Specific targeting of cytokine-secreting cells: A bispecific diabody recognizing human interleukin-6 and CD3 induces T cell-mediated killing

Journal of Interferon and Cytokine Research

Volumn 18, Issue 9, 1998, Pages 783-791

  Krebs, Barbara ^a,b   Ackermann, Birgit ^a   Rose John, Stefan ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b MORPHOSYS AG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIGEN; CYTOKINE; INTERLEUKIN 6;

ANTIBODY SPECIFICITY; ARTICLE; CELL DIFFERENTIATION; CELL KILLING; DRUG RECEPTOR BINDING; EFFECTOR CELL; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; IMMUNE RESPONSE; KILLER CELL; MOLECULAR RECOGNITION; PATHOPHYSIOLOGY; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; TARGET CELL; VIRUS PARTICLE;

EID: 0031717568     PISSN: 10799907     EISSN: None     Source Type: Journal    
DOI: 10.1089/jir.1998.18.783     Document Type: Article

References (44)

1. ARAI, K., LEE, F., MIYAJIMA, A., MIYATAKE, S., ARAI, N., and YOKOTA, T. (1990). Cytokines: coordinators of immune and inflammatory responses. Annu. Rev. Biochem. 59, 783-836.
2. KLEIN, B., ZHANG, X.G., JOURDAN, M., PORTIER, M., and BATAILLE, R. (1990). Interleukin-6 is a major myeloma cell growth factor In vitro and in vivo, especially in patients with terminal disease. Curr. Top. Microbiol. Immunol. 166, 23-31.
3. FELDMANN, M., BRENNAN, F.M., and MAINI, R.N. (1996). Role of cytokines in rheumatoid arthritis. Annu. Rev. Immunol. 14, 397-440.
4. KALLEN, K.-J., MEYER ZUM BÜSCHENFELDE, K., and ROSE-JOHN, S. (1997). The therapeutic potential of interleukin-6 hyperagonists and antagonists. Exp. Opin. Invest. Drugs 6, 237-266.
5. BAZAN, J.F. (1990). Hemopoietic receptors and helical cytokines. Immunol. Today 11, 350-354.
6. WELLS, J.A. (1996). Hematopoietic receptor complexes. Annu. Rev. Biochem. 65, 609-634.
7. TAGA, T., and KISHIMOTO, T. (1997). gp130 and the interleukin-6 family of cytokines. Annu. Rev. Immunol. 15, 797-819.
8. BAUER, J., and HERRMANN, F. (1991). Interleukin-6 in clinical medicine. Ann. Hematol. 62, 203-210.
9. AKIRA, S., TAGA, T., and KISHIMOTO, T. (1993). Interleukin-6 in biology and medicine. Adv. Immunol. 54, 1-78.
10. GAULDIE, J., RICHARDS, C., HARNISH, D., LANSDORP, P., and BAUMANN, H. (1987). Interferon beta 2/B-cell stimulatory factor type 2 shares identity with monocyte-derived hepatocyte-stimulating factor and regulates the major acute phase protein response in liver cells. Proc. Natl. Acad. Sci. USA 84, 7251-7255.
11. HIRANO, T., and KISHIMOTO, T. (1992). Molecular biology and immunology of interleukin-6. Res. Immunol. 143, 723-724.
12. KLEIN, B., WIJDENES, J., ZHANG, X.G., JOURDAN, M., BOIRON, J.M., BROCHIER, J., LIAUTARD, J., MERLIN, M., CLEMENT, C., MOREL FOURNIER, B., et al. (1991). Murine anti-interleukin-6 monoclonal antibody therapy for a patient with plasma cell leukemia. Blood 78, 1198-1204.
13. WENDLING, D., RACADOT, E., and WIJDENES, J. (1993). Treatment of severe rheumatoid arthritis by anti-interleukin 6 monoclonal antibodies. J. Rheumatol. 20, 259-262.
14. CASTELL, J., KLAPPROTH, J., GROSS, V., WALTER, E., ANDUS, T., SNYERS, L., CONTENT, J., and HEINRICH, P.C. (1990). Fate of interleukin-6 in the rat. Involvement of skin in its catabolism. Eur. J. Biochem. 189, 113-118.
15. BRAKENHOFF, J.P., DE HON, F.D., FONTAINE, V., TEN BOEKEL, E., SCHOOLTINK, H., ROSE-JOHN, S., HEINRICH, P.C., CONTENT, J., and AARDEN, L.A. (1994). Development of a human interleukin-6 receptor antagonist. J. Biol. Chem. 269, 86-93.
16. EHLERS, M., GRÖTZINGER, J., DEHON, F.D., MÜLLBERG, J., BRAKENHOFF, J.P., LIU, J., WOLLMER, A., and ROSE-JOHN, S. (1994). Identification of two novel regions of human IL-6 responsible for receptor binding and signal transduction. J. Immunol. 153, 1744-1753.
17. DEBETS, R., and SAVELKOUL, H.F. (1994). Cytokine antagonists and their potential therapeutic use. Immunol. Today 15, 455-458.
18. EHLERS, M., DE HON, F.D., BOS, H.K., HORSTEN, U., KURAPKAT, G., VAN DE LEUR, H.S., GRÖTZINGER, J., WOLLMER, A., BRAKENHOFF, J.P., and ROSE-JOHN, S. (1995). Combining two mutations of human interleukin-6 that affect gp130 activation results in a potent interleukin-6 receptor antagonist on human myeloma cells. J. Biol. Chem. 270, 8158-8163.
19. EHLERS, M., GRÖTZINGER, J., FISCHER, M., BOS, H.K., BRAKENHOFF, J.P.J., and ROSE-JOHN, S. (1996). Identification of single amino acid residues of human interleukin-6 involved in receptor binding and signal initiation. J. Interferon Cytokine Res. 16, 569-576.
20. SPORENO, E., SAVINO, R., CIAPPONI, L., PAONESSA, G., CABIBBO, A., LAHM, A., PULKKI, K., SUN, R.X., TONIATTI, C., KLEIN, B., and CILIBERTO, G. (1996). Human interleukin-6 receptor super-antagonists with high potency and wide spectrum on multiple myeloma cells. Blood 87, 4510-4519.
21. SIEGALL, C.B., CHAUDHARY, V.K., FITZGERALD, D.J., and PASTAN, I. (1988). Cytotoxic activity of an interleukin 6-Pseudomonas exotoxin fusion protein on human myeloma cells. Proc. Natl. Acad. Sci. USA 85, 9738-9742.
22. SIEGALL, C.B., FITZGERALD, D.J., and PASTAN, I. (1990). Selective killing of IL6 receptor bearing myeloma cells using recombinant IL6-Pseudomonas toxin. Curr. Top. Microbiol. Immunol. 166, 63-69.
23. KREITMAN, R.J., SIEGALL, C.B., FITZGERALD, D.J., EPSTEIN, J., BARLOGIE, B., and PASTAN, I. (1992). Interleukin-6 fused to a mutant form of Pseudomonas exotoxin kills malignant cells from patients with multiple myeloma. Blood 79, 1775-1780.
24. ASSENMACHER, M., SCHEFFOLD, A., SCHMITZ, J., SEGURA CHECA, J.A., MILTENYI, S., and RADBRUCH, A. (1996). Specific expression of surface interferon-gamma on interferon-gamma producing T cells from mouse and man. Eur. J. Immunol. 26, 263-267.
25. NEURATH, A.R., STRICK, N., and SPROUL, P. (1992). Search for hepatitis B virus cell receptors reveals binding sites for interleukin 6 on the virus envelope protein. J. Exp. Med. 175, 461-469.
26. NEURATH, R.A., STRICK, N., and LI, Y.-Y. (1992). Cells transfected with human interleukin 6 cDNA acquire binding sites for the hepatitis B virus envelope protein. J. Exp. Med. 176, 1561-1569.
27. RENNER, C., JUNG, W., SAHIN, U., DENFELD, R., POHL, C., TRUMPER, L., HARTMANN, F., DIEHL, V., VAN LIER, R., and PFREUNDSCHUH, M. (1994). Cure of xenografted human tumors by bispecific monoclonal antibodies and human T cells. Science 264, 833-835.
28. HOLLIGER, P., BRISSINCK, J., WILLIAMS, R.L., THIELEMANS, K., and WINTER, G. (1996). Specific killing of lymphoma cells by cytotoxic T-cells mediated by a bispecific diabody. Protein Eng. 9, 299-305.
29. KREBS, B., GRIIFIN, H., WINTER, G., and ROSE-JOHN, S. (1998). Recombinant human scFv antibodies recognizing human interleukin-6: specific targeting of cytokine secreting cells. J. Biol. Chem. 273, 2858-2865.
30. CLACKSON, T., HOOGENBOOM, H.R., GRIFFITHS, A.D., and WINTER, G. (1991). Making antibody fragments using phage display libraries. Nature 352, 624-628.
31. MACKIEWICZ, A., SCHOOLTINK, H., HEINRICH, P.C., and ROSE-JOHN, S. (1992). Complex of soluble human IL-6-receptor/IL-6 up-regulates expression of acute-phase proteins. J. Immunol. 149, 2021-2027.
32. SAMBROOK, J., FRITSCH, E.F., and MANIATIS, T. (1989). Molecular Cloning: A Laboratory Manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press.
33. VAN DAM, M., MÜLLBERG, J., SCHOOLTINK, H., STOYAN, T., BRAKENHOFF, J.P., GRAEVE, L., HEINRICH, P.C., and ROSE-JOHN, S. (1993). Structure-function analysis of interleukin-6 utilizing human/murine chimeric molecules. Involvement of two separate domains in receptor binding. J. Biol. Chem. 268, 15285-15290.
34. ACKERMANN, B., STAEGE, M.S., RESKE KUNZ, A.B., DIENES, H.P., MEYER ZUM BÜSCHENFELDE, K.H., and MÄRKER HERMANN, E. (1997). Enterobacteria-infected T cells as antigen-presenting cells for cytotoxic CD8 T cells: a contribution to the self-limitation of cellular immune reactions in reactive arthritis? J. Infect. Dis. 175, 1121-1127.
35. HOLLIGER, P., PROSPERO, T., and WINTER, G. (1993). "Diabodies": small bivalent and bispecific antibody fragments. Proc. Natl. Acad. Sci. USA 90, 6444-6448.
36. HOLLIGER, P., and WINTER, G. (1993). Engineering bispecific antibodies. Curr. Opin. Biotechnol. 4, 446-449.
37. ROSE-JOHN, S., SCHOOLTINK, H., SCHMITZ-VAN DE LEUR, H., MÜLLBERG, J., HEINRICH, P.C., and GRAEVE, L. (1993). Intracellular retention of interleukin-6 abrogates signaling. J. Biol. Chem. 268, 22084-22091.
38. NISSIM, A., HOOGENBOOM, H.R., TOMLINSON, I.M., FLYNN, G., MIDGLEY, C., LANE, D., and WINTER, G. (1994). Antibody fragments from a "single pot" phage display library as immunochemical reagents. EMBO J. 13, 692-698.
39. JOHNSON, K.S., and HAWKINS, R.E. (1996). Affinity maturation of antibodies using phage display. In: Antibody Engineering. J. McCafferty, H.R. Hoogenboom, and D.J. Chiswell (eds). Oxford, UK: Oxford University Press, pp. 41-58.
40. GRIFFITHS, A.D., WILLIAMS, S.C., HARTLEY, O., TOMLINSON, I.M., WATERHOUSE, P., CROSBY, W.L., KONTERMANN, R.E., JONES, P.T., LOW, N.M., ALLISON, T.J., PROSPERO, T.D., HOOGENBOOM, H.R., NISSIM, A., COX, J.P.L., HARRISON, J.L., ZACCOLO, M., GHERARDI, E., and WINTER, G. (1994). Isolation of high affinity human antibodies directly from large synthetic repertoires. EMBO J. 13, 3245-3260.
41. VAUGHAN, T.J., WILLIAMS, A.J., PRITCHARD, K., OSBOURN, J.K., POPE, A.R., EARNSHAW, J.C., MCCAFFERTY, J., HODITIS, R.A., WILTON, J., and JOHNSON, K.S. (1996). Human antibodies with sub-nanomolar affinities isolated from a large nonimmunized phage display library. Nat. Biotechnol 14, 309-314.
42. KASHMIRI, S.V., SHU, L., PADLAN, E.A., MILENIC, D.E., SCHLOM, J., and HAND, P.H. (1995). Generation, characterization, and in vivo studies of humanized anticarcinoma antibody CC49. Hybridoma 14, 461-473.
43. MOORE, P.S., BOSCHOFF, C., WEISS, R.A., and CHANG, Y. (1996). Molecular mimicry of human cytokine and cytokine response pathway genes by KSHV. Science 274, 1739-1744.
44. RETTIG, M.B., MA, H.J., VESCIO, R.A., POLD, M., SCHILLER, G., BELSON, D., SAVAGE, A., NISHIKUBO, C., WU, C., FRASER, J., SAID, J.W., and BERENSON, J.R. (1997). Kaposi's sarcoma-associated herpesvirus infection of bone marrow dendritic cells from multiple myeloma patients. Science 276, 1851-1854.