Alterations of p53 gene and Ha-ras gene are independent events in solar keratosis and squamous cell carcinoma

Pathology International

Volumn 48, Issue 9, 1998, Pages 689-694

  Taguchi, Masahito ^a   Tsuchida, Tetsuya ^a   Ikeda, Shigeo ^a   Sekiya, Takao ^b  

^a SAITAMA MEDICAL UNIVERSITY   (Japan)

^b NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

Author keywords

p53 gene; Polymerase chain reaction single strand conformation polymorphism; Ras gene; Solar keratosis; Squamous cell carcinoma; Ultraviolet carcinogenesis

Indexed keywords

DNA; PROTEIN P53;

ACTINIC KERATOSIS; ARTICLE; CLINICAL ARTICLE; GENE MUTATION; HUMAN; HUMAN TISSUE; ONCOGENE H RAS; POINT MUTATION; PRIORITY JOURNAL; SINGLE STRAND CONFORMATION POLYMORPHISM; SKIN CARCINOGENESIS; SKIN CARCINOMA; SQUAMOUS CELL CARCINOMA; TUMOR SUPPRESSOR GENE; ULTRAVIOLET IRRADIATION;

EID: 0031719242     PISSN: 13205463     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1440-1827.1998.tb03969.x     Document Type: Article

References (38)

1. Glass AG, Hoover RN. The emerging epidemic of melanoma and squamous cell skin cancer. J. Am. Med. Assoc. 1989; 262: 2097-2100.
2. Brash DE, Rudolph JA, Simon JA et al. A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma. Proc. Natl Acad. Sci. USA 1991; 88: 10124-10128.
3. Pierceall WE, Mukhopadhyay T, Goldberg LH, Ananthaswamy HN. Mutations in the p53 tumor suppressor gene in human cutaneous squamous cell carcinomas. Mol. Carcinog. 1992; 4: 445-449.
4. Molés J-P, Moyret C, Guillot B et al. p53 gene mutations in human epithelial skin cancers. Oncogens 1993; 8: 583-588.
5. Miller JH. Mutagenic specificity of ultraviolet light. J. Mol. Biol. 1985; 182: 45-68.
6. Brash DE, Seetharam S, Kraemer KH, Seidman MM, Bredberg A. Photoproduct frequency is not the major determinant of UV base substitution hot spots or cold spots in human cells. Proc. Natl Acad. Sci. USA 1987; 84: 3782-3786.
7. Drobetsky EA, Grosovsky AJ, Glickman BW. The specificity of UV-induced mutations at an endogenous locus in mammalian cells. Proc. Natl Acad. Sci. USA 1987; 84: 9103-9107.
8. McGregor WG, Chen R-H, Lukash L, Maher VM, McCormick JJ. Cell cycle-dependent strand bias for UV-induced mutations in the transcribed strand of excision repair-proficient human fibroblasts but not in repair-deficient cells. Mol. Cell. Biol. 1991; 11: 1927-1934.
9. Lever WF, Lever GS, eds. Histopathology of the Skin, 7th edn. JB Lippincott Co., Philadelphia, 1990.
10. Mercer WE, Avignolo C, Baserga R. Role of p53 protein in cell proliferation as studied by microinjection of monoclonal antibodies. Mol Cell. Biol. 1984; 4: 276-282.
11. Finlay CA, Hinds PH, Levine AJ. The p53 proto-oncogene can act as a suppressor of transformation. Cell 1989; 57: 1083-1093.
12. Taguchi M, Watanabe S, Yashima K, Murakami Y, Sekiya T, Ikeda S. Aberrations of the tumor suppressor p53 gene and p53 protein solar keratosis in human skin. J. Invest. Dermatol. 1994; 103: 500-503.
13. Campbell C, Quinn AG, Ro Y-S, Angus B, Rees JL. p53 Mutations are common and early events that precede tumor invasion in squamous cell neoplasia of the skin. J. Invest. Dermatol. 1993; 100: 746-748.
14. Gerrit van der Schroeff J, Evers LM, Boot AJM, Bos JL. Ras oncogene mutations in basal cell carcinomas and squamous cell carcinomas of human skin. J. Invest. Dermatol. 1990; 94: 423-425.
15. Pierceall WE, Goldberg LH, Tainsky MA, Mukhopadhyay T, Ananthaswamy HN. Ras gene mutation and amplification in human non-melanoma skin cancers. Mol. Carcinog. 1991; 3: 196-202.
16. Leon J, Kamino H, Steinberg JJ, Pellicer A. H-ras activation in benign and self-regressing skin tumors (keratoacanthomas) in both humans and an animal model system. Mol. Cell. Biol. 1988; 8: 786-793.
17. Burns PA, Kemp CJ, Gannon JV, Lane DP, Bremner R, Balmain A. Loss of heterozygosity and mutational alterations of the p53 gene in skin tumours of interspecific hybrid mice. Oncogene 1991; 6: 2363-2369.
18. Orita M, Iwahana H, Kanazawa H, Hayashi K, Sekiya T. Detection of polymorphisms of human DNA by gel electrophoresis as single-strand conformation polymorphisms. Proc. Natl Acad. Sci. USA 1989; 86: 2766-2770.
19. Sato Y, Mukai K, Watanabe S, Gotoh M, Shimosato Y. The AMeX method: A simplified technique of tissue processing and paraffin embedding with improved preservation of antigens for immunostaining. Am. J. Pathol. 1986; 125: 431-435.
20. Goelz SE, Hamilton SR, Vogelstein B. Purification of DNA from formaldehyde-fixed and paraffin-embedded human tissue. Biochem. Biophys. Res. Commun. 1985; 130: 118-126.
21. Saiki RK, Gelfand DH, Stoffel S et al. Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. Science 1988; 239: 487-491.
22. Murakami Y, Hayashi K, Hirohashi S, Sekiya T. Aberrations of the tumor suppressor p53 and retinoblastoma genes in human hepatocellular carcinomas. Cancer Res. 1991; 51: 5520-5525.
23. Hayashi K, Orita M, Suzuki Y, Sekiya T. Use of labeled primers in polymerase chain reaction (LP-PCR) for a rapid detection of the product. Nucl. Acid Res. 1989; 17: 3605.
24. Taguchi M, Watanabe S, Sato Y et al. Immunohistochemical examination of tumor-suppressor gene p53 product and pyrimidine dimer in solar keratosis. J. Cancer Res. Clin. Oncol. 1993; 119: 260-262.
25. Ananthaswamy HN, Pierceall WE. Molecular mechanisms of ultraviolet radiation carcinogenesis. Photochem. Photobiol. 1990; 52: 1119-1136.
26. Bermner R, Balmain A. Genetic changes in skin tumor progression: Correlation between presence of a mutant ras gene and loss of heterozygosity on mouse chromosome 7. Cell 1990; 61: 407-417.
27. Blanchi AB, Navone NM, Aldaz CM, Conti CJ. Overlapping loss of heterozygosity by mitotic recombination on mouse chromosome 7F1-ter in skin carcinogenesis. Proc. Natl Acad. Sci. USA 1991; 88: 7590-7594.
28. Greenhalgh DA, Welty DJ, Strickland JE, Yuspa SH. Spontaneous Ha-ras gene activation in cultured primary murine keratinocytes: Consequences of Ha-ras gene activation in malignant conversion and malignant progression. Mol. Carcinog. 1989; 2: 199-207.
29. Roop DR, Lowy DR, Tambourin PE et al. An activated Harvey ras oncogene produces benign tumours on mouse epidermal tissue. Nature 1986; 323: 822-824.
30. Campbell C, Quinn AG, Rees JL. Codon 12 Harvey-ras mutations are rare events in non-melanoma human skin cancer. Br. J. Dermatol. 1993; 128: 111-114.
31. Ziegler A, Jonason AS, Leffell DJ et al. Sunburn and p53 in the onset of skin cancer. Nature 1994; 372: 773-776.
32. Rideout WM III, Coetzee GA, Olumi AF, Jones PA. 5-Methylcytosine as an endogenous mutagen in the human LDL receptor and p53 genes. Science 1990; 249: 1288-1290.
33. Ziegler A, Jeffell DJ, Kunala S et al. Mutation hotspots due to sunlight in the p53 gene of non-melanoma skin cancers. Proc. Natl Acad. Sci. USA 1993; 90: 4216-4220.
34. Hollstein M, Sidransky D, Vogelstein B, Harris CC. p53 Mutations in human cancers. Science 1991; 253: 49-53.
35. Kemp CJ, Donehower LA, Bradley A, Balmain A. Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors. Cell 1993; 74: 813-822.
36. Bell SM, Scott N, Cross D et al. Prognostic value of p53 overexpression and c-Ki-ras gene mutations in colorectal cancer. Gastroenterol. 1993; 104: 57-64.
37. Laurent-Puig P, Delattre O, Olschwang S et al. A joint study of the Ki-ras oncogene and overexpression of the Tp53 oncogene in colorectal cancer. Gastroenterol. Clin. Biol. 1990; 14: 347-351.
38. Wyllie AH, Lang S, Purdie CA, Evans I, Bird CC. p53 and Ki-ras oncogenes do not co-operate in human colorectal carcinogenesis (abstract). J. Pathol. 1991; 169.