Evaluation of iron status in patients with chronic hepatitis C

Italian Journal of Gastroenterology and Hepatology

Volumn 30, Issue 4, 1998, Pages 396-401

  Sartori, M ^a,b   La Terra, G ^a   Boldorini, R ^a   Leone, F ^a   Pittau, S ^a   Zecchina, G ^a   Aglietta, M ^a   Saglio, G ^a  

^a UNIVERSITY OF TURIN   (Italy)

^b MAGGIORE DELLA CARITÀ HOSPITAL   (Italy)

Author keywords

Haemochromatosis; Hepatitis C; Iron; Liver fibrosis

Indexed keywords

AMINOTRANSFERASE; FERRITIN; HEPATITIS C ANTIGEN; IRON; MARKER;

ADULT; AGED; AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; BETA THALASSEMIA; CHRONIC HEPATITIS; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; FERRITIN BLOOD LEVEL; GENE MUTATION; HEMOCHROMATOSIS; HEPATITIS C; HEPATITIS C VIRUS; HETEROZYGOSITY; HUMAN; HUMAN TISSUE; IRON BINDING CAPACITY; IRON BLOOD LEVEL; IRON METABOLISM; IRON OVERLOAD; IRON STORAGE; LIVER BIOPSY; LIVER FIBROSIS; LIVER HISTOLOGY; MAJOR CLINICAL STUDY; MALE; VIRAL GENETICS;

ANALYSIS OF VARIANCE; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FERRITINS; HEPATITIS C, CHRONIC; HUMANS; IRON; IRON OVERLOAD; LIVER; LIVER CIRRHOSIS; MALE; MIDDLE AGED; POLYMERASE CHAIN REACTION; PREVALENCE; REGRESSION ANALYSIS; RNA, VIRAL; TRANSAMINASES;

EID: 0031719561     PISSN: 11258055     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Di Bisceglie AM, Axiotis CA, Hoofnagle JH, Bacon BR. Measurements of iron status in patients with chronic hepatitis. Gastroenterology 1992;102:2108-13.
2. Britton RS, Bacon BR, Ricknagel RO. Lipid peroxidation and associated hepatic organelle dysfunction in iron overload. Chem Phys Lipids 1987;45:207-39.
3. Caraceni P, Fagiuoli S. Iron reduction therapy: simply camouflage, or a real weapon? Am J Gastroenterol 1994;89:970-2.
4. Van Thiel DH, Friedlander L, Fagiuoli S, Wright HI, Irish W, Gavaler JS. Response to interferon alpha therapy is influenced by the iron content of the liver. J Hepatol 1994;20:410-5.
5. Olynyk JK, Reddy KR, Di Bisceglie AM, Jeffers LJ, Parker TI, Radick JL, et al. Hepatic iron concentration as a predictor of response to interferon alfa therapy in chronic hepatitis C. Gastroenterology 1995; 108:1104-9.
6. Van Thiel DH, Friedlander L, Molloy P, Kania RJ, Fagiuoli S, Wright HI, et al. Retreatment of hepatitis C interferon non-responders with larger doses of interferon with or without phlebotomy. Hepatogastroenterology 1996;43:1557-61.
7. Barton AL, Banner BF, Cable EE, Bonkovsky HL. Distribution of iron in the liver predicts the response of chronic hepatitis C infection to interferon therapy. Am J Clin Pathol 1995;103:419-24.
8. Arber N, Moshkowitz M, Konikoff F, Halpern Z, Hallak A, Santo M, et al. Elevated serum iron predicts poor response to interferon treatment in patients with chronic HCV infection. Dig Dis Sei 1995;40:2431-3.
9. Andreone P, Gramenzi A, Cursaro C, Buzzi A, Semerard R, Sica G, et al. Serum iron status and response to interferon alpha in patients with HCV chronic active hepatitis. Gastroenterology 1994;104:A859.
10. Girelli CM, Mirata C, Lesinigo E, Casiraghi A. Iron overload and response to interferon alpha in chronic hepatitis C. Am J Gastroenterol 1995 ;90:170-1.
11. Piperno A, Sampietro M, D'AIba R, Roffi L, Fargion S, Parma S, et al. Iron stores, response to alpha-interferon therapy, and effects of iron depletion in chronic hepatitis C. Liver 1996;16:248-54.
12. Hayashi H, Takikawa T, Nishimura N, Yano M, Isomura T, Sakamoto N. Improvement of serum aminotransferase levels after phlebotomy in patients with chronic active hepatitis C and excess hepatic iron. Am J Gastroenterol 1994;89:986-8.
13. Bacon BR, Rebholz AE, Fried M, Di Bisceglie AM. Beneficial effect of iron reduction therapy in patients with chronic hepatitis C who failed to respond to interferon-alpha. Hepatology 1993;18:150A.
14. Takikawa T, Hayashi H, Nishimura N, Yano M, Isomura T, Sakamoto N. Correlation between serum levels of alanine aminotransferase and ferritin in male blood donors with antibody to hepatitis C virus. J Gastroenterol 1994;29:593-7.
15. Hudes BK, Fabry TL, Klion FM. Hepatic iron metabolism in chronic hepatitis C. Hepatology 1992;16:A206.
16. Pipcmo A, D'AIba R, Fargion S, Roffi L, Samoietro M, Parma S, et al. Liver iron concentration in chronic viral hepatitis: a study of 98 patients. Eur J Gastroenterol Hepatol 1995;7:1203-8.
17. Stuyver L, Rossau R, Wyseur A, Duhamel M, Vanderborght B, Van Heuverswyn H, et al. Typing of hepatitis C virus isolates and characterization of new subgenotypes using a line probe assay. J GenVirol 1993;74:1093-102.
18. Simmonds P, Albert! A, Alter HJ, Bonino F, Bradley D.W, Bréchot C, et al. A proposed system for the nomenclature of hepatitis C viral genotypes. Hepatology 1994; 19:1321-4 (letter).
19. Ishak K, Baptista A, Bianchi L, Callea F, De Groote J, Guadat F, et al. Histological grading and staging of chronic hepatitis. J Hepatol 1995;22:696-9.
20. Searle JW, Kerr JFR, Halliday JW, Powell LW. Iron storage disease. In MacSween RNM, Antony PP, Scheuer PJ, editors. Pathology of the liver. 3rd ed. Edinburgh: Churchill Livingstone, 1994:223-4.
21. Carella M, D'Ambrosio L, Totaro A, Grifa A, Valentino MA, Piperno A, et al. Mutation analysis of the HLA-H gene in Italian hemochromatosis patients. Am J Hum Genet 1997; 60:828-32.
22. Cuzick J. A Wilcoxon-Type test for trend. Stat Med 1985;4:87-90.
23. Riggio O, Montagnese F, Fiore P, Folino S, Giambartolomei S, Gandin C, et al. Iron overload in patients with chronic viral hepatitis: How common is it? Am J Gastroenterol 1997;92:1298-301.
24. Bonkovsky HL, Banner BF, Rothman AL. Iron and chronic viral hepatitis. Hepatology 1997;25:759-68.
25. Farber JL. Mechanisms of cell injury by activated oxygen species. Environ Health Perspect 1994;102(Suppl 10):17-24.
26. Brock JH, Djeha A.'lsmail M, Oria R, Sinclair RH. Cellular responses to iron and iron compounds. Adv Exp ' Med Biol 1994;356:91-100.
27. Kühn LC. Molecular regulation of iron proteins. Ballieres Clin Haematol 1994;7:763-85
28. Martins EA, Robalinho RL, Meneghini R. Oxidative stress induces activation of a cytosolic protein responsible for control of iron uptake. Arch Biochem Biophys 1995:316:128-34.
29. Cairo G, Tacchini L, Pogliaghi G, Anzon E, Tomasi A, Bemelli Zazzera A. Induction of ferritin synthesis by oxidative stress. Transcriptional and post-transcriptional regulation by expansion of the "free" iron pool. J Biol Chem 1995;270:700-3.
30. Beinker NK, Voigt MD, Arendse M, Smit J, Stander IA, Kirsch RE. Threshold effect of liver iron content on hepatic inflammation and fibrosis in hepatitis B and C. J Hepatol 1996;25:633-8.
31. Ikura Y, Morimoto H, Johmura H, Fukui M, Sakurai M. Relationship between hepatic iron deposits and response to interferon . in chronic hepatitis C. Am J Gastroenterol 1996;91:1367-73.
32. Izumi N, Enomoto N, Uchihara M, Murakami T, Ono K, Noguchi O, et al. Hepatic iron contents and response to interferon-alpha in patients with chronic hepatitis C. Relationship to genotypes of hepatitis C virus. Dig Dis Sei 1996;41:989-94.
33. Kato S, Arao M, Kuriri J, Yagaya T, Takiya S, Kato K, et al. Biochemical improvement of chronic hepatitis C after gastrointestinal bleeding. Nagoya J Med Sei 1994;57:153-7.