Contact-dependent inhibition of angiogenesis by cardiac fibroblasts in three-dimensional fibrin gels in vitro: Implications for microvascular network remodeling and coronary collateral formation

Cell and Tissue Research

Volumn 293, Issue 3, 1998, Pages 479-488

  Nehls, Volker ^a   Herrmann, Rita ^a   Hühnken, Mirja ^a   Palmetshofer, Alois ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Angiogenesis; Collateral formation; Endothelial cell; Fibrin; Fibroblast; Heart; In vitro; Pericyte

Indexed keywords

FIBRIN;

ANGIOGENESIS; ANIMAL CELL; ARTICLE; CAPILLARY; COCULTURE; CONTACT INHIBITION; CORONARY ARTERY COLLATERAL CIRCULATION; ENDOTHELIUM CELL; FIBROBLAST; FIBROBLAST CULTURE; NONHUMAN; PRIORITY JOURNAL;

ANIMALIA;

EID: 0031721847     PISSN: 0302766X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004410051140     Document Type: Article

References (27)

1. Antonelli-Orlidge A, Saunders KB, Smith SR, D'Amore PA (1989) An activated form of transforming growth factor beta is produced by cocultures of endothelial cells and pericytes. Proc Natl Acad Sci USA 86:4544-4548
2. Clark ER, Clark EL (1925) The development of adventitial (Rouget) cells on the blood capillaries of amphibian larvae. Am J Anat 35:239-264
3. Cliff WJ (1963) Observations on healing tissue: a combined light and electron microscopic investigation. Philos Trans R Soc Lond 246:305-325
4. Diaz-Flores L, Gutierrez R, Varela H (1992) Behavior of postcapillary pericytes during postnatal angiogenesis. J Morphol 213:33-45
5. Folkman J, D'Amore PA (1996) Blood vessel formation: what is its molecular basis? Cell 87:1153-1155
6. Hansen-Smith FM, Hudlicka O, Egginton S (1996) In vivo angiogenesis in adult rat skeletal muscle: early changes in capillary network architecture and ultrastructure. Cell Tissue Res 286:123-136
7. Honig MG, Hume RI (1986) Fluorescent carbocyanine dyes allow living neurons of identified origin to be studied in long-term cultures. J Cell Biol 103:171-187
8. Hudlicka O (1991) What makes blood vessels grow? J Physiol 444:1-24
9. Montesano R, Pepper MS, Orci L (1993) Paracrine induction of angiogenesis in vitro by Swiss 3T3 fibroblasts. J Cell Sci 105: 1013-1024
10. Nehls V, Drenckhahn D (1991) Heterogeneity of microvascular pericytes for smooth muscle type alpha-actin. J Cell Biol 113:147-154
11. Nehls V, Drenckhahn D (1993) The versatility of microvascular pericytes: from mesenchyme to smooth muscle? Histochemistry 99:1-12
12. Nehls V, Drenckhahn D (1995a) A novel, microcarrier-based in vitro assay for rapid and reliable quantification of three-dimensional cell migration and angiogenesis. Microvasc Res 50:311-322
13. Nehls V, Drenckhahn D (1995b) A microcarrier-based cocultivation system for the investigation of factors and cells involved in angiogenesis in three-dimensional fibrin matrices in vitro. Histochem Cell Biol 104:459-466
14. Nehls V, Herrmann R (1996) The configuration of fibrin clots determines capillary morphogenesis and endothelial cell migration. Microvasc Res 51:347-364
15. Nehls V, Denzer K, Drenckhahn D (1992) Pericyte involvement in capillary sprouting during angiogenesis in situ. Cell Tissue Res 270:469-474
16. Nehls V, Schuchardt E, Drenckhahn D (1994) The effect of fibroblasts, vascular smooth muscle cells, and pericytes on sprout formation of endothelial cells in a fibrin gel angiogenesis system. Microvasc Res 48:349-363
17. Nehls V, Herrmann R, Hühnken M (1998) Guided migration as a novel mechanism of capillary network remodeling is regulated by basic fibroblast growth factor. Histochem Cell Biol (in press)
18. Rhodin JAG, Fujita H (1989) Capillary growth in the mesentery of normal young rats. Intravital video and electron microscope analyses. J Submicrosc Cytol Pathol 21:1-34
19. Sappino AP, Schürch W, Gabbiani G (1990) Differentiation repertoire of fibroblastic cells: expression of cytoskeletal proteins as marker of phenotypic modulations. Lab Invest 63:144-161
20. Sato Y, Rifkin DB (1989) Inhibition of endothelial cell movement by pericytes and smooth muscle cells: activation of a latent transforming growth factor-beta1-like molecule by plasmin during co-culture. J Cell Biol 109:309-315
21. Sato N, Sawasaki Y, Senoo A, Fuse Y, Hirano Y, Goto T (1987) Development of capillary networks from rat microvascular fragments in vitro: the role of myofibroblastic cells. Microvasc Res 33:194-210
22. Schaper W, Ito WD (1996) Molecular mechanisms of coronary collateral vessel growth. Circ Res 79:911-919
23. Schlingemann RO, Rietveld FJR, de Waal RMW, Ferrone S, Ruiter DJ (1990) Expression of the high molecular weight melanoma associated antigen by pericytes during angiogenesis in tumors and in healing wounds. Am J Pathol 136:1393-1405
24. Stein J, Drenckhahn D, Nehls V (1996) Development of pericyte-like cells during angiogenesis in quail chick chimeras as detected by combined Feulgen reaction and immunohistochemistry. Ann Anat 178:153-158
25. Todaro GJ, Aaronson SA (1969) Properties of clonal lines of murine sarcoma virus transformed Balb-3T3 cells. Virology 38:174-179
26. Verhoeven D, Buyssens N (1988) Desmin-positive stellate cells associated with angiogenesis in a tumour and non-tumour system. Virchows Arch Pathol Anat 54:263-272
27. Villaschi S, Nicosia RF (1994) Paracrine interactions between fibroblasts and endothelial cells in a serum-free coculture model. Modulation of angiogenesis and collagen gel contraction. Lab Invest 71:291-299