Selective muscarinic antagonists. I. Synthesis and antimuscarinic properties of 4-piperidyl benzhydrylcarbamate derivatives

Chemical and Pharmaceutical Bulletin

Volumn 46, Issue 8, 1998, Pages 1274-1285

  Naito, Ryo ^a   Takeuchi, Makoto ^a   Morihira, Koichiro ^a   Hayakawa, Masahiko ^a   Ikeda, Ken ^a   Shibanuma, Tadao ^a   Isomura, Yasuo ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

4 piperidyl benzhydrylcarbamate; Muscarinic antagonist; Salivary secretion; Urinary bladder contraction; Urinary urge incontinence; YM 58790

Indexed keywords

1 (4 METHYLAMINOBENZYL) 4 PIPERIDYLBENZHYDRYLCARBAMIC ACID; 4 DIPHENYLACETOXY 1 METHYLPIPERIDINE; 4 PIPERIDYLBENZHYDRYLCARBAMATE DERIVATIVE; MUSCARINIC M1 RECEPTOR; MUSCARINIC M2 RECEPTOR; MUSCARINIC M3 RECEPTOR; MUSCARINIC M3 RECEPTOR ANTAGONIST; MUSCARINIC RECEPTOR BLOCKING AGENT; OXOTREMORINE; OXYBUTYNIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; INCONTINENCE; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; RAT; SALIVATION; STRUCTURE ACTIVITY RELATION; URINE INCONTINENCE;

EID: 0031722980     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.46.1274     Document Type: Article

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