mauze S, Menon S, Caddle LB, Coffman RL: Inhibition of Th1 responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells. Immunity 1994;1:553-562.
46. Berg DJ, Davidson N, Kuhn R, Muller W, Menon S, Holland G, Thompson-Snipes L, Leach MW, Rennick D: Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4+ Th1-like responses. J Clin Invest 1996;98:1010-1020.
47. Neurath MF, Fuss I, Pasparakis M, Alexapoulou L, Haralambous S, Meyer zum Buschenfelde KH, Strober W, Kollias G: Predominant pathogenic role of tumor necrosis factor in experimental colitis. Eur J Immunol 1997;27:1743-1750.
48. Neurath MF, Fuss I, Kelsall BL, Stuber E, Strober W: Antibodies to interleukin 12 abrogate established experimental colitis in mice. J Exp Med 1995;182:1281-1290.
49. Liesenfeld O, Kosek J, Remington JS, Suzuki Y: Association of CD4+ T cell-dependent, interferon-γ-mediated necrosis of the small intestine with genetic susceptibility of mice to peroral infection with Toxoplasma gondii. J Exp Med 1996;184:597-607.
50. MacDonald SAC, Palmen MJHJ, Van Rees EP, MacDonald TT: Characterization of the mucosal cell-mediated immune response in IL-2 knockout mice before and after the onset of colitis. Immunology 1997;91:73-80.
51. Simpson SJ, Mizoguchi E, Allen D, Bhan AK, Terhorst C: Evidence that CD4+ but not CD8+ T cells are responsible for murine interleukin-2 deficient colitis. Eur J Immunol 1995;25:2618-2625.
52. Bonhagen K, Thoma S, Bland P, Bregenholt S, Rudolphi A, Claesson MH, Reimann J: Cytotoxic reactivity of gut lamina propria CD4+ alpha beta T cells in SCID mice with colitis. Eur J Immunol 1996;26:3074-3083.
53. low CD4+ T cells are important for the balance between protective and pathogenic cell-mediated immunity. J Exp Med 1994;179:589-600.
54. Powrie F, Carlino J, Leach MW, Mauze S, Coffman RL: A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4+ T cells. J Exp Med 1996;183:2669-2674.
55. Duchmann R, Schmitt E, Knolle P, Meyer zum Buschenfelde KH, Neurath M: Tolerance towards resident intestinal flora in mice is abrogated in experimental colitis and restored by treatment with interleukin-10 or antibodies to interleukin-12. Eur J Immunol 1996;26:934-938.
56. Madara JL, Stafford J: Interferon-γ directly affects barrier function of cultured intestinal epithelial monolayers. J Clin Invest 1989;83:724-727.
57. Heyman M, Darmon N, Dupont C, Dugas B, Hirribaren A, Blaton MA, Desjeux JF: Mononuclear cells from infants allergic to cow's milk secrete tumor necrosis factor α, altering intestinal function. Gastroenterology 1994;106:1514-1523.
58. Kaiser GC, Polk DB: Tumor necrosis factor α regulates proliferation in a mouse intestinal cell line. Gastroenterology 1997;112:1231-1240.
59. Pender SLF, Lionetti P, Murch SH, Wathan N, MacDonald TT: Proteolytic degradation of intestinal mucosal extracellular matrix after lamina propria T cell activation. Gut 1996;39:284-290.
60. Pender SLF, Tickle SP, Docherty AJP, Howie D, Wathen NC, MacDonald TT: A major role for matrix metalloproteinases in T cell injury in the gut. J Immunol 1997;158:1582-1590.
61. Pender SLF, Fell JMC, Chamow SM, Ashkenazi A, MacDonald TT: A p55 tumor necrosis factor (TNF) receptor immunoadhesin prevents T cell-mediated intestinal injury by inhibiting matrix metalloproteinase production. J Immunol 1998;160:4098-4103.
62. Saarialho-Kere UK, Vaalamo M, Puolakkainen P, Airola K, Parks WC, Karjalamen-Lindsberg ML: Enhanced expression of matrilysin, collagenase, and stromelysin-1 in gastrointestinal ulcers. Am J Pathol 1996;148:519-526.
63. Breese EJ, Michie CA, Nicholls SW, Murch SH, Williams CB, Domizio P, Walker-Smith JA, MacDonald TT: Tumour necrosis factor-alpha producing cells in the intestinal mucosa of children with inflammatory bowel disease. Gastroenterology 1994;106:1455-1466.
64. Targan SR, Hanauer SB, VanDeventer SJH, Mayer L, Present DH, Braakman T, DeWoody KL, Schaible TF, Rutgeerts PJ: A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor α for Crohn's disease. N Engl J Med 1997;337:1029-1035.
65. Finch PW, Pricolo V, Wu A, Finkelstein SD: Increased expression of keratinocyte growth factor messenger RNA associated with inflammatory bowel disease. Gastroenterology 1996;110:441-451.
66. Brauchle M, Madlener M, Wagner AD, Angermeyer K, Lauer U, Hofschneider PH, Gregor M, Werner S: Keratinocyte growth factor is highly overexpressed in inflammatory bowel disease. Am J Pathol 1996;149:521-529.
67. Bajaj-Elliott M, Breese E, Poulsom R, Fairclough PD, MacDonald TT: Keratinocyte growth factor in inflammatory bowel disease: Increased mRNA transcripts in ulcerative colitis compared to Crohn's disease in biopsies and isolated stromal cells. Am J Pathol 1997;151:1469-1476.
68. Goke M, Podolsky DK: Regulation of the mucosal epithelial barrier. Baillières Clin Gastroenterol 1996;10:393-405.