Lipolytic response during spontaneous hypoglycaemia in insulin-dependent diabetic subjects

Hormone and Metabolic Research

Volumn 30, Issue 9, 1998, Pages 586-593

  Hagstrom Toft E ^a   Hellstrom L ^a   Moberg, E ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Free fatty acids; Glycerol; Insulin; Lipolysis; Microdialysis

Indexed keywords

FATTY ACID; GLUCOSE; GLYCEROL;

ADULT; ARTICLE; CLINICAL ARTICLE; FEMALE; HOME MONITORING; HUMAN; HYPOGLYCEMIA; INSULIN DEPENDENT DIABETES MELLITUS; LIPOLYSIS; MALE; MICRODIALYSIS; PRIORITY JOURNAL; SUBCUTANEOUS FAT; VENOUS BLOOD;

EID: 0031721175     PISSN: 00185043     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2007-978938     Document Type: Article

References (37)

1. The Diabetes Control and Complication Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med 1993; 329: 977-86
2. Cryer PE, Binder C, Bolli GB, Cherrington AD, Gale EA, Gerich JE, Sherwin RS. Hypoglycemia in IDDM. Conference Summary. Diabetes 1989; 38: 1193-9
3. Arias P, Kerner W, Zier H, Navascues I, Pfeiffer E. Incidence of hypoglycemic episodes in diabetic patients under continuous subcutaneous insulin infusion and intensified conventional insulin treatment: assessment by means of semi-ambulatory, 24-hour, continuous blood glucose monitoring. Diabetes Care 1985; 8: 134-40
4. Bolli G, DeFeo P, Cartechini MG, Anfeletti G, Santeusanio F, Brunetti P. Important role of adrenergic mechanism in acute glucose counterregulation following insulin-induced hypoglycemia in type 1 diabetes: evidence for an effect mediated by beta-adrenoceptors. Diabetes 1982; 31: 641-7
5. DeFeo P, Bolli G, De Cosmo SD, et al. The adrenergic contribution to glucose counterregulation in type 1 diabetes mellitus: dependence on A-cell function and mediation through beta-adrenergic receptors. Diabetes 1983; 32: 887-93
6. DeFeo P, Perriello G, Torlone E, Fanelli C, Ventura MM, Santeusanio F, et al. Contribution of adrenergic mechanisms to glucose counterregulation in humans. AJ Physiol 1991; 261: E725-E736
7. Gerich J, Langlois M, Noacco C, Karam J, Forsham P. Lack of glucagon response to hypoglycemia in diabetes: evidence for an intrinsic pancreatic alpha-cell defect. Science 1973; 182: 171-3
8. Bolli G, DeFeo P, Compagnucci M, Cartechini MG, Angeletti G, Santeusanio F, et al. Abnormal glucose counterregulation in insulin-dependent diabetes mellitus: interaction of anti-insulin antibodies and impaired glucagon and epinephrine secretion. Diabetes 1983; 32: 134-41
9. Bolli GB, Dimitriades GD, Pehling GB, Baker B, Haymond M, Cryer P, Gerich JE. Abnormal glucose counterregulation after subcutaneous insulin in insulin-dependent diabetes mellitus. N Engl J Med 1984; 310: 1706-11
10. Rizza R, Cryer P, Haymond M, Gerich JE. Adrenergic mechanisms for the effects of epinephrine on glucose production and clearance in man. J Clin Invest 1980; 65: 682-9
11. Garber AJ, Cryer PE, Santiago JV, Haymond MW, Pagliara AS, Kipnis DM. The role of adrenergic mechanisms in the substrate and hormonal response to insulin-induced hypoglycemia in man. J Clin Invest 1976; 58: 7-15
12. Fanelli CG, DeFeo P, Porcellati F, Periello G, Torlone E, Saneusanio F, Brunetti P, Bolli GB. Adrenergic mechanisms contribute to the late phase of hypoglycemic glucose counterregulation in humans by stimulating lipolysis. J Clin Invest 1992; 89: 2005-13
13. DeFeo P, Perriello G, De Cosmo S, Ventura MM, Campbell PJ, Brunetti P, Gerich JE, Bolli GB. Comparison of glucose counterregulation during short-term and prolonged hypoglycemia in normal humans. Diabetes 1986; 35: 563-9
14. Bolinder J, Ungerstedt U, Arner P. Microdialysis measurement of the absolute glucose concentration in subcutaneous adipose tissue allowing glucose monitoring in diabetic patients. Diabetologia 1992; 35: 1177-80
15. Bolinder J, Ungerstedt U, Arner P. Long-term continuous glucose monitoring with microdialysis in ambulatory insulin-dependent diabetic patients. Lancet 1993; 342: 1080-5
16. Bolinder J, Sjöberg S, Arner P. Stimulation of adipose tissue lipolysis following insulin-induced hypoglycaemia: evidence of increased beta-adrenoceptor-mediated lipolytic response in IDDM. Diabetologia 1996; 39: 845-54
17. Tossman U, Ungerstedt U. Microdialysis in the study of extracellular levels of amino acids in the rat brain. Acta Physiol Scand 1986; 128: 9-14
18. Lafontan M, Arner P. Application of in situ microdialysis to measure metabolic and vascular responses in adipose tissue. Trends Pharmacol Sci 1996; 17: 309-13
19. Fischer U, Ertle R, Abel P, Rebrin K, Brunsten E, Hahn von Dorsche H, Freyse EJ. Assessment of subcutaneous glucose concentration: validation of the wick technique as a reference for implanted electrochemical sensors in normal and diabetic dogs. Diabetologia 1987; 30: 940-5
20. Lönnroth P, Jansson P-A, Smith U. A microdialysis method allowing characterization of intercellular water space in humans. AJ Physiol 1987; 253: E228-31
21. Kaddish AH, Little RL, Sternberg JC. A new and rapid method for the determination of glucose by measurement of the rate of oxygen consumption. Clin Chem 1968; 14: 116-31
22. Hellmér J, Arner P, Lundin A. Automatic luminometric kinetic assay of glycerol for lipolysis studies. Analyt Biochem 1989; 177: 132-7
23. Schmidt FJ, Sluiter WJ, Schoonen AJM. Glucose concentration in subcutaneous extracellular space. Diabetes Care 1993; 16: 695-700
24. Sternberg F, Meyerhoff C, Mennel FJ, Bischof F, Pfeiffer EF. Subcutaneous glucose concentration in humans. Diabetes Care 1995; 18: 1266-9
25. Coppack SW, Fisher RM, Gibbons GF, Humphreys SM, Donough MJM, Potts JL, Frayn KN. Postprandial substrate deposition in human forearm and adipose tissues in vivo. Clin Sci 1990; 79: 339-48
26. Hagström-Toft E, Enoksson S, Moberg E, Bolinder J, Arner P. Absolute concentrations of glycerol and lactate in human skeletal muscle, adipose tissue, and blood. Am J Physiol 1997; 273: E584-92
27. Moberg E, Hagström-Toft E, Bolinder J. Protracted glucose fall in subcutaneous adipose tissue and skeletal muscle compared with blood during insulin-induced hypoglycaemia. Diabetologia 1997; 40: 1320-6
28. Lönnroth P, Jansson P-A, Smith U. A microdialysis method allowing characterization of intercellular water space in humans. Am J Physiol 1987; 253: E228-31
29. Bolinder J, Hagström-Toft E, Ungerstedt U, Arner P. Self-monitoring of blood glucose in type-1 diabetic patients: comparison with continuous microdialysis measurements of glucose in subcutaneous adipose tissue during ordinary life conditions. Diab Care 1997; 20: 64-70
30. DeFeo P, Periello G, De Cosmo SD, Ventura MM, Torlone E, Fanelli C. Adrenergic mechanisms do not contribute to glucose counterregulation during acute insulin-induced hypoglycemia in normal man. Diabetes Nutr Metab 1989; 2: 111-8
31. Newrick PG, Braatvedt G, Stansbie D, Corral RJM. Suppression of lipolysis in normal man does not inhibit recovery from insulin-induced hypoglycemia. Europ J Clin Invest 1993; 23: 53-6
32. Rizza RA, Cryer PE, Gerich JE. Role of glucagon, catecholamines, and growth hormone in human glucose counterregulation: effects of somatostatin and combined alpha- and beta-adrenergic blockade on plasma glucose recovery and glucose flux rates after insulin-induced hypoglycemia. J Clin Invest 1979; 64: 62-71
33. DFronzo RA, Hendler R, Christensen N. Stimulation of counterregulatory hormonal responses in diabetic man by a fall in glucose concentration. Diabetes 1980; 29: 125-31
34. Boyle PJ, Schwarts NS, Shah SD, Clutter WE, Cryer PE. Plasma glucose concentrations at the onset of hypoglycemic symptoms in patients with poorly controlled diabetes and in nondiabetics. N Engl J Med 1988; 318: 1487-92
35. Amiel S, Tamborlane WV, Simonson DC, Scherwin RS. Defective glucose counterregulation after strict glycemia control of insulin-dependent diabetes mellitus. N Engl J Med 1987; 316: 1376-83
36. Fernqvist-Forbes E, Linde B, Gunnarsson R. Insulin absorption and subcutaneous blood flow in normal subjects during insulin-induced hypoglycemia. J Clin Endocrinol Metab 1988; 67: 619-23
37. Fernqvist-Forbes E, Gunnarsson R, Linde B. Insulin-induced hypoglycemia and absorption of injected insulin in diabetic patients. Diabetic Med 1989; 6: 621-6