Effects of oxysterols upon macrophage and lymphocyte functions in vitro

Prostaglandins and Other Lipid Mediators

Volumn 55, Issue 4, 1998, Pages 219-236

  Dushkin, Mikhail ^a   Schwartz, Yakov ^a   Volsky, Nikolaj ^b   Musatov, Mikhail ^b   Vereschagin, Eugeni ^a   Ragino, Julia ^a   Perminova, Olga ^b   Kozlov, Vladimir ^b  

^a ENERGY SYSTEMS INSTITUTE   (Russian Federation)

^b INSTITUTE OF CLINICAL IMMUNOLOGY   (Russian Federation)

Author keywords

Lymphocytes; Macrophages; Oxysterols

Indexed keywords

25 HYDROXYCHOLESTEROL; 7 OXOCHOLESTEROL; CHOLESTEROL DERIVATIVE; FC RECEPTOR; HLA ANTIGEN; HYDROXYSTEROL; INTERLEUKIN 1; LIPOPOLYSACCHARIDE; MACROPHAGE ACTIVATING FACTOR; NEOPTERIN; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; ZYMOSAN;

ANIMAL CELL; ARTICLE; ATHEROSCLEROSIS; CELL VIABILITY; CONTROLLED STUDY; DRUG EFFECT; ERYTHROCYTE; HUMAN; HUMAN CELL; LYMPHOCYTE FUNCTION; LYMPHOCYTE PROLIFERATION; MACROPHAGE FUNCTION; MALE; MIXED LEUKOCYTE CULTURE; MONONUCLEAR CELL; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PHAGOCYTOSIS; SHEEP; SPLEEN CELL;

ANIMALS; CHOLESTEROL; CULTURE MEDIA, CONDITIONED; ERYTHROCYTES; GROWTH INHIBITORS; HUMANS; HYDROXYCHOLESTEROLS; IMMUNOSUPPRESSIVE AGENTS; INTERLEUKIN-1; KETOCHOLESTEROLS; LIPOPOLYSACCHARIDES; LYMPHOCYTE ACTIVATION; LYMPHOCYTE CULTURE TEST, MIXED; LYMPHOCYTES; MACROPHAGE ACTIVATION; MACROPHAGE-ACTIVATING FACTORS; MACROPHAGES, PERITONEAL; MALE; MICE; MICE, INBRED C57BL; NEOPTERIN; PHAGOCYTOSIS; REACTIVE OXYGEN SPECIES; RECEPTORS, FC; SHEEP; SPLEEN; THYMUS GLAND;

EID: 0031715668     PISSN: 00906980     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0090-6980(98)00024-0     Document Type: Article

References (40)

1. Smith L.L., Johnson B.N. Biological activities of oxysterols. Free Radic. Biol. Med. 7:1989;285-332.
2. Van Lier J.E., Smith L.L. Autoxidation of cholesterol via hydroperoxide intermediates. J. Org. Chem. 35:1970;2627-2632.
3. Zhang H., Basra H.J.K., Steinbrecher U.P. Effect of oxidatively modified LDL on cholesterol esterification in cultured macrophages. J. Lipid Res. 31:1990;1361-1369.
4. Lund E., Bjorkhem I. Role of oxysterols in the regulation of cholesterol homeostasis A critical evaluation . Accounts Chem. Res. 28:1995;241-249.
5. Bjorkhem I., Andersson O., Diczfalusy U., Sevastik B., Yiu R.J., Duan C.G., Lund E. Atherosclerosis and sterol 27-hydroxylase Evidence for a role of this enzyme in elimination of cholesterol from human macrophage . Proc. Natl. Acad. Sci. USA. 91:1994;8592-8596.
6. Mattsson L.H., Lindmark H., Diczfalusy U., Bjorkhem J., Ottossan M., Liu J., Bondjers G., Wiklund O. Oxysterols present in atherosclerotic tissue decrease the expression of lipoprotein lipase messenger RNA in human monocyte-derived macrophages. J. Clin. Invest. 97:1996;461-468.
7. Wu G.S., Goto H., Sevanian A., Rao N.A. Retinal lipid peroxidation in intraocular inflammation. Free Radic. Biol. Med. 9:(Suppl. 1):1990;148.
8. Demopoulos H.B., Flamm E.S., Seligman M.L., Pietronigro D.D., Tomasula J., Decrescito J. Further studies on free-radical pathology in the major central nervous system disorders Effect of very high doses of methylprednisolone on the functional outcome, morphology, and chemistry of experimental spinal cord impact injury . Can. J. Physiol. Pharmacol. 60:1982;1415-1424.
9. Kostyuk V.A., Komura S., Yagi K. Reduction of various lipid hydroperoxides by rat liver homogenates. Biochem. Int. 11:1985;803-808.
10. Yachnin S. Mevalonic acid as an initiator of cell growth Studies using human lymphocytes and inhibitors of endogenous mevalonate biosynthesis . Oncodev. Biol. Med. 3:1982;111-123.
11. Heiniger H.J., Marshall J.D. Cholesterol synthesis in polyclonally activated cytotoxic lymphocytes and its requirement for differentiation and proliferation. Proc. Natl. Acad. Sci. USA. 79:1982;3823-3827.
12. Kucuk O., Stonerpicking S., Yachnin S., Gordon L.J., Williams R.M., Lis L.J., Westerman M.P. Inhibition of cytolytic T-lymphocyte activity by oxysterols. Lipids. 29:1994;657-660.
13. Moog C., Waltzinger Y.H.C., Luu B., Bischoff P. Studies on the immunological properties of oxysterols In vivo actions of 7,25-dihydroxycholesterol upon murine peritoneal cells . Immunology. 70:1990;344-350.
14. Christ M., Luu B., Mejia J.E., Moosbrugger J., Bischoff P. Apoptosis induced by oxysterols in murine lymphoma cells and in normal thymocytes. Immunology. 78:1993;455-460.
15. Aupeix K., Toti F., Satta N., Bischoff P., Freyssinet J.-M. Oxysterols induce membrane procoagulant activity in monocytic THP-1 cells. Biochem. J. 314:1996;1027-1033.
16. Dushkin M.I., Zenkov N.K., Menshikova E.B., Pivovarova E.H., Lyubimov G.Yu., Volsky N.N. Ketoconazole inhibits oxidative modification of low density lipoprotein. Atherosclerosis. 114:1995;9-18.
17. Phillips R., Rabson A.R. The effect of IL-1 containing supernatants on murine thymocyte maturation. J. Clin. Lab. Immunol. 11:(22):1983;101-104.
18. Rummage J.A., Lev R.W. Photometric microassay for quantitation of macrophage Fc- and C3b-receptor function. J.Immunol. Meth. 77:1985;155-163.
19. Werner E.R., Werner-Fermayer G., Fushs D., Hausen A., Reinbergger G., Wachter H. Impact of tumor necrosis factor (TNF)-alpha and interferon-gamma on tetrahydrobiopterin synthesis in murine fibroblasts and macrophages. Biochem. J. 280:1991;709-714.
20. Lyubimov G. Yu., Zenkov N.K., Volsky N.N. The influence of macrophage activating factor on peritoneal macrophage chemiluminescence response. Immunologia (Rus.). 31:1992;40-43.
21. Muto S., Igarashi K., Matsumoto Y., Ogino H., Yuki H. A simple and rapid method for the determination of macrophage activating factor involving a new type of apparatus suitable for the measurement of macrophage chemiluminescence. J. Immunol. Meth. 90:1986;51-56.
22. Seledtsov V.I., Suslov A.P., Brondz B.D. Production of factor inducing expression of Ia-proteins on macrophage membrane by primary mixed lymphocyte culture in vitro. Immunologia (Rus.). 26:1987;36-39.
23. Hietter, H., Moog, G., Luu, B., Beck, J.P., Bishoff, P. Effect of 7-β-hydroxycholesterol, and 7,25-dihydroxycholesterol towards cultured murine lymphoma cells: Conditions for cytotoxicity expression. Eur. J. Cell. Biol. 42(Suppl. 15):CT 15, 41, 1986.
24. Moog C., Luu B., Beck S.P., Italiano A., Bichoff P. Studies on the immunosuppressive properties of 7,25-dihydroxycholesterol I. Reduction of interleukin production by treated lymphocytes . Int. Immunopharmac. 10:1988;511-516.
25. Clare K., Hardwick S.J., Carpenter K.L.H., Weeratunge N., Mitchinson M.J. Toxicity of oxysterols to human monocyte-derived macrophages. Atherosclerosis. 118:1995;67-75.
26. 3H]-thymidin-plattchen-modification des LTT Die gemieschte lymphocyte Kultur in Vollblut under Einsatz eines stimulator Zellpooles . Acta Biol. Med. Germ. 39:1980;1045-1050.
27. Richert L., Besk J.P., Shinitzky M. Inhibition of IL-2 secretion and IL-2 receptor appearance of activated lymphocytes pretreated with hydroxylated sterols. Immunol. Lett. 13:1986;329-334.
28. Adams D.O. Molecular interactions in macrophage activation. Immunol. Today. 10:1989;33-35.
29. Hausen A., Fuchs D., Reibnegger G., Werner E.R., Werner-Fermayer G., Wachter H. Application of neopterin - a marker for activation of cellular immunity. Clin. Chem. Sci. Pharmac. 57:1989;249-264.
30. Wang X., Briggs M.R., Hua X., Yokogama C., Goldstein J.L., Brown M.S. Nuclear protein that binds sterol regulatory element of LDL receptor promoter II. Purification and characterization . J. Biol. Chem. 268:1993;14497-14504.
31. Goldstein J.L., Brown M.S. Regulation of the mevalonate pathway. Nature. 343:1990;425-430.
32. Luu B., Moog C. Oxysterols Biological activities and physicochemical studies . Biochemie. 73:1992;1317-1320.
33. Taylor F.R. Correlation among oxysterol potencies in regulation of the degradation of 3-hydroxy-3-methylglutaryl CoA reductase, the repression of 3-hydroxy-3-methylglutaryl CoA synthase and affinities for oxysterol receptor. Biochem. Biophys. Res. Commun. 186:1989;182-190.
34. Takagi K., Alvazez J.G., Favata M.F., Trzaskos J.M., Strauss J.F. Control of low density lipoprotein receptor gene promoter activity Ketoconazole inhibits serum lipoprotein but not oxysterol suppression of gene transcription . J. Biol. Chem. 264:1989;12352-12357.
35. Benga G., Hodarnan A., Jonesu M., Pop V.J., Frangopol P.T., Strujan V., Holmes R.P., Kummerow F.A. A comparison of the effects of cholesterol and 25-hydroxycholesterol on egg yolk lecithin liposomes Spin label studies . Ann. N.Y. Acad. Sci. 414:1983;140-152.
36. Rooney M., Tamura-Lis W., Lis L., Yachnin S., Kucuk O., Kauffman J.W. The influence of oxygenated sterol compounds on dipalmitoylphosphatidilcholine bilayer structure and packing. Chem. Phys. of Lipids. 41:1986;81-92.
37. Theunissen J.S.H., Jakson R.J., Kempen H.S.M., Deml R.A. Membrane properties of oxysterols Interfacial orientation, influence on membrane permeability and redistribution between membrane . Biochim. Biophys. Acta. 860:1986;66-74.
38. Axelson M., Larsson O. LDL cholesterol is converted to 27-hydroxycholesterol in human fibroblasts. J. Biol. Chem. 270:1995;15102-15110.
39. Winegar D.A., Salisbury J.A., Sundseth S.S., Hawke R.L. Effects of cyclosporin on cholesterol 27-hydroxylation and LDL receptor activity in HepG2 cells. J. Lipid Res. 37:1996;179-191.
40. Libby P., Hansson G.K. Biology of disease Involvement of the immune system in human atherosclerosis: current knowledge and unanswered questions . Lab. Invest. 64:1991;5-15.