Insulin receptors and signal transduction proteins in the hypothalamo- hypophyseal system: A review on morphological findings and functional implications

Histology and Histopathology

Volumn 13, Issue 4, 1998, Pages 1215-1224

  Unger, J W ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

Hypothalamus; Insulin receptor; Insulin receptor substrate 1; Phosphatidylinositol 3' kinase; Pituitary gland

Indexed keywords

INSULIN; INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE 1; PHOSPHATIDYLINOSITOL 3 KINASE; SOMATOMEDIN C;

ANIMAL TISSUE; HUMAN; HUMAN TISSUE; HYPOTHALAMUS HYPOPHYSIS SYSTEM; INSULIN METABOLISM; NEUROENDOCRINE SYSTEM; NONHUMAN; NUTRITION; RAT; RECEPTOR DENSITY; REVIEW; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; BLOOD-BRAIN BARRIER; BRAIN; HUMANS; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; INSULIN; NEUROPEPTIDES; PHOSPHOPROTEINS; PITUITARY GLAND, ANTERIOR; RECEPTOR, IGF TYPE 1; RECEPTOR, INSULIN; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 0031725083     PISSN: 02133911     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (7)

1. Baskin D.G., Figlewicz D.P., Woods S.C., Porte D. Jr, and Dorsa D.M. (1987). Insulin in the brain. Annu. Rev. Physiol. 49, 335-347.
2. Baskin D.G., Sipols A.J., Schwartz M.W. and White M.F. (1993). Immunocytochemical detection of insulin receptor substrate-1 (IRS-1) in rat brain: clocalization with phosphotyrosine. Regul. Peptides 48, 257-266.
3. Blasquez C., Jégou S., Friard O., Tonon M.C., Fournier A. and Vaudry H. (1995). Effect of centrally administered neuropeptide Y on hypothalamic and hypophyseal proopiomelanocortin-derived peptides in the rat. Neuroscience 68, 221-227.
4. Carpenter G. (1990). PLC and PKC: a tale of two messengers. Receptor-mediated stimulation of phosphoinositide metabolism and protein kinase C. New Biol. 2, 965-969.
5. Carpenter C.L., Auger K.R., Chanudhuri M., Yoakim M., Schaffhausen B., Shoelson S. and Cantley L.C. (1993). Phosphoinositide 3-kinase is activated by phosphopeptides that bind to the SH2 domains of the 85-kDa subunit. J. Biol Chem. 268, 9478-9483.
6. Chuang L.M., Hausdorff S.F., Myers M.G. Jr., White M.F., Birnbaum M.J. and Kahn C.R. (1994). Interactive roles of Ras, insulin receptor substrate-1, and proteins with Src homology-2 domains in insulin signaling xenopus oocytes. J. Biol. Chem. 269, 27645-27649.
7. Crone C. (1965). Facilitated transfer of glucose from blood into brain tissue. J. Physiol. (Lond.) 181, 103-113.