Occurrence of toxicity and cell proliferation after a single gavage administration of chloroform to male F344 rats

Journal of Toxicological Sciences

Volumn 23, Issue 3, 1998, Pages 205-211

  Miyagawa, Makoto ^a   Katsuta, Osamu ^a   Chida, Tetsuo ^a   Toyota, Naoto ^a   Tsuchitani, Minoru ^a   Yoshikawa, Kunie ^a   Fujii, Osamu ^a  

^a MITSUBISHI CHEMICAL CORPORATION   (Japan)

Author keywords

Chloroform; Hepatotoxicity; Male F344 rat; Nephrotoxicity; Nongenotoxic carcinogen; Replicative DNA synthesis(RDS)

Indexed keywords

CHLOROFORM;

ANIMAL CELL; ARTICLE; CARCINOGENICITY; CELL PROLIFERATION; DNA SYNTHESIS; GENOTOXICITY; LIVER TOXICITY; MALE; NEPHROTOXICITY; NONHUMAN; RAT;

ANIMALIA; BACTERIA (MICROORGANISMS); MAMMALIA; RODENTIA;

EID: 0031718548     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.23.3_205     Document Type: Article

References (31)

1. Bottaro, D. P., Rubin, J. S., Faletto, D. L., Chan, A. M.-L., Kmiecik, T. E., VandeWoude, G. F. and Aaronson, S. A. (1991): Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product. Science, 251, 802-804.
2. Bunn, W. W., Haas, B. B., Deane, E. R. and Kleopfer, R. D. (1975): Formation of trihalomethanes by chlorination of surface water. Environ. Lett., 10, 205-213.
3. Counts, J. L. and Goodman, J. I. (1995): Hypomethylation of DNA: A nongenotoxi cmechanism involved in tumor promotion. Toxicol. Lett., 82/83, 663-672.
4. Diaz Gomez, M.I. and Castro, J. A. (1980): Covalent binding of chloroform metabolites to nuclear proteins - No evidence for binding to nucleic acids. Cancer Lett., 9, 213-218.
5. DiRenzo, A. B., Gandolfi, A. J. and Sipes, I. G. (1982): Microsomal bioactivation and covalent binding of aliphatic halides to DNA. Toxicol. Lett., 11, 243-252.
6. Eschenbrenner, A. B. and Miller, E. (1945): Induction of hepatomas in mice by repeated oral administration of chloroform, with observations on sex differences. J. Natl. Cancer Inst., 5, 251-255.
7. Goodman, J. I. and Counts, J. L. (1993): Hypomethylation of DNA: A possible nongenotoxic mechanism underlying the role of cell proliferation in carcinogenesis. Environ. Health Perspect., 101 (Suppl. 5), 169-172.
8. Harris, C. C. (1995): 1995 Deichmann lecture - p53 tumor suppressor gene: At the crossroads of molecular carcinogenesis, molecular epidemiology and cancer risk assessment. Toxicol. Lett., 82/83, 1-7.
9. IARC (1979): IARC monographs on the evaluation of the carcinogenic risk of chemicals: Chloroform, IARC Monogr., 20, 401-427.
10. Ilett, K. F., Reid, W. D., Sipes, I. G. and Krishna, G. (1973): Chloroform toxicity in mice: Correlation of renal and hepatic necrosis with covalent binding of metabolites to tissue macromolecules. Exp. Mol. Pathol., 19, 215-229.
11. Ishidate Jr., M., Harnois, M. C. and Sofuni, T. (1988): A comparative analysis of data on the clastogenicity of 951 chemical substances tested in mammalian cell cultures. Mutation Res., 195, 151-213.
12. Jorgenson, T. A., Meierhenry, E. F., Rushbrook, C. J., Bull, R. J. and Robinson, M. (1985): Carcinogenicity of chloroform in drinking water to male Osborne-Mendel rats and female B6C3F1 mice. Fundam. Appl. Toxicol., 5, 760-769.
13. Kinoshita, T., Tashiro, K. and Nakamura, T. (1989): Marked increase of HGF mRNA in nonparenchymal liver cells of rats treated with hepatotoxins. Biochem. Biophys. Res. Commun., 165, 1229-1234.
14. Kono, S., Nagaike, M., Matsumoto, K. and Nakamura, T. (1992): Marked induction of hepatocyte growth factor mRNA in intact kidney and spleen in response to injury of distant organs. Biochem. Biophys. Res. Commun., 186, 991-998.
15. Larson, J. L., Wolf, D. C. and Butterworth, B. E. (1993): Acute hepatotoxic and nephrotoxic effects of chloroform in male F-344 rats and female B6C3F1 mice. Fundam. Appl. Toxicol., 20, 302-315.
16. Levine, A. J., Momand, J. and Finlay, C. A. (1991): The p53 tumour suppressor gene. Nature, 351, 453-456.
17. Marks, F. and Furstenberger, G. (1993): Proliferative responses of the skin to external stimuli. Environ. Health Perspect., 101 (Suppl. 5), 95-102.
18. Miyagawa, M., Takasawa, H., Sugiyama, A., Inoue, Y., Murata, T., Uno, Y. and Yoshikawa, K. (1995): The in vivo-in vitro replicative DNA synthesis (RDS) test with hepatocytes prepared from male B6C3F1 mice as an early prediction assay for putative nongenotoxic (Ames-negative) mouse hepatocarcinogens. Mutat. Res., 343, 157-183.
19. Miyagawa, M., Katsuta, O., Tsuchitani, M. and Yoshikawa, K. (1997): Measurement of replicative DNA synthesis (RDS) by a 5-bromo-2′-deoxyuridine (BrdU) labeling technique for detection of hepatocyte proliferation. J. Vet. Med. Sci., 59, 45-49.
20. Pohl, L.R., Bhooshan, B., Whittaker, N. F. and Krishna, G. (1977): Phosgene: A metabolite of chloroform. Biochem. Biophys. Res. Commun.,79, 684-691.
21. Razin, A. and Cedar, H. (1991): DNA methylation and gene expression. Microbiol. Rev., 55, 451-458.
22. Roe, F. J. C., Palmer, A. K.,Worden, A. N. and Van Abbe, N. J. (1979): Safety evaluation of toothpaste containing chloroform. I . Long-term studies in mice. J. Environ. Pathol. Toxicol., 2, 799-819.
23. Snedecor, G. W. and Cochran, W. G. (1967): Statistical methods, 6th ed., pp. 246-284. Iowa state University Press, Ames, Iowa.
24. Szyf, M. (1994): DNA methylation properties: Consequences for pharmacology. Trends Pharmacol. Sci., 15, 233-238.
25. Taya, Y. (1997): RB kinases and RB-binding proteins: New points of view. Trends Biochem. Sci., 22, 14-17.
26. Uehleke, H., Werner, T., Greim, H. and Kramer, M. (1977): Metabolic activation of haloalkanes and tests in vitro for mutagenicity. Xenobiotica, 7, 393-400.
27. Uno, Y., Takasawa, H., Miyagawa, M., Inoue, Y., Murata, T., Ogawa, M. and Yoshikawa, K. (1992a): In vivo-in vitro replicative DNA synthesis (RDS) test using perfused rat livers as an early prediction assay for nongenotoxic hepatocarcinogens: II. Establishment of a standard protocol. Toxicol. Lett., 63, 191-199.
28. Uno, Y, Takasawa, H., Miyagawa, M., Inoue, Y., Murata, T., Ogawa, M. andYoshikawa, K. (1992b): In vivo-in vitro replicative DNA synthesis (RDS) test using perfused rat livers as an early prediction assay for nongenotoxic hepatocarcinogens: II. Assessment of judgement criteria. Toxicol. Lett., 63, 201-209.
29. Uno, Y., Takasawa, H., Miyagawa, M., Inoue, Y., Murata, T. and Yoshikawa, K. (1994): An in vivo-in vitro replicative DNA synthesis (RDS) test using rat hepatocytes as an early prediction assay for nongenotoxic hepatocarcinogens: Screening of 22 known positives and 25 noncarcinogens. Mutat. Res., 320, 189-205.
30. Yoshikawa, K. (1995): Early induction of in vivo-in vitoro hepatocyte replicative DNA synthesis (RDS) by nongenotoxic and genotoxic hepatocarcinogens in male F344 rats and B6C3F1 mice. J. Toxicol. Pathol., 8, 291-302.
31. Yoshikawa, K. (1996): Anomalous nonidentity between Salmonella genotoxicants and rodent carcinogens: Nongenotoxic carcinogens and genotoxic noncarcinogens. Environ. Health Perspect., 104, 40-46.