Simultaneous determination of primidone and its three major metabolites in rat urine by high-performance liquid chromatography using solid-phase extraction

Journal of Chromatography B: Biomedical Applications

Volumn 718, Issue 1, 1998, Pages 199-204

  Ferranti, Vincent ^a   Chabenat, Christiane ^a   Ménager, Sabine ^a   Lafont, Olivier ^a  

^a Laboratoire de Pharmacochimie   (France)

Author keywords

p Hydroxyphenobarbital; Phenobarbital; Phenylethylmalonamide; Primidone

Indexed keywords

4' HYDROXYPHENOBARBITAL; DRUG METABOLITE; ETHYL(PHENYL)MALONAMIDE; PHENOBARBITAL; PRIMIDONE;

ACCURACY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALIBRATION; CONTROLLED STUDY; DRUG MIXTURE; DRUG URINE LEVEL; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT; SOLID PHASE EXTRACTION; TECHNIQUE;

ANIMALS; ANTICONVULSANTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; EVALUATION STUDIES; PHENOBARBITAL; PHENYLETHYLMALONAMIDE; PRIMIDONE; RABBITS; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS;

EID: 0031722781     PISSN: 15726495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4347(98)00356-9     Document Type: Article

References (10)

1. J.M. Streete, D.J. Berry, L.I. Pettit, J.E. Newberry, Ther. Drug Monit 8 (1986) 161.
2. J.M. Streete, D.J. Berry, J.E. Newberry, P. Crome, Eur. J. Clin. Pharmacol. 33 (1987) 431.
3. R.J. Perchalski, J. Wilder, J. Chromatogr 145 (1978) 97.
4. W. Kuhnz, H. Nau, Ther. Drug Monit. 6 (1984) 478.
5. M. Moriyama, K. Furuno, R. Oishi, Y. Gomita, J. Pharm. Sci. 83 (1994) 1751.
6. O. Lafont, C. Cavé, S. Ménager, M. Miocque, Eur. J. Chem 25 (1990) 61.
7. H. Liu, M. Delgado, L.J. Formann, C.M. Eggers, J.L. Montoya, J. Chromatogr. 616 (1993) 105.
8. J.D. Alvin, M.T. Bush, Mikrochim. Acta 1 (1975) 683.
9. J. Caporal-Gautier, J.M. Nivet, P. Algranti, M. Gilloteau, M. Histe, M. Lallier, J.J. N'guyen-Huu, R. Rusotto, Guide de Validation Analytique, Rapport d'une commission SFSTP, STP Pharma Pratiques 23 (1992) 205.
10. S.G. Paibir, W.H. Soine, J. Chromatogr. B 691 (1997) 111.