Mutational analysis of superantigen activity responsible for the induction of skin erythema by streptococcal pyrogenic exotoxin C

Infection and Immunity

Volumn 66, Issue 10, 1998, Pages 5020-5026

  Yamaoka, Junichi ^a   Nakamura, Eijiro ^a   Takeda, Yoshifumi ^b   Imamura, Sadao ^a   Minato, Nagahiro ^a  

^a KYOTO UNIVERSITY   (Japan)

^b NATIONAL CENTER FOR GLOBAL HEALTH AND MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL TOXIN; EXOTOXIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; SUPERANTIGEN; T LYMPHOCYTE RECEPTOR;

ANIMAL MODEL; ARTICLE; BACTERIAL INFECTION; DOSE RESPONSE; ERYTHEMA; NONHUMAN; PRIORITY JOURNAL; RABBIT; SCARLET FEVER; STREPTOCOCCUS INFECTION; T LYMPHOCYTE ACTIVATION;

EID: 0031716984     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.66.10.5020-5026.1998     Document Type: Article

References (52)

1. Abrahmsén, L., M. Dohlsren, S. Segrén, P. Björk, E. Jonsson, and T. Kalland. 1995. Characterization of two distinct MHC class II binding sites in superantigen staphylococcal enterotoxin A. EMBO J. 14:2978-2986.
2. Acharya, K. R., E. F. Passalacqua, E. Y. Jones, K. Harlos, D. I. Stuart, R. D. Brehm, and H. S. Tranter. 1994. Structural basis of superantigen action inferred from crystal structure of toxic-shock syndrome toxin-1. Nature 367:94-97.
3. Alber, G., D. K. Hammer, and B. Fleischer. 1990. Relationship between enterotoxic- and lymphocyte-stimulating activity of staphylococcal enterotoxin B. J. Immunol. 144:4501-4504.
4. Betley, M. J., D. W. Borst, and L. B. Legassa. 1992. Staphylococcal enterotoxins, toxic shock syndrome toxin and streptococcal pyrogenic exotoxins: a comparative study of their molecular biology. Chem. Immunol. 55:1-35.
5. Betley, M. J., V. L. Miller, and J. J. Mekalanos. 1986. Genetics of bacterial enterotoxins. Annu. Rev. Microbiol. 40:577-605.
6. Blanco, L., and E. M. Choi. 1990. Mutants of staphylococcal toxic shock syndrome toxin 1: mitogenicity and recognition by a neutralizing monoclonal antibody. Infect. Immun. 58:3020-3028.
7. Bohach, G. A., D. J. Fast, R. D. Nelson, and P. M. Schlievert. 1990. Staphylococcal and streptococcal pyrogenic toxins involved in toxic shock syndrome and related illness. Crit. Rev. Microbiol. 17(4):251-272.
8. Bohach, G. A., Y. Chi, and C. V. Stauffacher. 1992. Crystallization and preliminary X-ray diffraction analysis of staphylococcal enterotoxin C2. Protein 13:152-157.
9. Bonventre, P. F., H. Heeg, C. Cullen, and C.-J. Lian. 1993. Toxicity of recombinant toxic shock syndrome toxin 1 and mutant toxins produced by Staphylococcus aureus in a rabbit infection model of toxic shock syndrome. Infect. Immun. 61:793-799.
10. Braun, M. A., D. Gerlach, U. F. Hartwig, J.-H. Ozegouski, F. Romagé, S. Carrel, W. Köhler, and B. Fleischer. 1993. Stimulation of human T cells by streptococcal "superantigen" erythrogenic toxins (scarlet fever toxin). J. Immunol. 150:2457-2466.
11. Carlsson, R., and H. O. Sjogren. 1985. Kinetics of IL-2 and interferon-gamma production, expression of IL-2 receptors, and cell proliferation in human mononuclear cells exposed to staphylococcal enterotoxin A. Cell. Immunol. 96:175-183.
12. Emmel, E. A., C. L. Verweij, D. B. Durand, K. M. Higgins, E. Lacy, and G. R. Crabtree. 1989. Cyclosporin A specifically inhibits functions of nuclear proteins involved in T cell activation. Science 246:1617-1620.
13. Fast, D. J., P. M. Schlievert, and R. D. Nelson. 1989. Toxic shock syndrome-associated staphylococcal and streptococcal pyrogenic toxins are potent inducers of tumor necrosis factor production. Infect. Immun. 57:291-294.
14. Goshorn, S. C., and P. M. Schlievert. 1988. Nucleotide sequence of streptococcal pyrogenic exotoxin type C. Infect. Immun. 56:2518-2520.
15. Grossman, D., M. Van, J. A. Mollick, S. K. Highlander, and R. R. Rich. 1991. Mutation of the disulfide loop in staphylococcal enterotoxin A. Consequences for T cell recognition. J. Immunol. 147:32.74-3281.
16. Hackett, S. P., and D. L. Stevens. 1992. Streptococcal toxic shock syndrome synthesis of tumor necrosis factor and interleukin-1 by monocytes stimulated with pyrogenic exotoxin A and streptolysin O. J. Infect. Dis. 165:879-885.
17. Hackett, S. P., and D. L. Stevens. 1993. Superantigens associated with staphylococcal and streptococcal toxic shock syndrome arc potent inducers of tumor necrosis factor β synthesis. J. Infect. Dis. 168:232-235.
18. Harris T. O., D Grossman, J. W. Kappler, P. Marrack, R. K. Rich, and M. J. Betley. 1993. Lack of complete correlation between emetic and T-cell-stimulatory activities of staphylococcal enterotoxins. Infect. Immun. 61:3175-3183.
19. Harris, T. O., and M. J. Betley. 1995. Biological activities of staphylococcal enterotoxin type A mutants with N-terminal substitutions. Infect. Immun. 63:2133-2140.
20. Hartwig, U. F., and B. Fleischer. 1993. Mutations affecting MHC class II binding of the superantigen streptococcal erythrogenic toxin A. Int. Immunol. 5:869-875.
21. Hedlund, G., M. Dohlstein, T. Hermann, G. Buell, P. A. Lando, S. Segren, J. Schrimsher, H. R. Macdonald, H. D. Sjogren, and T. Kalland. 1991. A recombinant C-terminal fragment of staphylococcal enterotoxin A binds to human MHC class II products but does not activate T cells. J. Immunol. 147:4082-4085.
22. Iandolo, J. J. 1989. Genetic analysis of extracellular toxins of Staphylococcus aureus. Annu. Rev. Microbiol. 43:375-402.
23. Jardetzky, T. S., J. H. Brown, J. C. Gorga, L. J. Stern, R. G. Urban, Y. Chi, C. Stauffacher, J. L. Strominger, and D. C. Willey. 1994. Three-dimensional structure of a human class II histocompatibility molecule complexed with superantigen. Nature 368:711-718.
24. Jupin, C., S. Anderson, C. Damais, J. E. Alouf, and M. Parant. 1988. Toxic shock syndrome toxin 1 as an inducer of human tumor necrosis factors and gamma interferon. J. Exp. Mod. 167:752-761.
25. Kamezawa, Y., and T. Nakahara. 1989. Purification and characterization of streptococcal erythrogenic toxin type A produced by Streptococcus pyogenes strain NY-5 cultured in the synthetic medium NCTC-135. Comparison with the dialyzed medium (TP-medium)-derived toxin. Microbiol. Immunol. 33:183-194.
26. Kamezawa, Y., T. Nakahara, Y. Abe, and I. Kato. 1990. Increased vascular permeability, erythema, and leukocyte emigration induced in rabbit skin by streptococcal erythrogenic toxin type A. FEMS Lett. 68:159-162.
27. Kappler, J. W., A. Herman, J. Clements, and P. Marrack. 1992. Mutations defining functional regions of the superantigen staphylococcal enterotoxin B. J. Exp. Med. 175:387-396.
28. Kim, J., R. G. Urban, L. L. Strominger, and D. C. Willey. 1994. Toxic shock syndrome toxin-1 complexed with a class II major histocompatibility molecule HLA-DR1. Science 266:1870-1874.
29. Kunkel, T. A., J. D. Roberts, and R. A. Zakour. 1987. Rapid and efficient site-specific mutagenesis without phenotypic selection. Methods Enzymol. 154:367-384.
30. Li, L.-P., R. E. Tiedemann, S. L. Moffat, and J. D. Fraser. 1997. The superantigen streptococcal pyrogenic exotoxin C (SPE-C) exhibits a novel mode of action. J. Exp. Med. 186:375-383.
31. Marrack, P., and J. Kappler. 1990. The staphylococcal enterotoxins and their relatives. Science 248:705-711.
32. Mcfadden, J. M., W. C. Noble, and R. D. R. Camp. 1993. Superantigenic exotoxin-secreting potential of staphylococci isolated from atopic dermatitis. Br. J. Dermatol. 128:631-632.
33. Metzroth, B., and B. Fleischer. 1993. Concomitant loss of conformation and superantigenic activity of staphylococcal enterotoxin B deletion mutant proteins. Infect. Immun. 61:2445-2452.
34. Miethke, T., H. Gaus, C. Wahl, K. Heeg, and H. Wagner. 1992. T cell- dependent shock induced by a bacterial superantigen. Chem. Immunol. 55:172-184.
35. Müller-Alouf, H., J. E. Alouf, D. Gerlach, J.-H. Ozegowski, C. Fitting, and J.-M. Cavaillon. 1994. Comparative study of cytokine release by human peripheral blood mononuclear cells stimulated with Streptococcus pyogenes superantigenic erythrogenic toxins, heat-killed streptococci, and lipopolysaccharide. Infect. Immun. 62:4915-4921.
36. - α β T cells and endogenous IL-4 in non-MHC-restricted rejection of embryonal carcinoma in genetically resistant mice. J. Immunol. 158:5338-5348.
37. Norrby-Teglund, A., M. Norgren, S. E. Holm, U. Andersson, and J. Andersson. 1994. Similar cytokine induction profiles of a novel streptococci exotoxin, MF, and pyrogenic exotoxins A and B. Infect. Immun. 62:3731-3738.
38. Oku, Y., Y. Uesaka, T. Hirayama, and Y. Takeda. 1988. Development of highly sensitive bead-ELISA to detect bacterial protein toxins. Microbiol. Immunol. 32:807-816.
39. Papageorgiou, A. C., and K. K. Acharya. 1995. Crystal structure of the superantigenic enterotoxin C2 from Staphylococcus aureus reveals a zinc-binding site. Structure 3:769-779.
40. Passalacqua, E. F., R. D. Brehm, K. R. Acharya, and H. S. Tranter. 1993. Crystallization and preliminary X-ray analysis of a microbial superantigen staphylococcal enterotoxin C2. J. Mol. Biol. 233:170-172.
41. Pontzer, C., J. K. Russel, and H. M. Johnson. 1989. Localization of an immune functional site on staphylococcal enterotoxin A using the synthetic peptide approach. J. Immunol. 143:280-284.
42. Prasad, G. S., C. A. Earhart, D. L. Murray, R. P. Novick, P. M. Schlievert, and D. H. Ohlendorf. 1993. Structure of toxic shock syndrome-1. Biochemistry 32:13761-13766.
43. Roussel, A., B. F. Anderson, H. M. Baker, J. D. Fraser, and E. N. Baker. 1997. Crystal structure of the streptococcal superantigen SPE-C: dimerization and zinc binding suggest a novel mode of interaction with MHC class II molecules. Nat. Struct. Biol. 4:635-642.
44. Schad, E. M., I. Zaitseva, V. N. Zaltseva, M. Dohlsten, T. Kalland, P. M. Schlievert, D. H. Ohlendorf, and L. A. Svensson. 1995. Crystal structure of the superantigen staphylococcal enterotoxin type A. EMBO J. 14:3292-3301.
45. Schlievert, P. M., K. M. Bettin, and D. W. Watson. 1979. Reinterpretation of the Dick test: role of group A streptococcal pyrogenic exotoxin. Infect. Immun. 26:467-472.
46. Schlievert, P. M. 1993. Role of superantigen in human disease. J. Infect. Dis. 167:997-1002.
47. Schlievert, P. M., G. A. Bohach, D. H. Ohlendorf, C. V. Stauffacher, D. Y. M. Leung, D. A. Murray, C. A. Earhart, L. M. Jablonski, M. L. Hoffmann, and Y. Chi. 1995. Molecular structure of staphylococcal and streptococcal superantigens. J. Clin. Immunol. 15(Suppl. 6):4s-10s.
48. Seas, C. L., and J. B. Kaper. 1996. Enteric bacterial toxins: mechanisms of action and linkage to intestinal secretion. Microbiol. Rev. 60:167-215.
49. Sigal, N. H., and F. J. Dumont. 1992. Cyclosporin A, FK-506, and rapamycin: pharmacologic probes of lymphocyte signal transduction. Annu. Rev. Immunol. 10:519-560.
50. Smith, D. B., and K. S. Johnson. 1988. Single-step purification of polypeptides expressed in Escherichia coli as fusion with glutathione s-transferase. Gene 67:31-40.
51. Strange, P., L. Skov, S. Lisby, P. L. Nielsen, and O. Baadsgaad. 1996. Staphylococcal enterotoxin B applied on intact normal and intact atopic skin induces dermatitis. Arch. Dermatol. 132:27-33.
52. Swaminathan, S., W. Furey, J. Pleteher, and M. Sax. 1992. Crystal structure of staphylococcal enterotoxin B, a superantigen. Nature 359:801-806.