Effect of ultrasound application on skin metabolism of prednisolone 21- acetate

Pharmaceutical Research

Volumn 15, Issue 11, 1998, Pages 1680-1683

  Hikima, Tomohiro ^a   Hirai, Yoshiaki ^a   Tojo, Kakuji ^a  

^a KYUSHU INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

Enzyme deactivation; Free radicals; Penetration; Skin metabolism; Ultrasound pretreatment

Indexed keywords

PREDNISOLONE;

ANIMAL TISSUE; ARTICLE; DRUG DIFFUSION; DRUG METABOLISM; DRUG PENETRATION; DRUG POTENTIATION; ENZYME INACTIVATION; FEMALE; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; SKIN PENETRATION; ULTRASOUND THERAPY;

ANIMALS; FEMALE; FREE RADICALS; HEAT; MICE; MICE, INBRED HRS; PREDNISOLONE; PRODRUGS; SKIN;

EID: 0031725935     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1011944209274     Document Type: Article

References (14)

1. J. Saxena, N. Sharma, M. C. Makoid, and U. V. Banakar. Ultrasound mediated drug delivery. J. Biomaterials applications 7:277-296 (1993).
2. K. Tachibana and S. Tachibana. Use of ultrasound to enhance the local anesthetic. Effect of topical applied aqueous lidocaine. Anesthesiology 78:1091-1096 (1993).
3. J. C. McElnay, M. P. Matthews, R. Harland, and D. F. McCafferty. The effect of ultrasound on the percutaneous absorption of lignocaine. Br. J. Clin. Pharmacol. 20:421-424 (1985).
4. W. S. Quilline. Ultrasound phonophoresis. Phys. Sports Med. 10:211-212 (1982).
5. J. C. McElnary, T. A. Kennedy, and R. Harland. The influence of ultrasound on the percutaneous absorption of fluocinolone acetonide. Int. J. Pharm. 40:105-110 (1987).
6. T. N. Julian and G. M. J. Zentner. Ultrasonically mediated solute permeation through polymer barriers. Pharma. Pharmcol. 38:871-877 (1986).
7. F. W. Kremkau. Ultrasonic treatment of experimental animal tumors. Br. J. Cancer 45 (suppl V):226-232 (1982).
8. S. Mitragotri, D. Blankschtein, and R. Langer. Ultrasound-mediated transdermal protein delivery. Science 269:850-853 (1995).
9. D. Bommannan, G. K. Menon, H. Okuyama, P. M. Elias, and R. H. Guy. Sonophoresis. II. Examination of the mechanism(s) of ultrasound-enhanced transdermal drug delivery. Pharm. Res. 9:1043-1047 (1992).
10. S. Mitragotri, D. Blankschtein, and R. Langer. Transdermal drug delivery using low-frequency sonophoresis. Pharm. Res. 13:411-420 (1996).
11. W. T. Coakly, W. T. Brown, C. J. James, and R. K. Gould. The inactivation of enzymes by ultrasonic cavitation at 20 kHz. Arch. Biochem. Biophys. 159:722-725 (1973).
12. T. Hikima and K. Tojo. Percutaneous absorption of drugs accompanied by binding and metabolism in the skin. Yakuzaigaku 55:122-126 (1995).
13. M. A. Adnnos, A. M. Al-karmi, D. A. Stoltz, J. C. Matthews, and L. A. Crum. Effect of free radical scavengers on changes in ion conductance during exposure to therapeutic ultrasound. Memb. Biochem. 10:237-247 (1993).
14. P. Riesz and T. Kondo. Free radical formation induced by ultrasound and its biological implications. Free Radc. Biol. Med. 13: 247-270 (1992).