Quantification of cortisol inactivation in cirrhosis of the liver

Experimental and Clinical Endocrinology and Diabetes

Volumn 106, Issue 5, 1998, Pages 410-414

  Vogeser, M ^a   Fischer, G ^a   Jacob, K ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

11 hydroxysteroid; Cirrhosis of the liver; Cortisol inactivation; Dehydrogenase (11 HSD)

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; HYDROCORTISONE;

ADULT; AGED; ARTICLE; CAPILLARY GAS CHROMATOGRAPHY; CLINICAL ARTICLE; CONTROLLED STUDY; CORTICOSTEROID METABOLISM; ENZYME IMMUNOASSAY; FEMALE; HUMAN; HYDROCORTISONE URINE LEVEL; LIVER CIRRHOSIS; MALE; PRIORITY JOURNAL;

EID: 0031721535     PISSN: 09477349     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0029-1212007     Document Type: Article

References (17)

1. Bühler H, Perschel FH, Fitzner R, Hierholzer K: Endogenous inhibitors of 11 beta-OHSD: existence and possible significance. Steroids 59: 131-135, 1994
2. Cronholm T, Borg S, Viestam-Rains M, Sjövall J: Metabolic profiles of steroids in urine of alcoholics after withdrawal. J Steroid Biochem Molec Biol 49: 101-105, 1994
3. Diederich S, Quinkler M, Miller K, Heilmann P, Schoeneshofer M, Oelkers W: Human kidney 11β-hydroxysteroid dehydrogenase: regulation by adrenocorticotropin? Eur J Endocrinol 134: 301-307, 1996
4. Escher G, Meyer KV, Vishwanath BS, Frey BM, Frey FJ: Furosemide inhibits 11β-hydroxysteroid dehydrogenase in vitro and in vivo. Endocrinology 136: 1759-1765, 1995
5. Escher G, Nawrocki A, Staub T, Vishwanath BS, Frey BM, Reichen J, Frey FJ: Down-regulation of hepatic and renal 11β-hydroxysteroid dehydrogenase in rats with liver cirrhosis. Gastroenterology 114: 175-184, 1998
6. Kirkman S, Nelson DH: Alcohol-induced pseudo-Cushing's disease: a study of prevalence with review of the literature. Metabolism 37: 390-394, 1988
7. Luppa P, Müller B, Jacob K, Kimmig R, Strowitzki T, Hoess C, Weber MM, Engelhardt D, Lobo RA: Variations of steroid hormone metabolites in serum and urine in polycystic ovary syndrome after nafarelin stimulation: evidence for an altered corticoid excretion. J Clin Endocrinol Metab 80: 280-288, 1995
8. Mantero F, Palermo M, Petrelli MD, Tedde R, Stewart PM, Shackleton CHL: Apparent mineralocorticoid excess: type I and type II. Steroids 61: 193-196, 1996
9. McCann VJ, Fulton TT: Cortisol metabolism in chronic liver disease. J Clin Endocrinol Metab 40: 1038-1044, 1975
10. Niederberger M, Schrier RW: Pathogenesis of sodium and water retention in liver disease. Prog Liver Dis 10: 329-347, 1992
11. Phillipov G: Effect of hypercortisolism and ACTH on the metabolism of cortisol. Exp Clin Endocrinol Diabetes 106: 57-60, 1998
12. Stewart PM, Burra P, Shackleton CHL, Sheppard MC, Elias E: 11β-hydroxysteroid dehydrogenase deficiency and glucocorticoid status in patients with alcoholic and non-alcoholic chronic liver disease. J Clin Endocrinol Metabol 76: 748-751, 1993.
13. Teelucksingh S, Mackie ADR, Burt D, McIntyre MA, Brett L, Edwards CRW: Potentiation of hydrocortisone activity in skin by glycyrrhetinic acid. Lancet 335: 1060-1063, 1990
14. Ulick S, Tedde R, Wang JZ: Defective ring A reduction of cortisol as the major metabolic error in the syndrome of apparent mineralocorticoid excess. J Clin Endocrinol Metabol 74: 593-599, 1992.
15. Walker BR, Yau JL, Brett LP: 11β-hydroxysteroid dehydrogenase in vascular smooth muscle and heart: Implications for cardiovascular response to glucocorticoids. Endocrinology 129: 3305-3312, 1991
16. Whitworth JA, Stewart PM, Burst D, Atherden SM, Edwards CRW: The kidney is the major site of cortisone production in man. Clin Endocrinol 31: 355-361, 1989
17. Zumoff B, Bradlow L, Gallagher TF, Hellman L: Cortisol metabolism in cirrhosis. J Clin Invest 46: 1735-1743, 1967