Partial sequence and toxic effects of granulitoxin, a neurotoxic peptide from the sea anemone Bunodosoma granulifera

Brazilian Journal of Medical and Biological Research

Volumn 31, Issue 10, 1998, Pages 1335-1338

  Santana, A N C ^a   Leite, A B ^a   Franca M S F ^a   Franca L ^a   Vale, O C ^a   Cunha, R B ^c   Ricart, C A O ^c   Sousa, M V ^c   Carvalho, K M ^a,b  

^a FEDERAL UNIVERSITY OF CEARÁ   (Brazil)

^b STATE UNIVERSITY OF CEARÁ   (Brazil)

^c UNIVERSITY OF BRASILIA   (Brazil)

Author keywords

Bunodosoma granulifera; Sea anemones; Toxic peptides

Indexed keywords

ALANINE; ARGININE; CYSTEINE; GRANULITOXIN; NEUROTOXIN; UNCLASSIFIED DRUG;

AGGRESSION; AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; DYSPNEA; MOUSE; NEUROTOXICITY; NONHUMAN; PROTEIN ISOLATION; ROTATION; SEA ANEMONE; TONIC CLONIC SEIZURE;

ACTINIARIA; ANEMONE; ANEMONIA SULCATA; ANIMALIA; ANTHOPLEURA FUSCOVIRIDIS; BUNODOSOMA CAISSARUM; BUNODOSOMA GRANULIFERA;

EID: 0031725913     PISSN: 0100879X     EISSN: 1414431X     Source Type: Journal    
DOI: 10.1590/S0100-879X1998001000015     Document Type: Article

References (15)

1. Sunahara S, Muramoto K, Tenma K & Kamyia H (1987) Amino acid sequence of two sea anemone toxins from Anthopleura fuscoviridis. Toxicon, 25: 211-219.
2. Wunderer G & Eulitz M (1978). Amino acid sequence of toxin I from Anemonia sulcata. European Journal of Biochemistry, 89: 11-17.
3. Schweitz H, Bidard JN, Frelin C, Pauron D, Vijverberg HPM, Mahasneh DM, Lazdurski M, Vilbois F & Tsugita A (1985) Purification, sequence and pharmacological properties of sea anemone toxins from Radianthus paumotensis. A new class of sea anemone toxins acting on the sodium channel. Biochemistry, 24: 3554-3561.
4. Mahnir VM & Kozlovskaya EP (1991). Structure-toxicity relationships of neuro toxins RTX-III from the sea anemone Radianthus macrodactylus: modification of amino groups. Toxicon, 29: 819-826
5. Malpezzi ELA & Freitas JC (1991). Hemolytic activity of the nematocyst venom from the sea anemone Bunodosoma caissarum. Brazilian Journal of Medical and Biological Research, 24: 1245-1249
6. Malpezzi ELA, Freitas JC, Muramoto K & Kamyia H (1993). Characterization of peptides in sea anemone venom collected by a novel procedure. Toxicon, 31: 853-864.
7. Norton RS (1991). Structure and structure-function relationships of sea anemone proteins that interact with the sodium channel. Toxicon, 29: 1051-1084.
8. Cotton J, Crest M, Bouet F, Alessanori N, Gola M, Forest E, Karlsson E, Castaneda O, Harvey AL, Vista C & Menez A (1997). A potassium-channel toxin from the sea anemone Bunodosoma granulifera, an inhibitor for kv1 channels. Revision of the amino acid sequence, disulfide-bridge assignment, chemical synthesis, and biological activity. European Journal of Biochemistry, 244: 279-282.
9. Aneiros A, Garcia-Alonso I, Martinez JR, Harvey AL, Anderson AJ, Marshall DL, Emgstrom A, Hellman U & Karlsson E (1993). A potassium channel toxin from the secretion of the sea anemone Bunodosoma granulifera. Biochimica et Biophysica Acta, 1157: 86-92.
10. Loomis TA & Hayes AW (1996). Toxicologic testing methods. In: Loomis TA & Hayes AW (Editors), Loomis's Essentials of Toxicology. Academic Press, Inc., San Diego, CA, 205-248.
11. Fontes W, Cunha RB, Sousa MV & Morphy LM (1998). Improving the recovery of lysine in automated protein sequencing Analytical Biochemistry (in press).
12. Kalume DE, Sousa MV & Morphy LM (1995). Purification, characterization, sequence determination and mass spectrometric analysis of a trypsin inhibitor from seeds of the Brazilian tree Dypteryx alata (Leguminosae), Journal of Protein Chemistry, 14: 685-693.
13. Schweitz H, Vincent JP, Barhanin J, Frelin C, Linden G, Hugues M & Lazdunski M (1981). Purification and pharmacological properties of eight sea anemone toxins from Anemonia sulcata, Anthopleura xantogrammica, Stoichactis giganteus and Actinodendron plumosum. Biochemistry, 20: 5245-5252
14. Schweitz H (1984). Lethal potency in mice of toxins from scorpion, sea anemone, snake and bee venoms following intraperitoneal and intracisternal injection. Taxicon, 22: 308-311.
15. Cariello L, De Santis A, Fiore F, Piccoli R, Spagnuolo A, Zanetti L & Parente A (1989). Calitoxin, a neurotoxic peptide from the sea anemone Calliactis parasitica: Amiro acid sequence and electrophysiological properties. Biochemistry, 28: 2484-2489.