Clomipramine and imipramine suppress clinical signs and T and B cell response to myelin proteins in experimental autoimmune neuritis in Lewis rats

Journal of Autoimmunity

Volumn 11, Issue 4, 1998, Pages 319-327

  Zhu, Jie ^a   Bengtsson, Bengt Olof ^b   Mix, Eilhard ^c   Ekerling, Lena ^b   Thorell, Lars Håkan ^b   Olsson, Tomas ^a   Link, Hans ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b LINKÖPING UNIVERSITY HOSPITAL   (Sweden)

^c UNIVERSITY OF ROSTOCK   (Germany)

Author keywords

Experimental autoimmune neuritis; Immunopharmacology; Interferon ; Monoamine reuptake inhibiting antidepressants; Peripheral nerve myelin

Indexed keywords

CLOMIPRAMINE; IMIPRAMINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNE DISEASE; B LYMPHOCYTE ACTIVATION; DOSE RESPONSE; DRUG EFFECT; IMMUNOMODULATION; IMMUNOREGULATION; MALE; NEURITIS; NONHUMAN; PRIORITY JOURNAL; RAT; SEROTONIN UPTAKE; T LYMPHOCYTE ACTIVATION;

EID: 0031722007     PISSN: 08968411     EISSN: None     Source Type: Journal    
DOI: 10.1006/jaut.1998.0209     Document Type: Article

References (41)

1. Leonard B.E. 1994. Effect of antidepressants on specific neurotransmitters: are such effects relevant to the therapeutic action? In Handbook of Depression and Anxiety. A Biological Approach. J.A. den Boer, J.M. Ad Sitsen, eds. Marcel Dekker, New York, pp. 379-404
2. Stein M., Miller A.H., Trestman R.L. 1991. Depression and the immune system. In Psychoneuroimmunology, 2nd edn. R. Ader, D.L. Felten, N. Cohen, eds. Academic Press, San Diego, pp. 897-930
3. Krofol Z. 1994. Immune factors in depression and anxiety. In Handbook of Depression and Anxiety. A Biological Approach. J.A. den Boer, J.M. Ad Sitsen, eds. Marcel Dekker, New York, pp. 515-527
4. Maes M., Meltzer H., Jacobs J., Suy E., Calabrese J., Minner B., Raus J. 1993. Autoimmunity in depression: increased antiphospholipid autoantibodies. Acta Psychiatr. Scand. 87: 160-166
5. Miller A.H., Lackner C. 1989. Tricyclic antidepressants and immunity. In Depressive Disorders and Immunity. Progress in Psychiatry. A.H. Miller, ed. American Psychiatric Press, Washington, DC, pp. 87-103
6. Bengtsson B.-O., Zhu J., Thorell L.-H., Olsson T., Link H. 1992. Effects of zimeldine and its metabolites, clomipramine, imipramine and maprotiline in experimental allergic neuritis in Lewis rats. J. Neuroimmunol. 39: 109-122
7. Zhu J., Bengtsson B.-O., Mix E., Thorell L.-H., Olsson T., Link H. 1994. Effect of monoamine reuptake inhibitory antidepressants on major histocompatibility complex expression on macrophages in normal rats and rats with experimental allergic neuritis (EAN). Immunopharmacology 27: 225-244
8. Zhu J., Bengtsson B.-O., Mix E., Thorell L.-H., Olsson T., Link H. 1995. Peripheral nerve myelin modulates the effect of antidepressants on major histocompatibility complex expression on macrophages in experimental allergic neuritis. Int. J. Immunopathol. Pharmacol. 8: 185-198
9. Agius M.A., Arnason B.G.W. 1991. Autoimmune neurological diseases and their potential relevance to psychiatric diseases. In Psychoimmunology Update, Progress in Psychiatry. J.M. Gorman, R.M. Kertzner, eds. American Psychiatric Press, Washington, DC, pp. 9-29
10. Schmidt B., Stoll G., Van der Meide P., Jung S., Hartung H.-P. 1992. Transient cellular expression of y-interferon in myelin-induced and T-cell line-mediated experimental autoimmune neuritis. Brain 115: 1633-1646
11. Zhu J., Mix E., Issazadeh S., Link H. 1996. Dynamics of mRNA expression of interferon-γ, interleukin 4 and transforming growth factor-β in sciatic nerves and lymphoid organs in experimental allergic neuritis. Eur. J. Neurol. 3: 232-240
12. Zhu J., Mix E., Link H. 1998. Cytokine production and the pathogenesis of experimental allergic neuritis and Guillain-Barré syndrome. J. Neuroimmunol. 84: 40-52
13. Zhu J., Link H., Weerth S., Linington C., Mix E., Qiao J. 1994. The B cell repertoire in experimental allergic neuritis involves multiple myelin proteins and GM1. J. Neural. Sci. 125: 132-137
14. Aune T.M., Golder H.W., McGranth K.M. 1994. Inhibitors of secretion synthesis and antagonists of serotonin IA receptors inhibit T lymphocyte function in vitro and cell-mediated immunity in vivo. J. Immunol. 152: 489-498
15. Fagius J., Osterman P.O., Sidén Å., Wiholm B.E. 1985. Guillain-Barré syndrome following zimeldine treatment. J. Neurol. Neurosurg. Psychiatr. 48: 65-69
16. Eriksson E., Humble M. 1990. Serotonin in psychiatric pathophysiology. A review of data from experimental and clinical research. In The Biological Basis of Psychiatric Treatment. Prog Basic Clin Pharmacol, Vol. 3. R. Pohl, S. Gerson, eds. Karger, Basel, pp. 66-119
17. Norton W.I., Poduslo S.E. 1973. Myelination in rat nerve: Method of myelin isolation. J. Neurochem. 21: 749-757
18. Milner P.A., Lovelidge C.A., Taylor W.A., Hughes R.A.C. 1987. P0 protein produces experimental allergic neuritis in Lewis rats. J. Neural. Sci. 79: 275-285
19. Kadlubowski M., Hughes R.A.C., Gregson N.A. 1980. Experimental allergic neuritis in Lewis rat: characterization of the activity of peripheral myelin and its major basic protein P2. Brain Res. 184: 439-454
20. Lindström J., Einarson B., Tzartos S. 1981. Production and assay of antibodies to acetylcholine receptors. Methods Enzymol. 74: 432-460
21. Van der Meide P.H., Dubbeld M., Vijverberg K., Kos T., Schellekens H. 1986. The purification of rat gamma interferon by use of two monoclonal antibodies. J. Gen. Virol. 67: 1059-1071
22. Visser T.J., Oostelbos M.C., Toll P.J. 1984. Reliable routine methods for the determination of antidepressant drugs in plasma by high performance liquid chromatography. J. Chromatogr. 309: 81-93
23. Hartung H.P, Schäfer B., Van der Meide P.H., Fierz W., Heininger K., Toyka K.V. 1990. The role of interferon-gamma in the pathogenesis of experimental autoimmune disease of the peripheral nervous system. Ann. Neural. 27: 247-257
24. Adams D.O., Hamilton T.A. 1987. Molecular transductional mechanisms by which IFN-γ and other signals regulate macrophage development. Immunol. Rev. 97: 5-27
25. Duijvestijn A.M., Schreiber A.B., Butcher E.C. 1986. Interferon-gamma regulates an antigen specific for endothelial cells involved in lymphocyte traffic. Proc. Natl. Acad. Sci. USA 83: 9114-9118
26. Oppenheimer-Marks N., Ziff M. 1988. Migration of lymphocytes through endothelial cell monolayers: augmentation by interferon-g. Cell. Immunol. 114: 307-323
27. Hardy K.J., Sawada T. 1989. Human g-interferon strongly upregulates its own gene expression in peripheral blood lymphocytes. J. Exp. Med. 170: 1021-1026
28. Olsson T., Wang W.-Z., Höjeberg B., Kostulas V., Jiang Y.-P., Andersson G., Ekre H.-P., Link H. 1990. Autoreactive T lymphocytes in multiple sclerosis determined by antigen induced secretion of interferon-gamma. J. Clin. Invest. 86: 981-985
29. Toyka K.V., Heininger K. 1987. Humoral factors in peripheral nerve disease. Muscle Nerve 10: 222-232
30. Raine C., Bornstein M. 1979. Experimental allergic neuritis - ultrastructure of serum induced myelin aberrations in peripheral nervous system cultures. Lab. Invest. 40: 423-432
31. Saida T., Saida K., Silberberg D.H., Brown M.J. 1978. Transfer of demyelination by injection of experimental allergic neuritis serum. Nature 272: 639-641
32. Guillain-Barré Study Group. 1985. Plasmapheresis of acute Guillain-Barré syndrome. Neurology 35: 1096-1104
33. Koski C.L. 1990. Characterization of complement- fixing antibodies to peripheral nerve myelin in Guillain-Barré syndrome. Ann. Neurol. 27: 44-47
34. Felten S.Y, Felten D.L. 1991. Innervation of lymphoid tissue. In Psychoneuroimmunology, 2nd edn. R. Ader, D.L. Felten, N. Cohen, eds. Academic Press, San Diego, pp. 27-69
35. Walker R.F., Codd E.E. 1985. Neuroimmunomodulatory interaction of norepinephrine and serotonin. J. Neuroimmunol. 10: 41-58
36. Sternberg E.M., Wedner H.J., Leung M.K., Parker C.W. 1987. Effect of serotonin (5-HT) and other monoamines on murine macrophages: Modulation of interferon- gamma induced phagocytosis. J. Immunol. 138: 4360-4365
37. Zhu J. 1995. T and B cell response to myelin antigens and its modulation by monoamine reuptake inhibiting antidepressants in experimental allergic neuritis. Dissertation, Stockholm: Karolinska Institute, pp. 1-90
38. Shimomura T., Tanaka H., Takahashi K. 1990. Plasma serotonergic activation in rats during the course of experimental allergic neuritis. Jpn. J. Psychiatry Neurol. 44: 637-640
39. Zhu J., Liu D.-S., Yiao M.-L., Lin S.-H. 1991. Disturbance of immunoregulation in experimental allergic neuritis in rabbits: II. The relationship between the changes in CSF and serum serotonin concentrations and immune responses. Chinese Journal of Nervous and Mental Disease 24: 101-103
40. Halper J.P., Miller A.H., Trestman R.L., Santucci A.C., Lackner C., Stein M. 1991. Biochemical mechanisms of stress-induced impairment of rat T cell mitogenesis. J. Neuroimmunol. 32: 241-247
41. Munck A., Guyre P.M. 1991. Glucocorticoids and immune function. In Psychoneuroimmunology, 2nd edn. R. Ader, D.L. Felten, N. Coken, eds. Academic Press, San Diego, pp. 447-474