The interaction of myristylated peptides with the catalytic domain of protein kinase C revealed by their sequence palindromy and the identification of a myristyl binding site

Protein Engineering

Volumn 11, Issue 9, 1998, Pages 803-810

  Zaliani, Andrea ^a   Pinori, M ^a   Ball, H L ^a   DiGregorio, G ^a   Cremonesi, P ^a   Mascagni, Paolo ^a  

^a Italfarmaco SpA   (Italy)

Author keywords

Myristyl binding site; Myristylated peptides; Peptide inhibitors; Protein kinase C

Indexed keywords

CELL PROTEIN; ENZYME INHIBITOR; PALINDROMIC DNA; PEPTIDE; PROTAMINE KINASE; PROTEIN KINASE C; PROTEIN P47; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CHIRALITY; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME STRUCTURE; ENZYME SUBSTRATE; HUMAN; HUMAN CELL; MYRISTYLATION; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION;

EID: 0031716478     PISSN: 02692139     EISSN: None     Source Type: Journal    
DOI: 10.1093/protein/11.9.803     Document Type: Article

References (48)

1. Alexander, D.R., Hexham, J.M., Lucas, S.C., Graves, J.D., Cantrell, D.A. and Crumpton, M.J. (1989) Biochem. J., 260, 893-901.
2. Allen, L.-A.H. and Aderem, A. (1995) J. Exp. Med., 182, 829-840.
3. Asaoka, Y., Nakamura, S., Yoshida, K. and Nishizuka, Y. (1992) Trends Biochem. Sci., 17, 414-417.
4. Barja, P., Alavi-Nassab, A., Turck, C.W. and Freire-Moar, J. (1994) Cell. Immunol., 153, 28-38.
5. Benner, S.A. and Gerloff, D. (1991) Adv. Enz. Reg., 34, 121-127.
6. Bossmeyer, D., Engh, R.A., Kinzel, V., Postingl, H. and Huber, R. (1993) EMBO J., 12, 849-859.
7. Carver, J.A., Esposito, G., Viglino, P., Fogolari, F., Guichard, G., Briand, J.P., van Regenmortel, M.H., Brown, F. and Mascagni, P. (1997) Biopolymers, 41, 569-590.
8. Cazaubon, S., Bornancin, F. and Parker, P.J. (1994) Biochem. J., 301, 443-448.
9. Chan, J.K.-F., Hurst, M.O. and Graves, J.D. (1982) J. Biol. Chem. 257, 3655-3659.
10. Chen, S.J., Klann, E., Gower, M., Powell, C.M., Sessoms, J.S. and Sweatt, J.D. (1993) Biochemistry, 32, 1032-1039.
11. Chorev., M., Wilson, C.G. and Goodman, M. (1977) J. Am. Chem. Soc., 99, 8075-8081.
12. Doni, M.G. (1991) Biochim. Biophys. Acta, 1094, 323-328.
13. Eichholtz, T., Alblas, J., van Overveld, M., Moolenaar, W. and Ploegh, H. (1990) FEBS Lett., 261, 147-150.
14. Eichholtz, T., de Bont, D.B., de Widt, J. and Liskamp, R.M.J. (1993) J. Biol. Chem., 268, 1982-1986.
15. Epand, R.M. (1997) Biopolymers 43, 15-24.
16. Goodman, M. and Chorev, M. (1981) In Eberle, A. (ed.) Perspectives in Peptide Chemistry. S.Karger, Basel, Switzerland, pp. 283-294.
17. Graff, J.M., Rajan, R.R., Randall, R.R., Nairn, A.C. and Blackshear, P.J. (1991) J. Biol. Chem., 266, 14390-14398.
18. Guichard, G., Muller, M., van Regenmortel, M., Briand, J.P., Mascagni, P. and Giralt, E. (1996) Trends Biotechnol., 14, 35-36.
19. Gupta, K.P., Ward, N.E., Gravitt, K.R., Bergman, P.J. and O'Brian, C.A. (1996) J. Biol. Chem., 271, 2102-2111.
20. Hommel, U., Zurini, M. and Luyten, M. (1994) Nature Struct. Biol., 1, 383-387.
21. House, C. and Kemp, B.E. (1987) Science, 238, 1726-1728.
22. House, C. and Kemp, B.E. (1990) Cellular Signalling, 2, 187-190.
23. Ioannides, C.G., Freedman, R.S., Liskamp, R.M.J., Ward, N.E. and O'Brian, C.A. (1990) Cell Immunol., 131, 242-252.
24. Kemp, B.E. and Pearson, R.B. (1990) Trends Biochem. Sci., 15, 342-346.
25. Kikkawa, U. and Nishizuka, Y. (1986) In Boyer, P.D. and Krebs, E.G. (eds) The Enzymes: Control by Phosphorylation, Part A. Academic Press, New York, p. 167.
26. Knighton, D.R., Zheng, J., Ashford, V.A., Ten Eyck, L.F., Xuong, N., Taylor, S. and Sowadski, J.M. (1992a) Science, 253, 407-413.
27. Knighton, D.R., Zheng, J., Ashford, V.A., Ten Eyck, L.F., Xuong, N., Taylor, S. and Sowadski, J.M. (1992b) Science, 253, 414-421.
28. Mochly-Rosen, D. and Koshland, D.E. (1987) J. Biol. Chem., 262, 2291-2297.
29. Nishizuka, Y. (1988) Nature, 334, 661-665.
30. Noland, T.A., Raynor, R.L. and Kuo, J.F. (1989) J. Biol. Chem,. 264, 20778-20785.
31. O'Brian, C.A. and Ward, N.E. (1989) Mol. Pharmacol., 36, 355-359.
32. O'Brian, C.A. and Ward, N.E. (1991) Biochemistry, 30, 2549-2554.
33. O'Brian, C.A., Ward, N.E., Liskamp, R.M.J., de Bont, K.B. and van Boom, J.H. (1990) Biochem. Pharmacol. 39, 49-57.
34. Olah, G.A., Mitchell, R.D., Sosnick, T.R., Walsh, D.A. and Trewhella, J. (1993) Biochemistry, 32, 3649-3657.
35. Ono, Y., Fujii, T., Igarshi, K., Kuno, T., Tanaka, C., Kikkawa, U. and Nishizuka, Y. (1989) Proc. Natl. Acad. Sci. USA, 86, 4868-4871.
36. Orr, J.W. and Newton, A.C. (1994) J. Biol. Chem., 269, 8383-8387.
37. Pears, C.J., Kour, G., House, C., Kemp, B.E. and Parker, P.J. (1990) Eur. J. Biochem., 194, 89-94.
38. Peitzsch, R.M. and McLaughlin, S. (1993) Biochemistry, 32, 10436-10443.
39. Ricouart, A., Tartar, A. and Sergheraert, C. (1989) Biochem. Biophys. Res. Comm., 165, 1382-1388.
40. Rosen, A., Keenan, K.F., Thelen, M., Nairn, A.C. and Aderem, A.A. (1990) J. Exp. Med., 172, 1211-1215.
41. Sanchez, Y.M., Haack, T., Gonzalez, M.J., Ludevid, D. and Giralt, E. (1995) In Kaumaya, P.T.P. and Hodges, R.S. (eds), Peptides: Chemistry, Structure and Biology. ESCOM Science Publishers, Leiden, The Netherlands, pp. 558-560.
42. Srinavasan, N., Bax, B., Blundell, T.L. and Parker, P.J. (1996) Proteins Struct. Funct. Genet., 26, 217-235.
43. Su, H.D., Kemp, B.E., Turner, R.S. and Kuo, J.F. (1985) Biochem. Biophys. Res. Commun., 134, 78-84.
44. Turner, R.S., Kemp, B.E., Su, H.D. and Kuo, J.F. (1985) J. Biol. Chem., 260, 11503-11507.
45. Ward, N.E. and O'Brian, C.A. (1993) Biochemistry, 32, 11903-11909.
46. Williams, R.E., Chakravarthy, B.R. and Durkin, J.P. (1994) In Hernani, L.S.M. (ed.), Peptides 1994 Proceedings of the 23rd European Peptide Symposium. ESCOM Science Publishers, Leiden, The Netherlands, pp. 662-663.
47. Zaliani, A., Gromo, G., Pinori, M. and Mascagni, P. (1996) Drug Design Discovery, 13, 63-74.
48. Zhang, G., Kazanietz, M.G., Blumberg, P.M. and Hurley, J.H. (1995) Cell, 81, 917-924.